Click here to switch to the map view.

The map label for this gene is hemC [H]

Identifier: 160877198

GI number: 160877198

Start: 4827401

End: 4828333

Strand: Direct

Name: hemC [H]

Synonym: Sbal195_4094

Alternate gene names: 160877198

Gene position: 4827401-4828333 (Clockwise)

Preceding gene: 160877196

Following gene: 160877199

Centisome position: 90.28

GC content: 50.91

Gene sequence:

>933_bases
ATGTCTGAGAACCGCATACGTATCGCAACCCGCAAGAGTCCGCTGGCCATGTGGCAAGCTGAATTTGTTAAAGCCGAATT
AGAACGCATTCACCCAGGTATTGTGGTGGAATTGCTGCCAATGAGCACTAAAGGCGACGTTATCTTAGATACGCCGCTAG
CCAAAGTGGGCGGTAAAGGTTTGTTCGTCAAAGAGCTTGAAGTCGCTATGTTAGACGATCTTGCCGATATCGCAGTGCAC
TCAATGAAAGACGTGCCAGTCGACTTCCCTGAAGGCTTAGGCCTTGAAGTGATTTGCGAGCGCGAAGATCCCCGCGATGC
CTTTGTATCGAATTTATATAAATCGATCAGCGAATTACCATTAGGCGCAACTGTGGGCACCTCAAGCCTACGCCGTCAAT
GTCAGATACGAGCATCACGTCCCGACCTCATCATCAAAGATTTACGCGGTAACGTGGGTACGCGTTTAGCTAAGCTCGAT
AACGGCGAATACGATGCCATTATTCTTGCCGCTGCTGGCTTAATCCGTCTGAAATTGTCTGAGCGTATTGCCAGCTTTAT
TTCGGCCGAAGAATCCTTACCCGCCAACGGCCAAGGCGCCGTGGGTATCGAATGTCGCATCAACGACGAACGTGTTAAAG
CGCTACTGGCGCCATTAGAGCATTTAGAAACTCGCTACCGTGTTCTTGCCGAGCGCGCGATGAACACGCGCCTTGAAGGT
GGATGCCAAGTGCCGATTGGCGCATTTGCTGAAATCGATGGTGACGAGATGACGCTACGCGGCCTAGTCGGTAACCCAGA
TGGCAGTGAAATCATCGAAGGCGTGATCACAGGTCCAAAAACCGACGCCACGCAATTAGGTGTTGCCCTTGCTGAAGAGT
TACTCAGCAAAGGTGCCAAAAGCATTCTCGACGCCGTTTACGCTAAAGCCTAA

Upstream 100 bases:

>100_bases
TAGAACATCGCCGACTTCAAAGAATCGATACGGCTTCCTTACATAAACGATTTGCCAATGTTAGCATTGGCGCAACTAAG
ATCTTTGATGGAAACTAGGC

Downstream 100 bases:

>100_bases
GTCAATGAAAGTCTTACTGACGCGCCCCGAGGGGCGCAATCAGTCCATGGTCGATGCCTTGAATGAACGAGGCATTGCCC
ACTGGGTCACACCTCTGCTG

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase [H]

Number of amino acids: Translated: 310; Mature: 309

Protein sequence:

>310_residues
MSENRIRIATRKSPLAMWQAEFVKAELERIHPGIVVELLPMSTKGDVILDTPLAKVGGKGLFVKELEVAMLDDLADIAVH
SMKDVPVDFPEGLGLEVICEREDPRDAFVSNLYKSISELPLGATVGTSSLRRQCQIRASRPDLIIKDLRGNVGTRLAKLD
NGEYDAIILAAAGLIRLKLSERIASFISAEESLPANGQGAVGIECRINDERVKALLAPLEHLETRYRVLAERAMNTRLEG
GCQVPIGAFAEIDGDEMTLRGLVGNPDGSEIIEGVITGPKTDATQLGVALAEELLSKGAKSILDAVYAKA

Sequences:

>Translated_310_residues
MSENRIRIATRKSPLAMWQAEFVKAELERIHPGIVVELLPMSTKGDVILDTPLAKVGGKGLFVKELEVAMLDDLADIAVH
SMKDVPVDFPEGLGLEVICEREDPRDAFVSNLYKSISELPLGATVGTSSLRRQCQIRASRPDLIIKDLRGNVGTRLAKLD
NGEYDAIILAAAGLIRLKLSERIASFISAEESLPANGQGAVGIECRINDERVKALLAPLEHLETRYRVLAERAMNTRLEG
GCQVPIGAFAEIDGDEMTLRGLVGNPDGSEIIEGVITGPKTDATQLGVALAEELLSKGAKSILDAVYAKA
>Mature_309_residues
SENRIRIATRKSPLAMWQAEFVKAELERIHPGIVVELLPMSTKGDVILDTPLAKVGGKGLFVKELEVAMLDDLADIAVHS
MKDVPVDFPEGLGLEVICEREDPRDAFVSNLYKSISELPLGATVGTSSLRRQCQIRASRPDLIIKDLRGNVGTRLAKLDN
GEYDAIILAAAGLIRLKLSERIASFISAEESLPANGQGAVGIECRINDERVKALLAPLEHLETRYRVLAERAMNTRLEGG
CQVPIGAFAEIDGDEMTLRGLVGNPDGSEIIEGVITGPKTDATQLGVALAEELLSKGAKSILDAVYAKA

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps [H]

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family [H]

Homologues:

Organism=Homo sapiens, GI66933009, Length=332, Percent_Identity=41.2650602409639, Blast_Score=230, Evalue=1e-60,
Organism=Homo sapiens, GI20149500, Length=332, Percent_Identity=41.2650602409639, Blast_Score=230, Evalue=1e-60,
Organism=Escherichia coli, GI48994974, Length=307, Percent_Identity=69.7068403908795, Blast_Score=425, Evalue=1e-120,
Organism=Saccharomyces cerevisiae, GI6319996, Length=321, Percent_Identity=38.6292834890966, Blast_Score=195, Evalue=6e-51,
Organism=Drosophila melanogaster, GI20130425, Length=261, Percent_Identity=42.5287356321839, Blast_Score=206, Evalue=1e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418 [H]

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC [H]

EC number: =2.5.1.61 [H]

Molecular weight: Translated: 33433; Mature: 33302

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSENRIRIATRKSPLAMWQAEFVKAELERIHPGIVVELLPMSTKGDVILDTPLAKVGGKG
CCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCEEEECCHHHHCCCC
LFVKELEVAMLDDLADIAVHSMKDVPVDFPEGLGLEVICEREDPRDAFVSNLYKSISELP
EEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHCC
LGATVGTSSLRRQCQIRASRPDLIIKDLRGNVGTRLAKLDNGEYDAIILAAAGLIRLKLS
CCCCCCHHHHHHHHHHCCCCCCEEHHHHCCCHHHEEEECCCCCCCEEEEEHHHHHHHHHH
ERIASFISAEESLPANGQGAVGIECRINDERVKALLAPLEHLETRYRVLAERAMNTRLEG
HHHHHHHHHHHCCCCCCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
GCQVPIGAFAEIDGDEMTLRGLVGNPDGSEIIEGVITGPKTDATQLGVALAEELLSKGAK
CCCCCCCCCEECCCCCEEEEEECCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
SILDAVYAKA
HHHHHHHHCC
>Mature Secondary Structure 
SENRIRIATRKSPLAMWQAEFVKAELERIHPGIVVELLPMSTKGDVILDTPLAKVGGKG
CCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCEEEECCHHHHCCCC
LFVKELEVAMLDDLADIAVHSMKDVPVDFPEGLGLEVICEREDPRDAFVSNLYKSISELP
EEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHCC
LGATVGTSSLRRQCQIRASRPDLIIKDLRGNVGTRLAKLDNGEYDAIILAAAGLIRLKLS
CCCCCCHHHHHHHHHHCCCCCCEEHHHHCCCHHHEEEECCCCCCCEEEEEHHHHHHHHHH
ERIASFISAEESLPANGQGAVGIECRINDERVKALLAPLEHLETRYRVLAERAMNTRLEG
HHHHHHHHHHHCCCCCCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
GCQVPIGAFAEIDGDEMTLRGLVGNPDGSEIIEGVITGPKTDATQLGVALAEELLSKGAK
CCCCCCCCCEECCCCCEEEEEECCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
SILDAVYAKA
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA