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The map label for this gene is thrS [H]

Identifier: 160875442

GI number: 160875442

Start: 2747806

End: 2749734

Strand: Reverse

Name: thrS [H]

Synonym: Sbal195_2330

Alternate gene names: 160875442

Gene position: 2749734-2747806 (Counterclockwise)

Preceding gene: 160875445

Following gene: 160875441

Centisome position: 51.42

GC content: 45.62

Gene sequence:

>1929_bases
ATGCCTGTAATTACACTTCCCGATGGTAGCAAACGCGAGTTTGCTCATGCTGTATCGACCCTCGATGTTGCCGCCGATAT
TGGCCCAGGTTTAGCGAAAGCTTGTATCGCTGGCCGTGTTAATGGCGAATTAAAAGATGCTTGCGATCTCATTGAAACCG
ATGCAGAGCTATCAATCATTACCGCCAAAGACGAAGAAGGTGTTGAAATTCTTCGCCATTCTTGCGCACATTTATTAGGT
CATGCTATTAAGCAAATGTGGCCAGAAACCAAGATGGCGATTGGTCCTGTTATTGATAACGGCTTCTACTATGATATCGA
CCTTGAGCATAAGTTGACTCAAGATGACATCGACGCGTTAGAAAAGCGCATGCTTCAACTGGCCAAAACTAACTATGACG
TAGTTAAACGTGTGGTTAGCTGGCAAGAAGCGCGCGATGCATTCGCTGCGCGTGGCGAAGATTACAAGATTGCCATTCTG
GATGAAAACATCAGCAAAGATGCAACGCCTGCGCTGTATCATCACGAAGAATACACTGATATGTGTCGTGGACCGCACGT
ACCTAACATGCGTTTCTGCCAACATTTCAAATTAATGAGCATTGCTGGCGCTTATTGGCGTGGCAACTCAGAAAACAAGA
TGTTGCAACGTATCTATGGTACAGCTTGGGCTGACAAAAAAGCCTTGAGCACACACTTAACCCGTCTTGAAGAAGCGGCT
AAGCGTGACCACCGTAAAATCGGTAAGCAGCTCGACTTGTATCACATGCAAGAAGAAGCACCGGGTATGGTGTTCTGGCA
TAACGACGGCTGGAGCATCTTCCTCGAATTAGAAAGATTCATTCGCCGTAAGTTAAACCAATACACTTACCAAGAAGTAA
AAGGTCCATTAATGATGGACCGCGTGTTGTGGGAACGTTCTGGTCACTGGGATAAATACTCAGAAGCCATGTTCACGACC
AGCAGTGAAAACCGCGAATATGCTATCAAGCCAATGAACTGCCCAGGCCACGTGCAGATCTTCAACCAAGGGTTGAAATC
TTACCGCGACCTGCCATTACGTATGGCTGAGTTTGGTTGCTGTCACCGTAATGAACCTTCTGGTTCGTTACACGGATTAA
TGCGTGTACGTGGCTTTACCCAAGACGACGCCCATATTTTCTGTACTGACAGTCAAGTTCAAGAGGAAGTGAGTGCTTGT
ATCCAGATGGTTTACGATACATACGCCACCTTCGGCTTTGAAAATATCGTGGTAAAACTGTCGACTCGCCCAGAAAAACG
TATCGGTGACGATGCGATGTGGGACAGAGCGGAAGAAGCGCTTAAGCAAGCTCTGCGTGACAATAATATTGAATTCACCA
TTTTGCCTGGTGAAGGCGCCTTCTACGGACCAAAAATCGAATTTACTTTACACGATTGTTTGGACCGTGCGTGGCAATGT
GGTACTGTGCAGCTCGATTATGCGTTGCCAAGCCGTCTTGGTGCAACTTACGTTGCCGAAGATAATAGCCGTCAGACCCC
AGTGATGATCCATCGTGCCATTTTAGGCTCTTTGGAACGATTCTTGGGTATCTTGATAGAAGAATATGCAGGACGTTTCC
CAACTTGGTTAGCCCCAATGCAAGTTGTCGTGATGAATATCACTGATAAACAGGCTGATTATGTTGAAGAAGTCGTAAAA
TTCTTCAAAGAACAAGGTATTCGAGCGTCTTTTGACTTGAGGAATGAGAAAATAGGCTTTAAAATACGCGAACACACCTT
AAGGCGTGTCCCTTATTTGTTGGTCGTTGGCGATCAAGAAATGGAAAATAAGGAAGTAGCGGTGCGTACCCGTGATGGTA
TCGATTTAGGTAAGATGCGACTTGAAGATTTCGCCACTAAAATCCATCAACAGATTTCGCTCCGTAGTCTCAAATTGTTG
GAGGAATAG

Upstream 100 bases:

>100_bases
GGCTAAGACTCCTGTACTGTCTTAACCTAGCGAGCATTTCTCTTACATTAACTAAAACCAAGTGGCCCTACGTGTGGGTC
ACCACTGGAAAGGACATTTC

Downstream 100 bases:

>100_bases
GTCATAAAGATCAAAAAAACAGCAGGGCGTCAGCCGGCCCCTAATAGAATCAATGAAGAAATCACAGGTGTACCAGAAGT
ACGCTTAACTGGCATTGATG

Product: threonyl-tRNA synthetase

Products: NA

Alternate protein names: Threonine--tRNA ligase; ThrRS [H]

Number of amino acids: Translated: 642; Mature: 641

Protein sequence:

>642_residues
MPVITLPDGSKREFAHAVSTLDVAADIGPGLAKACIAGRVNGELKDACDLIETDAELSIITAKDEEGVEILRHSCAHLLG
HAIKQMWPETKMAIGPVIDNGFYYDIDLEHKLTQDDIDALEKRMLQLAKTNYDVVKRVVSWQEARDAFAARGEDYKIAIL
DENISKDATPALYHHEEYTDMCRGPHVPNMRFCQHFKLMSIAGAYWRGNSENKMLQRIYGTAWADKKALSTHLTRLEEAA
KRDHRKIGKQLDLYHMQEEAPGMVFWHNDGWSIFLELERFIRRKLNQYTYQEVKGPLMMDRVLWERSGHWDKYSEAMFTT
SSENREYAIKPMNCPGHVQIFNQGLKSYRDLPLRMAEFGCCHRNEPSGSLHGLMRVRGFTQDDAHIFCTDSQVQEEVSAC
IQMVYDTYATFGFENIVVKLSTRPEKRIGDDAMWDRAEEALKQALRDNNIEFTILPGEGAFYGPKIEFTLHDCLDRAWQC
GTVQLDYALPSRLGATYVAEDNSRQTPVMIHRAILGSLERFLGILIEEYAGRFPTWLAPMQVVVMNITDKQADYVEEVVK
FFKEQGIRASFDLRNEKIGFKIREHTLRRVPYLLVVGDQEMENKEVAVRTRDGIDLGKMRLEDFATKIHQQISLRSLKLL
EE

Sequences:

>Translated_642_residues
MPVITLPDGSKREFAHAVSTLDVAADIGPGLAKACIAGRVNGELKDACDLIETDAELSIITAKDEEGVEILRHSCAHLLG
HAIKQMWPETKMAIGPVIDNGFYYDIDLEHKLTQDDIDALEKRMLQLAKTNYDVVKRVVSWQEARDAFAARGEDYKIAIL
DENISKDATPALYHHEEYTDMCRGPHVPNMRFCQHFKLMSIAGAYWRGNSENKMLQRIYGTAWADKKALSTHLTRLEEAA
KRDHRKIGKQLDLYHMQEEAPGMVFWHNDGWSIFLELERFIRRKLNQYTYQEVKGPLMMDRVLWERSGHWDKYSEAMFTT
SSENREYAIKPMNCPGHVQIFNQGLKSYRDLPLRMAEFGCCHRNEPSGSLHGLMRVRGFTQDDAHIFCTDSQVQEEVSAC
IQMVYDTYATFGFENIVVKLSTRPEKRIGDDAMWDRAEEALKQALRDNNIEFTILPGEGAFYGPKIEFTLHDCLDRAWQC
GTVQLDYALPSRLGATYVAEDNSRQTPVMIHRAILGSLERFLGILIEEYAGRFPTWLAPMQVVVMNITDKQADYVEEVVK
FFKEQGIRASFDLRNEKIGFKIREHTLRRVPYLLVVGDQEMENKEVAVRTRDGIDLGKMRLEDFATKIHQQISLRSLKLL
EE
>Mature_641_residues
PVITLPDGSKREFAHAVSTLDVAADIGPGLAKACIAGRVNGELKDACDLIETDAELSIITAKDEEGVEILRHSCAHLLGH
AIKQMWPETKMAIGPVIDNGFYYDIDLEHKLTQDDIDALEKRMLQLAKTNYDVVKRVVSWQEARDAFAARGEDYKIAILD
ENISKDATPALYHHEEYTDMCRGPHVPNMRFCQHFKLMSIAGAYWRGNSENKMLQRIYGTAWADKKALSTHLTRLEEAAK
RDHRKIGKQLDLYHMQEEAPGMVFWHNDGWSIFLELERFIRRKLNQYTYQEVKGPLMMDRVLWERSGHWDKYSEAMFTTS
SENREYAIKPMNCPGHVQIFNQGLKSYRDLPLRMAEFGCCHRNEPSGSLHGLMRVRGFTQDDAHIFCTDSQVQEEVSACI
QMVYDTYATFGFENIVVKLSTRPEKRIGDDAMWDRAEEALKQALRDNNIEFTILPGEGAFYGPKIEFTLHDCLDRAWQCG
TVQLDYALPSRLGATYVAEDNSRQTPVMIHRAILGSLERFLGILIEEYAGRFPTWLAPMQVVVMNITDKQADYVEEVVKF
FKEQGIRASFDLRNEKIGFKIREHTLRRVPYLLVVGDQEMENKEVAVRTRDGIDLGKMRLEDFATKIHQQISLRSLKLLE
E

Specific function: Thrs Is Also A Translational Repressor Protein, It Controls The Translation Of Its Own Gene By Binding To Its mRNA. [C]

COG id: COG0441

COG function: function code J; Threonyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI38570111, Length=618, Percent_Identity=39.9676375404531, Blast_Score=456, Evalue=1e-128,
Organism=Homo sapiens, GI38202255, Length=643, Percent_Identity=37.6360808709176, Blast_Score=438, Evalue=1e-123,
Organism=Homo sapiens, GI20070344, Length=646, Percent_Identity=35.2941176470588, Blast_Score=392, Evalue=1e-109,
Organism=Escherichia coli, GI1788013, Length=642, Percent_Identity=77.2585669781931, Blast_Score=1073, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71984192, Length=631, Percent_Identity=37.7179080824089, Blast_Score=446, Evalue=1e-125,
Organism=Caenorhabditis elegans, GI71984184, Length=629, Percent_Identity=37.8378378378378, Blast_Score=446, Evalue=1e-125,
Organism=Saccharomyces cerevisiae, GI6322112, Length=628, Percent_Identity=37.7388535031847, Blast_Score=433, Evalue=1e-122,
Organism=Saccharomyces cerevisiae, GI6322654, Length=448, Percent_Identity=36.3839285714286, Blast_Score=301, Evalue=3e-82,
Organism=Drosophila melanogaster, GI24583839, Length=630, Percent_Identity=38.5714285714286, Blast_Score=464, Evalue=1e-130,
Organism=Drosophila melanogaster, GI24583842, Length=630, Percent_Identity=38.5714285714286, Blast_Score=464, Evalue=1e-130,
Organism=Drosophila melanogaster, GI28574141, Length=630, Percent_Identity=38.5714285714286, Blast_Score=464, Evalue=1e-130,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR012675
- InterPro:   IPR004095
- InterPro:   IPR012676
- InterPro:   IPR002320
- InterPro:   IPR018163
- InterPro:   IPR012947 [H]

Pfam domain/function: PF03129 HGTP_anticodon; PF02824 TGS; PF00587 tRNA-synt_2b; PF07973 tRNA_SAD [H]

EC number: =6.1.1.3 [H]

Molecular weight: Translated: 73717; Mature: 73586

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVITLPDGSKREFAHAVSTLDVAADIGPGLAKACIAGRVNGELKDACDLIETDAELSII
CCEEECCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHCCCCCEEEE
TAKDEEGVEILRHSCAHLLGHAIKQMWPETKMAIGPVIDNGFYYDIDLEHKLTQDDIDAL
EECCCCHHHHHHHHHHHHHHHHHHHHCCHHHHEECCEECCCEEEEEECCCCCCHHHHHHH
EKRMLQLAKTNYDVVKRVVSWQEARDAFAARGEDYKIAILDENISKDATPALYHHEEYTD
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCHHHCCHHHHH
MCRGPHVPNMRFCQHFKLMSIAGAYWRGNSENKMLQRIYGTAWADKKALSTHLTRLEEAA
HHCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
KRDHRKIGKQLDLYHMQEEAPGMVFWHNDGWSIFLELERFIRRKLNQYTYQEVKGPLMMD
HHHHHHHCCHHHHHHHHCCCCCEEEEECCCCEEHHHHHHHHHHHHHHHHHHHHCCCHHHH
RVLWERSGHWDKYSEAMFTTSSENREYAIKPMNCPGHVQIFNQGLKSYRDLPLRMAEFGC
HHHHHCCCCCCHHHHHHEECCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCHHHHHHCC
CHRNEPSGSLHGLMRVRGFTQDDAHIFCTDSQVQEEVSACIQMVYDTYATFGFENIVVKL
CCCCCCCHHHHHHHHHCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEE
STRPEKRIGDDAMWDRAEEALKQALRDNNIEFTILPGEGAFYGPKIEFTLHDCLDRAWQC
CCCCCHHCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCEECCEEEEEHHHHHHHHHCC
GTVQLDYALPSRLGATYVAEDNSRQTPVMIHRAILGSLERFLGILIEEYAGRFPTWLAPM
CCEEECCCCHHHCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCC
QVVVMNITDKQADYVEEVVKFFKEQGIRASFDLRNEKIGFKIREHTLRRVPYLLVVGDQE
EEEEEECCCCHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCHHHHHHHHCCEEEEECCCC
MENKEVAVRTRDGIDLGKMRLEDFATKIHQQISLRSLKLLEE
CCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PVITLPDGSKREFAHAVSTLDVAADIGPGLAKACIAGRVNGELKDACDLIETDAELSII
CEEECCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHCCCCCEEEE
TAKDEEGVEILRHSCAHLLGHAIKQMWPETKMAIGPVIDNGFYYDIDLEHKLTQDDIDAL
EECCCCHHHHHHHHHHHHHHHHHHHHCCHHHHEECCEECCCEEEEEECCCCCCHHHHHHH
EKRMLQLAKTNYDVVKRVVSWQEARDAFAARGEDYKIAILDENISKDATPALYHHEEYTD
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCHHHCCHHHHH
MCRGPHVPNMRFCQHFKLMSIAGAYWRGNSENKMLQRIYGTAWADKKALSTHLTRLEEAA
HHCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
KRDHRKIGKQLDLYHMQEEAPGMVFWHNDGWSIFLELERFIRRKLNQYTYQEVKGPLMMD
HHHHHHHCCHHHHHHHHCCCCCEEEEECCCCEEHHHHHHHHHHHHHHHHHHHHCCCHHHH
RVLWERSGHWDKYSEAMFTTSSENREYAIKPMNCPGHVQIFNQGLKSYRDLPLRMAEFGC
HHHHHCCCCCCHHHHHHEECCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCHHHHHHCC
CHRNEPSGSLHGLMRVRGFTQDDAHIFCTDSQVQEEVSACIQMVYDTYATFGFENIVVKL
CCCCCCCHHHHHHHHHCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEE
STRPEKRIGDDAMWDRAEEALKQALRDNNIEFTILPGEGAFYGPKIEFTLHDCLDRAWQC
CCCCCHHCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCEECCEEEEEHHHHHHHHHCC
GTVQLDYALPSRLGATYVAEDNSRQTPVMIHRAILGSLERFLGILIEEYAGRFPTWLAPM
CCEEECCCCHHHCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCC
QVVVMNITDKQADYVEEVVKFFKEQGIRASFDLRNEKIGFKIREHTLRRVPYLLVVGDQE
EEEEEECCCCHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCHHHHHHHHCCEEEEECCCC
MENKEVAVRTRDGIDLGKMRLEDFATKIHQQISLRSLKLLEE
CCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA