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The map label for this gene is frmA [H]

Identifier: 160875638

GI number: 160875638

Start: 2985316

End: 2986455

Strand: Reverse

Name: frmA [H]

Synonym: Sbal195_2526

Alternate gene names: 160875638

Gene position: 2986455-2985316 (Counterclockwise)

Preceding gene: 160875640

Following gene: 160875637

Centisome position: 55.85

GC content: 50.79

Gene sequence:

>1140_bases
ATGTCGAACGAAAAACCGCAGTTTATTAAATCAAAGGCCGCAGTTGCTTGGGGACCAGGACAACCACTGAAGATTGAAGA
AGTGGATGTGATGTTACCTAAAGCGGGCGAAGTCTTAGTGCGCATTGTGGCCACCGGCGTGTGTCACACGGATGCGTTTA
CCCTGAGCGGTGACGATCCTGAAGGGGTATTCCCGGCGATTCTAGGCCACGAAGGCGGCGGTATCGTTGAGCAAGTGGGT
GAGGGCGTGACCAGCGTGCAAGTGGGCGATCATGTGATCCCACTTTATACCCCCGAGTGCGGCGAGTGTAAGTTCTGCCT
ATCGGGCAAAACTAACCTGTGCCAAAAAATTCGCGCGACCCAAGGTAAAGGCTTAATGCCCGATGGCACCACGCGTTTTT
ATCTCGATGGCAAACCTATTTTCCATTACATGGGCTGCTCGACTTTCTCTGAATATACCGTGTTGCCTGAAATCTCATTG
GCGAAAGTCAATAAGAGCGCGCCATTAGAAGAAATTTGTCTGTTAGGTTGTGGCGTGACTACAGGCATGGGCGCTGTGAT
GAACACGGCCAAAGTGGAAGAAGGCGCGACCGTGGCGATTTTCGGCCTCGGCGGTATCGGTTTATCGGCGATCATTGGGG
CGACTATGGCAAAAGCCAGCCGCATTATCGCCATTGATATCAACGAGTCTAAATTCGAGTTAGCCAAAAAACTTGGTGCG
ACCGATTGCATCAACCCTAAATTACTCGATAAGCCCATCCAAGAGGTGATTGTTGAGATGACCGACGGCGGCGTAGATTA
CTCATTTGAGTGTATCGGCAACGTCAATGTGATGCGCAGCGCTTTAGAGTGTTGTCATAAGGGTTGGGGCGAGTCGGTGA
TTATCGGTGTTGCCGGTGCAGGCCAAGAGATTTCAACCCGTCCATTCCAATTAGTTACTGGCCGAGTGTGGCGCGGTTCT
GCCTTTGGCGGCGTGAAAGGGCGTTCTGAACTGCCACACATTGTTGAGCGTTACATGGCGGGTGAGTTTAAGCTCGATGA
CTTTATCACTCACACTATGGGGCTTGAGCAAATCAATGAAGCGTTCGAGCTGATGCACGAAGGTAAAAGCATCCGTAGCG
TGATCCATTTTGATAAATAA

Upstream 100 bases:

>100_bases
CCTTATTCTGAGTCTGTATGCTTGAACCAATATGCTTTAGCTTAAGTAGAATCGATTACAACAATAATTTTCTCCTATTA
CCTATCAAGGGACGGTAACA

Downstream 100 bases:

>100_bases
GCGGTTTCGCACTGTCAATTGATGCTTCAGCTTGATGTGACAAATCGGCAGACAGGTGACAATCTGTCTGCTGTGTTGCA
CTGAGCAGATGACAAACGCT

Product: S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase

Products: NA

Alternate protein names: Alcohol dehydrogenase class-3; Alcohol dehydrogenase class-III; Glutathione-dependent formaldehyde dehydrogenase; FALDH; FDH; GSH-FDH [H]

Number of amino acids: Translated: 379; Mature: 378

Protein sequence:

>379_residues
MSNEKPQFIKSKAAVAWGPGQPLKIEEVDVMLPKAGEVLVRIVATGVCHTDAFTLSGDDPEGVFPAILGHEGGGIVEQVG
EGVTSVQVGDHVIPLYTPECGECKFCLSGKTNLCQKIRATQGKGLMPDGTTRFYLDGKPIFHYMGCSTFSEYTVLPEISL
AKVNKSAPLEEICLLGCGVTTGMGAVMNTAKVEEGATVAIFGLGGIGLSAIIGATMAKASRIIAIDINESKFELAKKLGA
TDCINPKLLDKPIQEVIVEMTDGGVDYSFECIGNVNVMRSALECCHKGWGESVIIGVAGAGQEISTRPFQLVTGRVWRGS
AFGGVKGRSELPHIVERYMAGEFKLDDFITHTMGLEQINEAFELMHEGKSIRSVIHFDK

Sequences:

>Translated_379_residues
MSNEKPQFIKSKAAVAWGPGQPLKIEEVDVMLPKAGEVLVRIVATGVCHTDAFTLSGDDPEGVFPAILGHEGGGIVEQVG
EGVTSVQVGDHVIPLYTPECGECKFCLSGKTNLCQKIRATQGKGLMPDGTTRFYLDGKPIFHYMGCSTFSEYTVLPEISL
AKVNKSAPLEEICLLGCGVTTGMGAVMNTAKVEEGATVAIFGLGGIGLSAIIGATMAKASRIIAIDINESKFELAKKLGA
TDCINPKLLDKPIQEVIVEMTDGGVDYSFECIGNVNVMRSALECCHKGWGESVIIGVAGAGQEISTRPFQLVTGRVWRGS
AFGGVKGRSELPHIVERYMAGEFKLDDFITHTMGLEQINEAFELMHEGKSIRSVIHFDK
>Mature_378_residues
SNEKPQFIKSKAAVAWGPGQPLKIEEVDVMLPKAGEVLVRIVATGVCHTDAFTLSGDDPEGVFPAILGHEGGGIVEQVGE
GVTSVQVGDHVIPLYTPECGECKFCLSGKTNLCQKIRATQGKGLMPDGTTRFYLDGKPIFHYMGCSTFSEYTVLPEISLA
KVNKSAPLEEICLLGCGVTTGMGAVMNTAKVEEGATVAIFGLGGIGLSAIIGATMAKASRIIAIDINESKFELAKKLGAT
DCINPKLLDKPIQEVIVEMTDGGVDYSFECIGNVNVMRSALECCHKGWGESVIIGVAGAGQEISTRPFQLVTGRVWRGSA
FGGVKGRSELPHIVERYMAGEFKLDDFITHTMGLEQINEAFELMHEGKSIRSVIHFDK

Specific function: Has High Formaldehyde Dehydrogenase Activity In The Presence Of Glutathione And Catalyzes The Oxidation Of Normal Alcohols In A Reaction That Is Not Gsh-Dependent. In Addition, Hemithiolacetals Other Than Those Formed From Gsh, Including Omega-Thiol Fatty

COG id: COG1062

COG function: function code C; Zn-dependent alcohol dehydrogenases, class III

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily [H]

Homologues:

Organism=Homo sapiens, GI71565154, Length=375, Percent_Identity=65.8666666666667, Blast_Score=513, Evalue=1e-146,
Organism=Homo sapiens, GI34577061, Length=373, Percent_Identity=52.8150134048257, Blast_Score=413, Evalue=1e-115,
Organism=Homo sapiens, GI4501929, Length=373, Percent_Identity=52.0107238605898, Blast_Score=401, Evalue=1e-112,
Organism=Homo sapiens, GI71565152, Length=377, Percent_Identity=51.7241379310345, Blast_Score=400, Evalue=1e-111,
Organism=Homo sapiens, GI4501933, Length=373, Percent_Identity=51.4745308310992, Blast_Score=400, Evalue=1e-111,
Organism=Homo sapiens, GI156523966, Length=369, Percent_Identity=49.5934959349593, Blast_Score=385, Evalue=1e-107,
Organism=Homo sapiens, GI4501939, Length=363, Percent_Identity=49.862258953168, Blast_Score=381, Evalue=1e-106,
Organism=Homo sapiens, GI262073058, Length=369, Percent_Identity=49.5934959349593, Blast_Score=377, Evalue=1e-104,
Organism=Homo sapiens, GI71743840, Length=371, Percent_Identity=49.3261455525606, Blast_Score=376, Evalue=1e-104,
Organism=Escherichia coli, GI1786552, Length=369, Percent_Identity=69.9186991869919, Blast_Score=532, Evalue=1e-152,
Organism=Escherichia coli, GI1790045, Length=372, Percent_Identity=27.4193548387097, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI1787863, Length=359, Percent_Identity=26.1838440111421, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI87082125, Length=376, Percent_Identity=26.063829787234, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI1788073, Length=361, Percent_Identity=26.5927977839335, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI87081918, Length=228, Percent_Identity=34.6491228070175, Blast_Score=85, Evalue=6e-18,
Organism=Escherichia coli, GI1786825, Length=274, Percent_Identity=28.1021897810219, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI1788075, Length=367, Percent_Identity=26.158038147139, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1788407, Length=225, Percent_Identity=30.2222222222222, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI226510992, Length=355, Percent_Identity=22.5352112676056, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1786518, Length=372, Percent_Identity=26.0752688172043, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI25146526, Length=383, Percent_Identity=60.5744125326371, Blast_Score=489, Evalue=1e-138,
Organism=Caenorhabditis elegans, GI71997431, Length=385, Percent_Identity=60.2597402597403, Blast_Score=484, Evalue=1e-137,
Organism=Caenorhabditis elegans, GI17565904, Length=343, Percent_Identity=60.3498542274053, Blast_Score=445, Evalue=1e-125,
Organism=Caenorhabditis elegans, GI17562584, Length=367, Percent_Identity=28.0653950953678, Blast_Score=88, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI17562582, Length=382, Percent_Identity=27.7486910994764, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI71988145, Length=362, Percent_Identity=26.7955801104972, Blast_Score=85, Evalue=7e-17,
Organism=Saccharomyces cerevisiae, GI6320033, Length=375, Percent_Identity=59.4666666666667, Blast_Score=472, Evalue=1e-134,
Organism=Saccharomyces cerevisiae, GI6319621, Length=378, Percent_Identity=29.1005291005291, Blast_Score=96, Evalue=7e-21,
Organism=Saccharomyces cerevisiae, GI6323099, Length=379, Percent_Identity=29.023746701847, Blast_Score=95, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6323729, Length=366, Percent_Identity=28.6885245901639, Blast_Score=92, Evalue=9e-20,
Organism=Saccharomyces cerevisiae, GI6324486, Length=364, Percent_Identity=26.9230769230769, Blast_Score=89, Evalue=8e-19,
Organism=Saccharomyces cerevisiae, GI6323961, Length=364, Percent_Identity=26.6483516483516, Blast_Score=86, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6319258, Length=266, Percent_Identity=27.0676691729323, Blast_Score=74, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6322619, Length=362, Percent_Identity=26.5193370165746, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI17737895, Length=379, Percent_Identity=63.3245382585752, Blast_Score=504, Evalue=1e-143,
Organism=Drosophila melanogaster, GI17137530, Length=348, Percent_Identity=27.5862068965517, Blast_Score=83, Evalue=4e-16,
Organism=Drosophila melanogaster, GI17737897, Length=373, Percent_Identity=25.4691689008043, Blast_Score=73, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014183
- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.284; =1.1.1.1 [H]

