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The map label for this gene is hemD [H]

Identifier: 160877199

GI number: 160877199

Start: 4828338

End: 4829078

Strand: Direct

Name: hemD [H]

Synonym: Sbal195_4095

Alternate gene names: 160877199

Gene position: 4828338-4829078 (Clockwise)

Preceding gene: 160877198

Following gene: 160877200

Centisome position: 90.3

GC content: 52.36

Gene sequence:

>741_bases
ATGAAAGTCTTACTGACGCGCCCCGAGGGGCGCAATCAGTCCATGGTCGATGCCTTGAATGAACGAGGCATTGCCCACTG
GGTCACACCTCTGCTGTGTGTCGAAGCAACGCCCGCTATCGCAACGAATACCCCGCATCCTTTGGCACACGCCGATATGA
TTATCTGCATCAGCGCCAATGCTGTAACTTTTGCAGATAACGCCTTAACAGCTGCGAATCCACACACCAAAGCTTGGCCT
CCAGCTCAGTACTTCGCCGTGGGCCATGCGACTTGGGACGCATTAGACCAACTCGGTATTTCTGCCCTCGAAGCCCCAGA
TGATTGCCAGCAGACCGAAGGGCTACTCACACTCGCGCCGCTGCAAGAGATTAAAGGTAAGCAGATTACTATTATACGTG
GTGTCGGTGGCCGCGAAGCCTTAGCCGAACAACTGGCTGCGCGCGGTGCACATTTGCGCTATTGGGAAGTGTATCAACGA
GCTTGCCCGCCACTCGATGGTCAACAGTTAGCTCTGCAATGGCAAGCCTTCGGGATAGACACTATTGTGGTGACCAGCGG
TGAAGTACTGGATAACCTGATTAATTTAGTGCCAAAAGAGTTATTTGCATGGCTGCGCTCATGTCATATCATAGTCCCAA
GTAACCGAGTAGAAGCTCAAGCTCACGCCTTTGGTATAACCCAAGTCACCAATGCCAATGCCGCCAACAGCAAAGCCGTG
CTAAACGCCCTTAAACTCTAA

Upstream 100 bases:

>100_bases
AAAACCGACGCCACGCAATTAGGTGTTGCCCTTGCTGAAGAGTTACTCAGCAAAGGTGCCAAAAGCATTCTCGACGCCGT
TTACGCTAAAGCCTAAGTCA

Downstream 100 bases:

>100_bases
GCGCTATTTAGCCCGATTTTACTCGAATTTCGGCAGTAGCATGTTTTCAAGGACTGTTAAATGGATAACAACAAGCACGA
CGCCAAGAGCCCAGAATCAG

Product: uroporphyrinogen III synthase HEM4

Products: NA

Alternate protein names: UROS; Hydroxymethylbilane hydrolyase [cyclizing]; Uroporphyrinogen-III cosynthase [H]

Number of amino acids: Translated: 246; Mature: 246

Protein sequence:

>246_residues
MKVLLTRPEGRNQSMVDALNERGIAHWVTPLLCVEATPAIATNTPHPLAHADMIICISANAVTFADNALTAANPHTKAWP
PAQYFAVGHATWDALDQLGISALEAPDDCQQTEGLLTLAPLQEIKGKQITIIRGVGGREALAEQLAARGAHLRYWEVYQR
ACPPLDGQQLALQWQAFGIDTIVVTSGEVLDNLINLVPKELFAWLRSCHIIVPSNRVEAQAHAFGITQVTNANAANSKAV
LNALKL

Sequences:

>Translated_246_residues
MKVLLTRPEGRNQSMVDALNERGIAHWVTPLLCVEATPAIATNTPHPLAHADMIICISANAVTFADNALTAANPHTKAWP
PAQYFAVGHATWDALDQLGISALEAPDDCQQTEGLLTLAPLQEIKGKQITIIRGVGGREALAEQLAARGAHLRYWEVYQR
ACPPLDGQQLALQWQAFGIDTIVVTSGEVLDNLINLVPKELFAWLRSCHIIVPSNRVEAQAHAFGITQVTNANAANSKAV
LNALKL
>Mature_246_residues
MKVLLTRPEGRNQSMVDALNERGIAHWVTPLLCVEATPAIATNTPHPLAHADMIICISANAVTFADNALTAANPHTKAWP
PAQYFAVGHATWDALDQLGISALEAPDDCQQTEGLLTLAPLQEIKGKQITIIRGVGGREALAEQLAARGAHLRYWEVYQR
ACPPLDGQQLALQWQAFGIDTIVVTSGEVLDNLINLVPKELFAWLRSCHIIVPSNRVEAQAHAFGITQVTNANAANSKAV
LNALKL

Specific function: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III [H]

COG id: COG1587

COG function: function code H; Uroporphyrinogen-III synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen-III synthase family [H]

Homologues:

Organism=Escherichia coli, GI1790236, Length=250, Percent_Identity=34.8, Blast_Score=134, Evalue=4e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003754 [H]

Pfam domain/function: PF02602 HEM4 [H]

EC number: =4.2.1.75 [H]

Molecular weight: Translated: 26584; Mature: 26584

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVLLTRPEGRNQSMVDALNERGIAHWVTPLLCVEATPAIATNTPHPLAHADMIICISAN
CEEEEECCCCCCHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECC
AVTFADNALTAANPHTKAWPPAQYFAVGHATWDALDQLGISALEAPDDCQQTEGLLTLAP
EEEEECCCEECCCCCCCCCCCHHHEEECHHHHHHHHHHCCHHCCCCCHHHHHCCCEEEEC
LQEIKGKQITIIRGVGGREALAEQLAARGAHLRYWEVYQRACPPLDGQQLALQWQAFGID
HHHHCCCEEEEEECCCCHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCEEEEEEEEECCE
TIVVTSGEVLDNLINLVPKELFAWLRSCHIIVPSNRVEAQAHAFGITQVTNANAANSKAV
EEEEECHHHHHHHHHHHHHHHHHHHHHCEEEECCCCCCHHHHHCCEEEECCCCCCCHHHH
LNALKL
HHHHCC
>Mature Secondary Structure
MKVLLTRPEGRNQSMVDALNERGIAHWVTPLLCVEATPAIATNTPHPLAHADMIICISAN
CEEEEECCCCCCHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECC
AVTFADNALTAANPHTKAWPPAQYFAVGHATWDALDQLGISALEAPDDCQQTEGLLTLAP
EEEEECCCEECCCCCCCCCCCHHHEEECHHHHHHHHHHCCHHCCCCCHHHHHCCCEEEEC
LQEIKGKQITIIRGVGGREALAEQLAARGAHLRYWEVYQRACPPLDGQQLALQWQAFGID
HHHHCCCEEEEEECCCCHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCEEEEEEEEECCE
TIVVTSGEVLDNLINLVPKELFAWLRSCHIIVPSNRVEAQAHAFGITQVTNANAANSKAV
EEEEECHHHHHHHHHHHHHHHHHHHHHCEEEECCCCCCHHHHHCCEEEECCCCCCCHHHH
LNALKL
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11677609 [H]