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The map label for this gene is glcD [H]

Identifier: 160901622

GI number: 160901622

Start: 132839

End: 134257

Strand: Direct

Name: glcD [H]

Synonym: Pmob_0132

Alternate gene names: 160901622

Gene position: 132839-134257 (Clockwise)

Preceding gene: 160901621

Following gene: 160901623

Centisome position: 6.12

GC content: 38.83

Gene sequence:

>1419_bases
ATGAGTGAATACAGAAAGGTAACTACCAATACCGTTGAAAAGTTGAGAAAAATATTAAAAAACGATGCACTGTTGATATA
CGAGGATACAGAAAGTCTAAAAAGTTACTCAAACGATGAATCAGGTGGAGAGTATTACGCACACATGCCAGATGTTGTAG
TGAAACCAGAAACCAAAGAGCAAATTTCCCAAATAATAAAATTGGCAAACGACGAAATGATTCCCATAACACCACGAGGA
GCTGGCAGTGGATTGGCTGGTGCGGATATACCAATATATGGTGGGATAGTAATATCACTTGAGAGAATGAACAGAATAAT
AGAAATAGATTCAGAAAACTTAGTCGCTGTGGTTGAACCAGGGGTAGTCACTAACGATCTATGTAGAATTGTATCAGATA
AGGGATTATACTACGCGGGATATCCCATGAGTGTAGAAACGAGTTTCATTGGAGGCAACGTTGCTACCAATGCAGGTGGA
AGTAAGGTAATAAAATATGGAAACACAGCTCACCATATATTGGGATTAGAGGTAGTAATGCCTGACGGTGAGATAGTAGA
ATATGGGGGAAAAAGAAGAAAAGATTCTAGTGGTTACAACCTATTACAACTTTTCATTGGCTCAGAAGGAACGCTTGGAA
TATTCACAAAGATATACGTGAATCTCATACCTCAACCAGGAAAAGTCGTTGACCTGCTGGTTCCCTTTGAAAGTGTTGAA
AAAGCTATAAGCAATGTTGCACCCTTAATGGTCGAAACAAAGAGTTTGCCCTCAGGAATAGAATTCATAGACAAGAAATC
CATTTACTATGCTTCAAAATACACTGGAATGAAATTACCCTACCAAGACGAGGTAGAATCGTATCTCATAGTTCAATACG
AAGCAACGAGCTTGCAAGAAATTGAAGAATTGTACGAAAAAGGTGGAAAAGCCTTACAAAAAAATGGAGCAAAAGACGTA
TTCATAGCAGATAACAGAAGTAATTCTGAAAAGATATGGCGTATGAGAAGGAACTGGCTGGAAAGCTTAAAAGCCGTAGA
TCCGTATGTACCCACAGGAGATGTCGTAGTACCAACATCTAAGATACCTGAAATGATGACATACATCAACGAAGTAGCCA
ACGAGTTTAAAATAGATATTCCTGTGGCAGGACATGCAGCTGATGGTAACCTCCATCCTGCACCATTAAAACCAAAAAAT
CTTCCACCAAATGAATGGAAAACCTTATCGGAAGAGATACTTGGAAAAATAGCGATGAAAGCTGCCCAAATGGGTGGAGC
CATAAGCGGGGAACATGGAGTAGGGTTCATAAAAAAGGAGTTACTAAAAAAGACAAAACCAAAACAGTACAAATGGATGC
AAGAGGTAAAAGAAACGCTTGACCCTAATAACATTATGAACCCAGGGAAGTTATTCTAA

Upstream 100 bases:

>100_bases
CCAGAGGCACCGATTTTCAAGATATCTGATCTTGGAATAGTATGTGATGCTTTGGATATACTGCCGTTGTTAGAAAAAGA
AATAAAATCAGGTGATCAAA

Downstream 100 bases:

>100_bases
AAAAATTTTCAAAGAAAAGGTGATAATTTTGAAATATCTACACTTAGCTATCGACCTCGGAGCGTCAGGTGGAAAAGTAA
TGGCAGGTAACATACAGAAT

Product: FAD linked oxidase domain-containing protein

Products: 2-oxo acid; H2O2

Alternate protein names: NA

Number of amino acids: Translated: 472; Mature: 471

Protein sequence:

>472_residues
MSEYRKVTTNTVEKLRKILKNDALLIYEDTESLKSYSNDESGGEYYAHMPDVVVKPETKEQISQIIKLANDEMIPITPRG
AGSGLAGADIPIYGGIVISLERMNRIIEIDSENLVAVVEPGVVTNDLCRIVSDKGLYYAGYPMSVETSFIGGNVATNAGG
SKVIKYGNTAHHILGLEVVMPDGEIVEYGGKRRKDSSGYNLLQLFIGSEGTLGIFTKIYVNLIPQPGKVVDLLVPFESVE
KAISNVAPLMVETKSLPSGIEFIDKKSIYYASKYTGMKLPYQDEVESYLIVQYEATSLQEIEELYEKGGKALQKNGAKDV
FIADNRSNSEKIWRMRRNWLESLKAVDPYVPTGDVVVPTSKIPEMMTYINEVANEFKIDIPVAGHAADGNLHPAPLKPKN
LPPNEWKTLSEEILGKIAMKAAQMGGAISGEHGVGFIKKELLKKTKPKQYKWMQEVKETLDPNNIMNPGKLF

Sequences:

>Translated_472_residues
MSEYRKVTTNTVEKLRKILKNDALLIYEDTESLKSYSNDESGGEYYAHMPDVVVKPETKEQISQIIKLANDEMIPITPRG
AGSGLAGADIPIYGGIVISLERMNRIIEIDSENLVAVVEPGVVTNDLCRIVSDKGLYYAGYPMSVETSFIGGNVATNAGG
SKVIKYGNTAHHILGLEVVMPDGEIVEYGGKRRKDSSGYNLLQLFIGSEGTLGIFTKIYVNLIPQPGKVVDLLVPFESVE
KAISNVAPLMVETKSLPSGIEFIDKKSIYYASKYTGMKLPYQDEVESYLIVQYEATSLQEIEELYEKGGKALQKNGAKDV
FIADNRSNSEKIWRMRRNWLESLKAVDPYVPTGDVVVPTSKIPEMMTYINEVANEFKIDIPVAGHAADGNLHPAPLKPKN
LPPNEWKTLSEEILGKIAMKAAQMGGAISGEHGVGFIKKELLKKTKPKQYKWMQEVKETLDPNNIMNPGKLF
>Mature_471_residues
SEYRKVTTNTVEKLRKILKNDALLIYEDTESLKSYSNDESGGEYYAHMPDVVVKPETKEQISQIIKLANDEMIPITPRGA
GSGLAGADIPIYGGIVISLERMNRIIEIDSENLVAVVEPGVVTNDLCRIVSDKGLYYAGYPMSVETSFIGGNVATNAGGS
KVIKYGNTAHHILGLEVVMPDGEIVEYGGKRRKDSSGYNLLQLFIGSEGTLGIFTKIYVNLIPQPGKVVDLLVPFESVEK
AISNVAPLMVETKSLPSGIEFIDKKSIYYASKYTGMKLPYQDEVESYLIVQYEATSLQEIEELYEKGGKALQKNGAKDVF
IADNRSNSEKIWRMRRNWLESLKAVDPYVPTGDVVVPTSKIPEMMTYINEVANEFKIDIPVAGHAADGNLHPAPLKPKNL
PPNEWKTLSEEILGKIAMKAAQMGGAISGEHGVGFIKKELLKKTKPKQYKWMQEVKETLDPNNIMNPGKLF

Specific function: Unknown

COG id: COG0277

COG function: function code C; FAD/FMN-containing dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

Organism=Homo sapiens, GI37595756, Length=454, Percent_Identity=32.15859030837, Blast_Score=233, Evalue=4e-61,
Organism=Homo sapiens, GI37595754, Length=477, Percent_Identity=30.8176100628931, Blast_Score=226, Evalue=3e-59,
Organism=Homo sapiens, GI119964728, Length=423, Percent_Identity=30.7328605200946, Blast_Score=202, Evalue=6e-52,
Organism=Homo sapiens, GI4501993, Length=258, Percent_Identity=27.1317829457364, Blast_Score=100, Evalue=3e-21,
Organism=Escherichia coli, GI1789351, Length=448, Percent_Identity=33.2589285714286, Blast_Score=239, Evalue=4e-64,
Organism=Escherichia coli, GI1787977, Length=502, Percent_Identity=24.9003984063745, Blast_Score=124, Evalue=2e-29,
Organism=Escherichia coli, GI48994907, Length=219, Percent_Identity=29.6803652968037, Blast_Score=80, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71992373, Length=469, Percent_Identity=30.2771855010661, Blast_Score=207, Evalue=9e-54,
Organism=Caenorhabditis elegans, GI71992381, Length=469, Percent_Identity=29.2110874200426, Blast_Score=190, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI17534361, Length=485, Percent_Identity=25.979381443299, Blast_Score=168, Evalue=5e-42,
Organism=Caenorhabditis elegans, GI71992392, Length=390, Percent_Identity=28.974358974359, Blast_Score=157, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17556096, Length=182, Percent_Identity=35.1648351648352, Blast_Score=99, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6320023, Length=480, Percent_Identity=29.375, Blast_Score=202, Evalue=9e-53,
Organism=Saccharomyces cerevisiae, GI6320764, Length=490, Percent_Identity=27.3469387755102, Blast_Score=191, Evalue=3e-49,
Organism=Saccharomyces cerevisiae, GI6320027, Length=480, Percent_Identity=28.3333333333333, Blast_Score=174, Evalue=2e-44,
Organism=Drosophila melanogaster, GI18921117, Length=434, Percent_Identity=27.1889400921659, Blast_Score=186, Evalue=4e-47,
Organism=Drosophila melanogaster, GI24639277, Length=434, Percent_Identity=27.1889400921659, Blast_Score=186, Evalue=4e-47,
Organism=Drosophila melanogaster, GI24639275, Length=434, Percent_Identity=27.1889400921659, Blast_Score=186, Evalue=4e-47,
Organism=Drosophila melanogaster, GI24653753, Length=287, Percent_Identity=27.1777003484321, Blast_Score=105, Evalue=6e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR016164
- InterPro:   IPR016168
- InterPro:   IPR004113
- InterPro:   IPR004490
- InterPro:   IPR006094
- InterPro:   IPR016171 [H]

