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The map label for this gene is prs [H]

Identifier: 159901001

GI number: 159901001

Start: 5747452

End: 5748390

Strand: Direct

Name: prs [H]

Synonym: Haur_4488

Alternate gene names: 159901001

Gene position: 5747452-5748390 (Clockwise)

Preceding gene: 159901000

Following gene: 159901002

Centisome position: 90.56

GC content: 51.97

Gene sequence:

>939_bases
ATGGACGGGCGATTGCAGATTTTTACGGGTAATGCCAACATCCCGTTAGCTCGCAGTATCGCATCGCATCTGAATTTGAA
TTTAGGTCGGGCTATTGTCGGCGTTTTCAAGAATGGCGAAACTCGCGTGCAGCTTGAAGAAAACGTGCGTGGCTCCGATG
TATTTATCGTGCAATCCTTAACTACGCCAGTTGATCATCATCTCATGGAGTTGTTGTTGATGATCGATGCCCTACGCCGA
GCTTCGGCTCAACGGGTAACAGCGGTGATTCCTTACTATGGCTATGCCAAGCAAGAGAAGAAAACCACTGGGCGCGAGCC
AATCTCAGCCAAATTGGTCGCCAATTTGATCGCGACCGCCGGAGCTGATCGAGTGCTGACTATGGATTTGCATGCGCCAG
CAATCGAGGGCTTTTTCGATATTCCCGTTGATCACTTGCAAGCTGGGCCACTAATCGCCGACCACTTTCGCAGCCGCAAC
ATGAAAAATGTGGTAGTGGTTTCGCCCGATGCTGGCGGTGTGGGTCGCGCTAATAAATTTCGCGAACGGATTGGTGCAAG
TTTGGCGATTATTGCCAAGCAACGCCCAGCGCCCGATGTTTCCGAAGTGGTCGAAATGGTCGGTGATGTTGCTGGCAAGC
ACGCGGTAATCTTCGACGACATGATTTCAACTGGGGGAACCTTGGCCGAAGCCGCCAAAACCCTCAAAGAACGCGGCGCA
ATTAGCGTGGTGGCCTGTGCCACTCACGGCATCTTTGCTGGCAATGCGGTCGAATTGCTGGGCGATTCGGTGATGGAAGA
AGTGCTGGTTACCGACACGATTCCTTTGCCTGCTGAAGCTAGCGCCGCACGGATTGCCCAAATTTCGGTGGCCTCGTTGT
TTGCAGAAGCCATTATTCGGATTCACAAAGATCTTTCCTTGAGCGCATTATTCAGCTAA

Upstream 100 bases:

>100_bases
TATGCCAGCCCGCGTCATTCGCCACCGCAAGCTTGAGCAGAGTGAGAACGAGTAGGCAACGGATTTTTCATTGACCAATT
ACTAACTTGGGGGGCATCGA

Downstream 100 bases:

>100_bases
AATCAACGTACAGATAAACTTAATCAAGCGCTGCTAGCTTTATTTCTAGCAGCGCTTTTTTTGTTTGGCGGAGCAAAACT
TGCCCTCCTGATGAGATGCG

Product: ribose-phosphate pyrophosphokinase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 312; Mature: 312

Protein sequence:

>312_residues
MDGRLQIFTGNANIPLARSIASHLNLNLGRAIVGVFKNGETRVQLEENVRGSDVFIVQSLTTPVDHHLMELLLMIDALRR
ASAQRVTAVIPYYGYAKQEKKTTGREPISAKLVANLIATAGADRVLTMDLHAPAIEGFFDIPVDHLQAGPLIADHFRSRN
MKNVVVVSPDAGGVGRANKFRERIGASLAIIAKQRPAPDVSEVVEMVGDVAGKHAVIFDDMISTGGTLAEAAKTLKERGA
ISVVACATHGIFAGNAVELLGDSVMEEVLVTDTIPLPAEASAARIAQISVASLFAEAIIRIHKDLSLSALFS

Sequences:

>Translated_312_residues
MDGRLQIFTGNANIPLARSIASHLNLNLGRAIVGVFKNGETRVQLEENVRGSDVFIVQSLTTPVDHHLMELLLMIDALRR
ASAQRVTAVIPYYGYAKQEKKTTGREPISAKLVANLIATAGADRVLTMDLHAPAIEGFFDIPVDHLQAGPLIADHFRSRN
MKNVVVVSPDAGGVGRANKFRERIGASLAIIAKQRPAPDVSEVVEMVGDVAGKHAVIFDDMISTGGTLAEAAKTLKERGA
ISVVACATHGIFAGNAVELLGDSVMEEVLVTDTIPLPAEASAARIAQISVASLFAEAIIRIHKDLSLSALFS
>Mature_312_residues
MDGRLQIFTGNANIPLARSIASHLNLNLGRAIVGVFKNGETRVQLEENVRGSDVFIVQSLTTPVDHHLMELLLMIDALRR
ASAQRVTAVIPYYGYAKQEKKTTGREPISAKLVANLIATAGADRVLTMDLHAPAIEGFFDIPVDHLQAGPLIADHFRSRN
MKNVVVVSPDAGGVGRANKFRERIGASLAIIAKQRPAPDVSEVVEMVGDVAGKHAVIFDDMISTGGTLAEAAKTLKERGA
ISVVACATHGIFAGNAVELLGDSVMEEVLVTDTIPLPAEASAARIAQISVASLFAEAIIRIHKDLSLSALFS

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI4506127, Length=311, Percent_Identity=45.016077170418, Blast_Score=265, Evalue=3e-71,
Organism=Homo sapiens, GI28557709, Length=311, Percent_Identity=44.6945337620579, Blast_Score=263, Evalue=1e-70,
Organism=Homo sapiens, GI4506129, Length=309, Percent_Identity=44.336569579288, Blast_Score=263, Evalue=2e-70,
Organism=Homo sapiens, GI84875539, Length=312, Percent_Identity=43.9102564102564, Blast_Score=257, Evalue=8e-69,
Organism=Homo sapiens, GI4506133, Length=346, Percent_Identity=34.6820809248555, Blast_Score=194, Evalue=9e-50,
Organism=Homo sapiens, GI194018537, Length=350, Percent_Identity=35.7142857142857, Blast_Score=192, Evalue=3e-49,
Organism=Homo sapiens, GI310128524, Length=146, Percent_Identity=28.0821917808219, Blast_Score=76, Evalue=4e-14,
Organism=Homo sapiens, GI310115209, Length=146, Percent_Identity=28.0821917808219, Blast_Score=76, Evalue=4e-14,
Organism=Homo sapiens, GI310118259, Length=146, Percent_Identity=28.0821917808219, Blast_Score=76, Evalue=4e-14,
Organism=Homo sapiens, GI310119946, Length=146, Percent_Identity=28.0821917808219, Blast_Score=76, Evalue=4e-14,
Organism=Escherichia coli, GI1787458, Length=310, Percent_Identity=50.6451612903226, Blast_Score=308, Evalue=4e-85,
Organism=Caenorhabditis elegans, GI25149168, Length=311, Percent_Identity=44.3729903536978, Blast_Score=255, Evalue=2e-68,
Organism=Caenorhabditis elegans, GI17554704, Length=309, Percent_Identity=44.6601941747573, Blast_Score=254, Evalue=4e-68,
Organism=Caenorhabditis elegans, GI17554702, Length=311, Percent_Identity=44.3729903536978, Blast_Score=254, Evalue=4e-68,
Organism=Caenorhabditis elegans, GI71989924, Length=311, Percent_Identity=44.3729903536978, Blast_Score=253, Evalue=1e-67,
Organism=Caenorhabditis elegans, GI17570245, Length=335, Percent_Identity=33.134328358209, Blast_Score=191, Evalue=6e-49,
Organism=Saccharomyces cerevisiae, GI6319403, Length=313, Percent_Identity=43.4504792332268, Blast_Score=246, Evalue=5e-66,
Organism=Saccharomyces cerevisiae, GI6320946, Length=312, Percent_Identity=41.6666666666667, Blast_Score=240, Evalue=2e-64,
Organism=Saccharomyces cerevisiae, GI6321776, Length=300, Percent_Identity=41.6666666666667, Blast_Score=230, Evalue=3e-61,
Organism=Saccharomyces cerevisiae, GI6322667, Length=194, Percent_Identity=37.6288659793814, Blast_Score=142, Evalue=6e-35,
Organism=Saccharomyces cerevisiae, GI6324511, Length=86, Percent_Identity=46.5116279069767, Blast_Score=85, Evalue=2e-17,
Organism=Drosophila melanogaster, GI21355239, Length=311, Percent_Identity=45.3376205787781, Blast_Score=265, Evalue=2e-71,
Organism=Drosophila melanogaster, GI45551540, Length=334, Percent_Identity=42.2155688622754, Blast_Score=253, Evalue=1e-67,
Organism=Drosophila melanogaster, GI281362873, Length=351, Percent_Identity=33.048433048433, Blast_Score=189, Evalue=2e-48,
Organism=Drosophila melanogaster, GI24651454, Length=351, Percent_Identity=33.048433048433, Blast_Score=189, Evalue=2e-48,
Organism=Drosophila melanogaster, GI24651458, Length=351, Percent_Identity=33.048433048433, Blast_Score=189, Evalue=2e-48,
Organism=Drosophila melanogaster, GI24651456, Length=351, Percent_Identity=33.048433048433, Blast_Score=189, Evalue=2e-48,
Organism=Drosophila melanogaster, GI24651462, Length=199, Percent_Identity=36.6834170854271, Blast_Score=135, Evalue=3e-32,
Organism=Drosophila melanogaster, GI24651464, Length=199, Percent_Identity=36.6834170854271, Blast_Score=135, Evalue=3e-32,
Organism=Drosophila melanogaster, GI45552010, Length=199, Percent_Identity=36.6834170854271, Blast_Score=135, Evalue=4e-32,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 33241; Mature: 33241

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDGRLQIFTGNANIPLARSIASHLNLNLGRAIVGVFKNGETRVQLEENVRGSDVFIVQSL
CCCEEEEEECCCCCCHHHHHHHHHCCCCCHHHEEEECCCCEEEEECCCCCCCEEEEEEEC
TTPVDHHLMELLLMIDALRRASAQRVTAVIPYYGYAKQEKKTTGREPISAKLVANLIATA
CCCHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCHHHHCCCCCCHHHHHHHHHHHHC
GADRVLTMDLHAPAIEGFFDIPVDHLQAGPLIADHFRSRNMKNVVVVSPDAGGVGRANKF
CCCEEEEEECCCCHHCCHHCCCHHHHCCCCHHHHHHHCCCCCEEEEECCCCCCCCCHHHH
RERIGASLAIIAKQRPAPDVSEVVEMVGDVAGKHAVIFDDMISTGGTLAEAAKTLKERGA
HHHHCCEEEEEECCCCCCCHHHHHHHHHHHCCCCEEEEHHHHHCCCHHHHHHHHHHHCCC
ISVVACATHGIFAGNAVELLGDSVMEEVLVTDTIPLPAEASAARIAQISVASLFAEAIIR
EEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
IHKDLSLSALFS
HHCCCCHHHHCC
>Mature Secondary Structure
MDGRLQIFTGNANIPLARSIASHLNLNLGRAIVGVFKNGETRVQLEENVRGSDVFIVQSL
CCCEEEEEECCCCCCHHHHHHHHHCCCCCHHHEEEECCCCEEEEECCCCCCCEEEEEEEC
TTPVDHHLMELLLMIDALRRASAQRVTAVIPYYGYAKQEKKTTGREPISAKLVANLIATA
CCCHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCHHHHCCCCCCHHHHHHHHHHHHC
GADRVLTMDLHAPAIEGFFDIPVDHLQAGPLIADHFRSRNMKNVVVVSPDAGGVGRANKF
CCCEEEEEECCCCHHCCHHCCCHHHHCCCCHHHHHHHCCCCCEEEEECCCCCCCCCHHHH
RERIGASLAIIAKQRPAPDVSEVVEMVGDVAGKHAVIFDDMISTGGTLAEAAKTLKERGA
HHHHCCEEEEEECCCCCCCHHHHHHHHHHHCCCCEEEEHHHHHCCCHHHHHHHHHHHCCC
ISVVACATHGIFAGNAVELLGDSVMEEVLVTDTIPLPAEASAARIAQISVASLFAEAIIR
EEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
IHKDLSLSALFS
HHCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]