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The map label for this gene is comEA [H]

Identifier: 160874763

GI number: 160874763

Start: 1987966

End: 1988334

Strand: Direct

Name: comEA [H]

Synonym: Sbal195_1646

Alternate gene names: 160874763

Gene position: 1987966-1988334 (Clockwise)

Preceding gene: 160874762

Following gene: 160874770

Centisome position: 37.18

GC content: 46.88

Gene sequence:

>369_bases
ATGAACATCACCAAATGTATACCCGCTATTATGAGCGCCATGGCATTAACGGCTTTTTTAACAACGCCAGCAATCGCCGC
AGACACCCCGACTAAAGCCGCCGCTAAAATGCAGACTCAGGCTAAAACCGAGGCGAGCGATATGGCATCTGATGCGAAGA
AAGCTATGCCGGATGCTGCTCAAGTCAACATCAATACGGCTTCAGCCGAGCAGTTACAAGTGCTAAAAGGGATAGGTGCC
GCTAAGGCGCAAGCGATTGTCGATTACCGAACCAAAAATGGTAAGTTCAATGCAATTGATGATTTAGCCAATGTCTCGGG
TGTTGGGGCTAAGTTGATTGAGCAGAATCGTCATTTGATTAAGTTGTAA

Upstream 100 bases:

>100_bases
GCGGCGCCGATTTGGTATTTCATAACAGCATGGACTATTTTTGATTTGAGGCCACGGAAGTAGGAAGAGAGGCCGCAATT
CATGGAATAGAGGAAGAGTT

Downstream 100 bases:

>100_bases
TTATCCCAGTCGATGATTAAGTTGCATTATGTATTGAGTTTTACTCTTGTTGAATTTTTAATATGCCAAGTTTGACACCG
TGAAACTCAGGGAAATGTCT

Product: helix-hairpin-helix repeat-containing competence protein ComEA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 122; Mature: 122

Protein sequence:

>122_residues
MNITKCIPAIMSAMALTAFLTTPAIAADTPTKAAAKMQTQAKTEASDMASDAKKAMPDAAQVNINTASAEQLQVLKGIGA
AKAQAIVDYRTKNGKFNAIDDLANVSGVGAKLIEQNRHLIKL

Sequences:

>Translated_122_residues
MNITKCIPAIMSAMALTAFLTTPAIAADTPTKAAAKMQTQAKTEASDMASDAKKAMPDAAQVNINTASAEQLQVLKGIGA
AKAQAIVDYRTKNGKFNAIDDLANVSGVGAKLIEQNRHLIKL
>Mature_122_residues
MNITKCIPAIMSAMALTAFLTTPAIAADTPTKAAAKMQTQAKTEASDMASDAKKAMPDAAQVNINTASAEQLQVLKGIGA
AKAQAIVDYRTKNGKFNAIDDLANVSGVGAKLIEQNRHLIKL

Specific function: Needed for both DNA binding and transport. It is absolutely required for the uptake of transforming DNA but not for binding. Its role in binding may be indirect [H]

COG id: COG1555

COG function: function code L; DNA uptake protein and related DNA-binding proteins

Gene ontology:

Cell location: Cell membrane; Single-pass type II membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 HhH domains [H]

Homologues:

Organism=Escherichia coli, GI1786646, Length=91, Percent_Identity=39.5604395604396, Blast_Score=65, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004787
- InterPro:   IPR004509
- InterPro:   IPR000445
- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR019554 [H]

Pfam domain/function: PF00633 HHH; PF10531 SLBB [H]

EC number: NA

Molecular weight: Translated: 12743; Mature: 12743

Theoretical pI: Translated: 9.99; Mature: 9.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNITKCIPAIMSAMALTAFLTTPAIAADTPTKAAAKMQTQAKTEASDMASDAKKAMPDAA
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
QVNINTASAEQLQVLKGIGAAKAQAIVDYRTKNGKFNAIDDLANVSGVGAKLIEQNRHLI
EEECCCCCHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCHHHHHHHCHHHHHHHHCCCCEE
KL
CC
>Mature Secondary Structure
MNITKCIPAIMSAMALTAFLTTPAIAADTPTKAAAKMQTQAKTEASDMASDAKKAMPDAA
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
QVNINTASAEQLQVLKGIGAAKAQAIVDYRTKNGKFNAIDDLANVSGVGAKLIEQNRHLI
EEECCCCCHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCHHHHHHHCHHHHHHHHCCCCEE
KL
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7968523; 8969508; 9384377; 7768800 [H]