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The map label for this gene is trxA [H]

Identifier: 160877174

GI number: 160877174

Start: 4802403

End: 4802729

Strand: Direct

Name: trxA [H]

Synonym: Sbal195_4070

Alternate gene names: 160877174

Gene position: 4802403-4802729 (Clockwise)

Preceding gene: 160877171

Following gene: 160877175

Centisome position: 89.81

GC content: 41.28

Gene sequence:

>327_bases
ATGAGCGATAAAATTATATACCTGAGTGACGACAGCTTCGAAAACGACGTATTAAAGTCTGATTTGCCAGTATTGGTAGA
CTTCTGGGCCGAGTGGTGTGGTCCTTGTAAAATGATCGCTCCAATTTTAGACGATGTGTCTGAAGAATATGCAGGCCGCG
TGACTATCGCTAAATTAAACGTTGACCAAAACAATGTTTCTCCAGCGAAATATGGTGTTCGTGGCATCCCAACTTTACTG
TTATTCAAGAACGGCGAATTAGCCGCAACTAAAGTTGGTGCACTATCAAAAACGCAATTAAAAGAGTTTATCGACGCGCA
AATCTAA

Upstream 100 bases:

>100_bases
GCCACATTGTAAAAAGGTAACTTGAAAAGCTATTTTTCAGCCCCAATATACATGGTAAGCCATTAACAAACCAGCAATGG
CACCCAAACTGGAGAACATC

Downstream 100 bases:

>100_bases
TTTGATGTGGTAATGAGTGACCTCCGGCACAAGCTATAAATTAATTGTGCCGGAATTTCCCTAAATTTCTGGACGCCCCG
CTTTGTTAGTGCTACTTTAA

Product: thioredoxin

Products: NA

Alternate protein names: Trx-1 [H]

Number of amino acids: Translated: 108; Mature: 107

Protein sequence:

>108_residues
MSDKIIYLSDDSFENDVLKSDLPVLVDFWAEWCGPCKMIAPILDDVSEEYAGRVTIAKLNVDQNNVSPAKYGVRGIPTLL
LFKNGELAATKVGALSKTQLKEFIDAQI

Sequences:

>Translated_108_residues
MSDKIIYLSDDSFENDVLKSDLPVLVDFWAEWCGPCKMIAPILDDVSEEYAGRVTIAKLNVDQNNVSPAKYGVRGIPTLL
LFKNGELAATKVGALSKTQLKEFIDAQI
>Mature_107_residues
SDKIIYLSDDSFENDVLKSDLPVLVDFWAEWCGPCKMIAPILDDVSEEYAGRVTIAKLNVDQNNVSPAKYGVRGIPTLLL
FKNGELAATKVGALSKTQLKEFIDAQI

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=92, Percent_Identity=38.0434782608696, Blast_Score=79, Evalue=5e-16,
Organism=Homo sapiens, GI5031973, Length=100, Percent_Identity=35, Blast_Score=74, Evalue=3e-14,
Organism=Homo sapiens, GI21361657, Length=91, Percent_Identity=37.3626373626374, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI87082331, Length=108, Percent_Identity=74.0740740740741, Blast_Score=176, Evalue=2e-46,
Organism=Escherichia coli, GI1788936, Length=92, Percent_Identity=40.2173913043478, Blast_Score=94, Evalue=1e-21,
Organism=Escherichia coli, GI87081747, Length=64, Percent_Identity=40.625, Blast_Score=65, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI212646193, Length=97, Percent_Identity=41.2371134020619, Blast_Score=86, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71998175, Length=71, Percent_Identity=47.887323943662, Blast_Score=72, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI115532254, Length=113, Percent_Identity=33.6283185840708, Blast_Score=69, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI115532252, Length=113, Percent_Identity=33.6283185840708, Blast_Score=69, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17556044, Length=86, Percent_Identity=34.8837209302326, Blast_Score=69, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17510299, Length=100, Percent_Identity=37, Blast_Score=65, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17509965, Length=90, Percent_Identity=31.1111111111111, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17554386, Length=88, Percent_Identity=35.2272727272727, Blast_Score=62, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6323072, Length=80, Percent_Identity=47.5, Blast_Score=74, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6321648, Length=86, Percent_Identity=38.3720930232558, Blast_Score=67, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24639826, Length=87, Percent_Identity=41.3793103448276, Blast_Score=81, Evalue=2e-16,
Organism=Drosophila melanogaster, GI28573567, Length=96, Percent_Identity=36.4583333333333, Blast_Score=80, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24664269, Length=87, Percent_Identity=36.7816091954023, Blast_Score=70, Evalue=2e-13,
Organism=Drosophila melanogaster, GI19921434, Length=88, Percent_Identity=38.6363636363636, Blast_Score=69, Evalue=7e-13,
Organism=Drosophila melanogaster, GI17648013, Length=85, Percent_Identity=38.8235294117647, Blast_Score=67, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24583090, Length=85, Percent_Identity=38.8235294117647, Blast_Score=67, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24639068, Length=103, Percent_Identity=30.0970873786408, Blast_Score=62, Evalue=9e-11,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11921; Mature: 11790

Theoretical pI: Translated: 4.34; Mature: 4.34

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDKIIYLSDDSFENDVLKSDLPVLVDFWAEWCGPCKMIAPILDDVSEEYAGRVTIAKLN
CCCCEEEEECCCCCCHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCEEEEEEE
VDQNNVSPAKYGVRGIPTLLLFKNGELAATKVGALSKTQLKEFIDAQI
CCCCCCCHHHCCCCCCCEEEEEECCCEEEHHHCCCCHHHHHHHHHCCC
>Mature Secondary Structure 
SDKIIYLSDDSFENDVLKSDLPVLVDFWAEWCGPCKMIAPILDDVSEEYAGRVTIAKLN
CCCEEEEECCCCCCHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCEEEEEEE
VDQNNVSPAKYGVRGIPTLLLFKNGELAATKVGALSKTQLKEFIDAQI
CCCCCCCHHHCCCCCCCEEEEEECCCEEEHHHCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]