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The map label for this gene is yhaR [H]

Identifier: 160876085

GI number: 160876085

Start: 3533836

End: 3534705

Strand: Direct

Name: yhaR [H]

Synonym: Sbal195_2975

Alternate gene names: 160876085

Gene position: 3533836-3534705 (Clockwise)

Preceding gene: 160876084

Following gene: 160876086

Centisome position: 66.09

GC content: 49.89

Gene sequence:

>870_bases
ATGACCAACAGATTAAACAGCACTAGCGGCACAAAGGATTTAAGCAACTTGCAGCACGTCACTTACGCACTCAATAACGG
CGTTGCTGAGCTTATTCTTGACCGAGCAGAAGTACACAACGCCTTCGATGAAGTGATGATTAGCGAGATGATTAGCGTCC
TTAGCTATTTTGCTGAGCACAAGCAATGCCAAGTGCTGGTACTCAAAGCGAACGGCAAAAACTTCAGCGCCGGCGCCGAT
CTCAATTGGATGCGCAAGCAAGCCAAAATGGACTTTGAGCAAAATCTAAATGATGCCAAAGCCTTAGCAAAACTGATGCA
GGATTTAGATACCTTTCCAAAACCCACCATTGCATTAGTGCAAGGCGCAGCCTTTGGCGGTGCACTGGGGCTGATTTGCG
CCAGCGATATCGCTATCGCCACGACGCGCGCCAGTTTTTGCTTGAGCGAAGTGAAACTCGGATTAATTCCTGCGGTGATA
AGCCCTTACGTTGCCCGCGCTATGGGTAACCGCGCATCGCGCCGCTACATGTTAACGGCTGAGCGTTTTAGTGCAGACAC
TGCATTAAAGCTTAATGTCATTCATGAGATCAGCGATGACTTAGACGCCGCCGCAAAGCCTATGATTGACGCGCTACTGG
CCAATAGTCCGCAAGGCATGGCGTGGGTAAAAACACTGCTGTCGCATCTTGAAGATGGCGTGATAGACCAAAACACCATT
GATTACACTAGCGAGCGTATCGCCCGCATTCGGGTATCAACCGAGGGCCAAGAAGGCTTAAACGCCTTTTTTGAGAAACG
TCTGCCTAACTGGCAACAAGCGCTCTCAACTCCCACGCAAAAGCCAAGTGATACCCAAGGAGCCCTTTGA

Upstream 100 bases:

>100_bases
GCGTTAAACGCCCCTATCGAAGACACCCGCTTTGGTGTGTTCCGTATGTAAAGGCACATGTGAAAAACATATGCCACACA
ATAAGATAGGGGAAAGAATA

Downstream 100 bases:

>100_bases
TGTTAACCAAGCAAATGTTTACCAAGCTATTGATTGCTAACCGCGGTGAAATCGCCTGTCGCATCATCAAAACCGCCCAT
GCCATGGGTGTTCGCACCGT

Product: enoyl-CoA hydratase/isomerase

Products: trans-2-enoyl-CoA; trans-3-enoyl-CoA; H2O

Alternate protein names: NA

Number of amino acids: Translated: 289; Mature: 288

Protein sequence:

>289_residues
MTNRLNSTSGTKDLSNLQHVTYALNNGVAELILDRAEVHNAFDEVMISEMISVLSYFAEHKQCQVLVLKANGKNFSAGAD
LNWMRKQAKMDFEQNLNDAKALAKLMQDLDTFPKPTIALVQGAAFGGALGLICASDIAIATTRASFCLSEVKLGLIPAVI
SPYVARAMGNRASRRYMLTAERFSADTALKLNVIHEISDDLDAAAKPMIDALLANSPQGMAWVKTLLSHLEDGVIDQNTI
DYTSERIARIRVSTEGQEGLNAFFEKRLPNWQQALSTPTQKPSDTQGAL

Sequences:

>Translated_289_residues
MTNRLNSTSGTKDLSNLQHVTYALNNGVAELILDRAEVHNAFDEVMISEMISVLSYFAEHKQCQVLVLKANGKNFSAGAD
LNWMRKQAKMDFEQNLNDAKALAKLMQDLDTFPKPTIALVQGAAFGGALGLICASDIAIATTRASFCLSEVKLGLIPAVI
SPYVARAMGNRASRRYMLTAERFSADTALKLNVIHEISDDLDAAAKPMIDALLANSPQGMAWVKTLLSHLEDGVIDQNTI
DYTSERIARIRVSTEGQEGLNAFFEKRLPNWQQALSTPTQKPSDTQGAL
>Mature_288_residues
TNRLNSTSGTKDLSNLQHVTYALNNGVAELILDRAEVHNAFDEVMISEMISVLSYFAEHKQCQVLVLKANGKNFSAGADL
NWMRKQAKMDFEQNLNDAKALAKLMQDLDTFPKPTIALVQGAAFGGALGLICASDIAIATTRASFCLSEVKLGLIPAVIS
PYVARAMGNRASRRYMLTAERFSADTALKLNVIHEISDDLDAAAKPMIDALLANSPQGMAWVKTLLSHLEDGVIDQNTID
YTSERIARIRVSTEGQEGLNAFFEKRLPNWQQALSTPTQKPSDTQGAL

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI31542718, Length=252, Percent_Identity=25.3968253968254, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI194097323, Length=256, Percent_Identity=29.296875, Blast_Score=79, Evalue=7e-15,
Organism=Homo sapiens, GI70995211, Length=191, Percent_Identity=27.2251308900524, Blast_Score=66, Evalue=4e-11,
Organism=Escherichia coli, GI87082183, Length=262, Percent_Identity=27.0992366412214, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1787659, Length=245, Percent_Identity=27.3469387755102, Blast_Score=88, Evalue=6e-19,
Organism=Escherichia coli, GI1788597, Length=261, Percent_Identity=25.6704980842912, Blast_Score=87, Evalue=9e-19,
Organism=Escherichia coli, GI221142681, Length=275, Percent_Identity=27.2727272727273, Blast_Score=78, Evalue=7e-16,
Organism=Escherichia coli, GI1787660, Length=272, Percent_Identity=28.3088235294118, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1790281, Length=175, Percent_Identity=27.4285714285714, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17535521, Length=261, Percent_Identity=26.4367816091954, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17540714, Length=180, Percent_Identity=29.4444444444444, Blast_Score=71, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17534483, Length=233, Percent_Identity=25.3218884120172, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI25145438, Length=250, Percent_Identity=26, Blast_Score=68, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17536985, Length=222, Percent_Identity=25.6756756756757, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17549921, Length=221, Percent_Identity=27.1493212669683, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24653139, Length=266, Percent_Identity=27.4436090225564, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI19920382, Length=182, Percent_Identity=29.1208791208791, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI20129971, Length=269, Percent_Identity=25.2788104089219, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24653477, Length=269, Percent_Identity=25.2788104089219, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI19922422, Length=253, Percent_Identity=22.1343873517787, Blast_Score=65, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001753 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: 4.2.1.17

Molecular weight: Translated: 31589; Mature: 31458

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNRLNSTSGTKDLSNLQHVTYALNNGVAELILDRAEVHNAFDEVMISEMISVLSYFAEH
CCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
KQCQVLVLKANGKNFSAGADLNWMRKQAKMDFEQNLNDAKALAKLMQDLDTFPKPTIALV
CCEEEEEEEECCCCCCCCCCHHHHHHHHHCCHHHCCCHHHHHHHHHHHHHCCCCCHHHHH
QGAAFGGALGLICASDIAIATTRASFCLSEVKLGLIPAVISPYVARAMGNRASRRYMLTA
HCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCEEEEEH
ERFSADTALKLNVIHEISDDLDAAAKPMIDALLANSPQGMAWVKTLLSHLEDGVIDQNTI
HHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCH
DYTSERIARIRVSTEGQEGLNAFFEKRLPNWQQALSTPTQKPSDTQGAL
HHHHHHHHHEEECCCCHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
TNRLNSTSGTKDLSNLQHVTYALNNGVAELILDRAEVHNAFDEVMISEMISVLSYFAEH
CCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
KQCQVLVLKANGKNFSAGADLNWMRKQAKMDFEQNLNDAKALAKLMQDLDTFPKPTIALV
CCEEEEEEEECCCCCCCCCCHHHHHHHHHCCHHHCCCHHHHHHHHHHHHHCCCCCHHHHH
QGAAFGGALGLICASDIAIATTRASFCLSEVKLGLIPAVISPYVARAMGNRASRRYMLTA
HCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCEEEEEH
ERFSADTALKLNVIHEISDDLDAAAKPMIDALLANSPQGMAWVKTLLSHLEDGVIDQNTI
HHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCH
DYTSERIARIRVSTEGQEGLNAFFEKRLPNWQQALSTPTQKPSDTQGAL
HHHHHHHHHEEECCCCHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (3S)-3-hydroxyacyl-CoA

Specific reaction: (3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H2O

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9384377; 9579061 [H]