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The map label for this gene is prpC [H]

Identifier: 160877244

GI number: 160877244

Start: 4902151

End: 4903290

Strand: Direct

Name: prpC [H]

Synonym: Sbal195_4141

Alternate gene names: 160877244

Gene position: 4902151-4903290 (Clockwise)

Preceding gene: 160877243

Following gene: 160877245

Centisome position: 91.68

GC content: 51.67

Gene sequence:

>1140_bases
ATGTCAGAAGCTAAAACTGTCGATAAAAAATTGAGCGGTGCAGGATTACGTGGCCAGAGCGCAGGCGAAACGGCATTGAG
CACAGTGGGCGTGTCAGGCAGCGGCCTCACGTACCGCGGTTATGATGTGAAAGATCTCGGTGAAAATGCCACCTTCGAAG
AAGTCGCCTATCTCATTCTTTACGGCGAGTTGCCCACTCAAGCCCAGCTTGATGCCTACAAAACCAAACTCAAAGGCCTT
CGCGGTCTGCCGCAAGCCTTAAAAGAAGTATTAGAACGCATTCCTGCCGAGACTCATCCTATGGATGTGATGCGTACTGG
CTGCTCTATGCTAGGTAACTTAGAAGCCGAGCACAGCTTTGCCGATCAGAGTGAAATCACCGACCGCCTATTGGCTGCGT
TCCCATCGATCATCTGTTACTGGTATCGCTTTAGTCACGATGGCGTGCGTATCGACACTGAAACCGATGACGATCAAATT
GGCGCACACTTCCTGCACTTATTACATGGTAAAGCGCCGTCGGCACTGCATGCTAAAGTGATGGACGTATCGTTAATTCT
TTATGCAGAACATGAGTTTAACGCATCAACCTTTACCGCTCGCGTCTGTGCTTCAACTCTGTCAGACATGCATTCGTGCG
TCACTGGGGCGATTGGTTCACTGCGCGGCCCGCTGCATGGCGGCGCGAACGAAGCGGCGATGGAACTCATTCAAGATATG
AAAGATGAAGCCGATGCGCGCGACATCTTAATGGGCAAACTCGAGCGTAAAGATAAGATCATGGGCTTTGGCCACGCGAT
TTACCGCGATAGCGATCCACGTAATGCCATCATCAAAGAATGGTCAGAAAAACTGGCTGCCGCCAACGGTGACGACCGTC
TATACCGCGTATCGGTTGCCTGTGAAGCCCTGATGTGGGAACAGAAAAAACTCTTCTGTAATGCAGATTTTTTCCACGCC
AGCGCGTACCACTACATGGACATTCCGACTAAGTTGTTCACGCCTATCTTCGTGTGTTCACGGGTAACGGGCTGGGCTGC
GCACGTGATGGAGCAACGCTCTAACAACCGCATCATCCGCCCAAGTGCCGATTATGTGGGCGTAGCGCCACGCAAAGTCG
TCCCCATTGCCAACCGTTAA

Upstream 100 bases:

>100_bases
AGTGCAGCCTTAACCAATAAATGTCGGCGAATGAACACTCAAAAATAAGTGTATTCATCCACCAGCAATAACCACACAGA
GTTAACGGAAGGGAAGGATT

Downstream 100 bases:

>100_bases
GCCAAGCTAACGACTCTTGGCGCGAGACTTCTGTTAAAGAAATGTCTGTGAATAGACAGTCTCGCGCCAACTTCATTTTC
CGAAATGGATGATGTTATGA

Product: methylcitrate synthase

Products: NA

Alternate protein names: Citrate synthase 2; Methylcitrate synthase [H]

Number of amino acids: Translated: 379; Mature: 378

Protein sequence:

>379_residues
MSEAKTVDKKLSGAGLRGQSAGETALSTVGVSGSGLTYRGYDVKDLGENATFEEVAYLILYGELPTQAQLDAYKTKLKGL
RGLPQALKEVLERIPAETHPMDVMRTGCSMLGNLEAEHSFADQSEITDRLLAAFPSIICYWYRFSHDGVRIDTETDDDQI
GAHFLHLLHGKAPSALHAKVMDVSLILYAEHEFNASTFTARVCASTLSDMHSCVTGAIGSLRGPLHGGANEAAMELIQDM
KDEADARDILMGKLERKDKIMGFGHAIYRDSDPRNAIIKEWSEKLAAANGDDRLYRVSVACEALMWEQKKLFCNADFFHA
SAYHYMDIPTKLFTPIFVCSRVTGWAAHVMEQRSNNRIIRPSADYVGVAPRKVVPIANR

Sequences:

>Translated_379_residues
MSEAKTVDKKLSGAGLRGQSAGETALSTVGVSGSGLTYRGYDVKDLGENATFEEVAYLILYGELPTQAQLDAYKTKLKGL
RGLPQALKEVLERIPAETHPMDVMRTGCSMLGNLEAEHSFADQSEITDRLLAAFPSIICYWYRFSHDGVRIDTETDDDQI
GAHFLHLLHGKAPSALHAKVMDVSLILYAEHEFNASTFTARVCASTLSDMHSCVTGAIGSLRGPLHGGANEAAMELIQDM
KDEADARDILMGKLERKDKIMGFGHAIYRDSDPRNAIIKEWSEKLAAANGDDRLYRVSVACEALMWEQKKLFCNADFFHA
SAYHYMDIPTKLFTPIFVCSRVTGWAAHVMEQRSNNRIIRPSADYVGVAPRKVVPIANR
>Mature_378_residues
SEAKTVDKKLSGAGLRGQSAGETALSTVGVSGSGLTYRGYDVKDLGENATFEEVAYLILYGELPTQAQLDAYKTKLKGLR
GLPQALKEVLERIPAETHPMDVMRTGCSMLGNLEAEHSFADQSEITDRLLAAFPSIICYWYRFSHDGVRIDTETDDDQIG
AHFLHLLHGKAPSALHAKVMDVSLILYAEHEFNASTFTARVCASTLSDMHSCVTGAIGSLRGPLHGGANEAAMELIQDMK
DEADARDILMGKLERKDKIMGFGHAIYRDSDPRNAIIKEWSEKLAAANGDDRLYRVSVACEALMWEQKKLFCNADFFHAS
AYHYMDIPTKLFTPIFVCSRVTGWAAHVMEQRSNNRIIRPSADYVGVAPRKVVPIANR

Specific function: Catalyzes the synthesis of 2-methylcitrate from propionyl-CoA and oxaloacetate. Also catalyzes the condensation of oxaloacetate with acetyl-CoA but with a lower specificity [H]

COG id: COG0372

COG function: function code C; Citrate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the citrate synthase family [H]

Homologues:

Organism=Homo sapiens, GI38327625, Length=377, Percent_Identity=23.0769230769231, Blast_Score=79, Evalue=1e-14,
Organism=Escherichia coli, GI1786527, Length=382, Percent_Identity=51.5706806282722, Blast_Score=399, Evalue=1e-112,
Organism=Escherichia coli, GI1786939, Length=378, Percent_Identity=29.8941798941799, Blast_Score=171, Evalue=7e-44,
Organism=Caenorhabditis elegans, GI17555174, Length=354, Percent_Identity=24.0112994350282, Blast_Score=93, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6319850, Length=372, Percent_Identity=24.1935483870968, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6324328, Length=281, Percent_Identity=24.9110320284698, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24640126, Length=379, Percent_Identity=23.2189973614776, Blast_Score=93, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24640124, Length=379, Percent_Identity=23.2189973614776, Blast_Score=92, Evalue=5e-19,
Organism=Drosophila melanogaster, GI21356863, Length=362, Percent_Identity=21.8232044198895, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011278
- InterPro:   IPR016142
- InterPro:   IPR016143
- InterPro:   IPR002020
- InterPro:   IPR016141
- InterPro:   IPR019810 [H]

Pfam domain/function: PF00285 Citrate_synt [H]

EC number: =2.3.3.5 [H]

Molecular weight: Translated: 41850; Mature: 41719

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: PS00480 CITRATE_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEAKTVDKKLSGAGLRGQSAGETALSTVGVSGSGLTYRGYDVKDLGENATFEEVAYLIL
CCCHHHHHHHHCCCCCCCCCCCCHHHHHCCCCCCCCEECCCCHHHCCCCCCHHHHEEEEE
YGELPTQAQLDAYKTKLKGLRGLPQALKEVLERIPAETHPMDVMRTGCSMLGNLEAEHSF
ECCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCHHHCC
ADQSEITDRLLAAFPSIICYWYRFSHDGVRIDTETDDDQIGAHFLHLLHGKAPSALHAKV
CCHHHHHHHHHHHHHHHHHHHHEECCCCEEEECCCCCHHHHHHHHHHHHCCCCHHHHHHH
MDVSLILYAEHEFNASTFTARVCASTLSDMHSCVTGAIGSLRGPLHGGANEAAMELIQDM
EEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
KDEADARDILMGKLERKDKIMGFGHAIYRDSDPRNAIIKEWSEKLAAANGDDRLYRVSVA
HHHCCHHHHHHHHHHHHHHHHHCCHHEECCCCCHHHHHHHHHHHHHCCCCCCCEEEHHHH
CEALMWEQKKLFCNADFFHASAYHYMDIPTKLFTPIFVCSRVTGWAAHVMEQRSNNRIIR
HHHHHHHHHHHEECCCHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEC
PSADYVGVAPRKVVPIANR
CCCCCCCCCCCEECCCCCC
>Mature Secondary Structure 
SEAKTVDKKLSGAGLRGQSAGETALSTVGVSGSGLTYRGYDVKDLGENATFEEVAYLIL
CCHHHHHHHHCCCCCCCCCCCCHHHHHCCCCCCCCEECCCCHHHCCCCCCHHHHEEEEE
YGELPTQAQLDAYKTKLKGLRGLPQALKEVLERIPAETHPMDVMRTGCSMLGNLEAEHSF
ECCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCHHHCC
ADQSEITDRLLAAFPSIICYWYRFSHDGVRIDTETDDDQIGAHFLHLLHGKAPSALHAKV
CCHHHHHHHHHHHHHHHHHHHHEECCCCEEEECCCCCHHHHHHHHHHHHCCCCHHHHHHH
MDVSLILYAEHEFNASTFTARVCASTLSDMHSCVTGAIGSLRGPLHGGANEAAMELIQDM
EEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
KDEADARDILMGKLERKDKIMGFGHAIYRDSDPRNAIIKEWSEKLAAANGDDRLYRVSVA
HHHCCHHHHHHHHHHHHHHHHHCCHHEECCCCCHHHHHHHHHHHHHCCCCCCCEEEHHHH
CEALMWEQKKLFCNADFFHASAYHYMDIPTKLFTPIFVCSRVTGWAAHVMEQRSNNRIIR
HHHHHHHHHHHEECCCHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEC
PSADYVGVAPRKVVPIANR
CCCCCCCCCCCEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9278503; 8508809; 9325432 [H]