Pfam domain/function: PF02913 FAD-oxidase_C; PF01565 FAD_binding_4 [H]

EC number: 1.1.3.15

Molecular weight: Translated: 52218; Mature: 52087

Theoretical pI: Translated: 5.60; Mature: 5.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEYRKVTTNTVEKLRKILKNDALLIYEDTESLKSYSNDESGGEYYAHMPDVVVKPETKE
CCCHHHHHHHHHHHHHHHHCCCCEEEEECHHHHHHCCCCCCCCEEEEECCCEEECCCHHH
QISQIIKLANDEMIPITPRGAGSGLAGADIPIYGGIVISLERMNRIIEIDSENLVAVVEP
HHHHHHHHCCCCEEEECCCCCCCCCCCCCCCEECCEEEEEHHCCCEEEECCCCEEEEECC
GVVTNDLCRIVSDKGLYYAGYPMSVETSFIGGNVATNAGGSKVIKYGNTAHHILGLEVVM
CCHHHHHHHHHHCCCEEEECCCCEEEEEECCCCEEECCCCCEEEECCCCEEEEEEEEEEC
PDGEIVEYGGKRRKDSSGYNLLQLFIGSEGTLGIFTKIYVNLIPQPGKVVDLLVPFESVE
CCCCEECCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCCCEEEEECCHHHHH
KAISNVAPLMVETKSLPSGIEFIDKKSIYYASKYTGMKLPYQDEVESYLIVQYEATSLQE
HHHHHCCCCEEECCCCCCCHHHHCCCCEEEEECCCCCCCCCHHCCCCEEEEEECCCCHHH
IEELYEKGGKALQKNGAKDVFIADNRSNSEKIWRMRRNWLESLKAVDPYVPTGDVVVPTS
HHHHHHHCCHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCH
KIPEMMTYINEVANEFKIDIPVAGHAADGNLHPAPLKPKNLPPNEWKTLSEEILGKIAMK
HHHHHHHHHHHHHHHEEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
AAQMGGAISGEHGVGFIKKELLKKTKPKQYKWMQEVKETLDPNNIMNPGKLF
HHHHCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
SEYRKVTTNTVEKLRKILKNDALLIYEDTESLKSYSNDESGGEYYAHMPDVVVKPETKE
CCHHHHHHHHHHHHHHHHCCCCEEEEECHHHHHHCCCCCCCCEEEEECCCEEECCCHHH
QISQIIKLANDEMIPITPRGAGSGLAGADIPIYGGIVISLERMNRIIEIDSENLVAVVEP
HHHHHHHHCCCCEEEECCCCCCCCCCCCCCCEECCEEEEEHHCCCEEEECCCCEEEEECC
GVVTNDLCRIVSDKGLYYAGYPMSVETSFIGGNVATNAGGSKVIKYGNTAHHILGLEVVM
CCHHHHHHHHHHCCCEEEECCCCEEEEEECCCCEEECCCCCEEEECCCCEEEEEEEEEEC
PDGEIVEYGGKRRKDSSGYNLLQLFIGSEGTLGIFTKIYVNLIPQPGKVVDLLVPFESVE
CCCCEECCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCCCEEEEECCHHHHH
KAISNVAPLMVETKSLPSGIEFIDKKSIYYASKYTGMKLPYQDEVESYLIVQYEATSLQE
HHHHHCCCCEEECCCCCCCHHHHCCCCEEEEECCCCCCCCCHHCCCCEEEEEECCCCHHH
IEELYEKGGKALQKNGAKDVFIADNRSNSEKIWRMRRNWLESLKAVDPYVPTGDVVVPTS
HHHHHHHCCHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCH
KIPEMMTYINEVANEFKIDIPVAGHAADGNLHPAPLKPKNLPPNEWKTLSEEILGKIAMK
HHHHHHHHHHHHHHHEEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
AAQMGGAISGEHGVGFIKKELLKKTKPKQYKWMQEVKETLDPNNIMNPGKLF
HHHHCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-2-hydroxy acid; O2

Specific reaction: (S)-2-hydroxy acid + O2 = 2-oxo acid + H2O2

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969504; 9384377 [H]