Molecular weight: Translated: 40531; Mature: 40400

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
3.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNEKPQFIKSKAAVAWGPGQPLKIEEVDVMLPKAGEVLVRIVATGVCHTDAFTLSGDDP
CCCCCCCHHHHCCEEEECCCCCCEEEEEEEECCCHHHHHHHHHHHCCCCCCEEEECCCCC
EGVFPAILGHEGGGIVEQVGEGVTSVQVGDHVIPLYTPECGECKFCLSGKTNLCQKIRAT
CCCCHHEECCCCCCHHHHHCCCCEEEEECCEEEEEECCCCCCEEEEECCCHHHHHHHHHC
QGKGLMPDGTTRFYLDGKPIFHYMGCSTFSEYTVLPEISLAKVNKSAPLEEICLLGCGVT
CCCCCCCCCCEEEEECCCCEEEEECCCCCCCEEECCCCHHHHCCCCCCHHHHHHHHCCHH
TGMGAVMNTAKVEEGATVAIFGLGGIGLSAIIGATMAKASRIIAIDINESKFELAKKLGA
HHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHCCEEEEEEECCHHHHHHHHCCC
TDCINPKLLDKPIQEVIVEMTDGGVDYSFECIGNVNVMRSALECCHKGWGESVIIGVAGA
CCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHCCCCCEEEEEEECC
GQEISTRPFQLVTGRVWRGSAFGGVKGRSELPHIVERYMAGEFKLDDFITHTMGLEQINE
CCCCCCCCEEEEECEEECCCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHCHHHHHH
AFELMHEGKSIRSVIHFDK
HHHHHHCCHHHHHHHCCCC
>Mature Secondary Structure 
SNEKPQFIKSKAAVAWGPGQPLKIEEVDVMLPKAGEVLVRIVATGVCHTDAFTLSGDDP
CCCCCCHHHHCCEEEECCCCCCEEEEEEEECCCHHHHHHHHHHHCCCCCCEEEECCCCC
EGVFPAILGHEGGGIVEQVGEGVTSVQVGDHVIPLYTPECGECKFCLSGKTNLCQKIRAT
CCCCHHEECCCCCCHHHHHCCCCEEEEECCEEEEEECCCCCCEEEEECCCHHHHHHHHHC
QGKGLMPDGTTRFYLDGKPIFHYMGCSTFSEYTVLPEISLAKVNKSAPLEEICLLGCGVT
CCCCCCCCCCEEEEECCCCEEEEECCCCCCCEEECCCCHHHHCCCCCCHHHHHHHHCCHH
TGMGAVMNTAKVEEGATVAIFGLGGIGLSAIIGATMAKASRIIAIDINESKFELAKKLGA
HHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHCCEEEEEEECCHHHHHHHHCCC
TDCINPKLLDKPIQEVIVEMTDGGVDYSFECIGNVNVMRSALECCHKGWGESVIIGVAGA
CCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHCCCCCEEEEEEECC
GQEISTRPFQLVTGRVWRGSAFGGVKGRSELPHIVERYMAGEFKLDDFITHTMGLEQINE
CCCCCCCCEEEEECEEECCCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHCHHHHHH
AFELMHEGKSIRSVIHFDK
HHHHHHCCHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]