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The map label for this gene is lysS [H]

Identifier: 160901648

GI number: 160901648

Start: 159783

End: 161291

Strand: Direct

Name: lysS [H]

Synonym: Pmob_0159

Alternate gene names: 160901648

Gene position: 159783-161291 (Clockwise)

Preceding gene: 160901647

Following gene: 160901649

Centisome position: 7.36

GC content: 34.99

Gene sequence:

>1509_bases
ATGGACCTTAGAAATATACGAATGCATCAATTAAAAGAAATGAGGGAAAAAGGATACAATCCGTATAAGTACAATTTTCA
AAAAAATTATACTTCCCAACAAATCAAAGACCTTTTCGATAGTAAAATAGAGGCTGGCCAACAATTACCGGATGAAGTTT
TTAATTTCGGCGGAAGGCTGATGAATTTAAGAAAACATGGCAAATCTGCTTTTGCTGATTTAAAAGATGAATTTGGACGT
ATCCAGGTATATATCCGTTTGGATCAAGTAGGGCAAGAAAACTATGATTTTTTCAAAGAATATATTGATATTGGAGACTG
GATAGGAATAAAAGGTTATCCCTTCAAAACGAGAACTGGCGAATTAACTCTTTTGGCTTTAGATATAGAATTACTCTCAA
AAGCTATTCGCCCTCTTCCTGAAAAATGGCATGGCCTTAAAGATAAAGAAGTTCGATATAGACAAAGATATGTGGATATG
ATCGCAAACGATGACACCATTAAAACCCTCAGAACACGTTTTTTAATCATAAAATACATCAGAGAGTATTTAAACAACAA
AGGTTTTTTAGAAGTTGAAACCCCAGTTCTTCAAAGTATAATGGGTGGAGCAAATGCAAGACCTTTTATTACCCATCTAA
ACGTATATGATATAGATATGTACTTACGCATAGCCACGGAATTACATCTAAAAAGACTAGTCGTAGGTGGGATGGAGAAA
GTTTATGAAATAGGGAAAATATTCAGAAACGAAGGTGTTTCAAACAAACATAATCCTGAATTCACATCTATTGAATTGTA
CCAAGCTTTCGCTGACTACAACGATATGATGGAACTAACCGAAGATCTCTTATACAACATTACCAAAAAAGTTCACAACA
AAGCAAAGATTATGTACCAAGGAGAAGAAATAGATTTCACACCTCCTTTCAAAAGAATAAAGATGAGAGAATTCATACAA
GAAAATCTTGGAATAGATATAGTGGAAGCTAGTGATCAGGAACTGAAAGAGTTTTTGAAAAACAAGGGTGAAGAGGTAGA
AATAGAAGACAGATACCATTACCTCGACAAAGTATGGGATTTAGTCGAAGATAAGATCGTTCAACCTACTTTTGTTATGG
ATTATCCTATCGAATTATCTCCACTGGCAAAAAGAAAAAAAGATGATCCAAGGTTAACCGAAAGGTTTGAATTAATAATA
AAGGGCAATGAAATAGCGAACGCCTTTTCTGAATTGAACGATCCTCAAGACCAATTTGAAAGGTTTAAAAAGCAAATGGA
ACTGAAAGAGTTGGGCGATGAAGAAGCTCAAATGATGGATCTTGATTTCATTAGGGCATTAGAATATGGTTTGCCTCCAA
CTGGAGGACTAGGAATAGGTATTGACAGGGTTTGTATGCTGCTTACTGATACTCCAACTATTCGCGACATTATACCTTTT
CCAATTGTAAAACCCATGGCTTTCGAAGACGAAGAAGCCATGTTAAAAGAAGAAGAGACAAACGAATGA

Upstream 100 bases:

>100_bases
ATTAAAACCGCCAGAGGAAGTTCAAAAAAAATAGAAATCAAAGAGATAAGCTAAGATTTCATAGATCACAAAACTAACCT
TACCAAGCAGGAGGCAAAGT

Downstream 100 bases:

>100_bases
AAGAGGAGTTAAATGCATTTAAAAGCCTTTGGGAAAGTTAACCTTTACTTAGATGTAATTAGTAGGAGAAAAGATAATTA
CCATAATATTTTAACCCTTT

Product: lysyl-tRNA synthetase

Products: NA

Alternate protein names: Lysine--tRNA ligase; LysRS [H]

Number of amino acids: Translated: 502; Mature: 502

Protein sequence:

>502_residues
MDLRNIRMHQLKEMREKGYNPYKYNFQKNYTSQQIKDLFDSKIEAGQQLPDEVFNFGGRLMNLRKHGKSAFADLKDEFGR
IQVYIRLDQVGQENYDFFKEYIDIGDWIGIKGYPFKTRTGELTLLALDIELLSKAIRPLPEKWHGLKDKEVRYRQRYVDM
IANDDTIKTLRTRFLIIKYIREYLNNKGFLEVETPVLQSIMGGANARPFITHLNVYDIDMYLRIATELHLKRLVVGGMEK
VYEIGKIFRNEGVSNKHNPEFTSIELYQAFADYNDMMELTEDLLYNITKKVHNKAKIMYQGEEIDFTPPFKRIKMREFIQ
ENLGIDIVEASDQELKEFLKNKGEEVEIEDRYHYLDKVWDLVEDKIVQPTFVMDYPIELSPLAKRKKDDPRLTERFELII
KGNEIANAFSELNDPQDQFERFKKQMELKELGDEEAQMMDLDFIRALEYGLPPTGGLGIGIDRVCMLLTDTPTIRDIIPF
PIVKPMAFEDEEAMLKEEETNE

Sequences:

>Translated_502_residues
MDLRNIRMHQLKEMREKGYNPYKYNFQKNYTSQQIKDLFDSKIEAGQQLPDEVFNFGGRLMNLRKHGKSAFADLKDEFGR
IQVYIRLDQVGQENYDFFKEYIDIGDWIGIKGYPFKTRTGELTLLALDIELLSKAIRPLPEKWHGLKDKEVRYRQRYVDM
IANDDTIKTLRTRFLIIKYIREYLNNKGFLEVETPVLQSIMGGANARPFITHLNVYDIDMYLRIATELHLKRLVVGGMEK
VYEIGKIFRNEGVSNKHNPEFTSIELYQAFADYNDMMELTEDLLYNITKKVHNKAKIMYQGEEIDFTPPFKRIKMREFIQ
ENLGIDIVEASDQELKEFLKNKGEEVEIEDRYHYLDKVWDLVEDKIVQPTFVMDYPIELSPLAKRKKDDPRLTERFELII
KGNEIANAFSELNDPQDQFERFKKQMELKELGDEEAQMMDLDFIRALEYGLPPTGGLGIGIDRVCMLLTDTPTIRDIIPF
PIVKPMAFEDEEAMLKEEETNE
>Mature_502_residues
MDLRNIRMHQLKEMREKGYNPYKYNFQKNYTSQQIKDLFDSKIEAGQQLPDEVFNFGGRLMNLRKHGKSAFADLKDEFGR
IQVYIRLDQVGQENYDFFKEYIDIGDWIGIKGYPFKTRTGELTLLALDIELLSKAIRPLPEKWHGLKDKEVRYRQRYVDM
IANDDTIKTLRTRFLIIKYIREYLNNKGFLEVETPVLQSIMGGANARPFITHLNVYDIDMYLRIATELHLKRLVVGGMEK
VYEIGKIFRNEGVSNKHNPEFTSIELYQAFADYNDMMELTEDLLYNITKKVHNKAKIMYQGEEIDFTPPFKRIKMREFIQ
ENLGIDIVEASDQELKEFLKNKGEEVEIEDRYHYLDKVWDLVEDKIVQPTFVMDYPIELSPLAKRKKDDPRLTERFELII
KGNEIANAFSELNDPQDQFERFKKQMELKELGDEEAQMMDLDFIRALEYGLPPTGGLGIGIDRVCMLLTDTPTIRDIIPF
PIVKPMAFEDEEAMLKEEETNE

Specific function: Also Can Synthesize A Number Of Adenyl Dinucleotides (In Particular Appppa). These Dinucleotides Have Been Proposed To Act As Modulators Of The Heat-Shock Response And Stress Response. [C]

COG id: COG1190

COG function: function code J; Lysyl-tRNA synthetase (class II)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI5031815, Length=503, Percent_Identity=41.5506958250497, Blast_Score=375, Evalue=1e-104,
Organism=Homo sapiens, GI194272210, Length=503, Percent_Identity=41.5506958250497, Blast_Score=375, Evalue=1e-104,
Organism=Homo sapiens, GI45439306, Length=465, Percent_Identity=23.6559139784946, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI226491502, Length=369, Percent_Identity=23.5772357723577, Blast_Score=83, Evalue=5e-16,
Organism=Homo sapiens, GI4758762, Length=345, Percent_Identity=23.768115942029, Blast_Score=79, Evalue=7e-15,
Organism=Escherichia coli, GI1790571, Length=496, Percent_Identity=46.7741935483871, Blast_Score=446, Evalue=1e-126,
Organism=Escherichia coli, GI1789256, Length=501, Percent_Identity=45.5089820359281, Blast_Score=439, Evalue=1e-124,
Organism=Escherichia coli, GI87082379, Length=330, Percent_Identity=30, Blast_Score=143, Evalue=2e-35,
Organism=Escherichia coli, GI1788173, Length=254, Percent_Identity=25.5905511811024, Blast_Score=72, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17535925, Length=500, Percent_Identity=40.6, Blast_Score=370, Evalue=1e-103,
Organism=Caenorhabditis elegans, GI17535927, Length=500, Percent_Identity=40.6, Blast_Score=370, Evalue=1e-103,
Organism=Caenorhabditis elegans, GI71994340, Length=499, Percent_Identity=40.4809619238477, Blast_Score=367, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI17551876, Length=467, Percent_Identity=24.8394004282655, Blast_Score=90, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI32566633, Length=183, Percent_Identity=26.775956284153, Blast_Score=73, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6320242, Length=520, Percent_Identity=40.7692307692308, Blast_Score=370, Evalue=1e-103,
Organism=Saccharomyces cerevisiae, GI6324256, Length=480, Percent_Identity=32.7083333333333, Blast_Score=216, Evalue=5e-57,
Organism=Saccharomyces cerevisiae, GI6323011, Length=463, Percent_Identity=23.3261339092873, Blast_Score=96, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6321807, Length=458, Percent_Identity=24.8908296943231, Blast_Score=87, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24640849, Length=501, Percent_Identity=41.1177644710579, Blast_Score=393, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24640851, Length=501, Percent_Identity=41.1177644710579, Blast_Score=392, Evalue=1e-109,
Organism=Drosophila melanogaster, GI17136276, Length=452, Percent_Identity=22.3451327433628, Blast_Score=89, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24584738, Length=226, Percent_Identity=27.8761061946903, Blast_Score=72, Evalue=9e-13,
Organism=Drosophila melanogaster, GI19921528, Length=333, Percent_Identity=24.9249249249249, Blast_Score=66, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004364
- InterPro:   IPR018150
- InterPro:   IPR006195
- InterPro:   IPR002313
- InterPro:   IPR018149
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR004365 [H]

Pfam domain/function: PF00152 tRNA-synt_2; PF01336 tRNA_anti [H]

EC number: =6.1.1.6 [H]

Molecular weight: Translated: 59144; Mature: 59144

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLRNIRMHQLKEMREKGYNPYKYNFQKNYTSQQIKDLFDSKIEAGQQLPDEVFNFGGRL
CCCCHHHHHHHHHHHHCCCCCEEECCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHCCHHH
MNLRKHGKSAFADLKDEFGRIQVYIRLDQVGQENYDFFKEYIDIGDWIGIKGYPFKTRTG
HHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCC
ELTLLALDIELLSKAIRPLPEKWHGLKDKEVRYRQRYVDMIANDDTIKTLRTRFLIIKYI
CEEEEEECHHHHHHHHHCCCHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
REYLNNKGFLEVETPVLQSIMGGANARPFITHLNVYDIDMYLRIATELHLKRLVVGGMEK
HHHHCCCCEEEECHHHHHHHHCCCCCCCEEEECEEEEHHHHHHHHHHHHHHHHHHHHHHH
VYEIGKIFRNEGVSNKHNPEFTSIELYQAFADYNDMMELTEDLLYNITKKVHNKAKIMYQ
HHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEC
GEEIDFTPPFKRIKMREFIQENLGIDIVEASDQELKEFLKNKGEEVEIEDRYHYLDKVWD
CCCCCCCCCHHHHHHHHHHHHHCCEEEEECCHHHHHHHHHCCCCEEEHHHHHHHHHHHHH
LVEDKIVQPTFVMDYPIELSPLAKRKKDDPRLTERFELIIKGNEIANAFSELNDPQDQFE
HHHHHCCCCEEEEECCCCCCHHHHCCCCCCHHHHHHHHEEECCHHHHHHHHCCCCHHHHH
RFKKQMELKELGDEEAQMMDLDFIRALEYGLPPTGGLGIGIDRVCMLLTDTPTIRDIIPF
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCHHHCCCC
PIVKPMAFEDEEAMLKEEETNE
CCCCCCCCCCHHHHHHHHCCCC
>Mature Secondary Structure
MDLRNIRMHQLKEMREKGYNPYKYNFQKNYTSQQIKDLFDSKIEAGQQLPDEVFNFGGRL
CCCCHHHHHHHHHHHHCCCCCEEECCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHCCHHH
MNLRKHGKSAFADLKDEFGRIQVYIRLDQVGQENYDFFKEYIDIGDWIGIKGYPFKTRTG
HHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCC
ELTLLALDIELLSKAIRPLPEKWHGLKDKEVRYRQRYVDMIANDDTIKTLRTRFLIIKYI
CEEEEEECHHHHHHHHHCCCHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
REYLNNKGFLEVETPVLQSIMGGANARPFITHLNVYDIDMYLRIATELHLKRLVVGGMEK
HHHHCCCCEEEECHHHHHHHHCCCCCCCEEEECEEEEHHHHHHHHHHHHHHHHHHHHHHH
VYEIGKIFRNEGVSNKHNPEFTSIELYQAFADYNDMMELTEDLLYNITKKVHNKAKIMYQ
HHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEC
GEEIDFTPPFKRIKMREFIQENLGIDIVEASDQELKEFLKNKGEEVEIEDRYHYLDKVWD
CCCCCCCCCHHHHHHHHHHHHHCCEEEEECCHHHHHHHHHCCCCEEEHHHHHHHHHHHHH
LVEDKIVQPTFVMDYPIELSPLAKRKKDDPRLTERFELIIKGNEIANAFSELNDPQDQFE
HHHHHCCCCEEEEECCCCCCHHHHCCCCCCHHHHHHHHEEECCHHHHHHHHCCCCHHHHH
RFKKQMELKELGDEEAQMMDLDFIRALEYGLPPTGGLGIGIDRVCMLLTDTPTIRDIIPF
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCHHHCCCC
PIVKPMAFEDEEAMLKEEETNE
CCCCCCCCCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA