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The map label for this gene is proC [H]

Identifier: 160901706

GI number: 160901706

Start: 220768

End: 221592

Strand: Direct

Name: proC [H]

Synonym: Pmob_0218

Alternate gene names: 160901706

Gene position: 220768-221592 (Clockwise)

Preceding gene: 160901705

Following gene: 160901707

Centisome position: 10.18

GC content: 38.42

Gene sequence:

>825_bases
ATGAATGAAAAACTGTGTGTAATAGGATTGGGAAAAATGGGGAGCACGTTAGTAAAAGGTCTAATCCAAACAAAAACACT
TAAAAGAGAACAAATAATCGGAACAGATCTCTTTGAATACGATTCTGAAAAAAATTCTAATTACTCCGACATAAAAACTA
TCTCGGATAACGCAAAAGCGGTGAAAGAATCCGACATCGTTCTTTTAGCTGTGAAACCACAAGTAATAGACAAAGTATTG
GAAGAAATAAGTTCTTCTTGTGAAAACAAGATAGTTATATCAATAGCTGCAGGAGTAAGTCTGCGCCATTTGGATAAAGC
TTTACCAACTTCATCAAAGATAATAAGAGCTATGCCCAACACCCCTATTTTAGTAGGTGAAGGTGTTATTGCTATTAGCA
AAAAGAAGAACGTTGACGAAAATGACTTGAAAAGGGTTAAGGAGATTTTGGAAAGCGTTGGAAAGGTATATTTGGTTGAA
GAGGATATAATGGATGCGATAACGGCTTTAAGCGGGAGCGGACCAGCATATGTCTATATGATGATAGAGGCTTTATCCGA
CGGCGGTGTCCTGATGGGTTTACCTAGAGAGCTTTCCACTGAATTTGCCGCAAGAACATTACTTGGCGCTGCAAGGATGG
TTTTAGAAACGGGAAAACATCCTGGAGAGTTGAAAGATATGGTTACTTCCCCAGGAGGCACAGCAATTAAAGGAATAGAA
GTTTTAGAATCTCATGGTTTACGAGGTATCCTTATGGACGCAGTAAAAGAAGCAACTATAAGGTCAAAAGAACTTAATTC
ACAAAGGGGTGTGGATGTTGATTGA

Upstream 100 bases:

>100_bases
GGAATAAGTACACAAAAATTACATGTTCGAGGACCGATTGGAATCAACGAATTAACGACCACCAAATATATTATCTTGGG
AAACGGGCAGGTTAGATAGT

Downstream 100 bases:

>100_bases
AAGGTACTCTCTTTCTCCAATTAAAGACATTTGGACTTTAGATGCCCAGTATAAAAGATGGCTTGAAGTAGAAATAGCTG
TAATAGAAGCCTTTGAAGAA

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 274; Mature: 274

Protein sequence:

>274_residues
MNEKLCVIGLGKMGSTLVKGLIQTKTLKREQIIGTDLFEYDSEKNSNYSDIKTISDNAKAVKESDIVLLAVKPQVIDKVL
EEISSSCENKIVISIAAGVSLRHLDKALPTSSKIIRAMPNTPILVGEGVIAISKKKNVDENDLKRVKEILESVGKVYLVE
EDIMDAITALSGSGPAYVYMMIEALSDGGVLMGLPRELSTEFAARTLLGAARMVLETGKHPGELKDMVTSPGGTAIKGIE
VLESHGLRGILMDAVKEATIRSKELNSQRGVDVD

Sequences:

>Translated_274_residues
MNEKLCVIGLGKMGSTLVKGLIQTKTLKREQIIGTDLFEYDSEKNSNYSDIKTISDNAKAVKESDIVLLAVKPQVIDKVL
EEISSSCENKIVISIAAGVSLRHLDKALPTSSKIIRAMPNTPILVGEGVIAISKKKNVDENDLKRVKEILESVGKVYLVE
EDIMDAITALSGSGPAYVYMMIEALSDGGVLMGLPRELSTEFAARTLLGAARMVLETGKHPGELKDMVTSPGGTAIKGIE
VLESHGLRGILMDAVKEATIRSKELNSQRGVDVD
>Mature_274_residues
MNEKLCVIGLGKMGSTLVKGLIQTKTLKREQIIGTDLFEYDSEKNSNYSDIKTISDNAKAVKESDIVLLAVKPQVIDKVL
EEISSSCENKIVISIAAGVSLRHLDKALPTSSKIIRAMPNTPILVGEGVIAISKKKNVDENDLKRVKEILESVGKVYLVE
EDIMDAITALSGSGPAYVYMMIEALSDGGVLMGLPRELSTEFAARTLLGAARMVLETGKHPGELKDMVTSPGGTAIKGIE
VLESHGLRGILMDAVKEATIRSKELNSQRGVDVD

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI24797095, Length=269, Percent_Identity=40.5204460966543, Blast_Score=206, Evalue=2e-53,
Organism=Homo sapiens, GI24797097, Length=269, Percent_Identity=40.5204460966543, Blast_Score=205, Evalue=3e-53,
Organism=Homo sapiens, GI21361454, Length=266, Percent_Identity=39.4736842105263, Blast_Score=199, Evalue=3e-51,
Organism=Homo sapiens, GI198041662, Length=263, Percent_Identity=36.5019011406844, Blast_Score=186, Evalue=2e-47,
Organism=Escherichia coli, GI1786585, Length=270, Percent_Identity=40.7407407407407, Blast_Score=197, Evalue=4e-52,
Organism=Caenorhabditis elegans, GI17569021, Length=267, Percent_Identity=43.4456928838951, Blast_Score=216, Evalue=8e-57,
Organism=Caenorhabditis elegans, GI17540664, Length=279, Percent_Identity=34.4086021505376, Blast_Score=149, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6320861, Length=288, Percent_Identity=32.2916666666667, Blast_Score=146, Evalue=3e-36,
Organism=Drosophila melanogaster, GI21358587, Length=265, Percent_Identity=37.7358490566038, Blast_Score=197, Evalue=7e-51,
Organism=Drosophila melanogaster, GI24648116, Length=277, Percent_Identity=38.2671480144404, Blast_Score=189, Evalue=1e-48,
Organism=Drosophila melanogaster, GI24647700, Length=169, Percent_Identity=42.0118343195266, Blast_Score=152, Evalue=2e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 29523; Mature: 29523

Theoretical pI: Translated: 5.50; Mature: 5.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNEKLCVIGLGKMGSTLVKGLIQTKTLKREQIIGTDLFEYDSEKNSNYSDIKTISDNAKA
CCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCHHHHHHHCCCHHH
VKESDIVLLAVKPQVIDKVLEEISSSCENKIVISIAAGVSLRHLDKALPTSSKIIRAMPN
HCCCCEEEEEECHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHCCCHHHHHHCCCC
TPILVGEGVIAISKKKNVDENDLKRVKEILESVGKVYLVEEDIMDAITALSGSGPAYVYM
CCEEECCCEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHCCCCCEEEEE
MIEALSDGGVLMGLPRELSTEFAARTLLGAARMVLETGKHPGELKDMVTSPGGTAIKGIE
EEEHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCHHHHHH
VLESHGLRGILMDAVKEATIRSKELNSQRGVDVD
HHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MNEKLCVIGLGKMGSTLVKGLIQTKTLKREQIIGTDLFEYDSEKNSNYSDIKTISDNAKA
CCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCHHHHHHHCCCHHH
VKESDIVLLAVKPQVIDKVLEEISSSCENKIVISIAAGVSLRHLDKALPTSSKIIRAMPN
HCCCCEEEEEECHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHCCCHHHHHHCCCC
TPILVGEGVIAISKKKNVDENDLKRVKEILESVGKVYLVEEDIMDAITALSGSGPAYVYM
CCEEECCCEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHCCCCCEEEEE
MIEALSDGGVLMGLPRELSTEFAARTLLGAARMVLETGKHPGELKDMVTSPGGTAIKGIE
EEEHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCHHHHHH
VLESHGLRGILMDAVKEATIRSKELNSQRGVDVD
HHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11844777; 11932238 [H]