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The map label for this gene is hutH [H]

Identifier: 160901725

GI number: 160901725

Start: 252464

End: 254014

Strand: Direct

Name: hutH [H]

Synonym: Pmob_0239

Alternate gene names: 160901725

Gene position: 252464-254014 (Clockwise)

Preceding gene: 160901710

Following gene: 160901726

Centisome position: 11.64

GC content: 38.1

Gene sequence:

>1551_bases
TTGATCGAAAGTGAGGTCTTATATTTGAAAAAGGTCTATATAGACGGTGAACATCTGAGTTTGGAAGATGTGATTAATGT
AGCTAAACATTATTACGAAGTGGCTATCGATAAATCTGTCCTTGAGAACATTGAGAACTCCAGAAAAATTGTAGAAAAGT
TTGCAGAAGAGGAAAAAGTCATATATGGTATAACTACTGGCTTTGGAGAACTCTGTAATGTTTTCATTTCGAACGATAAA
ACAGAGAAATTACAAAAGAATCTGATCAGAAGCCATGCATGCGGAATTGGGGATCCTTTGGATATAGAAACTGTTAGAGC
GATTATGTTGCTTCGTGCGAATTCTTTGGTCAAAGGTTTTTCTGGAATAAGGTTATCCACCATACAATCTCTGATTGATA
TGATCAACAAGAAGGTTCACCCAATAATACCAGAAAAAGGATCTTTAGGAGCCAGTGGTGATCTTGCTCCTTTAGCCCAT
ATGGTTTTACCGATGATAGGAGAAGGAGAAGCTTATTACGAGGGCAAACGGTTAAATGGAAAAGAAGCGATGAAGTTGGC
GGGAATAGATACGATAAATCTTGTTGCCAAGGAAGGTCTCGCTTTGATAAATGGAACACAAGTTATGACGGCTATAGGTG
CATTATCGATATACGATAGCATAGAACTTTTAAAAACAGCAGACATAATTTCATCGTTGAGTTTTGAGGCGCTGAACGGT
GTCATCGAGGCTTTTGATGACAGGGTACACAATCTAAGACCTCATAAAGGGCAAATTGGGTCCGCTAATAATTTAAGGAA
AATACTTGAAGGTAGTAAAATGGTGTCTCATCAAGGGGTATTACGTGTTCAAGATGCTTATTCCTTGAGATGTATCCCGC
AGGTTCACGGTGCTTCACGTGATGCGGTAAATTATGTAGAAGATATCATCGTGAAAGAGATGAATGCAGCAACCGATAAT
CCTTTGATATTTTCAAAAGAAGAAGAAGCAATATCCGCGGGGAATTTTCACGGCCAACCAATTGCATTGGGCATGGACTT
TTTGGCGATTGCTTTGTCTGAAATTGCAAATATATCAGAAAGACGAATAGAAAGGCTTGTTAATCCTAAATTGAGTGGAT
TACCTCCTTTTCTGATAGAAGAAAGTGGATTGAATTCTGGGTTTATGCTGGTTCAATATTCAGCCGCTTCGTTGGTTTCA
GAAAACAAAGTCTTAGCCCATCCTGCAAGTGTTGACTCAATTCCTTCTTCTGCAAACCAGGAAGATCACGTTTCTATGGG
TACAATCGCAGCGAGAAAGGCAAAGAATATTCTAAACAACGTCCAAAAAGTATTAGCTATGGAAATGCTGTGTGCTTGCC
AAGCGATAGACTTACGAGGAAATAAAGGTTTAGGAAAAGGTTCAAAGATAGTATATGATATAGTTAGAGATAAGGTACCG
AAGATAACCGAAGACAGAGCGATGTACGAAATGATAGATAAGAGTGAAGAAATCTTAAAATCTGGCATAATCGTTAAAGA
AGTGGAAAAAGAAACTGGTAAATTATTTTAA

Upstream 100 bases:

>100_bases
CGACTTAGATTGTTTTTAATCACCATTAATTAGCTCTATTTGAAAGTGAGAAATTTTTTTCACAGTGTTATAATTTTGTT
AGAAGATGGGAAATTTTTGT

Downstream 100 bases:

>100_bases
AGAAAGGAGAAATTATCATGGTGAACAATATTGATATTTCAAATGCAATGTCCATTAAGTTGGATGATGAACTCCCTCCT
ATGCCCAAATTCATCGAAGG

Product: histidine ammonia-lyase

Products: NA

Alternate protein names: Histidase [H]

Number of amino acids: Translated: 516; Mature: 516

Protein sequence:

>516_residues
MIESEVLYLKKVYIDGEHLSLEDVINVAKHYYEVAIDKSVLENIENSRKIVEKFAEEEKVIYGITTGFGELCNVFISNDK
TEKLQKNLIRSHACGIGDPLDIETVRAIMLLRANSLVKGFSGIRLSTIQSLIDMINKKVHPIIPEKGSLGASGDLAPLAH
MVLPMIGEGEAYYEGKRLNGKEAMKLAGIDTINLVAKEGLALINGTQVMTAIGALSIYDSIELLKTADIISSLSFEALNG
VIEAFDDRVHNLRPHKGQIGSANNLRKILEGSKMVSHQGVLRVQDAYSLRCIPQVHGASRDAVNYVEDIIVKEMNAATDN
PLIFSKEEEAISAGNFHGQPIALGMDFLAIALSEIANISERRIERLVNPKLSGLPPFLIEESGLNSGFMLVQYSAASLVS
ENKVLAHPASVDSIPSSANQEDHVSMGTIAARKAKNILNNVQKVLAMEMLCACQAIDLRGNKGLGKGSKIVYDIVRDKVP
KITEDRAMYEMIDKSEEILKSGIIVKEVEKETGKLF

Sequences:

>Translated_516_residues
MIESEVLYLKKVYIDGEHLSLEDVINVAKHYYEVAIDKSVLENIENSRKIVEKFAEEEKVIYGITTGFGELCNVFISNDK
TEKLQKNLIRSHACGIGDPLDIETVRAIMLLRANSLVKGFSGIRLSTIQSLIDMINKKVHPIIPEKGSLGASGDLAPLAH
MVLPMIGEGEAYYEGKRLNGKEAMKLAGIDTINLVAKEGLALINGTQVMTAIGALSIYDSIELLKTADIISSLSFEALNG
VIEAFDDRVHNLRPHKGQIGSANNLRKILEGSKMVSHQGVLRVQDAYSLRCIPQVHGASRDAVNYVEDIIVKEMNAATDN
PLIFSKEEEAISAGNFHGQPIALGMDFLAIALSEIANISERRIERLVNPKLSGLPPFLIEESGLNSGFMLVQYSAASLVS
ENKVLAHPASVDSIPSSANQEDHVSMGTIAARKAKNILNNVQKVLAMEMLCACQAIDLRGNKGLGKGSKIVYDIVRDKVP
KITEDRAMYEMIDKSEEILKSGIIVKEVEKETGKLF
>Mature_516_residues
MIESEVLYLKKVYIDGEHLSLEDVINVAKHYYEVAIDKSVLENIENSRKIVEKFAEEEKVIYGITTGFGELCNVFISNDK
TEKLQKNLIRSHACGIGDPLDIETVRAIMLLRANSLVKGFSGIRLSTIQSLIDMINKKVHPIIPEKGSLGASGDLAPLAH
MVLPMIGEGEAYYEGKRLNGKEAMKLAGIDTINLVAKEGLALINGTQVMTAIGALSIYDSIELLKTADIISSLSFEALNG
VIEAFDDRVHNLRPHKGQIGSANNLRKILEGSKMVSHQGVLRVQDAYSLRCIPQVHGASRDAVNYVEDIIVKEMNAATDN
PLIFSKEEEAISAGNFHGQPIALGMDFLAIALSEIANISERRIERLVNPKLSGLPPFLIEESGLNSGFMLVQYSAASLVS
ENKVLAHPASVDSIPSSANQEDHVSMGTIAARKAKNILNNVQKVLAMEMLCACQAIDLRGNKGLGKGSKIVYDIVRDKVP
KITEDRAMYEMIDKSEEILKSGIIVKEVEKETGKLF

Specific function: Unknown

COG id: COG2986

COG function: function code E; Histidine ammonia-lyase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAL/histidase family [H]

Homologues:

Organism=Homo sapiens, GI4504333, Length=497, Percent_Identity=45.6740442655936, Blast_Score=458, Evalue=1e-129,
Organism=Caenorhabditis elegans, GI17567831, Length=512, Percent_Identity=45.703125, Blast_Score=430, Evalue=1e-121,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005921
- InterPro:   IPR008948
- InterPro:   IPR001106
- InterPro:   IPR022313 [H]

Pfam domain/function: PF00221 PAL [H]

EC number: =4.3.1.3 [H]

Molecular weight: Translated: 56452; Mature: 56452

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: PS00488 PAL_HISTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIESEVLYLKKVYIDGEHLSLEDVINVAKHYYEVAIDKSVLENIENSRKIVEKFAEEEKV
CCCCCEEEEEHEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCE
IYGITTGFGELCNVFISNDKTEKLQKNLIRSHACGIGDPLDIETVRAIMLLRANSLVKGF
EEEEECCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHC
SGIRLSTIQSLIDMINKKVHPIIPEKGSLGASGDLAPLAHMVLPMIGEGEAYYEGKRLNG
CCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCEECCCCCCH
KEAMKLAGIDTINLVAKEGLALINGTQVMTAIGALSIYDSIELLKTADIISSLSFEALNG
HHHHHHCCCCHHHHHHHCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VIEAFDDRVHNLRPHKGQIGSANNLRKILEGSKMVSHQGVLRVQDAYSLRCIPQVHGASR
HHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCHHHHHCCCEEECCCCCEEEEHHHCCCCH
DAVNYVEDIIVKEMNAATDNPLIFSKEEEAISAGNFHGQPIALGMDFLAIALSEIANISE
HHHHHHHHHHHHHHCCCCCCCEEECCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHH
RRIERLVNPKLSGLPPFLIEESGLNSGFMLVQYSAASLVSENKVLAHPASVDSIPSSANQ
HHHHHHHCCCCCCCCCCEEECCCCCCCEEEEEEHHHHHHCCCCEEECCCCCCCCCCCCCC
EDHVSMGTIAARKAKNILNNVQKVLAMEMLCACQAIDLRGNKGLGKGSKIVYDIVRDKVP
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCC
KITEDRAMYEMIDKSEEILKSGIIVKEVEKETGKLF
CCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCC
>Mature Secondary Structure
MIESEVLYLKKVYIDGEHLSLEDVINVAKHYYEVAIDKSVLENIENSRKIVEKFAEEEKV
CCCCCEEEEEHEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCE
IYGITTGFGELCNVFISNDKTEKLQKNLIRSHACGIGDPLDIETVRAIMLLRANSLVKGF
EEEEECCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHC
SGIRLSTIQSLIDMINKKVHPIIPEKGSLGASGDLAPLAHMVLPMIGEGEAYYEGKRLNG
CCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCEECCCCCCH
KEAMKLAGIDTINLVAKEGLALINGTQVMTAIGALSIYDSIELLKTADIISSLSFEALNG
HHHHHHCCCCHHHHHHHCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VIEAFDDRVHNLRPHKGQIGSANNLRKILEGSKMVSHQGVLRVQDAYSLRCIPQVHGASR
HHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCHHHHHCCCEEECCCCCEEEEHHHCCCCH
DAVNYVEDIIVKEMNAATDNPLIFSKEEEAISAGNFHGQPIALGMDFLAIALSEIANISE
HHHHHHHHHHHHHHCCCCCCCEEECCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHH
RRIERLVNPKLSGLPPFLIEESGLNSGFMLVQYSAASLVSENKVLAHPASVDSIPSSANQ
HHHHHHHCCCCCCCCCCEEECCCCCCCEEEEEEHHHHHHCCCCEEECCCCCCCCCCCCCC
EDHVSMGTIAARKAKNILNNVQKVLAMEMLCACQAIDLRGNKGLGKGSKIVYDIVRDKVP
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCC
KITEDRAMYEMIDKSEEILKSGIIVKEVEKETGKLF
CCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA