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The map label for this gene is thiC [H]

Identifier: 160875551

GI number: 160875551

Start: 2883769

End: 2885892

Strand: Reverse

Name: thiC [H]

Synonym: Sbal195_2439

Alternate gene names: 160875551

Gene position: 2885892-2883769 (Counterclockwise)

Preceding gene: 160875552

Following gene: 160875550

Centisome position: 53.97

GC content: 51.18

Gene sequence:

>2124_bases
ATGTCCAGTTCAAACCAAAACCCAGCTGTAGCTGCCAATGCGATAGAAATCACTGCGCCAGAATCGACAATCCCTAATAA
ATCGACAGTGGCTAATAAATCGGCTGAGTCTAGTCAATCAATCGTGCCTAAGGCGCCGAGTCGCCGCGAAACCCGCGCGC
AGGCTCAAGCCTTTATCGATACGTTAGCGCCGCTGCAACATCCTAATTCACAAAAGATTTATCTCGAAGGTTCCAGTGCC
GATATTCGCGTTGGCATGCGGCAAATTCTGCAGACTGACACGCTTGTCGGCGGTACAGATGATGCGCCAATCATGGAAAA
AAATCCGCCAATCCGCGTGTATGATTGCGCTGGACCTTATTCCGATCCTGAGGCCGACATCAATGTGCGTCTAGGCCTTG
GTAAATTAAGACAAAACTGGATCCTAGCCCGCAACGATACAGAGCAATTACCCTGCGCGACCTCAGATTTTACCCAACAA
AGACTCGCTGACGACGGTTTAGACCATCTGCGTTTTGAGGTGGGCTCGAGTGCCATTGTCCGCCCACGCAGAGCGCTGCA
GGGCAAACGAGTTAGTCAATTACACTATGCCCGTCAAGGGATTATCACGCCCGAAATGGAATATGTGGCGATCCGCGAGA
ACATGGCACTTGCGCAAGTACAGGATGAAATCCTCAATCGTAAAGCCAAGGGCGAAGCTTTTGGTGCCTTAGTCGGCGAA
CCGATTACCGCCGAATTTGTCCGCGCCGAAGTTGCCCGTGGCCGCGCGATTATTCCGCTGAATATTAACCATCCCGAAGC
CGAACCTATGATTATCGGGCGTAATTTTCTGGTGAAAGTGAACGCCAATATCGGTAACTCGGCGGTGACGTCTTCCATCG
AGGAAGAAGTGGAAAAGCTTGTCTGGTCAACCCGTTGGGGGGCAGATACTGTCATGGATTTATCCACGGGTCGTTATATT
CACGAAACCCGCGAGTGGATCATCCGCAACTCACCAGTGCCCATCGGCACAGTGCCGATTTATCAAGCGCTGGAGAAAGT
GAACGGCGTGGCAGAGGATTTAACCTGGGAAGTGTTCCGCGATACCTTGATTGAACAAGCTGAGCAAGGTGTTGATTACT
TTACTATTCATGCTGGTGTGCTGCTGCGTTATGTGCCGATGACGGCTAAACGTGTTACTGGGATCGTTTCTCGCGGCGGT
TCAATTATGGCCAAATGGTGCCTGAGTCATCACAAGGAAAACTTCCTCTACAGCCATTTTCGTGAGATCTGTGAGCTTTG
CGTCGCCTACGATGTATCCCTGTCTTTAGGTGATGGTATGCGTCCCGGATCGATTGCCGACGCTAATGATGCTGCCCAGT
TTGCAGAGCTTGAAACCTTAGGTGAGCTAGTCAAAATCGCGTGGGAATACGACGTACAAACCATTATCGAAGGGCCGGGA
CATATCCCGATGCAGCTCATTAAAGAGAACATGGACAAGCAGTTAGCTCACTGCGATGAGGCGCCGTTTTACACGCTTGG
CCCGCAAATCACTGATATCGCACCTGGGTATGATCATTTCACCTCCGGCATAGGCGCGGCCATGATTGCTTGGTACGGCT
GCGCTATGTTGTGTTATGTCACGCCAAAAGAACACTTAGGATTACCGAATAAACAAGATGTTAAGCAAGGTTTGATTGCT
TATAAGATTGCCGCCCACGCCGCCGATGTGGCGAAAGGTCATCCGAGTGCGCAAATTCGTGATAATGCGCTGGCAAAGGC
GCGGTTCGAATTCCGCTGGGAAGATCAATATAACTTAGGACTCGATCCTGAAACCGCACGTGCTTATCACGATGAATCTT
TACCGCAGGAATCCGCTAAAGTCGCGCATTTTTGCTCTATGTGCGGCCCTAAATTTTGTTCGATGAAAATCACCCAAGAT
GTGCGCGCCTATGCCGCTGGCTTAGAGGCGGCACAAGCGAAGGCGGAGCAAGTTGAAGCGGCTGCCCAAGCCATGCAAGT
CACAGTCAAGACGCCGCAGGAGTTGGAAGCGGCAATGGCGCTAAAATCGGCAGAGTTTGCTGCTTCGGGCGCCGAGATCT
ATCACGTGAAAGACAAGCTTGTCGCCGAAGCTGAGGAAGCCTAA

Upstream 100 bases:

>100_bases
TTTGAAGCCAGTGTTGGCCACAAAAATTGATTGCCATGTCTAGCTATCAACAACTCAATTCTCCAGACAAGCAACTCCAT
TTTTTAACGTGAGATTGCTT

Downstream 100 bases:

>100_bases
TTATGCAGGGTATTCATGGGGGGAAATTGCCCATGAGTACCGAGCGTCCCGCGTTTGTTTGGACCATAGCTGGTTCAGAC
AGTGGCGGTGGTGCCGGTAT

Product: thiamine biosynthesis protein ThiC

Products: @AMIN06.txt*4-amino-2-methyl-5-hydroxymethylpyrimidine!; 4-amino-5-hydroxymethyl-2-methylpyrimidine-phosphate [C]

Alternate protein names: Hydroxymethylpyrimidine phosphate synthase; HMP-P synthase; HMP-phosphate synthase; HMPP synthase; Thiamine biosynthesis protein thiC [H]

Number of amino acids: Translated: 707; Mature: 706

Protein sequence:

>707_residues
MSSSNQNPAVAANAIEITAPESTIPNKSTVANKSAESSQSIVPKAPSRRETRAQAQAFIDTLAPLQHPNSQKIYLEGSSA
DIRVGMRQILQTDTLVGGTDDAPIMEKNPPIRVYDCAGPYSDPEADINVRLGLGKLRQNWILARNDTEQLPCATSDFTQQ
RLADDGLDHLRFEVGSSAIVRPRRALQGKRVSQLHYARQGIITPEMEYVAIRENMALAQVQDEILNRKAKGEAFGALVGE
PITAEFVRAEVARGRAIIPLNINHPEAEPMIIGRNFLVKVNANIGNSAVTSSIEEEVEKLVWSTRWGADTVMDLSTGRYI
HETREWIIRNSPVPIGTVPIYQALEKVNGVAEDLTWEVFRDTLIEQAEQGVDYFTIHAGVLLRYVPMTAKRVTGIVSRGG
SIMAKWCLSHHKENFLYSHFREICELCVAYDVSLSLGDGMRPGSIADANDAAQFAELETLGELVKIAWEYDVQTIIEGPG
HIPMQLIKENMDKQLAHCDEAPFYTLGPQITDIAPGYDHFTSGIGAAMIAWYGCAMLCYVTPKEHLGLPNKQDVKQGLIA
YKIAAHAADVAKGHPSAQIRDNALAKARFEFRWEDQYNLGLDPETARAYHDESLPQESAKVAHFCSMCGPKFCSMKITQD
VRAYAAGLEAAQAKAEQVEAAAQAMQVTVKTPQELEAAMALKSAEFAASGAEIYHVKDKLVAEAEEA

Sequences:

>Translated_707_residues
MSSSNQNPAVAANAIEITAPESTIPNKSTVANKSAESSQSIVPKAPSRRETRAQAQAFIDTLAPLQHPNSQKIYLEGSSA
DIRVGMRQILQTDTLVGGTDDAPIMEKNPPIRVYDCAGPYSDPEADINVRLGLGKLRQNWILARNDTEQLPCATSDFTQQ
RLADDGLDHLRFEVGSSAIVRPRRALQGKRVSQLHYARQGIITPEMEYVAIRENMALAQVQDEILNRKAKGEAFGALVGE
PITAEFVRAEVARGRAIIPLNINHPEAEPMIIGRNFLVKVNANIGNSAVTSSIEEEVEKLVWSTRWGADTVMDLSTGRYI
HETREWIIRNSPVPIGTVPIYQALEKVNGVAEDLTWEVFRDTLIEQAEQGVDYFTIHAGVLLRYVPMTAKRVTGIVSRGG
SIMAKWCLSHHKENFLYSHFREICELCVAYDVSLSLGDGMRPGSIADANDAAQFAELETLGELVKIAWEYDVQTIIEGPG
HIPMQLIKENMDKQLAHCDEAPFYTLGPQITDIAPGYDHFTSGIGAAMIAWYGCAMLCYVTPKEHLGLPNKQDVKQGLIA
YKIAAHAADVAKGHPSAQIRDNALAKARFEFRWEDQYNLGLDPETARAYHDESLPQESAKVAHFCSMCGPKFCSMKITQD
VRAYAAGLEAAQAKAEQVEAAAQAMQVTVKTPQELEAAMALKSAEFAASGAEIYHVKDKLVAEAEEA
>Mature_706_residues
SSSNQNPAVAANAIEITAPESTIPNKSTVANKSAESSQSIVPKAPSRRETRAQAQAFIDTLAPLQHPNSQKIYLEGSSAD
IRVGMRQILQTDTLVGGTDDAPIMEKNPPIRVYDCAGPYSDPEADINVRLGLGKLRQNWILARNDTEQLPCATSDFTQQR
LADDGLDHLRFEVGSSAIVRPRRALQGKRVSQLHYARQGIITPEMEYVAIRENMALAQVQDEILNRKAKGEAFGALVGEP
ITAEFVRAEVARGRAIIPLNINHPEAEPMIIGRNFLVKVNANIGNSAVTSSIEEEVEKLVWSTRWGADTVMDLSTGRYIH
ETREWIIRNSPVPIGTVPIYQALEKVNGVAEDLTWEVFRDTLIEQAEQGVDYFTIHAGVLLRYVPMTAKRVTGIVSRGGS
IMAKWCLSHHKENFLYSHFREICELCVAYDVSLSLGDGMRPGSIADANDAAQFAELETLGELVKIAWEYDVQTIIEGPGH
IPMQLIKENMDKQLAHCDEAPFYTLGPQITDIAPGYDHFTSGIGAAMIAWYGCAMLCYVTPKEHLGLPNKQDVKQGLIAY
KIAAHAADVAKGHPSAQIRDNALAKARFEFRWEDQYNLGLDPETARAYHDESLPQESAKVAHFCSMCGPKFCSMKITQDV
RAYAAGLEAAQAKAEQVEAAAQAMQVTVKTPQELEAAMALKSAEFAASGAEIYHVKDKLVAEAEEA

Specific function: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction [H]

COG id: COG0422

COG function: function code H; Thiamine biosynthesis protein ThiC

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiC family [H]

Homologues:

Organism=Escherichia coli, GI1790427, Length=653, Percent_Identity=72.7411944869831, Blast_Score=1000, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002817 [H]

Pfam domain/function: PF01964 ThiC [H]

EC number: NA

Molecular weight: Translated: 77654; Mature: 77523

Theoretical pI: Translated: 5.20; Mature: 5.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSSNQNPAVAANAIEITAPESTIPNKSTVANKSAESSQSIVPKAPSRRETRAQAQAFID
CCCCCCCCCEEECEEEEECCCCCCCCCHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
TLAPLQHPNSQKIYLEGSSADIRVGMRQILQTDTLVGGTDDAPIMEKNPPIRVYDCAGPY
HHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEECCCCC
SDPEADINVRLGLGKLRQNWILARNDTEQLPCATSDFTQQRLADDGLDHLRFEVGSSAIV
CCCCCCEEEEEEHHHHCCCEEEECCCCCCCCCCCCHHHHHHHHHCCHHHHHHHCCCCHHC
RPRRALQGKRVSQLHYARQGIITPEMEYVAIRENMALAQVQDEILNRKAKGEAFGALVGE
CCHHHHCCCHHHHHHHHHHCCCCCCCCEEEECCCHHHHHHHHHHHCCCCCCCHHHHHHCC
PITAEFVRAEVARGRAIIPLNINHPEAEPMIIGRNFLVKVNANIGNSAVTSSIEEEVEKL
CHHHHHHHHHHHCCCEEEEEECCCCCCCCEEECCEEEEEEECCCCCHHHHHHHHHHHHHH
VWSTRWGADTVMDLSTGRYIHETREWIIRNSPVPIGTVPIYQALEKVNGVAEDLTWEVFR
HHHCCCCCCCEEECCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHH
DTLIEQAEQGVDYFTIHAGVLLRYVPMTAKRVTGIVSRGGSIMAKWCLSHHKENFLYSHF
HHHHHHHHCCCCEEEEHHHHHHHHHCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
REICELCVAYDVSLSLGDGMRPGSIADANDAAQFAELETLGELVKIAWEYDVQTIIEGPG
HHHHHHHHHHCCEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCC
HIPMQLIKENMDKQLAHCDEAPFYTLGPQITDIAPGYDHFTSGIGAAMIAWYGCAMLCYV
CCHHHHHHHHHHHHHHHCCCCCCEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHEEEE
TPKEHLGLPNKQDVKQGLIAYKIAAHAADVAKGHPSAQIRDNALAKARFEFRWEDQYNLG
CCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHEEEEEEEECCCCCCC
LDPETARAYHDESLPQESAKVAHFCSMCGPKFCSMKITQDVRAYAAGLEAAQAKAEQVEA
CCCHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
AAQAMQVTVKTPQELEAAMALKSAEFAASGAEIYHVKDKLVAEAEEA
HHHHHEEEECCHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHCCCC
>Mature Secondary Structure 
SSSNQNPAVAANAIEITAPESTIPNKSTVANKSAESSQSIVPKAPSRRETRAQAQAFID
CCCCCCCCEEECEEEEECCCCCCCCCHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
TLAPLQHPNSQKIYLEGSSADIRVGMRQILQTDTLVGGTDDAPIMEKNPPIRVYDCAGPY
HHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEECCCCC
SDPEADINVRLGLGKLRQNWILARNDTEQLPCATSDFTQQRLADDGLDHLRFEVGSSAIV
CCCCCCEEEEEEHHHHCCCEEEECCCCCCCCCCCCHHHHHHHHHCCHHHHHHHCCCCHHC
RPRRALQGKRVSQLHYARQGIITPEMEYVAIRENMALAQVQDEILNRKAKGEAFGALVGE
CCHHHHCCCHHHHHHHHHHCCCCCCCCEEEECCCHHHHHHHHHHHCCCCCCCHHHHHHCC
PITAEFVRAEVARGRAIIPLNINHPEAEPMIIGRNFLVKVNANIGNSAVTSSIEEEVEKL
CHHHHHHHHHHHCCCEEEEEECCCCCCCCEEECCEEEEEEECCCCCHHHHHHHHHHHHHH
VWSTRWGADTVMDLSTGRYIHETREWIIRNSPVPIGTVPIYQALEKVNGVAEDLTWEVFR
HHHCCCCCCCEEECCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHH
DTLIEQAEQGVDYFTIHAGVLLRYVPMTAKRVTGIVSRGGSIMAKWCLSHHKENFLYSHF
HHHHHHHHCCCCEEEEHHHHHHHHHCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
REICELCVAYDVSLSLGDGMRPGSIADANDAAQFAELETLGELVKIAWEYDVQTIIEGPG
HHHHHHHHHHCCEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCC
HIPMQLIKENMDKQLAHCDEAPFYTLGPQITDIAPGYDHFTSGIGAAMIAWYGCAMLCYV
CCHHHHHHHHHHHHHHHCCCCCCEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHEEEE
TPKEHLGLPNKQDVKQGLIAYKIAAHAADVAKGHPSAQIRDNALAKARFEFRWEDQYNLG
CCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHEEEEEEEECCCCCCC
LDPETARAYHDESLPQESAKVAHFCSMCGPKFCSMKITQDVRAYAAGLEAAQAKAEQVEA
CCCHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
AAQAMQVTVKTPQELEAAMALKSAEFAASGAEIYHVKDKLVAEAEEA
HHHHHEEEECCHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ?; ?; 5'-phosphoribosyl-5-aminoimidazole [C]

Specific reaction: Synthesis of @AMIN06.txt*4-amino-2-methyl-5-hydroxymethylpyrimidine! 5'-phosphoribosyl-5-aminoimidazole = 4-amino-5-hydroxymethyl-2-methylpyrimidine-phosphate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA