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The map label for this gene is hemF [H]

Identifier: 160873163

GI number: 160873163

Start: 40886

End: 41857

Strand: Direct

Name: hemF [H]

Synonym: Sbal195_0037

Alternate gene names: 160873163

Gene position: 40886-41857 (Clockwise)

Preceding gene: 160873162

Following gene: 160873165

Centisome position: 0.76

GC content: 49.69

Gene sequence:

>972_bases
ATGCACGAAGCGGCAAAATTTTACGAAATGGACAATGAGCAAACCAATAATAAGGATAACAAGATGAGTGTGCCTGATGC
TGCAGTGGTAAAAGCGTTTTTACTCGATTTACAAAACCGAATTTGTGCCGGTTTACAGGCTCTGGATGGCCAAGCAACGT
TTGCCGCCGATTCATGGACCCGCGCCGAAGGCGGTGGTGGCACGAGCCGAGTATTAACCCAAGGTGCAGTATTCGAGCAA
GCTGGAGTTAACTTTTCCCATGTGACTGGCGCCGCTATGCCGGCGTCAGCTACGGCGCATCGCCCAGAATTGGCGGGTCG
CAGTTTTGAAGCTATGGGTGTGTCTTTAGTGATCCATCCTAACAATCCGTATATACCGACAACTCACGCCAATGTGCGCT
TCTTCATCGCCCAAAAAGAGGGGGCCGATCCTGTGTGGTGGTTTGGCGGTGGTTTTGACTTAACACCTTATTATCCATTT
GAGGAAGATGTGCGCGAGTGGCATCAAACATCTAAGGATATTTGTGCGCCTTTCGGGGATGAGGTTTATCCCAAATATAA
GAAATGGTGCGATGAGTATTTCTTCCTGCCGCATCGTAATGAAACCCGCGGCGTAGGCGGACTGTTTTTCGATGACTTGA
ATCAAGCAGGATTCGAGCAAAGCTTTAGCTTTATGCAAGCCGTGGGTAATGGCTTCTTAACGGCTTATGCGCCGATTGTT
GAGCGTCGTAAGGATACTGAGTTCGGTGAGCGTGAGCGTCAGTTCCAACTCTATCGCCGTGGTCGTTATGTTGAGTTCAA
CTTAGTCTACGACAGAGGCACGCTGTTTGGTCTGCAGACAGGTGGACGTACCGAGTCTATCTTAATGTCGATGCCGCCAT
TAGTGCGTTGGCAATATGCTTATACACCAGAGGCGGGAAGCCCAGAGGCAGATTTGTACGATAACTACCTCAAACCCCGC
GACTGGGTTTAG

Upstream 100 bases:

>100_bases
GCATTAACTGCCGCTGAAATCCTCGCTGATTTTACCGGTAAAATCGATGCACTGGTATTAGGCGAACTCGGCGAACAACG
TCAGCCCTCGACCATTATCG

Downstream 100 bases:

>100_bases
CCGTTAATCATAAAAAGTGGATGCCATATCCACTTTATTGATTACGCATATGATCGGCCAGAGTTGAAATCGCCTCAAAA
ATGGCGGCTCGATGCTCTGG

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 323; Mature: 323

Protein sequence:

>323_residues
MHEAAKFYEMDNEQTNNKDNKMSVPDAAVVKAFLLDLQNRICAGLQALDGQATFAADSWTRAEGGGGTSRVLTQGAVFEQ
AGVNFSHVTGAAMPASATAHRPELAGRSFEAMGVSLVIHPNNPYIPTTHANVRFFIAQKEGADPVWWFGGGFDLTPYYPF
EEDVREWHQTSKDICAPFGDEVYPKYKKWCDEYFFLPHRNETRGVGGLFFDDLNQAGFEQSFSFMQAVGNGFLTAYAPIV
ERRKDTEFGERERQFQLYRRGRYVEFNLVYDRGTLFGLQTGGRTESILMSMPPLVRWQYAYTPEAGSPEADLYDNYLKPR
DWV

Sequences:

>Translated_323_residues
MHEAAKFYEMDNEQTNNKDNKMSVPDAAVVKAFLLDLQNRICAGLQALDGQATFAADSWTRAEGGGGTSRVLTQGAVFEQ
AGVNFSHVTGAAMPASATAHRPELAGRSFEAMGVSLVIHPNNPYIPTTHANVRFFIAQKEGADPVWWFGGGFDLTPYYPF
EEDVREWHQTSKDICAPFGDEVYPKYKKWCDEYFFLPHRNETRGVGGLFFDDLNQAGFEQSFSFMQAVGNGFLTAYAPIV
ERRKDTEFGERERQFQLYRRGRYVEFNLVYDRGTLFGLQTGGRTESILMSMPPLVRWQYAYTPEAGSPEADLYDNYLKPR
DWV
>Mature_323_residues
MHEAAKFYEMDNEQTNNKDNKMSVPDAAVVKAFLLDLQNRICAGLQALDGQATFAADSWTRAEGGGGTSRVLTQGAVFEQ
AGVNFSHVTGAAMPASATAHRPELAGRSFEAMGVSLVIHPNNPYIPTTHANVRFFIAQKEGADPVWWFGGGFDLTPYYPF
EEDVREWHQTSKDICAPFGDEVYPKYKKWCDEYFFLPHRNETRGVGGLFFDDLNQAGFEQSFSFMQAVGNGFLTAYAPIV
ERRKDTEFGERERQFQLYRRGRYVEFNLVYDRGTLFGLQTGGRTESILMSMPPLVRWQYAYTPEAGSPEADLYDNYLKPR
DWV

Specific function: Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III [H]

COG id: COG0408

COG function: function code H; Coproporphyrinogen III oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI41393599, Length=302, Percent_Identity=46.3576158940397, Blast_Score=288, Evalue=5e-78,
Organism=Escherichia coli, GI1788777, Length=299, Percent_Identity=74.5819397993311, Blast_Score=470, Evalue=1e-134,
Organism=Saccharomyces cerevisiae, GI6320249, Length=320, Percent_Identity=45.3125, Blast_Score=277, Evalue=2e-75,
Organism=Drosophila melanogaster, GI17864388, Length=303, Percent_Identity=47.5247524752475, Blast_Score=292, Evalue=2e-79,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001260
- InterPro:   IPR018375 [H]

Pfam domain/function: PF01218 Coprogen_oxidas [H]

EC number: =1.3.3.3 [H]

Molecular weight: Translated: 36539; Mature: 36539

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: PS01021 COPROGEN_OXIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHEAAKFYEMDNEQTNNKDNKMSVPDAAVVKAFLLDLQNRICAGLQALDGQATFAADSWT
CCCHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCC
RAEGGGGTSRVLTQGAVFEQAGVNFSHVTGAAMPASATAHRPELAGRSFEAMGVSLVIHP
CCCCCCCHHHHHHCCCHHHHHCCCHHHHCCCCCCCCCCCCCCHHCCCCEEECCEEEEEEC
NNPYIPTTHANVRFFIAQKEGADPVWWFGGGFDLTPYYPFEEDVREWHQTSKDICAPFGD
CCCCCCCCCCCEEEEEEECCCCCEEEEECCCCCCCCCCCCHHHHHHHHHCCHHHCCCCCC
EVYPKYKKWCDEYFFLPHRNETRGVGGLFFDDLNQAGFEQSFSFMQAVGNGFLTAYAPIV
CCCHHHHHHHHHHEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
ERRKDTEFGERERQFQLYRRGRYVEFNLVYDRGTLFGLQTGGRTESILMSMPPLVRWQYA
HHCCCCCCHHHHHHHHHHHCCCEEEEEEEEECCEEEEECCCCCCHHHHHCCCCCCEEEEE
YTPEAGSPEADLYDNYLKPRDWV
ECCCCCCCCHHHHHCCCCCCCCC
>Mature Secondary Structure
MHEAAKFYEMDNEQTNNKDNKMSVPDAAVVKAFLLDLQNRICAGLQALDGQATFAADSWT
CCCHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCC
RAEGGGGTSRVLTQGAVFEQAGVNFSHVTGAAMPASATAHRPELAGRSFEAMGVSLVIHP
CCCCCCCHHHHHHCCCHHHHHCCCHHHHCCCCCCCCCCCCCCHHCCCCEEECCEEEEEEC
NNPYIPTTHANVRFFIAQKEGADPVWWFGGGFDLTPYYPFEEDVREWHQTSKDICAPFGD
CCCCCCCCCCCEEEEEEECCCCCEEEEECCCCCCCCCCCCHHHHHHHHHCCHHHCCCCCC
EVYPKYKKWCDEYFFLPHRNETRGVGGLFFDDLNQAGFEQSFSFMQAVGNGFLTAYAPIV
CCCHHHHHHHHHHEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
ERRKDTEFGERERQFQLYRRGRYVEFNLVYDRGTLFGLQTGGRTESILMSMPPLVRWQYA
HHCCCCCCHHHHHHHHHHHCCCEEEEEEEEECCEEEEECCCCCCHHHHHCCCCCCEEEEE
YTPEAGSPEADLYDNYLKPRDWV
ECCCCCCCCHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA