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The map label for this gene is phoP [H]

Identifier: 160875726

GI number: 160875726

Start: 3099386

End: 3100069

Strand: Direct

Name: phoP [H]

Synonym: Sbal195_2614

Alternate gene names: 160875726

Gene position: 3099386-3100069 (Clockwise)

Preceding gene: 160875725

Following gene: 160875727

Centisome position: 57.96

GC content: 44.3

Gene sequence:

>684_bases
ATGTATATTATGAGAATTTTGGTTGTTGAAGACGATCCTATTTTATCCCACCACTTAAAAGTGCAATTAAGCGATCTCGG
CAATCAAGTTCAAGTGGCGCTCACTGCCAAAGAAGGTTTCTATCAAGCCACGAATTATCCCATCGATGTGGCTATTGTCG
ATTTAGGTTTACCCGATCAAGATGGCATTAGCTTAATTGAACAACTCAGAGAAGCGGGTCTTAAAGCGCCGATATTAATC
CTCACCGCCCGAGTTAATTGGCAGGATAAAGTCGAAGGCCTTAATGCTGGTGCCGATGACTATTTAGTCAAGCCCTTTCA
AAAAGAAGAACTCGTCGCGAGACTCGATGCCTTAGTACGCCGCAGTGCAGGTTTTGTTAAACCTGTGATTTGCAGTGGAG
AATTAAAACTCGATCTCGCCGCTAAACAAGTCACCCTGAGCGATGAAATCATGGAAGTCACCGCCTTTGAATATTTGATC
CTCGAATATTTAATGCGTCATTGCCATGAGGTGGTTGCCAAACAACGTTTGCTCGATGTGATTTATGGCGATAAAGAAGG
CGATCCGAATACGATTGAAGTCATGGTCAGCCGCCTGCGCAAAAAACTGACCCGCGATGGGATAGACAATCCTATCGTCA
CCATTCGCGGCCAAGGATATAAATTTAACCTGCCATGCAACTAA

Upstream 100 bases:

>100_bases
GTTAAGTTCAACTAAGATATGCTGATACTCTATTTGGTTATCAGTGTGATTTTGCGTAGACTGCTTTGCTAACTAAGGCT
TAGCTCATCCACTTTAAGGC

Downstream 100 bases:

>100_bases
GATTAAAATTTAAGAAACGTCTGCTGACGCGGATGTTTCTCACCTCGCTATCGATTATTGCCTTAGTGGGTTTTGGTCTC
GCATGGATGGTTAATATTCT

Product: two component transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 227; Mature: 227

Protein sequence:

>227_residues
MYIMRILVVEDDPILSHHLKVQLSDLGNQVQVALTAKEGFYQATNYPIDVAIVDLGLPDQDGISLIEQLREAGLKAPILI
LTARVNWQDKVEGLNAGADDYLVKPFQKEELVARLDALVRRSAGFVKPVICSGELKLDLAAKQVTLSDEIMEVTAFEYLI
LEYLMRHCHEVVAKQRLLDVIYGDKEGDPNTIEVMVSRLRKKLTRDGIDNPIVTIRGQGYKFNLPCN

Sequences:

>Translated_227_residues
MYIMRILVVEDDPILSHHLKVQLSDLGNQVQVALTAKEGFYQATNYPIDVAIVDLGLPDQDGISLIEQLREAGLKAPILI
LTARVNWQDKVEGLNAGADDYLVKPFQKEELVARLDALVRRSAGFVKPVICSGELKLDLAAKQVTLSDEIMEVTAFEYLI
LEYLMRHCHEVVAKQRLLDVIYGDKEGDPNTIEVMVSRLRKKLTRDGIDNPIVTIRGQGYKFNLPCN
>Mature_227_residues
MYIMRILVVEDDPILSHHLKVQLSDLGNQVQVALTAKEGFYQATNYPIDVAIVDLGLPDQDGISLIEQLREAGLKAPILI
LTARVNWQDKVEGLNAGADDYLVKPFQKEELVARLDALVRRSAGFVKPVICSGELKLDLAAKQVTLSDEIMEVTAFEYLI
LEYLMRHCHEVVAKQRLLDVIYGDKEGDPNTIEVMVSRLRKKLTRDGIDNPIVTIRGQGYKFNLPCN

Specific function: Member of the two-component regulatory system phoQ/phoP which regulates the expression of genes involved in virulence and resistance to host defense antimicrobial peptides [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1787375, Length=222, Percent_Identity=49.5495495495495, Blast_Score=215, Evalue=2e-57,
Organism=Escherichia coli, GI1789402, Length=221, Percent_Identity=38.0090497737557, Blast_Score=140, Evalue=9e-35,
Organism=Escherichia coli, GI1786784, Length=224, Percent_Identity=35.7142857142857, Blast_Score=134, Evalue=5e-33,
Organism=Escherichia coli, GI1790552, Length=220, Percent_Identity=38.6363636363636, Blast_Score=130, Evalue=6e-32,
Organism=Escherichia coli, GI1786911, Length=228, Percent_Identity=34.2105263157895, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI1786599, Length=223, Percent_Identity=34.9775784753363, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI1789809, Length=228, Percent_Identity=33.7719298245614, Blast_Score=118, Evalue=3e-28,
Organism=Escherichia coli, GI87082012, Length=220, Percent_Identity=32.7272727272727, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI1790860, Length=222, Percent_Identity=34.2342342342342, Blast_Score=113, Evalue=9e-27,
Organism=Escherichia coli, GI2367329, Length=227, Percent_Identity=31.7180616740088, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI1787229, Length=224, Percent_Identity=29.0178571428571, Blast_Score=91, Evalue=6e-20,
Organism=Escherichia coli, GI1788394, Length=223, Percent_Identity=28.2511210762332, Blast_Score=86, Evalue=1e-18,
Organism=Escherichia coli, GI1790863, Length=235, Percent_Identity=30.6382978723404, Blast_Score=85, Evalue=4e-18,
Organism=Escherichia coli, GI1788550, Length=109, Percent_Identity=29.3577981651376, Blast_Score=64, Evalue=6e-12,
Organism=Escherichia coli, GI145693157, Length=102, Percent_Identity=34.3137254901961, Blast_Score=61, Evalue=6e-11,
Organism=Escherichia coli, GI145693140, Length=234, Percent_Identity=26.0683760683761, Blast_Score=60, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25487; Mature: 25487

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYIMRILVVEDDPILSHHLKVQLSDLGNQVQVALTAKEGFYQATNYPIDVAIVDLGLPDQ
CEEEEEEEECCCCCHHHHEEEEECCCCCEEEEEEEECCCCEECCCCCEEEEEEEECCCCC
DGISLIEQLREAGLKAPILILTARVNWQDKVEGLNAGADDYLVKPFQKEELVARLDALVR
CHHHHHHHHHHCCCCCCEEEEEEECCCHHHHCCCCCCCCCHHCCCCCHHHHHHHHHHHHH
RSAGFVKPVICSGELKLDLAAKQVTLSDEIMEVTAFEYLILEYLMRHCHEVVAKQRLLDV
HCCCCCCEEEECCCEEEEEEHHEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IYGDKEGDPNTIEVMVSRLRKKLTRDGIDNPIVTIRGQGYKFNLPCN
HCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCEEEECCCC
>Mature Secondary Structure
MYIMRILVVEDDPILSHHLKVQLSDLGNQVQVALTAKEGFYQATNYPIDVAIVDLGLPDQ
CEEEEEEEECCCCCHHHHEEEEECCCCCEEEEEEEECCCCEECCCCCEEEEEEEECCCCC
DGISLIEQLREAGLKAPILILTARVNWQDKVEGLNAGADDYLVKPFQKEELVARLDALVR
CHHHHHHHHHHCCCCCCEEEEEEECCCHHHHCCCCCCCCCHHCCCCCHHHHHHHHHHHHH
RSAGFVKPVICSGELKLDLAAKQVTLSDEIMEVTAFEYLILEYLMRHCHEVVAKQRLLDV
HCCCCCCEEEECCCEEEEEEHHEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IYGDKEGDPNTIEVMVSRLRKKLTRDGIDNPIVTIRGQGYKFNLPCN
HCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA