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The map label for this gene is hemA

Identifier: 160876842

GI number: 160876842

Start: 4404461

End: 4405711

Strand: Reverse

Name: hemA

Synonym: Sbal195_3738

Alternate gene names: 160876842

Gene position: 4405711-4404461 (Counterclockwise)

Preceding gene: 160876846

Following gene: 160876841

Centisome position: 82.39

GC content: 48.52

Gene sequence:

>1251_bases
ATGAGCCTTGTAGCAATCGGTATTAACCATAAAACAGCCACGGTAGACCTGCGCGAGAAAGTTGCCTTCTCTCCGGACAA
AATTCATGACGCTATGAAGAGTCTGGCCAGTCGTACACGCTCGGGTGAAGCCGTTATTGTCTCGACCTGTAATCGCACTG
AGTTGTATTGCAACAACGGCGATGAGGCCGACATTATTGCGTGGCTTGAAGAATATCACGGCCTTGATCATAAGGACGTC
GCGCCTTGTCTCTATAATTATCACGGTCAGGATGCCGTCAGGCATTTGATGCGTGTGGCCTCTGGGCTCGATTCGTTGAT
CTTGGGTGAACCGCAAATTCTCGGCCAAGTAAAACAAGCATTCGTTAAGGCCAAAGAGGCTGGAACTGTTGCACTAACCA
TAGACAGACTCTTTCAAAATACCTTTTCTGTCGCTAAGAAAGTTCGCACCGACACTGAAATCGGCGCCGCCGCAGTGTCA
GTGGCATTTGCCGCGGTTAGCATGGCGAAACATATTTTCTCGTCGATATCGACCACAAAAGTGCTATTGATTGGCGCGGG
TGAAACCATAGAGCTGGTTGCTAAGCATCTTAAAGACAACGGCGTGGCTTCAATGGTGGTGGCAAACCGGACGTTAGAAC
GTGCTCAAGGCATGTGCGAGGAGTTTGGTGCAACAGCAATTACACTGGCACAGATACCAGATTATCTCCCAAAAGCCGAT
ATCGTGATATCCTCTACCGCCAGCCCTCTGCCTATCTTAGGTAAAGGCATGGTCGAAAAAGCGCTAAAGCAGCGTCGCCA
TCAACCTATGTTATTGGTTGATATAGCAGTTCCCCGGGATATTGAGCCGGAAGTCGCCGATTTGGATGACGCGTTTCTGT
ATACAGTGGACGACCTGCATAGCATTATTGAACAGAATATGGCTTCTCGAAAAGAAGCCGCCGAGCAAGCTGAAGTAATT
ACTGAAGAACAATCTTTCTTATTTATGGATTGGATCCGTTCTTTAGAGTCGGTCGACAGTATTCGCGAGTATCGCAGCCA
GAGCATGGCGGTAAAAGATGAGTTAGTGGAACGCGCCCTGAATAAATTAGCCCAGGGCTCAGACACTGAGCAGGTATTGA
TTGAACTAGCCAATCGCCTGACCAATAAACTTATCCACGCACCGACACAGGCCCTCACGGCAGCGAGTCGTCAGGGCGAT
TTGAATACTCTCGGTCAGTTAAGATCAGCGCTTGGATTAGATAAAAACTAA

Upstream 100 bases:

>100_bases
GACCTTTATTCGGTTTTGTTAAGCGTATTCTGTTTTTAGTTGGGCCGATTCAGTAGAATGCCCTTATTAAGAGAGTCGCC
AAGAATCTAGAAAGAGTCAG

Downstream 100 bases:

>100_bases
GGTTAGCGAGTTAAATGAAGGAATCCGTTATCCGCAAGCTGGAAGGCTTGCTCGAGCGCAATGAAGAAGTCATGGCTTTG
CTGGGTGATGCTAGCGTCAT

Product: glutamyl-tRNA reductase

Products: NA

Alternate protein names: GluTR

Number of amino acids: Translated: 416; Mature: 415

Protein sequence:

>416_residues
MSLVAIGINHKTATVDLREKVAFSPDKIHDAMKSLASRTRSGEAVIVSTCNRTELYCNNGDEADIIAWLEEYHGLDHKDV
APCLYNYHGQDAVRHLMRVASGLDSLILGEPQILGQVKQAFVKAKEAGTVALTIDRLFQNTFSVAKKVRTDTEIGAAAVS
VAFAAVSMAKHIFSSISTTKVLLIGAGETIELVAKHLKDNGVASMVVANRTLERAQGMCEEFGATAITLAQIPDYLPKAD
IVISSTASPLPILGKGMVEKALKQRRHQPMLLVDIAVPRDIEPEVADLDDAFLYTVDDLHSIIEQNMASRKEAAEQAEVI
TEEQSFLFMDWIRSLESVDSIREYRSQSMAVKDELVERALNKLAQGSDTEQVLIELANRLTNKLIHAPTQALTAASRQGD
LNTLGQLRSALGLDKN

Sequences:

