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The map label for this gene is sdhA [H]

Identifier: 160875742

GI number: 160875742

Start: 3116096

End: 3117862

Strand: Reverse

Name: sdhA [H]

Synonym: Sbal195_2630

Alternate gene names: 160875742

Gene position: 3117862-3116096 (Counterclockwise)

Preceding gene: 160875743

Following gene: 160875741

Centisome position: 58.31

GC content: 47.88

Gene sequence:

>1767_bases
GTGAGTATTCCAGTACGCGAATTTGATGCTGTAGTGATCGGTGCCGGTGGCGCTGGTATGCGTGCAGCGCTGCAGATTTC
CAAAGAAGGTAAAAGCTGTGCGCTTTTATCAAAAGTATTCCCAACCCGTTCTCATACCGTATCTGCGCAGGGTGGTATCA
CTGTTGCGTTAGGTAACGCCCATGAAGATCATTGGGAACAACACATGTACGATACCGTGAAAGGTTCCGATTTTATCGGT
GACCAAGAAGCGATCGAGTTCATGTGTAAAACCGGTCCTGAAGCCGTGATTGAACTTGAGCAAATGGGTTTGCCTTTCTC
TCGTTTCGAAAATGGTACGATTTACCAACGTCCATTTGGTGGTCAATCTAAGAACTTTGGTGGCGAGCAGGCTGCGCGTA
CTGCGGCAGCTGCCGACCGTACTGGTCATGCTTTGCTTCACTGTTTATACCAACAAAACGTTAAGCATAAGACGCAAGTC
TTCTCAGAATGGTATGCATTAGATCTCGTTAAAAACGATGATGGCGCCGTTGTGGGTTGTACTGCGATTGAAATTGAAAC
GGGCGATATCGTTTATTTCAAAGCTAAGGCAACGATTCTAGCGACAGGTGGTGCAGGGCGTATTTACGCTTCTACTACTA
ACGCGCATATCAACACCGGTGACGGCGTAGGTATGGCAATGCGTGCTGGCGTGCAAATGCAAGACATGGAAATGTGGCAA
TTCCACCCAACTGGCATCGCCGGCGCGGGTGTACTTGTGACTGAAGGTTGTCGTGGTGAAGGCGGTTATCTGCTGAACAA
AGACGGCGAGCGTTTCATGGAGCGTTATGCCCCTAACGCGAAAGATTTGGCATCACGCGACGTGGTAGCACGTTCAATGA
TGACTGAAATCCGCGAAGGTCGTGGTTTAGACGGTCCATTAGGTCCACACTGTTTACTCAAGCTTGATCACTTAGGTAAA
GAAACATTAGAAGCACGTTTACCAGGCGTGTGTGAATTGTCTCGTACCTTTGCTCATATCGATCCGGCCGATGGTCCAAT
CCCAGTATTACCAACCTGTCACTATATGATGGGCGGTCTGCCAACTAAGGTCAGTGGTCAAGTTATTCGTAAGAATGAAG
ACGGCACTGAACACGATGTTATCGGTCTGTTTGCTGTGGGTGAGATTGCCTGTGTATCTGTTCACGGTGCAAACCGCTTA
GGTGGTAACTCATTGCTCGACTTAGTGGTCTTTGGCCGCGCAGCGGGTCAGCATTTAGGTAAAGCTTTGGATGAGACTGA
CGATCCAAAAGACGCAAGCGATGCGGATATTCAAGCATCTCTGGCGCGTCTGAATCGTTGGGAAAGCAACAAAGATGGCG
AAGATCCAGCGCAAATCCGTAAGGATCTGCAACTGTGTATGCAATTAAACTTCTCTGTATTCCGTCGTGGCGATGCTATG
GCTGAAGGTTTAGAGCAGTTGAAAGTGATTCGCGAACGTCTTGCAAATGCTAAATTGTCTGATAACTCTCGTGAATTCAA
CACTCAACGTATTGAATGCTTAGAGTTAGATAACTTAATGGCAACGGCGATTGCAACGGCTTATGCGGCTAACTTCCGTA
CTGAAAGTCGCGGTGCTCACTCACGTGAAGATTATTTAGAGCGTGATGATGAGAACTGGTTATGCCACAGCTTATTTGAC
CCAATCACTGAAACGATGGATCGTCGTGCAGTGAACATGGCACCTAAGTTACGTGAAGCATTCCCGCCGAAGAAACGTAC
CTACTAG

Upstream 100 bases:

>100_bases
CGTCAAGTGCACGTCGTTACGTGGTGTTTTACAGTTCACCTTTGTCGTTACCGTATTTTGTTATTTAGCGGCCGGCATTG
TTATTGTGTGGGGTGTCTAA

Downstream 100 bases:

>100_bases
GAGTTGCAAAGATGAAATTGACATTTGCAGTTTATCGCTACAATCCTGACGTAGATACTAAACCGTATATGCAGGATTAC
ACCTTAGAAGTGGCTGAAGG

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 588; Mature: 587

Protein sequence:

>588_residues
MSIPVREFDAVVIGAGGAGMRAALQISKEGKSCALLSKVFPTRSHTVSAQGGITVALGNAHEDHWEQHMYDTVKGSDFIG
DQEAIEFMCKTGPEAVIELEQMGLPFSRFENGTIYQRPFGGQSKNFGGEQAARTAAAADRTGHALLHCLYQQNVKHKTQV
FSEWYALDLVKNDDGAVVGCTAIEIETGDIVYFKAKATILATGGAGRIYASTTNAHINTGDGVGMAMRAGVQMQDMEMWQ
FHPTGIAGAGVLVTEGCRGEGGYLLNKDGERFMERYAPNAKDLASRDVVARSMMTEIREGRGLDGPLGPHCLLKLDHLGK
ETLEARLPGVCELSRTFAHIDPADGPIPVLPTCHYMMGGLPTKVSGQVIRKNEDGTEHDVIGLFAVGEIACVSVHGANRL
GGNSLLDLVVFGRAAGQHLGKALDETDDPKDASDADIQASLARLNRWESNKDGEDPAQIRKDLQLCMQLNFSVFRRGDAM
AEGLEQLKVIRERLANAKLSDNSREFNTQRIECLELDNLMATAIATAYAANFRTESRGAHSREDYLERDDENWLCHSLFD
PITETMDRRAVNMAPKLREAFPPKKRTY

Sequences:

>Translated_588_residues
MSIPVREFDAVVIGAGGAGMRAALQISKEGKSCALLSKVFPTRSHTVSAQGGITVALGNAHEDHWEQHMYDTVKGSDFIG
DQEAIEFMCKTGPEAVIELEQMGLPFSRFENGTIYQRPFGGQSKNFGGEQAARTAAAADRTGHALLHCLYQQNVKHKTQV
FSEWYALDLVKNDDGAVVGCTAIEIETGDIVYFKAKATILATGGAGRIYASTTNAHINTGDGVGMAMRAGVQMQDMEMWQ
FHPTGIAGAGVLVTEGCRGEGGYLLNKDGERFMERYAPNAKDLASRDVVARSMMTEIREGRGLDGPLGPHCLLKLDHLGK
ETLEARLPGVCELSRTFAHIDPADGPIPVLPTCHYMMGGLPTKVSGQVIRKNEDGTEHDVIGLFAVGEIACVSVHGANRL
GGNSLLDLVVFGRAAGQHLGKALDETDDPKDASDADIQASLARLNRWESNKDGEDPAQIRKDLQLCMQLNFSVFRRGDAM
AEGLEQLKVIRERLANAKLSDNSREFNTQRIECLELDNLMATAIATAYAANFRTESRGAHSREDYLERDDENWLCHSLFD
PITETMDRRAVNMAPKLREAFPPKKRTY
>Mature_587_residues
SIPVREFDAVVIGAGGAGMRAALQISKEGKSCALLSKVFPTRSHTVSAQGGITVALGNAHEDHWEQHMYDTVKGSDFIGD
QEAIEFMCKTGPEAVIELEQMGLPFSRFENGTIYQRPFGGQSKNFGGEQAARTAAAADRTGHALLHCLYQQNVKHKTQVF
SEWYALDLVKNDDGAVVGCTAIEIETGDIVYFKAKATILATGGAGRIYASTTNAHINTGDGVGMAMRAGVQMQDMEMWQF
HPTGIAGAGVLVTEGCRGEGGYLLNKDGERFMERYAPNAKDLASRDVVARSMMTEIREGRGLDGPLGPHCLLKLDHLGKE
TLEARLPGVCELSRTFAHIDPADGPIPVLPTCHYMMGGLPTKVSGQVIRKNEDGTEHDVIGLFAVGEIACVSVHGANRLG
GNSLLDLVVFGRAAGQHLGKALDETDDPKDASDADIQASLARLNRWESNKDGEDPAQIRKDLQLCMQLNFSVFRRGDAMA
EGLEQLKVIRERLANAKLSDNSREFNTQRIECLELDNLMATAIATAYAANFRTESRGAHSREDYLERDDENWLCHSLFDP
ITETMDRRAVNMAPKLREAFPPKKRTY

Specific function: Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth [H]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=546, Percent_Identity=53.4798534798535, Blast_Score=525, Evalue=1e-149,
Organism=Escherichia coli, GI1786942, Length=588, Percent_Identity=80.2721088435374, Blast_Score=929, Evalue=0.0,
Organism=Escherichia coli, GI1790597, Length=573, Percent_Identity=39.2670157068063, Blast_Score=382, Evalue=1e-107,
Organism=Escherichia coli, GI1788928, Length=569, Percent_Identity=29.701230228471, Blast_Score=209, Evalue=3e-55,
Organism=Caenorhabditis elegans, GI17505833, Length=589, Percent_Identity=48.0475382003396, Blast_Score=528, Evalue=1e-150,
Organism=Caenorhabditis elegans, GI17550100, Length=592, Percent_Identity=48.1418918918919, Blast_Score=527, Evalue=1e-150,
Organism=Caenorhabditis elegans, GI71986328, Length=78, Percent_Identity=48.7179487179487, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6322701, Length=593, Percent_Identity=51.2647554806071, Blast_Score=563, Evalue=1e-161,
Organism=Saccharomyces cerevisiae, GI6322416, Length=554, Percent_Identity=53.971119133574, Blast_Score=562, Evalue=1e-161,
Organism=Saccharomyces cerevisiae, GI6320788, Length=490, Percent_Identity=26.734693877551, Blast_Score=104, Evalue=5e-23,
Organism=Saccharomyces cerevisiae, GI6322511, Length=488, Percent_Identity=23.9754098360656, Blast_Score=94, Evalue=5e-20,
Organism=Drosophila melanogaster, GI17137288, Length=546, Percent_Identity=52.9304029304029, Blast_Score=534, Evalue=1e-152,
Organism=Drosophila melanogaster, GI24655642, Length=546, Percent_Identity=52.9304029304029, Blast_Score=534, Evalue=1e-152,
Organism=Drosophila melanogaster, GI24655647, Length=546, Percent_Identity=52.9304029304029, Blast_Score=534, Evalue=1e-152,
Organism=Drosophila melanogaster, GI24663005, Length=548, Percent_Identity=48.9051094890511, Blast_Score=505, Evalue=1e-143,

Paralogues:

None

Copy number: 1900 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 1360 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 1100 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011281
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 64204; Mature: 64073

Theoretical pI: Translated: 5.72; Mature: 5.72

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIPVREFDAVVIGAGGAGMRAALQISKEGKSCALLSKVFPTRSHTVSAQGGITVALGNA
CCCCCCCCCEEEEECCCCCCEEEEEECCCCCHHHHHHHHCCCCCCEEECCCCEEEEECCC
HEDHWEQHMYDTVKGSDFIGDQEAIEFMCKTGPEAVIELEQMGLPFSRFENGTIYQRPFG
CHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHCCCHHHCCCCEEEECCCC
GQSKNFGGEQAARTAAAADRTGHALLHCLYQQNVKHKTQVFSEWYALDLVKNDDGAVVGC
CCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHEEEEEECCCCCEEEE
TAIEIETGDIVYFKAKATILATGGAGRIYASTTNAHINTGDGVGMAMRAGVQMQDMEMWQ
EEEEEECCCEEEEEEEEEEEEECCCCEEEEECCCCEEECCCCCCHHHHCCCCEECCHHEE
FHPTGIAGAGVLVTEGCRGEGGYLLNKDGERFMERYAPNAKDLASRDVVARSMMTEIREG
ECCCCCCCCCEEEECCCCCCCCEEECCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHC
RGLDGPLGPHCLLKLDHLGKETLEARLPGVCELSRTFAHIDPADGPIPVLPTCHYMMGGL
CCCCCCCCCHHEEEEHHCCHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHCCC
PTKVSGQVIRKNEDGTEHDVIGLFAVGEIACVSVHGANRLGGNSLLDLVVFGRAAGQHLG
CCCCCCEEEECCCCCCCCCEEEEEEECCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHH
KALDETDDPKDASDADIQASLARLNRWESNKDGEDPAQIRKDLQLCMQLNFSVFRRGDAM
HHHCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCHHHHHCCHHH
AEGLEQLKVIRERLANAKLSDNSREFNTQRIECLELDNLMATAIATAYAANFRTESRGAH
HHHHHHHHHHHHHHCCCCCCCCCCCCCCHHEEEHHHHHHHHHHHHHHHHHHCCCCCCCCC
SREDYLERDDENWLCHSLFDPITETMDRRAVNMAPKLREAFPPKKRTY
CHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCC
>Mature Secondary Structure 
SIPVREFDAVVIGAGGAGMRAALQISKEGKSCALLSKVFPTRSHTVSAQGGITVALGNA
CCCCCCCCEEEEECCCCCCEEEEEECCCCCHHHHHHHHCCCCCCEEECCCCEEEEECCC
HEDHWEQHMYDTVKGSDFIGDQEAIEFMCKTGPEAVIELEQMGLPFSRFENGTIYQRPFG
CHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHCCCHHHCCCCEEEECCCC
GQSKNFGGEQAARTAAAADRTGHALLHCLYQQNVKHKTQVFSEWYALDLVKNDDGAVVGC
CCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHEEEEEECCCCCEEEE
TAIEIETGDIVYFKAKATILATGGAGRIYASTTNAHINTGDGVGMAMRAGVQMQDMEMWQ
EEEEEECCCEEEEEEEEEEEEECCCCEEEEECCCCEEECCCCCCHHHHCCCCEECCHHEE
FHPTGIAGAGVLVTEGCRGEGGYLLNKDGERFMERYAPNAKDLASRDVVARSMMTEIREG
ECCCCCCCCCEEEECCCCCCCCEEECCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHC
RGLDGPLGPHCLLKLDHLGKETLEARLPGVCELSRTFAHIDPADGPIPVLPTCHYMMGGL
CCCCCCCCCHHEEEEHHCCHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHCCC
PTKVSGQVIRKNEDGTEHDVIGLFAVGEIACVSVHGANRLGGNSLLDLVVFGRAAGQHLG
CCCCCCEEEECCCCCCCCCEEEEEEECCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHH
KALDETDDPKDASDADIQASLARLNRWESNKDGEDPAQIRKDLQLCMQLNFSVFRRGDAM
HHHCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCHHHHHCCHHH
AEGLEQLKVIRERLANAKLSDNSREFNTQRIECLELDNLMATAIATAYAANFRTESRGAH
HHHHHHHHHHHHHHCCCCCCCCCCCCCCHHEEEHHHHHHHHHHHHHHHHHHCCCCCCCCC
SREDYLERDDENWLCHSLFDPITETMDRRAVNMAPKLREAFPPKKRTY
CHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]