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The map label for this gene is czcD [H]

Identifier: 159901094

GI number: 159901094

Start: 5860791

End: 5861726

Strand: Direct

Name: czcD [H]

Synonym: Haur_4582

Alternate gene names: 159901094

Gene position: 5860791-5861726 (Clockwise)

Preceding gene: 159901093

Following gene: 159901095

Centisome position: 92.35

GC content: 51.5

Gene sequence:

>936_bases
ATGAGCGGACATCACGACCACGGACATCATCACCATCATAGCGTGCCTGCCGATGCTGGTGGCCGCTTAATTTGGGCTTT
GGCAATCACGTTTGGCTTTGTGGGGGTTGAAATTGTTGCTGGGTTGTGGGCTAATAGTTTGGCCTTGCTCACCGATGCTG
CCCATAACGCCAGCGATGTGTTGGCGTTGTTGATTAGCTGGATTGCCCTCTGGCTAACCCGCCGCCCAGCCCATGCCCGC
AAAACCTTTGGCTACCATCGCGCTGGCATTTTGGCGGCCTTTGTTAATTCGCTGACCTTGGTCGGTATCGCCTTAGGCAT
CGGCTGGGAAGCAATTGAGCGCTTGCGCAGCCCCTTAGAAGTTGATGCTCCGGTGATGATCGGGGTTTCGTTGTTGGCGG
TTTTGGTTAATGCTGGCACGGCATGGTTGGTGCATCGCGGCAGCGAAAACGACCTCAATCTGCGCAGTGCCTTTGTACAT
TTGATGGGCGATGTACTTTCGACAATTGGCGCAACAATTGCTGGGGTTTTGATCTTCTTCACCAATTGGCGCTGGCTTGA
TCCGCTGGTTTCAGTATTAATTGCTGGCTTTATCATCTGGCATGCCTGGCAAATTCTGCGCGATTCGATCGATGTTTTGT
TGGAAGCTACGCCTCGTGATATTGATGTCGAAAAAGTGGTCAGCGATTTGCAAACCATTCCTGGAGTGCAAGCGATTCAC
GATTTGCATATTTGGAGCATCACTGCCAGTATGCGAGCGCTCTCAGCCCATGTTGTGACCGATCAACAAGGCCCACAGCG
TAGCCCACAATTGATCAGTACCATTAACGAAGTGCTGTGCCATCGCTACAACATTGGCCATGCTACCTTGCAACTTGAAT
GCTCATGCAATACGCCACAACTCTATTGCACCCTAACTGAGCAACACCAACATTGA

Upstream 100 bases:

>100_bases
ATGTGCGAGTGCTCGTGCTGGTTTGTCTGAATCATATTCGCCATGGCTCTACGCCTGATCCATCGGTTGCGCCCATTTTA
GCTGTGTTGGAGGAAGAACG

Downstream 100 bases:

>100_bases
GAAAGGCTGAGGGATGAAGGCTGAGGGATGAAGGCCACTTGATTAGAGCAATCATTCCTCTGTGATTCTGCATTAAAAAT
TTCTTCCTTCATAATTCATC

Product: cation diffusion facilitator family transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 311; Mature: 310

Protein sequence:

>311_residues
MSGHHDHGHHHHHSVPADAGGRLIWALAITFGFVGVEIVAGLWANSLALLTDAAHNASDVLALLISWIALWLTRRPAHAR
KTFGYHRAGILAAFVNSLTLVGIALGIGWEAIERLRSPLEVDAPVMIGVSLLAVLVNAGTAWLVHRGSENDLNLRSAFVH
LMGDVLSTIGATIAGVLIFFTNWRWLDPLVSVLIAGFIIWHAWQILRDSIDVLLEATPRDIDVEKVVSDLQTIPGVQAIH
DLHIWSITASMRALSAHVVTDQQGPQRSPQLISTINEVLCHRYNIGHATLQLECSCNTPQLYCTLTEQHQH

Sequences:

>Translated_311_residues
MSGHHDHGHHHHHSVPADAGGRLIWALAITFGFVGVEIVAGLWANSLALLTDAAHNASDVLALLISWIALWLTRRPAHAR
KTFGYHRAGILAAFVNSLTLVGIALGIGWEAIERLRSPLEVDAPVMIGVSLLAVLVNAGTAWLVHRGSENDLNLRSAFVH
LMGDVLSTIGATIAGVLIFFTNWRWLDPLVSVLIAGFIIWHAWQILRDSIDVLLEATPRDIDVEKVVSDLQTIPGVQAIH
DLHIWSITASMRALSAHVVTDQQGPQRSPQLISTINEVLCHRYNIGHATLQLECSCNTPQLYCTLTEQHQH
>Mature_310_residues
SGHHDHGHHHHHSVPADAGGRLIWALAITFGFVGVEIVAGLWANSLALLTDAAHNASDVLALLISWIALWLTRRPAHARK
TFGYHRAGILAAFVNSLTLVGIALGIGWEAIERLRSPLEVDAPVMIGVSLLAVLVNAGTAWLVHRGSENDLNLRSAFVHL
MGDVLSTIGATIAGVLIFFTNWRWLDPLVSVLIAGFIIWHAWQILRDSIDVLLEATPRDIDVEKVVSDLQTIPGVQAIHD
LHIWSITASMRALSAHVVTDQQGPQRSPQLISTINEVLCHRYNIGHATLQLECSCNTPQLYCTLTEQHQH

Specific function: Involved in divalent cation and potassium homeostasis in the cell. Catalyzes the active efflux of zinc, cadmium and cobalt, in exchange for potassium and H(+) ions [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI52352805, Length=309, Percent_Identity=31.7152103559871, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI21361112, Length=322, Percent_Identity=30.7453416149068, Blast_Score=149, Evalue=3e-36,
Organism=Homo sapiens, GI289803013, Length=304, Percent_Identity=32.2368421052632, Blast_Score=130, Evalue=1e-30,
Organism=Homo sapiens, GI289803009, Length=304, Percent_Identity=32.2368421052632, Blast_Score=130, Evalue=1e-30,
Organism=Homo sapiens, GI289803007, Length=304, Percent_Identity=32.2368421052632, Blast_Score=130, Evalue=1e-30,
Organism=Homo sapiens, GI289803003, Length=304, Percent_Identity=32.2368421052632, Blast_Score=130, Evalue=1e-30,
Organism=Homo sapiens, GI64762489, Length=304, Percent_Identity=32.2368421052632, Blast_Score=130, Evalue=1e-30,
Organism=Homo sapiens, GI21359890, Length=301, Percent_Identity=27.906976744186, Blast_Score=128, Evalue=8e-30,
Organism=Homo sapiens, GI20070323, Length=296, Percent_Identity=27.7027027027027, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI14210520, Length=217, Percent_Identity=28.5714285714286, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI52352803, Length=127, Percent_Identity=41.7322834645669, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI52351208, Length=151, Percent_Identity=25.8278145695364, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI222080086, Length=125, Percent_Identity=33.6, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI40255009, Length=125, Percent_Identity=33.6, Blast_Score=69, Evalue=6e-12,
Organism=Escherichia coli, GI1786966, Length=298, Percent_Identity=38.255033557047, Blast_Score=172, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI17555794, Length=330, Percent_Identity=32.1212121212121, Blast_Score=165, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI193210990, Length=318, Percent_Identity=32.3899371069182, Blast_Score=162, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI17555796, Length=324, Percent_Identity=32.0987654320988, Blast_Score=160, Evalue=7e-40,
Organism=Caenorhabditis elegans, GI32564488, Length=297, Percent_Identity=27.9461279461279, Blast_Score=118, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI17550442, Length=123, Percent_Identity=28.4552845528455, Blast_Score=66, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17550440, Length=123, Percent_Identity=28.4552845528455, Blast_Score=65, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6324892, Length=161, Percent_Identity=36.0248447204969, Blast_Score=100, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6320411, Length=223, Percent_Identity=30.9417040358744, Blast_Score=91, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6323899, Length=145, Percent_Identity=33.7931034482759, Blast_Score=80, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24583858, Length=331, Percent_Identity=30.8157099697885, Blast_Score=138, Evalue=6e-33,
Organism=Drosophila melanogaster, GI24584409, Length=161, Percent_Identity=29.1925465838509, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI28574430, Length=161, Percent_Identity=29.1925465838509, Blast_Score=92, Evalue=5e-19,
Organism=Drosophila melanogaster, GI24585900, Length=161, Percent_Identity=31.055900621118, Blast_Score=92, Evalue=6e-19,
Organism=Drosophila melanogaster, GI24585898, Length=161, Percent_Identity=31.055900621118, Blast_Score=92, Evalue=6e-19,
Organism=Drosophila melanogaster, GI24585896, Length=161, Percent_Identity=31.055900621118, Blast_Score=92, Evalue=6e-19,
Organism=Drosophila melanogaster, GI19921672, Length=161, Percent_Identity=31.055900621118, Blast_Score=92, Evalue=6e-19,
Organism=Drosophila melanogaster, GI24645863, Length=105, Percent_Identity=41.9047619047619, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24656728, Length=118, Percent_Identity=30.5084745762712, Blast_Score=65, Evalue=7e-11,
Organism=Drosophila melanogaster, GI24656724, Length=118, Percent_Identity=30.5084745762712, Blast_Score=65, Evalue=7e-11,
Organism=Drosophila melanogaster, GI24656720, Length=118, Percent_Identity=30.5084745762712, Blast_Score=65, Evalue=7e-11,
Organism=Drosophila melanogaster, GI24656715, Length=118, Percent_Identity=30.5084745762712, Blast_Score=65, Evalue=7e-11,
Organism=Drosophila melanogaster, GI21357035, Length=118, Percent_Identity=30.5084745762712, Blast_Score=65, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 34082; Mature: 33950

Theoretical pI: Translated: 6.71; Mature: 6.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGHHDHGHHHHHSVPADAGGRLIWALAITFGFVGVEIVAGLWANSLALLTDAAHNASDV
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
LALLISWIALWLTRRPAHARKTFGYHRAGILAAFVNSLTLVGIALGIGWEAIERLRSPLE
HHHHHHHHHHHHHCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCC
VDAPVMIGVSLLAVLVNAGTAWLVHRGSENDLNLRSAFVHLMGDVLSTIGATIAGVLIFF
CCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TNWRWLDPLVSVLIAGFIIWHAWQILRDSIDVLLEATPRDIDVEKVVSDLQTIPGVQAIH
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCHHHHH
DLHIWSITASMRALSAHVVTDQQGPQRSPQLISTINEVLCHRYNIGHATLQLECSCNTPQ
HHHHHHHHHHHHHHHHHHEECCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCE
LYCTLTEQHQH
EEEEECCCCCC
>Mature Secondary Structure 
SGHHDHGHHHHHSVPADAGGRLIWALAITFGFVGVEIVAGLWANSLALLTDAAHNASDV
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
LALLISWIALWLTRRPAHARKTFGYHRAGILAAFVNSLTLVGIALGIGWEAIERLRSPLE
HHHHHHHHHHHHHCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCC
VDAPVMIGVSLLAVLVNAGTAWLVHRGSENDLNLRSAFVHLMGDVLSTIGATIAGVLIFF
CCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TNWRWLDPLVSVLIAGFIIWHAWQILRDSIDVLLEATPRDIDVEKVVSDLQTIPGVQAIH
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCHHHHH
DLHIWSITASMRALSAHVVTDQQGPQRSPQLISTINEVLCHRYNIGHATLQLECSCNTPQ
HHHHHHHHHHHHHHHHHHEECCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCE
LYCTLTEQHQH
EEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9308178; 9384377; 9099864 [H]