>Translated_416_residues
MSLVAIGINHKTATVDLREKVAFSPDKIHDAMKSLASRTRSGEAVIVSTCNRTELYCNNGDEADIIAWLEEYHGLDHKDV
APCLYNYHGQDAVRHLMRVASGLDSLILGEPQILGQVKQAFVKAKEAGTVALTIDRLFQNTFSVAKKVRTDTEIGAAAVS
VAFAAVSMAKHIFSSISTTKVLLIGAGETIELVAKHLKDNGVASMVVANRTLERAQGMCEEFGATAITLAQIPDYLPKAD
IVISSTASPLPILGKGMVEKALKQRRHQPMLLVDIAVPRDIEPEVADLDDAFLYTVDDLHSIIEQNMASRKEAAEQAEVI
TEEQSFLFMDWIRSLESVDSIREYRSQSMAVKDELVERALNKLAQGSDTEQVLIELANRLTNKLIHAPTQALTAASRQGD
LNTLGQLRSALGLDKN
>Mature_415_residues
SLVAIGINHKTATVDLREKVAFSPDKIHDAMKSLASRTRSGEAVIVSTCNRTELYCNNGDEADIIAWLEEYHGLDHKDVA
PCLYNYHGQDAVRHLMRVASGLDSLILGEPQILGQVKQAFVKAKEAGTVALTIDRLFQNTFSVAKKVRTDTEIGAAAVSV
AFAAVSMAKHIFSSISTTKVLLIGAGETIELVAKHLKDNGVASMVVANRTLERAQGMCEEFGATAITLAQIPDYLPKADI
VISSTASPLPILGKGMVEKALKQRRHQPMLLVDIAVPRDIEPEVADLDDAFLYTVDDLHSIIEQNMASRKEAAEQAEVIT
EEQSFLFMDWIRSLESVDSIREYRSQSMAVKDELVERALNKLAQGSDTEQVLIELANRLTNKLIHAPTQALTAASRQGDL
NTLGQLRSALGLDKN

Specific function: Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)

COG id: COG0373

COG function: function code H; Glutamyl-tRNA reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutamyl-tRNA reductase family

Homologues:

Organism=Escherichia coli, GI1787461, Length=419, Percent_Identity=57.0405727923628, Blast_Score=463, Evalue=1e-131,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEM1_SHEB2 (B8E816)

Other databases:

- EMBL:   CP001252
- RefSeq:   YP_002359452.1
- ProteinModelPortal:   B8E816
- SMR:   B8E816
- GeneID:   7088660
- GenomeReviews:   CP001252_GR
- KEGG:   sbp:Sbal223_3547
- HOGENOM:   HBG732626
- OMA:   IVANRTY
- ProtClustDB:   PRK00045
- GO:   GO:0005737
- HAMAP:   MF_00087
- InterPro:   IPR000343
- InterPro:   IPR015896
- InterPro:   IPR015895
- InterPro:   IPR016040
- InterPro:   IPR018214
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF000445
- TIGRFAMs:   TIGR01035

Pfam domain/function: PF00745 GlutR_dimer; PF05201 GlutR_N; PF01488 Shikimate_DH; SSF69075 4pyrrol_synth_GluRdtase_C; SSF69742 GlutR

EC number: =1.2.1.70

Molecular weight: Translated: 45445; Mature: 45313

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: PS00747 GLUTR

Important sites: ACT_SITE 50-50 BINDING 105-105 BINDING 116-116

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLVAIGINHKTATVDLREKVAFSPDKIHDAMKSLASRTRSGEAVIVSTCNRTELYCNNG
CCEEEEECCCCEEEEEHHHHHCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCEEEECCC
DEADIIAWLEEYHGLDHKDVAPCLYNYHGQDAVRHLMRVASGLDSLILGEPQILGQVKQA
CCHHHHHHHHHHCCCCCCCHHHHHHCCCCHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHH
FVKAKEAGTVALTIDRLFQNTFSVAKKVRTDTEIGAAAVSVAFAAVSMAKHIFSSISTTK
HHHHHCCCEEEEEHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCE
VLLIGAGETIELVAKHLKDNGVASMVVANRTLERAQGMCEEFGATAITLAQIPDYLPKAD
EEEEECCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHCCCCCCCCC
IVISSTASPLPILGKGMVEKALKQRRHQPMLLVDIAVPRDIEPEVADLDDAFLYTVDDLH
EEEECCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHCCCCHHHHHHHHHH
SIIEQNMASRKEAAEQAEVITEEQSFLFMDWIRSLESVDSIREYRSQSMAVKDELVERAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NKLAQGSDTEQVLIELANRLTNKLIHAPTQALTAASRQGDLNTLGQLRSALGLDKN
HHHHCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SLVAIGINHKTATVDLREKVAFSPDKIHDAMKSLASRTRSGEAVIVSTCNRTELYCNNG
CEEEEECCCCEEEEEHHHHHCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCEEEECCC
DEADIIAWLEEYHGLDHKDVAPCLYNYHGQDAVRHLMRVASGLDSLILGEPQILGQVKQA
CCHHHHHHHHHHCCCCCCCHHHHHHCCCCHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHH
FVKAKEAGTVALTIDRLFQNTFSVAKKVRTDTEIGAAAVSVAFAAVSMAKHIFSSISTTK
HHHHHCCCEEEEEHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCE
VLLIGAGETIELVAKHLKDNGVASMVVANRTLERAQGMCEEFGATAITLAQIPDYLPKAD
EEEEECCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHCCCCCCCCC
IVISSTASPLPILGKGMVEKALKQRRHQPMLLVDIAVPRDIEPEVADLDDAFLYTVDDLH
EEEECCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHCCCCHHHHHHHHHH
SIIEQNMASRKEAAEQAEVITEEQSFLFMDWIRSLESVDSIREYRSQSMAVKDELVERAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NKLAQGSDTEQVLIELANRLTNKLIHAPTQALTAASRQGDLNTLGQLRSALGLDKN
HHHHCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA