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The map label for this gene is yngE [H]

Identifier: 160876084

GI number: 160876084

Start: 3532179

End: 3533786

Strand: Direct

Name: yngE [H]

Synonym: Sbal195_2974

Alternate gene names: 160876084

Gene position: 3532179-3533786 (Clockwise)

Preceding gene: 160876083

Following gene: 160876085

Centisome position: 66.06

GC content: 52.49

Gene sequence:

>1608_bases
GTGACGCAAATAAGCAGTCGTATCAACGCCCGTAGCGATGAATTTAAAGCAAAATCCGACGATATGGCCGCTCTAGTGGC
CGATCTTAAAACTAAACTCAATAAAATCGAACTCGGCGGCGGCCCTGTGGCGCTGGAGCGTCATTTATCCCGCGGTAAAT
TACTGCCACGTCAACGGGTTGAAAAGCTACTCGATGCGGGCTCGCCCTTTTTAGAACTGTCGCAATTTGCGGCGTTTGAA
GTCTACGACGAAGAAGTGCCCGCAGCGGGCATTATTGCCGGTATCGGCCGTGTGAGTGGCGTGGAATGCATGATCATCGC
CAACGACGCCACAGTGAAAGGCGGCACTTACTACCCGATTACCGTCAAAAAACACCTTCGCGCCCAAGATATTGCCAGCC
GTTGTCACTTGCCTTGTATTTATTTAGTCGACTCGGGCGGCGCTAACCTGCCCCGCCAAGATGAAGTGTTCCCCGACCGC
GACCATTTCGGCCGCATCTTTTACAACCAAGCGCAAATGTCCGCCAAAGGTATCCCACAAATCGCTGTGGTGATGGGTTT
ATGTACCGCGGGCGGCGCTTATGTGCCTGCCATGGCGGATGAATCCATTATCGTAAAAGATCAAGGCACTATCTTCTTAG
CAGGCCCGCCATTAGTGAAAGCGGCAACTGGCGAAGAAGTTAGCGCCGAAGAACTGGGCGGCGCCGAAGTCCACACCAAA
ATTTCCGGCGTAGCAGACCATTTAGCCCAAAACGATGAGCACGCGTTAGAACTTGCCCGCCGCGCGGTATCACGCCTGAA
TCATCAAAAAGAAATCAAATCACTCTTAAGCCCAGTCAAGCCGCCAAAATTCGATATCAGCGAACTGTATGGCATTGTCG
GCACTGATTTGAAAAAGCCCTTTGATGTCAAAGAAGTGATCGCCCGTATCGTCGATGATTCTGATTTTGATGAGTTTAAA
GCCAACTATGGCGCGACCTTAGTGTGCGGTTTTGCCCGTATTCACGGCTACCCAGTCGGCATTGTCGCCAACAACGGCAT
TCTGTTCTCTGAGTCAGCGCAAAAAGGCGCGCACTTTATCGAACTGTGCTGCCAGCGCAAAATTCCACTGCTGTTCCTAC
AAAATATCACCGGCTTTATGGTGGGTAAAAAGTACGAACACGAAGGCATAGCTAAACACGGCGCTAAAATGGTGACCGCG
GTTTCTTGCGCCAATGTGCCTAAATTCACTGTGATTATCGGCGGCAGCTACGGCGCGGGTAACTACGGTATGTGTGGCCG
CGCGTTCGAACCGACCATGATGTGGATGTGGCCTAACGCCCGTATCTCAGTGATGGGTGGCGAGCAAGCGGCTGGCGTAC
TCGCCACAGTGCGTCGCGACGGTTTAGCCCGTAAAGGTGAAGAATGGTCAGCTGAAGCTGAAAAAGCCTTTAAAGCGCCG
ATTGTCGCCCAGTACGACAAAGAAGGTCATCCGTATCATGCCAGCGCCCGTTTATGGGATGACGGCATTATTGATCCAGC
GCAAACCCGCGATGTGGTCGGCCTTGCCCTATCGGCGGCGTTAAACGCCCCTATCGAAGACACCCGCTTTGGTGTGTTCC
GTATGTAA

Upstream 100 bases:

>100_bases
CTCTCACAAGTGAATGGGTAGCACTGCACTGTAATTTACAGTTTGCGCCACCCATTCGAGCAAGGTGATACCGAGTTTCC
GCTTTATAAGGACAATCAAA

Downstream 100 bases:

>100_bases
AGGCACATGTGAAAAACATATGCCACACAATAAGATAGGGGAAAGAATAATGACCAACAGATTAAACAGCACTAGCGGCA
CAAAGGATTTAAGCAACTTG

Product: propionyl-CoA carboxylase

Products: ADP; phosphate; 3-methylglutaconyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 535; Mature: 534

Protein sequence:

>535_residues
MTQISSRINARSDEFKAKSDDMAALVADLKTKLNKIELGGGPVALERHLSRGKLLPRQRVEKLLDAGSPFLELSQFAAFE
VYDEEVPAAGIIAGIGRVSGVECMIIANDATVKGGTYYPITVKKHLRAQDIASRCHLPCIYLVDSGGANLPRQDEVFPDR
DHFGRIFYNQAQMSAKGIPQIAVVMGLCTAGGAYVPAMADESIIVKDQGTIFLAGPPLVKAATGEEVSAEELGGAEVHTK
ISGVADHLAQNDEHALELARRAVSRLNHQKEIKSLLSPVKPPKFDISELYGIVGTDLKKPFDVKEVIARIVDDSDFDEFK
ANYGATLVCGFARIHGYPVGIVANNGILFSESAQKGAHFIELCCQRKIPLLFLQNITGFMVGKKYEHEGIAKHGAKMVTA
VSCANVPKFTVIIGGSYGAGNYGMCGRAFEPTMMWMWPNARISVMGGEQAAGVLATVRRDGLARKGEEWSAEAEKAFKAP
IVAQYDKEGHPYHASARLWDDGIIDPAQTRDVVGLALSAALNAPIEDTRFGVFRM

Sequences:

>Translated_535_residues
MTQISSRINARSDEFKAKSDDMAALVADLKTKLNKIELGGGPVALERHLSRGKLLPRQRVEKLLDAGSPFLELSQFAAFE
VYDEEVPAAGIIAGIGRVSGVECMIIANDATVKGGTYYPITVKKHLRAQDIASRCHLPCIYLVDSGGANLPRQDEVFPDR
DHFGRIFYNQAQMSAKGIPQIAVVMGLCTAGGAYVPAMADESIIVKDQGTIFLAGPPLVKAATGEEVSAEELGGAEVHTK
ISGVADHLAQNDEHALELARRAVSRLNHQKEIKSLLSPVKPPKFDISELYGIVGTDLKKPFDVKEVIARIVDDSDFDEFK
ANYGATLVCGFARIHGYPVGIVANNGILFSESAQKGAHFIELCCQRKIPLLFLQNITGFMVGKKYEHEGIAKHGAKMVTA
VSCANVPKFTVIIGGSYGAGNYGMCGRAFEPTMMWMWPNARISVMGGEQAAGVLATVRRDGLARKGEEWSAEAEKAFKAP
IVAQYDKEGHPYHASARLWDDGIIDPAQTRDVVGLALSAALNAPIEDTRFGVFRM
>Mature_534_residues
TQISSRINARSDEFKAKSDDMAALVADLKTKLNKIELGGGPVALERHLSRGKLLPRQRVEKLLDAGSPFLELSQFAAFEV
YDEEVPAAGIIAGIGRVSGVECMIIANDATVKGGTYYPITVKKHLRAQDIASRCHLPCIYLVDSGGANLPRQDEVFPDRD
HFGRIFYNQAQMSAKGIPQIAVVMGLCTAGGAYVPAMADESIIVKDQGTIFLAGPPLVKAATGEEVSAEELGGAEVHTKI
SGVADHLAQNDEHALELARRAVSRLNHQKEIKSLLSPVKPPKFDISELYGIVGTDLKKPFDVKEVIARIVDDSDFDEFKA
NYGATLVCGFARIHGYPVGIVANNGILFSESAQKGAHFIELCCQRKIPLLFLQNITGFMVGKKYEHEGIAKHGAKMVTAV
SCANVPKFTVIIGGSYGAGNYGMCGRAFEPTMMWMWPNARISVMGGEQAAGVLATVRRDGLARKGEEWSAEAEKAFKAPI
VAQYDKEGHPYHASARLWDDGIIDPAQTRDVVGLALSAALNAPIEDTRFGVFRM

Specific function: Unknown

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI11545863, Length=522, Percent_Identity=69.7318007662835, Blast_Score=745, Evalue=0.0,
Organism=Homo sapiens, GI119943100, Length=499, Percent_Identity=33.4669338677355, Blast_Score=240, Evalue=3e-63,
Organism=Homo sapiens, GI295821216, Length=518, Percent_Identity=32.4324324324324, Blast_Score=229, Evalue=6e-60,
Organism=Homo sapiens, GI310133460, Length=132, Percent_Identity=64.3939393939394, Blast_Score=159, Evalue=8e-39,
Organism=Caenorhabditis elegans, GI17552936, Length=533, Percent_Identity=63.6022514071295, Blast_Score=714, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25147359, Length=493, Percent_Identity=32.657200811359, Blast_Score=243, Evalue=2e-64,
Organism=Caenorhabditis elegans, GI25147362, Length=493, Percent_Identity=32.657200811359, Blast_Score=243, Evalue=2e-64,
Organism=Drosophila melanogaster, GI24586065, Length=549, Percent_Identity=65.9380692167577, Blast_Score=745, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: 6.4.1.4

Molecular weight: Translated: 57886; Mature: 57755

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQISSRINARSDEFKAKSDDMAALVADLKTKLNKIELGGGPVALERHLSRGKLLPRQRV
CCCCHHHHCCCCHHCCCCCCHHHHHHHHHHHHHCEEECCCCCHHHHHHHHCCCCCCHHHH
EKLLDAGSPFLELSQFAAFEVYDEEVPAAGIIAGIGRVSGVECMIIANDATVKGGTYYPI
HHHHHCCCCHHHHHHHHHHEEECCCCCHHHHHHHHHCCCCEEEEEEECCCEECCCEEEEE
TVKKHLRAQDIASRCHLPCIYLVDSGGANLPRQDEVFPDRDHFGRIFYNQAQMSAKGIPQ
EHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCHHHCCCEEEEHHHHCCCCCCH
IAVVMGLCTAGGAYVPAMADESIIVKDQGTIFLAGPPLVKAATGEEVSAEELGGAEVHTK
HHHHHHHHHCCCCEEECCCCCEEEEECCCEEEEECCCEEEECCCCCCCHHHCCCCHHHHH
ISGVADHLAQNDEHALELARRAVSRLNHQKEIKSLLSPVKPPKFDISELYGIVGTDLKKP
HHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCC
FDVKEVIARIVDDSDFDEFKANYGATLVCGFARIHGYPVGIVANNGILFSESAQKGAHFI
CCHHHHHHHHHCCCCHHHHHHCCCCEEEEEHHHHCCEEEEEEECCCEEEECCHHHHHHHH
ELCCQRKIPLLFLQNITGFMVGKKYEHEGIAKHGAKMVTAVSCANVPKFTVIIGGSYGAG
HHHHHCCCCEEEHHCCHHHHCCCCCCCCCHHHHCHHHEEEEHHCCCCEEEEEEECCCCCC
NYGMCGRAFEPTMMWMWPNARISVMGGEQAAGVLATVRRDGLARKGEEWSAEAEKAFKAP
CCCCCCCCCCCEEEEECCCCEEEEECCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCC
IVAQYDKEGHPYHASARLWDDGIIDPAQTRDVVGLALSAALNAPIEDTRFGVFRM
CEEEECCCCCCEECCCEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEECC
>Mature Secondary Structure 
TQISSRINARSDEFKAKSDDMAALVADLKTKLNKIELGGGPVALERHLSRGKLLPRQRV
CCCHHHHCCCCHHCCCCCCHHHHHHHHHHHHHCEEECCCCCHHHHHHHHCCCCCCHHHH
EKLLDAGSPFLELSQFAAFEVYDEEVPAAGIIAGIGRVSGVECMIIANDATVKGGTYYPI
HHHHHCCCCHHHHHHHHHHEEECCCCCHHHHHHHHHCCCCEEEEEEECCCEECCCEEEEE
TVKKHLRAQDIASRCHLPCIYLVDSGGANLPRQDEVFPDRDHFGRIFYNQAQMSAKGIPQ
EHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCHHHCCCEEEEHHHHCCCCCCH
IAVVMGLCTAGGAYVPAMADESIIVKDQGTIFLAGPPLVKAATGEEVSAEELGGAEVHTK
HHHHHHHHHCCCCEEECCCCCEEEEECCCEEEEECCCEEEECCCCCCCHHHCCCCHHHHH
ISGVADHLAQNDEHALELARRAVSRLNHQKEIKSLLSPVKPPKFDISELYGIVGTDLKKP
HHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCC
FDVKEVIARIVDDSDFDEFKANYGATLVCGFARIHGYPVGIVANNGILFSESAQKGAHFI
CCHHHHHHHHHCCCCHHHHHHCCCCEEEEEHHHHCCEEEEEEECCCEEEECCHHHHHHHH
ELCCQRKIPLLFLQNITGFMVGKKYEHEGIAKHGAKMVTAVSCANVPKFTVIIGGSYGAG
HHHHHCCCCEEEHHCCHHHHCCCCCCCCCHHHHCHHHEEEEHHCCCCEEEEEEECCCCCC
NYGMCGRAFEPTMMWMWPNARISVMGGEQAAGVLATVRRDGLARKGEEWSAEAEKAFKAP
CCCCCCCCCCCEEEEECCCCEEEEECCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCC
IVAQYDKEGHPYHASARLWDDGIIDPAQTRDVVGLALSAALNAPIEDTRFGVFRM
CEEEECCCCCCEECCCEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; 3-methylcrotonoyl-CoA; HCO3-

Specific reaction: ATP + 3-methylcrotonoyl-CoA + HCO3- = ADP + phosphate + 3-methylglutaconyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 9387222 [H]