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The map label for this gene is proA

Identifier: 160901705

GI number: 160901705

Start: 219516

End: 220766

Strand: Direct

Name: proA

Synonym: Pmob_0217

Alternate gene names: 160901705

Gene position: 219516-220766 (Clockwise)

Preceding gene: 160901704

Following gene: 160901706

Centisome position: 10.12

GC content: 36.45

Gene sequence:

>1251_bases
GTGAATTTACAGGAATATGTCTTAAATAAGGCAAAAAAGGCTAAAGATACTTCAAGAAAATTTAGCTCCTCTTCCGAAAC
AGATAAGATCAGAATTCTTAACTATATTTCGGAAGAGCTAATGGCCAATAAAAACTATATAATATCAGAAAACCAAAAGG
ATGTCGAATCGGCTAAAAACACTGGGATGTCAAGCAGTCTTTTAGATAGATTGTTACTGAACCAGGAAAGAATCACCAAA
ATGGCTGAAGGTGTCCAAAAAGTCGCACAACTTCAAAGTAGTGTGGGCAACATCTCTCAGATGTGGAAAAGACCAAACGG
CTTGATGATTGGAAAGATGGTAGTTCCTTTAGGGGTAATCGCCATTATATATGAAAGCAGACCAAATGTAACAGTAGATG
CAGCTGCTTTATGTATAAAATCTGGTAATTGTGTGGTATTAAGAGGTGGTTCTGAAGCGATTCATTCTAACAATGCCTTA
GTAAAAATTATCCACCAAGCTATTGAAAGAGCTGGTTTCTCAAAGGATATAGTGCAGTTCATTGAGATTACAGATAGGAA
AGCCGTTGATGAATTGATGAAACTGTACGAATACATCGATGTTTTGATACCTCGAGGCGGACCATCTTTAATTAAAAATA
CCGTTGAAAATTCTATGATCCCTGTTATACAAACGGGGGCTGGAAACTGTCACGTTTATGTTGATAGACAAGCAGATCTC
GAAAAGGCACTAAAAATCGTTGAAAACGCTAAAATAAGCAGACCATCAGTATGTAACGCCGCAGAAAAATTGTTGGTTCA
CAAAGATATAGCGGAAGAGTTTCTACCAAAAATATATACACTCTTTGAAAAGAAAGTAGAATTAAGAGGTTGTGAAAAAA
CCTTGAAAATAATACCTCAAATGAAAGCGGCACAAGAAGAAGACTGGTCAACTGAATATTTAGATTACATAATGGCAGTA
AAAATTGTTGATAGCACTGAAGAAGCGATAAACCATATAAACAAGTACAGCACAAAACATTCTGAAGCCATTATAACCGA
AAATTATACGATCGCTCAAAAATTTCTAAACGAAATAGACTCTGCTGCGGTTTATGTCAATGCTTCTACGAGATTTACCG
ATGGTGAAGAGTTCGGTTTTGGTGCAGAAATGGGAATAAGTACACAAAAATTACATGTTCGAGGACCGATTGGAATCAAC
GAATTAACGACCACCAAATATATTATCTTGGGAAACGGGCAGGTTAGATAG

Upstream 100 bases:

>100_bases
GGTGAGATTTGCCTTTACTTTCACATTCAAAAAGTTATGATATAATTAAAAAACATAGAAAAAAGAACGGGGAAAAGATC
GACAGAGGGAGGGTATAATA

Downstream 100 bases:

>100_bases
TATGAATGAAAAACTGTGTGTAATAGGATTGGGAAAAATGGGGAGCACGTTAGTAAAAGGTCTAATCCAAACAAAAACAC
TTAAAAGAGAACAAATAATC

Product: gamma-glutamyl phosphate reductase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase

Number of amino acids: Translated: 416; Mature: 416

Protein sequence:

>416_residues
MNLQEYVLNKAKKAKDTSRKFSSSSETDKIRILNYISEELMANKNYIISENQKDVESAKNTGMSSSLLDRLLLNQERITK
MAEGVQKVAQLQSSVGNISQMWKRPNGLMIGKMVVPLGVIAIIYESRPNVTVDAAALCIKSGNCVVLRGGSEAIHSNNAL
VKIIHQAIERAGFSKDIVQFIEITDRKAVDELMKLYEYIDVLIPRGGPSLIKNTVENSMIPVIQTGAGNCHVYVDRQADL
EKALKIVENAKISRPSVCNAAEKLLVHKDIAEEFLPKIYTLFEKKVELRGCEKTLKIIPQMKAAQEEDWSTEYLDYIMAV
KIVDSTEEAINHINKYSTKHSEAIITENYTIAQKFLNEIDSAAVYVNASTRFTDGEEFGFGAEMGISTQKLHVRGPIGIN
ELTTTKYIILGNGQVR

Sequences:

>Translated_416_residues
MNLQEYVLNKAKKAKDTSRKFSSSSETDKIRILNYISEELMANKNYIISENQKDVESAKNTGMSSSLLDRLLLNQERITK
MAEGVQKVAQLQSSVGNISQMWKRPNGLMIGKMVVPLGVIAIIYESRPNVTVDAAALCIKSGNCVVLRGGSEAIHSNNAL
VKIIHQAIERAGFSKDIVQFIEITDRKAVDELMKLYEYIDVLIPRGGPSLIKNTVENSMIPVIQTGAGNCHVYVDRQADL
EKALKIVENAKISRPSVCNAAEKLLVHKDIAEEFLPKIYTLFEKKVELRGCEKTLKIIPQMKAAQEEDWSTEYLDYIMAV
KIVDSTEEAINHINKYSTKHSEAIITENYTIAQKFLNEIDSAAVYVNASTRFTDGEEFGFGAEMGISTQKLHVRGPIGIN
ELTTTKYIILGNGQVR
>Mature_416_residues
MNLQEYVLNKAKKAKDTSRKFSSSSETDKIRILNYISEELMANKNYIISENQKDVESAKNTGMSSSLLDRLLLNQERITK
MAEGVQKVAQLQSSVGNISQMWKRPNGLMIGKMVVPLGVIAIIYESRPNVTVDAAALCIKSGNCVVLRGGSEAIHSNNAL
VKIIHQAIERAGFSKDIVQFIEITDRKAVDELMKLYEYIDVLIPRGGPSLIKNTVENSMIPVIQTGAGNCHVYVDRQADL
EKALKIVENAKISRPSVCNAAEKLLVHKDIAEEFLPKIYTLFEKKVELRGCEKTLKIIPQMKAAQEEDWSTEYLDYIMAV
KIVDSTEEAINHINKYSTKHSEAIITENYTIAQKFLNEIDSAAVYVNASTRFTDGEEFGFGAEMGISTQKLHVRGPIGIN
ELTTTKYIILGNGQVR

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family

Homologues:

Organism=Homo sapiens, GI62912457, Length=419, Percent_Identity=34.8448687350835, Blast_Score=264, Evalue=1e-70,
Organism=Homo sapiens, GI21361368, Length=419, Percent_Identity=34.8448687350835, Blast_Score=264, Evalue=1e-70,
Organism=Escherichia coli, GI1786438, Length=408, Percent_Identity=44.8529411764706, Blast_Score=356, Evalue=2e-99,
Organism=Caenorhabditis elegans, GI17569967, Length=410, Percent_Identity=37.3170731707317, Blast_Score=290, Evalue=9e-79,
Organism=Caenorhabditis elegans, GI17569969, Length=410, Percent_Identity=37.3170731707317, Blast_Score=290, Evalue=1e-78,
Organism=Saccharomyces cerevisiae, GI6324899, Length=437, Percent_Identity=36.8421052631579, Blast_Score=281, Evalue=1e-76,
Organism=Drosophila melanogaster, GI21357643, Length=409, Percent_Identity=34.9633251833741, Blast_Score=275, Evalue=5e-74,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PROA_PETMO (A9BJ18)

Other databases:

- EMBL:   CP000879
- RefSeq:   YP_001567286.1
- ProteinModelPortal:   A9BJ18
- SMR:   A9BJ18
- GeneID:   5757670
- GenomeReviews:   CP000879_GR
- KEGG:   pmo:Pmob_0217
- HOGENOM:   HBG318080
- OMA:   QYPAACN
- BioCyc:   PMOB403833:PMOB_0217-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00412
- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR000965
- InterPro:   IPR020593
- InterPro:   IPR012134
- Gene3D:   G3DSA:3.40.309.10
- Gene3D:   G3DSA:3.40.605.10
- PANTHER:   PTHR11063:SF1
- PIRSF:   PIRSF000151
- TIGRFAMs:   TIGR00407

Pfam domain/function: PF00171 Aldedh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.2.1.41

Molecular weight: Translated: 46410; Mature: 46410

Theoretical pI: Translated: 7.53; Mature: 7.53

Prosite motif: PS01223 PROA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLQEYVLNKAKKAKDTSRKFSSSSETDKIRILNYISEELMANKNYIISENQKDVESAKN
CCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHC
TGMSSSLLDRLLLNQERITKMAEGVQKVAQLQSSVGNISQMWKRPNGLMIGKMVVPLGVI
CCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHH
AIIYESRPNVTVDAAALCIKSGNCVVLRGGSEAIHSNNALVKIIHQAIERAGFSKDIVQF
HHEEECCCCEEEHHHHHEEECCCEEEEECCCHHHHCCCHHHHHHHHHHHHCCCHHHHHHH
IEITDRKAVDELMKLYEYIDVLIPRGGPSLIKNTVENSMIPVIQTGAGNCHVYVDRQADL
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEEECCCCEEEEECCHHHH
EKALKIVENAKISRPSVCNAAEKLLVHKDIAEEFLPKIYTLFEKKVELRGCEKTLKIIPQ
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MKAAQEEDWSTEYLDYIMAVKIVDSTEEAINHINKYSTKHSEAIITENYTIAQKFLNEID
HHHCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHC
SAAVYVNASTRFTDGEEFGFGAEMGISTQKLHVRGPIGINELTTTKYIILGNGQVR
CCEEEEECCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCEEEEEECCCCCC
>Mature Secondary Structure
MNLQEYVLNKAKKAKDTSRKFSSSSETDKIRILNYISEELMANKNYIISENQKDVESAKN
CCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHC
TGMSSSLLDRLLLNQERITKMAEGVQKVAQLQSSVGNISQMWKRPNGLMIGKMVVPLGVI
CCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHH
AIIYESRPNVTVDAAALCIKSGNCVVLRGGSEAIHSNNALVKIIHQAIERAGFSKDIVQF
HHEEECCCCEEEHHHHHEEECCCEEEEECCCHHHHCCCHHHHHHHHHHHHCCCHHHHHHH
IEITDRKAVDELMKLYEYIDVLIPRGGPSLIKNTVENSMIPVIQTGAGNCHVYVDRQADL
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEEECCCCEEEEECCHHHH
EKALKIVENAKISRPSVCNAAEKLLVHKDIAEEFLPKIYTLFEKKVELRGCEKTLKIIPQ
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MKAAQEEDWSTEYLDYIMAVKIVDSTEEAINHINKYSTKHSEAIITENYTIAQKFLNEID
HHHCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHC
SAAVYVNASTRFTDGEEFGFGAEMGISTQKLHVRGPIGINELTTTKYIILGNGQVR
CCEEEEECCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA