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The map label for this gene is mepA [H]

Identifier: 160875751

GI number: 160875751

Start: 3129181

End: 3130728

Strand: Reverse

Name: mepA [H]

Synonym: Sbal195_2639

Alternate gene names: 160875751

Gene position: 3130728-3129181 (Counterclockwise)

Preceding gene: 160875752

Following gene: 160875749

Centisome position: 58.55

GC content: 50.78

Gene sequence:

>1548_bases
ATGACGCAAGCCAAGTTTGTTGAAGGCCCCATATTACGCCACATCTTAGTGATGAGTTCGACCGCCGCTGTGGGGATTTC
TGCCTTATTTGTAGTGGATTTACTGGATATCTTTTTCCTGAGCTTATTGGGGGAGCATGAGCTTGCTGCTGCTGTGGGTT
ATGCCGGCAGCATCTCCTTTTTCACTACGTCCATTGGGATAGGGTTATCAATTGCTTTAGGCGCTTTAGTGTCTCGCTCG
ATAGGCGCAAAAGATGTGGTGCTGGCAAAGCGGTTATTGCTCAATAGCGCTGTTGTGACAACGCTGATTAGTGTGCTGGT
GGCCGCGGTGGTCACTACCTTCATCCCTGAGTTGGTTGCCTTAGTGGGCGCGAGTGGCCATACGGCTGAGCTCGCTGCCA
GCTACTTGTATATCTTAGTGCCTTCCTTGCCCTTTATTTGTCTTGCTATGGCGCTCGGCGGGGCTTTGCGCGCCGTGGGT
GATGCAAAGTTATCCATGATGTCGACCTTAGCGGGCGGCGGAGTCAATGCGGTGCTCGACCCGATTTTTATCTTCATGTT
CGCCATGGGGATAGAAGGTGCGGCATTGGCATCAGTCTTAGCGCGGGTGGCGGTATTTGTGATTGCTGGTCGCGGCGTTG
TAGTTAAGCATAAGTTGTTAGGTCATTTCGATAAGGCGCATTTTGTCGCCGATCTTAAACCCATCTTTGCCATTGCGGGC
CCTGCGATGTTAACCAATGTGGCAACGCCTATCGGTAATGCCTTTGTGACCCGAGCCATTGCCGATTTCGGTGACGCTTA
TGTGGCGGGCTGGGCGGTATTAGGGCGCTTAATCCCTGTGACCTTTGGGATGATCTTTGCGCTCTCGGGCGCGATTGGCC
CTATTGTTGGGCAAAACTTCGGTGCGGGGCAGTTTGACCGAGTGCGCGAGAGTTTAACCCGCGCCATTCAGTTTTGTACT
GTGTATGTGTTGGTGATGTCTCTGTTGCTGTTTGTGCTTAAGTCGCATTTGGTCAATGTGTTTGATATGAAGGGCGACAG
CGCCGACCTTATCCACTTCTTCTGCAGTTATATCGCGGTATTCTTTATCTTTTCGGGGATTTTATTTGTGGCGAATGCGT
CCTTTAATAACCTCGGTAAGGCAAAATACTCCACCCTGTTCAATGTCGGTAAAGCCACCTTAGGCACAGTGCCTTTTGTG
TATTTTGGTGCACTCTGGGGCGGAGTTTACGGCGTATTGATTGGGCAAATATTAGGGTCTATTTTGTTTGGCACCTTAGG
TGTGTGGGTTGCTTATCGTTTAGTGGATAAAGTGGCGGCGCAGGCCCAGTTTTCCGCGATGGCGAATGTCGGTGGCGTTA
ATGCTGTTCCCTGCAATGTTGCGCTGACTGAGGAAGAAGAAATCGCTAATTGTGTAGCGGAGAACTTGCCGAGCGCGACC
AATCCGCTTTCATCCTCTTGCGTGCAGATGGCGCAATTAACCGAGGAGCAAGAGAGTGAGTCGGTATTGCCGATAACGTA
TTTGGAAGAAGGTAAAAAGCCGAACTGA

Upstream 100 bases:

>100_bases
TTGCGGATGCGAGTTAGATAGCCTAGATACCCCCGTTGAAAAAGGCGCTTAGTCATTGCGTTGGCGGACACTTATTATTT
TTTGCAGGTAAAACACACGT

Downstream 100 bases:

>100_bases
CTTTATAGGCTATGTGGTTTGCCAAAGCAGGCTAGCAGCGCTCCCTTAGGAATACAGAAAAACAAAATGCCACAAGATTG
CTTGTGGCATTTTTGTTTGA

Product: MATE efflux family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 515; Mature: 514

Protein sequence:

>515_residues
MTQAKFVEGPILRHILVMSSTAAVGISALFVVDLLDIFFLSLLGEHELAAAVGYAGSISFFTTSIGIGLSIALGALVSRS
IGAKDVVLAKRLLLNSAVVTTLISVLVAAVVTTFIPELVALVGASGHTAELAASYLYILVPSLPFICLAMALGGALRAVG
DAKLSMMSTLAGGGVNAVLDPIFIFMFAMGIEGAALASVLARVAVFVIAGRGVVVKHKLLGHFDKAHFVADLKPIFAIAG
PAMLTNVATPIGNAFVTRAIADFGDAYVAGWAVLGRLIPVTFGMIFALSGAIGPIVGQNFGAGQFDRVRESLTRAIQFCT
VYVLVMSLLLFVLKSHLVNVFDMKGDSADLIHFFCSYIAVFFIFSGILFVANASFNNLGKAKYSTLFNVGKATLGTVPFV
YFGALWGGVYGVLIGQILGSILFGTLGVWVAYRLVDKVAAQAQFSAMANVGGVNAVPCNVALTEEEEIANCVAENLPSAT
NPLSSSCVQMAQLTEEQESESVLPITYLEEGKKPN

Sequences:

>Translated_515_residues
MTQAKFVEGPILRHILVMSSTAAVGISALFVVDLLDIFFLSLLGEHELAAAVGYAGSISFFTTSIGIGLSIALGALVSRS
IGAKDVVLAKRLLLNSAVVTTLISVLVAAVVTTFIPELVALVGASGHTAELAASYLYILVPSLPFICLAMALGGALRAVG
DAKLSMMSTLAGGGVNAVLDPIFIFMFAMGIEGAALASVLARVAVFVIAGRGVVVKHKLLGHFDKAHFVADLKPIFAIAG
PAMLTNVATPIGNAFVTRAIADFGDAYVAGWAVLGRLIPVTFGMIFALSGAIGPIVGQNFGAGQFDRVRESLTRAIQFCT
VYVLVMSLLLFVLKSHLVNVFDMKGDSADLIHFFCSYIAVFFIFSGILFVANASFNNLGKAKYSTLFNVGKATLGTVPFV
YFGALWGGVYGVLIGQILGSILFGTLGVWVAYRLVDKVAAQAQFSAMANVGGVNAVPCNVALTEEEEIANCVAENLPSAT
NPLSSSCVQMAQLTEEQESESVLPITYLEEGKKPN
>Mature_514_residues
TQAKFVEGPILRHILVMSSTAAVGISALFVVDLLDIFFLSLLGEHELAAAVGYAGSISFFTTSIGIGLSIALGALVSRSI
GAKDVVLAKRLLLNSAVVTTLISVLVAAVVTTFIPELVALVGASGHTAELAASYLYILVPSLPFICLAMALGGALRAVGD
AKLSMMSTLAGGGVNAVLDPIFIFMFAMGIEGAALASVLARVAVFVIAGRGVVVKHKLLGHFDKAHFVADLKPIFAIAGP
AMLTNVATPIGNAFVTRAIADFGDAYVAGWAVLGRLIPVTFGMIFALSGAIGPIVGQNFGAGQFDRVRESLTRAIQFCTV
YVLVMSLLLFVLKSHLVNVFDMKGDSADLIHFFCSYIAVFFIFSGILFVANASFNNLGKAKYSTLFNVGKATLGTVPFVY
FGALWGGVYGVLIGQILGSILFGTLGVWVAYRLVDKVAAQAQFSAMANVGGVNAVPCNVALTEEEEIANCVAENLPSATN
PLSSSCVQMAQLTEEQESESVLPITYLEEGKKPN

Specific function: Multidrug resistance efflux protein [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily [H]

Homologues:

Organism=Homo sapiens, GI22907060, Length=521, Percent_Identity=22.8406909788868, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528
- InterPro:   IPR015522 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 53939; Mature: 53808

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQAKFVEGPILRHILVMSSTAAVGISALFVVDLLDIFFLSLLGEHELAAAVGYAGSISF
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCHHH
FTTSIGIGLSIALGALVSRSIGAKDVVLAKRLLLNSAVVTTLISVLVAAVVTTFIPELVA
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVGASGHTAELAASYLYILVPSLPFICLAMALGGALRAVGDAKLSMMSTLAGGGVNAVLD
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
PIFIFMFAMGIEGAALASVLARVAVFVIAGRGVVVKHKLLGHFDKAHFVADLKPIFAIAG
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHC
PAMLTNVATPIGNAFVTRAIADFGDAYVAGWAVLGRLIPVTFGMIFALSGAIGPIVGQNF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GAGQFDRVRESLTRAIQFCTVYVLVMSLLLFVLKSHLVNVFDMKGDSADLIHFFCSYIAV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
FFIFSGILFVANASFNNLGKAKYSTLFNVGKATLGTVPFVYFGALWGGVYGVLIGQILGS
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ILFGTLGVWVAYRLVDKVAAQAQFSAMANVGGVNAVPCNVALTEEEEIANCVAENLPSAT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCHHHHHHHHHHCCCCCC
NPLSSSCVQMAQLTEEQESESVLPITYLEEGKKPN
CCHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCC
>Mature Secondary Structure 
TQAKFVEGPILRHILVMSSTAAVGISALFVVDLLDIFFLSLLGEHELAAAVGYAGSISF
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCHHH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CCHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA