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The map label for this gene is hmrR [H]

Identifier: 160874651

GI number: 160874651

Start: 1847322

End: 1847870

Strand: Reverse

Name: hmrR [H]

Synonym: Sbal195_1534

Alternate gene names: 160874651

Gene position: 1847870-1847322 (Counterclockwise)

Preceding gene: 160874654

Following gene: 160874639

Centisome position: 34.56

GC content: 46.45

Gene sequence:

>549_bases
ATGGGTAAGACCATTCAGTTACTCAAAGAAGAGGTCAAGATGAAGATAGGCGAAGTGGCGAAACAAACGGGCTTAAGCGT
TAAGAGTATCCGTTATTACCATGATATTGGCTTAGTGTGCGGCGAGCGAAATGAGGCGGGTTATCGGGTTTATCGCCATC
AAGATATTGAAGCGCTTAAGTTTGTGCATCAATGTCGCCACTTAGGTTTTAGCCTAGAAGATTGCAAATCCTTGCTTGGC
CTTAAGGGCAATGAAAGCCGTAATGCCGAAGATGTTAAACAACTTACCCGTACTCACCTTGCCTATGTCGAAGAGCAAAT
CAATAAGTTGCAACAGCTTAGGGCGCAATTACAACACATGGTGACCCAATGCCAAGGCGGCGATCAGCCTCACTGCGCGA
TTATCGATAGCCTAAGCCATGAGGACAACGAGAGTCATGGGAGTCATGAGACTGACGAAGACAAATCCCATAAAAATCAA
AGCCTGCACGATGCAGGCTCTGAGTGTTGTCGTAAAGCCAGTCGCAATAGCAACGGCCAAGAGCAATAA

Upstream 100 bases:

>100_bases
ATGTTTTACACTATAGGTCTAAGATAAAGTCTCCCATTGCGGGAGAGTCAAGGATGAATTTGCTCAATGTGATCACATCG
ACAATTAATTGCTGGGCGAA

Downstream 100 bases:

>100_bases
CGGTAAATACTGCGTTATTGATTGCGGACTAAGGTCGGCTTTAACGCCGCAGCATTATCCAGCACCAATGTTGCTAGCTT
ACCCGCAGGGGTGAAGTTAA

Product: MerR family transcriptional regulator

Products: NA

Alternate protein names: Copper efflux regulator; Copper export regulator [H]

Number of amino acids: Translated: 182; Mature: 181

Protein sequence:

>182_residues
MGKTIQLLKEEVKMKIGEVAKQTGLSVKSIRYYHDIGLVCGERNEAGYRVYRHQDIEALKFVHQCRHLGFSLEDCKSLLG
LKGNESRNAEDVKQLTRTHLAYVEEQINKLQQLRAQLQHMVTQCQGGDQPHCAIIDSLSHEDNESHGSHETDEDKSHKNQ
SLHDAGSECCRKASRNSNGQEQ

Sequences:

>Translated_182_residues
MGKTIQLLKEEVKMKIGEVAKQTGLSVKSIRYYHDIGLVCGERNEAGYRVYRHQDIEALKFVHQCRHLGFSLEDCKSLLG
LKGNESRNAEDVKQLTRTHLAYVEEQINKLQQLRAQLQHMVTQCQGGDQPHCAIIDSLSHEDNESHGSHETDEDKSHKNQ
SLHDAGSECCRKASRNSNGQEQ
>Mature_181_residues
GKTIQLLKEEVKMKIGEVAKQTGLSVKSIRYYHDIGLVCGERNEAGYRVYRHQDIEALKFVHQCRHLGFSLEDCKSLLGL
KGNESRNAEDVKQLTRTHLAYVEEQINKLQQLRAQLQHMVTQCQGGDQPHCAIIDSLSHEDNESHGSHETDEDKSHKNQS
LHDAGSECCRKASRNSNGQEQ

Specific function: Regulates the transcription of actP. It detects cytoplasmic copper stress and activates transcription in response to increasing copper concentrations. In the absence of copper, it negatively regulates the transcription of actP [H]

COG id: COG0789

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH merR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786695, Length=127, Percent_Identity=40.9448818897638, Blast_Score=99, Evalue=2e-22,
Organism=Escherichia coli, GI1789687, Length=128, Percent_Identity=33.59375, Blast_Score=72, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011789
- InterPro:   IPR009061
- InterPro:   IPR000551
- InterPro:   IPR015358 [H]

Pfam domain/function: PF00376 MerR; PF09278 MerR-DNA-bind [H]

EC number: NA

Molecular weight: Translated: 20637; Mature: 20506

Theoretical pI: Translated: 6.94; Mature: 6.94

Prosite motif: PS50937 HTH_MERR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
3.9 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKTIQLLKEEVKMKIGEVAKQTGLSVKSIRYYHDIGLVCGERNEAGYRVYRHQDIEALK
CCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHCCHHHHH
FVHQCRHLGFSLEDCKSLLGLKGNESRNAEDVKQLTRTHLAYVEEQINKLQQLRAQLQHM
HHHHHHHCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VTQCQGGDQPHCAIIDSLSHEDNESHGSHETDEDKSHKNQSLHDAGSECCRKASRNSNGQ
HHHHCCCCCCCHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCC
EQ
CC
>Mature Secondary Structure 
GKTIQLLKEEVKMKIGEVAKQTGLSVKSIRYYHDIGLVCGERNEAGYRVYRHQDIEALK
CHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHCCHHHHH
FVHQCRHLGFSLEDCKSLLGLKGNESRNAEDVKQLTRTHLAYVEEQINKLQQLRAQLQHM
HHHHHHHCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VTQCQGGDQPHCAIIDSLSHEDNESHGSHETDEDKSHKNQSLHDAGSECCRKASRNSNGQ
HHHHCCCCCCCHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCC
EQ
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11936079 [H]