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The map label for this gene is gor [H]

Identifier: 160877497

GI number: 160877497

Start: 5192231

End: 5193589

Strand: Direct

Name: gor [H]

Synonym: Sbal195_4395

Alternate gene names: 160877497

Gene position: 5192231-5193589 (Clockwise)

Preceding gene: 160877496

Following gene: 160877498

Centisome position: 97.1

GC content: 50.99

Gene sequence:

>1359_bases
ATGGCTCAACATTTTGACTATATCTGCCTAGGCGCAGGCAGCGGCGGTATCGCCTCAGCAAACCGAGCAGCAATGCGTGG
CGCTAAGGTTCTACTCATCGAAGCCAAACACGTAGGTGGCACCTGTGTAAACGTAGGCTGTGTGCCGAAAAAAGTCATGT
GGTATGGCGCCCATGTTGCCGAAGCGATGAACCTTTACGCCAAAGATTATGGTTTCGACGTCACTGTTAATAAATTCGAT
TGGAATACCTTGGTCGAGAACCGCGAAGCCTACATTGGCCGTATTCATGATGCCTACGGCCGTGGTTTTGCCAACAACAA
AGTGACGCTATTAAATGGCTACGGCCGTTTTGTCGATGGCAACACTATTGAAGTGGATGGCGAACATTACACCGCCGATC
ATATCCTTATCGCCACTGGCGGCGCGCCGACTATTCCGAATATTCCTGGTGCCGAATACGGTATCGACTCCGATGGTTTC
TTCGCCCTGCGTGAGCAACCAAAACGCGTTGCCGTTGTGGGCGCGGGCTATATCGCCGTTGAAGTCGCTGGCGTGTTACA
CGCTCTGGGCAGTGAAACTCACTTATTAGTGCGTAAACATGCGCCGCTACGTAACTTTGACCCCATCTTAGTCGACGCCC
TCGTTGAGGCCATGGCGACCGAAGGCCCAACATTGCACACCCATAGCGTGCCAAAAGCCGTGGTTAAAAATGCCGATGAC
AGCCTAACACTGAGCTTAGAAAACGGTGAAAGCATCACAGTCGATTGCTTGATTTGGGCAATTGGCCGTTCACCTGCGAC
GGGCAATATCGGCTTAGAAAACACCGAAGTGCAGTTAGATAGCAAAGGCTATGTCATCACTGACGAGCAACAAAATACGA
CTCACAAAGGAATTTACTGTGTCGGTGACATTATGGCGGGCGGTGTAGAGCTCACCCCAGTTGCGGTTAAAGCGGGCCGT
TTGTTATCCGAGCGTTTATTTAACGGCATGACAGATGCCAAAATGGATTACAGCCTGATCCCTACCGTCGTGTTCAGCCA
TCCACCAATCGGCACTATGGGTTTGACCGAACCAGAAGCCCGTACTCAATACGGCGATGATAACGTCAAAGTGTATACCT
CGACGTTTACCTCAATGTACACCGCCGTTACGGCCCATCGCCAAGCCTGTAAGATGAAGTTAGTCTGCGCTGGCAAGGAC
GAAAAAGTCGTCGGTATTCATGGTATTGGTTTTGGTATGGACGAAATCCTCCAAGGTTTCGGCGTCGCTATGAAAATGGG
CGCAACTAAGGCCGATTTCGATGCGGTCGTTGCTATCCACCCAACGGGCGCTGAAGAGTTCGTTACTATGAAGGGTTAG

Upstream 100 bases:

>100_bases
ATGCGTTAGTCATGCAATGGGCTGGTCTGTTATCGCAAACACCCCTACAATGACCTTCTGCTGTAAAGCATCTCATCCTT
GAAGTAAGACGGAGAAACTC

Downstream 100 bases:

>100_bases
TGTAGAAACTTAACTTACACACGTTCAGAAATCTGGAAAAACAATCTACACCACCTACACTTTTATATAATCAGTGAAGG
TGGTGTTACTTTCTAGGTGG

Product: glutathione reductase

Products: NA

Alternate protein names: GR; GRase [H]

Number of amino acids: Translated: 452; Mature: 451

Protein sequence:

>452_residues
MAQHFDYICLGAGSGGIASANRAAMRGAKVLLIEAKHVGGTCVNVGCVPKKVMWYGAHVAEAMNLYAKDYGFDVTVNKFD
WNTLVENREAYIGRIHDAYGRGFANNKVTLLNGYGRFVDGNTIEVDGEHYTADHILIATGGAPTIPNIPGAEYGIDSDGF
FALREQPKRVAVVGAGYIAVEVAGVLHALGSETHLLVRKHAPLRNFDPILVDALVEAMATEGPTLHTHSVPKAVVKNADD
SLTLSLENGESITVDCLIWAIGRSPATGNIGLENTEVQLDSKGYVITDEQQNTTHKGIYCVGDIMAGGVELTPVAVKAGR
LLSERLFNGMTDAKMDYSLIPTVVFSHPPIGTMGLTEPEARTQYGDDNVKVYTSTFTSMYTAVTAHRQACKMKLVCAGKD
EKVVGIHGIGFGMDEILQGFGVAMKMGATKADFDAVVAIHPTGAEEFVTMKG

Sequences:

>Translated_452_residues
MAQHFDYICLGAGSGGIASANRAAMRGAKVLLIEAKHVGGTCVNVGCVPKKVMWYGAHVAEAMNLYAKDYGFDVTVNKFD
WNTLVENREAYIGRIHDAYGRGFANNKVTLLNGYGRFVDGNTIEVDGEHYTADHILIATGGAPTIPNIPGAEYGIDSDGF
FALREQPKRVAVVGAGYIAVEVAGVLHALGSETHLLVRKHAPLRNFDPILVDALVEAMATEGPTLHTHSVPKAVVKNADD
SLTLSLENGESITVDCLIWAIGRSPATGNIGLENTEVQLDSKGYVITDEQQNTTHKGIYCVGDIMAGGVELTPVAVKAGR
LLSERLFNGMTDAKMDYSLIPTVVFSHPPIGTMGLTEPEARTQYGDDNVKVYTSTFTSMYTAVTAHRQACKMKLVCAGKD
EKVVGIHGIGFGMDEILQGFGVAMKMGATKADFDAVVAIHPTGAEEFVTMKG
>Mature_451_residues
AQHFDYICLGAGSGGIASANRAAMRGAKVLLIEAKHVGGTCVNVGCVPKKVMWYGAHVAEAMNLYAKDYGFDVTVNKFDW
NTLVENREAYIGRIHDAYGRGFANNKVTLLNGYGRFVDGNTIEVDGEHYTADHILIATGGAPTIPNIPGAEYGIDSDGFF
ALREQPKRVAVVGAGYIAVEVAGVLHALGSETHLLVRKHAPLRNFDPILVDALVEAMATEGPTLHTHSVPKAVVKNADDS
LTLSLENGESITVDCLIWAIGRSPATGNIGLENTEVQLDSKGYVITDEQQNTTHKGIYCVGDIMAGGVELTPVAVKAGRL
LSERLFNGMTDAKMDYSLIPTVVFSHPPIGTMGLTEPEARTQYGDDNVKVYTSTFTSMYTAVTAHRQACKMKLVCAGKDE
KVVGIHGIGFGMDEILQGFGVAMKMGATKADFDAVVAIHPTGAEEFVTMKG

Specific function: Maintains high levels of reduced glutathione in the cytosol [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI50301238, Length=460, Percent_Identity=51.304347826087, Blast_Score=437, Evalue=1e-122,
Organism=Homo sapiens, GI22035672, Length=459, Percent_Identity=35.5119825708061, Blast_Score=253, Evalue=4e-67,
Organism=Homo sapiens, GI33519430, Length=461, Percent_Identity=36.6594360086768, Blast_Score=253, Evalue=4e-67,
Organism=Homo sapiens, GI33519428, Length=461, Percent_Identity=36.6594360086768, Blast_Score=253, Evalue=4e-67,
Organism=Homo sapiens, GI33519426, Length=461, Percent_Identity=36.6594360086768, Blast_Score=253, Evalue=4e-67,
Organism=Homo sapiens, GI148277065, Length=461, Percent_Identity=36.6594360086768, Blast_Score=252, Evalue=4e-67,
Organism=Homo sapiens, GI148277071, Length=435, Percent_Identity=37.7011494252874, Blast_Score=252, Evalue=4e-67,
Organism=Homo sapiens, GI291045266, Length=459, Percent_Identity=33.1154684095861, Blast_Score=226, Evalue=4e-59,
Organism=Homo sapiens, GI291045268, Length=459, Percent_Identity=30.0653594771242, Blast_Score=188, Evalue=9e-48,
Organism=Homo sapiens, GI91199540, Length=459, Percent_Identity=28.5403050108932, Blast_Score=167, Evalue=1e-41,
Organism=Escherichia coli, GI1789915, Length=451, Percent_Identity=68.2926829268293, Blast_Score=628, Evalue=0.0,
Organism=Escherichia coli, GI1786307, Length=448, Percent_Identity=27.6785714285714, Blast_Score=151, Evalue=7e-38,
Organism=Escherichia coli, GI87082354, Length=460, Percent_Identity=25.4347826086956, Blast_Score=132, Evalue=7e-32,
Organism=Escherichia coli, GI87081717, Length=455, Percent_Identity=23.0769230769231, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI1787114, Length=250, Percent_Identity=30.8, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71983419, Length=452, Percent_Identity=54.646017699115, Blast_Score=429, Evalue=1e-120,
Organism=Caenorhabditis elegans, GI71983429, Length=452, Percent_Identity=54.646017699115, Blast_Score=429, Evalue=1e-120,
Organism=Caenorhabditis elegans, GI17557007, Length=473, Percent_Identity=35.3065539112051, Blast_Score=276, Evalue=1e-74,
Organism=Caenorhabditis elegans, GI71982272, Length=438, Percent_Identity=34.4748858447489, Blast_Score=244, Evalue=8e-65,
Organism=Caenorhabditis elegans, GI32565766, Length=464, Percent_Identity=28.448275862069, Blast_Score=157, Evalue=8e-39,
Organism=Saccharomyces cerevisiae, GI6325166, Length=465, Percent_Identity=49.6774193548387, Blast_Score=426, Evalue=1e-120,
Organism=Saccharomyces cerevisiae, GI6321091, Length=464, Percent_Identity=27.801724137931, Blast_Score=145, Evalue=9e-36,
Organism=Saccharomyces cerevisiae, GI6325240, Length=472, Percent_Identity=24.1525423728814, Blast_Score=111, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24640553, Length=470, Percent_Identity=37.8723404255319, Blast_Score=267, Evalue=1e-71,
Organism=Drosophila melanogaster, GI24640551, Length=470, Percent_Identity=37.8723404255319, Blast_Score=266, Evalue=2e-71,
Organism=Drosophila melanogaster, GI24640549, Length=470, Percent_Identity=37.8723404255319, Blast_Score=266, Evalue=2e-71,
Organism=Drosophila melanogaster, GI17737741, Length=473, Percent_Identity=35.7293868921776, Blast_Score=249, Evalue=4e-66,
Organism=Drosophila melanogaster, GI21358499, Length=461, Percent_Identity=28.6334056399132, Blast_Score=149, Evalue=3e-36,

Paralogues:

None

Copy number: 650 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006322
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.7 [H]

Molecular weight: Translated: 48314; Mature: 48182

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQHFDYICLGAGSGGIASANRAAMRGAKVLLIEAKHVGGTCVNVGCVPKKVMWYGAHVA
CCCCCCEEEEECCCCCCCCCCHHHHCCCEEEEEEECCCCCEEEEECCCCCHHHHHHHHHH
EAMNLYAKDYGFDVTVNKFDWNTLVENREAYIGRIHDAYGRGFANNKVTLLNGYGRFVDG
HHHHHHHHHCCCEEEEEECCCHHHHCCCHHHHEEHHHHHCCCCCCCEEEEEECCCEEECC
NTIEVDGEHYTADHILIATGGAPTIPNIPGAEYGIDSDGFFALREQPKRVAVVGAGYIAV
CEEEECCCEEEECEEEEEECCCCCCCCCCCCCCCCCCCCEEEECCCCCEEEEEECCHHHH
EVAGVLHALGSETHLLVRKHAPLRNFDPILVDALVEAMATEGPTLHTHSVPKAVVKNADD
HHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEECCCCCHHHHCCCCC
SLTLSLENGESITVDCLIWAIGRSPATGNIGLENTEVQLDSKGYVITDEQQNTTHKGIYC
CEEEEECCCCEEEEEEEEEEECCCCCCCCCCCCCCEEEECCCCCEEECCCCCCCCCCEEE
VGDIMAGGVELTPVAVKAGRLLSERLFNGMTDAKMDYSLIPTVVFSHPPIGTMGLTEPEA
EEEHHCCCEEEEEEEHHHHHHHHHHHHCCCCCCCCCCEEECEEEECCCCCCCCCCCCCHH
RTQYGDDNVKVYTSTFTSMYTAVTAHRQACKMKLVCAGKDEKVVGIHGIGFGMDEILQGF
HCCCCCCCEEEEEEHHHHHHHHHHHHHHHCEEEEEEECCCCEEEEEEECCCCHHHHHHHC
GVAMKMGATKADFDAVVAIHPTGAEEFVTMKG
CCEEECCCCCCCCCEEEEEECCCCHHEEEECC
>Mature Secondary Structure 
AQHFDYICLGAGSGGIASANRAAMRGAKVLLIEAKHVGGTCVNVGCVPKKVMWYGAHVA
CCCCCEEEEECCCCCCCCCCHHHHCCCEEEEEEECCCCCEEEEECCCCCHHHHHHHHHH
EAMNLYAKDYGFDVTVNKFDWNTLVENREAYIGRIHDAYGRGFANNKVTLLNGYGRFVDG
HHHHHHHHHCCCEEEEEECCCHHHHCCCHHHHEEHHHHHCCCCCCCEEEEEECCCEEECC
NTIEVDGEHYTADHILIATGGAPTIPNIPGAEYGIDSDGFFALREQPKRVAVVGAGYIAV
CEEEECCCEEEECEEEEEECCCCCCCCCCCCCCCCCCCCEEEECCCCCEEEEEECCHHHH
EVAGVLHALGSETHLLVRKHAPLRNFDPILVDALVEAMATEGPTLHTHSVPKAVVKNADD
HHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEECCCCCHHHHCCCCC
SLTLSLENGESITVDCLIWAIGRSPATGNIGLENTEVQLDSKGYVITDEQQNTTHKGIYC
CEEEEECCCCEEEEEEEEEEECCCCCCCCCCCCCCEEEECCCCCEEECCCCCCCCCCEEE
VGDIMAGGVELTPVAVKAGRLLSERLFNGMTDAKMDYSLIPTVVFSHPPIGTMGLTEPEA
EEEHHCCCEEEEEEEHHHHHHHHHHHHCCCCCCCCCCEEECEEEECCCCCCCCCCCCCHH
RTQYGDDNVKVYTSTFTSMYTAVTAHRQACKMKLVCAGKDEKVVGIHGIGFGMDEILQGF
HCCCCCCCEEEEEEHHHHHHHHHHHHHHHCEEEEEEECCCCEEEEEEECCCCHHHHHHHC
GVAMKMGATKADFDAVVAIHPTGAEEFVTMKG
CCEEECCCCCCCCCEEEEEECCCCHHEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3521741; 8041620; 9278503; 2006135; 8061609 [H]