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The map label for this gene is glmU [H]

Identifier: 159901000

GI number: 159901000

Start: 5746027

End: 5747406

Strand: Direct

Name: glmU [H]

Synonym: Haur_4487

Alternate gene names: 159901000

Gene position: 5746027-5747406 (Clockwise)

Preceding gene: 159900996

Following gene: 159901001

Centisome position: 90.54

GC content: 53.48

Gene sequence:

>1380_bases
ATGACACTCGGTGTGGTTGTGTTGGCTGCTGGTCAAGGGACGCGCATGCGTTCGAGCTTACCGAAAGTTTTACATCCTGT
TGCCGGATTGCCATTAGTTGAGCATGTGACCCGTCTGGCCGATGCGGTTGGCGCACAGCAGATTGTATTGGTCGTGAGCG
AAGATACTTTAGCCCCAATTAGTGCCGCGTTTGGCCATCGCTATCGCTATGTGGTGCAACATGAGCGGCTTGGCACAGGC
CATGCGGTGGCGCAAGCTCGCGCCGAACTCGAAGGCAAAGTCGATGAAGTGCTGGTGTTGTATGGCGCTGATCCATTGAT
GCGCCATGAATCGCTGCTCGAATTATTGGCAGTGCGCCGCACCACCAACGCCAAAGCCGCGATCGTCAGCTTTCAAGCCA
ATCCACCAACTGGTTATGGCCGAATTGTGCGCGACGAAACAGGCGCAGTTCAGGCGATTGTTGAAGAACGCAACGCCACC
CCCGAACAACGCCGAATTACAGAGGTGAACCAAGGTGTGGCGCTCTACGATGGCGCTTGGCTCTGGAATGCCCTCGATCA
GATACAGCCCAATAGCCTAAATGGCGAATATTATTTGACCGATTTGGTCGAGATTGCGCTGCACGAGCATGGCCTTGGCG
CAGTAGCTGCTATTCAGTTACGCGACCCCGATGAAGCCTTGGGGGTAAATGATCGAATTCAGTTGGCCCAAGTTGGGGCA
ATTTTGAATGCGCGAAAAATTCGGGCCTTGATGTTGGCCGGAGTGACCGTGGTTGATCCTGCCACGACCTTTGTTGATCA
CGATGTGCAGGTTGGTATGGATACGACCTTGCTGCCTGGCACGATCCTCAAAGGCCGCACCACAATTGGGGCAAATTGTA
TGATCGGCCCCAACAGCTTAATTGAAGATTCGCAGATTGGTGACCATTGCAAAATTAGCTATTCAGTCGTTGAGCAAGCG
CAGATGGATCTCGGAGCCAACATCGGGCCATATGGGCATCTGCGCCGCGGTGCACACCTGATGGAGCATGTTCATATGGG
CAACTTCGGCGAGGTGAAAAACGCGACCCTTGGCGCTGGCACAAAAATGGGCCATTTTTCCTATGTTGGCGATGCCACAA
TCGGCGAAAATGTAAATATTGGTGCTGGCACGATTACTTGCAATTTTACTGCTGATGGCAAAAAGCATCGCACCGAAATT
GGCGCGAATGCCTTTATTGGCTCCGATTCGTTGTTGCGTGCGCCAGTTAAAATTGGCGCAGGTGCAATTACCGGAGCCGG
TTCAGTTGTGACCAAAGATATACCTGATGGCGGCGTGGCCGTGGGTATGCCAGCCCGCGTCATTCGCCACCGCAAGCTTG
AGCAGAGTGAGAACGAGTAG

Upstream 100 bases:

>100_bases
AAAGTTCCCTCGCAGAAGCGCCCGCGTCGCCGCAATTTTCTGCTAAGATAGCCCTTGGATAGATTTACGATATTTAGCTT
GCAATGGGGAGCGTTGAACT

Downstream 100 bases:

>100_bases
GCAACGGATTTTTCATTGACCAATTACTAACTTGGGGGGCATCGAATGGACGGGCGATTGCAGATTTTTACGGGTAATGC
CAACATCCCGTTAGCTCGCA

Product: UDP-N-acetylglucosamine pyrophosphorylase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase [H]

Number of amino acids: Translated: 459; Mature: 458

Protein sequence:

>459_residues
MTLGVVVLAAGQGTRMRSSLPKVLHPVAGLPLVEHVTRLADAVGAQQIVLVVSEDTLAPISAAFGHRYRYVVQHERLGTG
HAVAQARAELEGKVDEVLVLYGADPLMRHESLLELLAVRRTTNAKAAIVSFQANPPTGYGRIVRDETGAVQAIVEERNAT
PEQRRITEVNQGVALYDGAWLWNALDQIQPNSLNGEYYLTDLVEIALHEHGLGAVAAIQLRDPDEALGVNDRIQLAQVGA
ILNARKIRALMLAGVTVVDPATTFVDHDVQVGMDTTLLPGTILKGRTTIGANCMIGPNSLIEDSQIGDHCKISYSVVEQA
QMDLGANIGPYGHLRRGAHLMEHVHMGNFGEVKNATLGAGTKMGHFSYVGDATIGENVNIGAGTITCNFTADGKKHRTEI
GANAFIGSDSLLRAPVKIGAGAITGAGSVVTKDIPDGGVAVGMPARVIRHRKLEQSENE

Sequences:

>Translated_459_residues
MTLGVVVLAAGQGTRMRSSLPKVLHPVAGLPLVEHVTRLADAVGAQQIVLVVSEDTLAPISAAFGHRYRYVVQHERLGTG
HAVAQARAELEGKVDEVLVLYGADPLMRHESLLELLAVRRTTNAKAAIVSFQANPPTGYGRIVRDETGAVQAIVEERNAT
PEQRRITEVNQGVALYDGAWLWNALDQIQPNSLNGEYYLTDLVEIALHEHGLGAVAAIQLRDPDEALGVNDRIQLAQVGA
ILNARKIRALMLAGVTVVDPATTFVDHDVQVGMDTTLLPGTILKGRTTIGANCMIGPNSLIEDSQIGDHCKISYSVVEQA
QMDLGANIGPYGHLRRGAHLMEHVHMGNFGEVKNATLGAGTKMGHFSYVGDATIGENVNIGAGTITCNFTADGKKHRTEI
GANAFIGSDSLLRAPVKIGAGAITGAGSVVTKDIPDGGVAVGMPARVIRHRKLEQSENE
>Mature_458_residues
TLGVVVLAAGQGTRMRSSLPKVLHPVAGLPLVEHVTRLADAVGAQQIVLVVSEDTLAPISAAFGHRYRYVVQHERLGTGH
AVAQARAELEGKVDEVLVLYGADPLMRHESLLELLAVRRTTNAKAAIVSFQANPPTGYGRIVRDETGAVQAIVEERNATP
EQRRITEVNQGVALYDGAWLWNALDQIQPNSLNGEYYLTDLVEIALHEHGLGAVAAIQLRDPDEALGVNDRIQLAQVGAI
LNARKIRALMLAGVTVVDPATTFVDHDVQVGMDTTLLPGTILKGRTTIGANCMIGPNSLIEDSQIGDHCKISYSVVEQAQ
MDLGANIGPYGHLRRGAHLMEHVHMGNFGEVKNATLGAGTKMGHFSYVGDATIGENVNIGAGTITCNFTADGKKHRTEIG
ANAFIGSDSLLRAPVKIGAGAITGAGSVVTKDIPDGGVAVGMPARVIRHRKLEQSENE

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-GlcNAc. Responsible for the acetylation of Glc-N-1-P to give GlcNAc-1-P and for the uridyl transfer from UTP to GlcNAc-1-P which produces UDP-GlcNAc [H]

COG id: COG1207

COG function: function code M; N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Escherichia coli, GI1790168, Length=445, Percent_Identity=41.5730337078652, Blast_Score=314, Evalue=9e-87,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005882
- InterPro:   IPR018357
- InterPro:   IPR005835
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.23; =2.3.1.157 [H]

Molecular weight: Translated: 48817; Mature: 48686

Theoretical pI: Translated: 6.46; Mature: 6.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLGVVVLAAGQGTRMRSSLPKVLHPVAGLPLVEHVTRLADAVGAQQIVLVVSEDTLAPI
CCEEEEEEECCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEEEEECCCCCHH
SAAFGHRYRYVVQHERLGTGHAVAQARAELEGKVDEVLVLYGADPLMRHESLLELLAVRR
HHHHCCCEEEEEECCCCCCCHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHC
TTNAKAAIVSFQANPPTGYGRIVRDETGAVQAIVEERNATPEQRRITEVNQGVALYDGAW
CCCCCEEEEEEECCCCCCCCEEEECCCHHHHHHHHHHCCCHHHHHHHHHHCCEEEECCHH
LWNALDQIQPNSLNGEYYLTDLVEIALHEHGLGAVAAIQLRDPDEALGVNDRIQLAQVGA
HHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEECCCHHHCCCCCCCHHHHHHH
ILNARKIRALMLAGVTVVDPATTFVDHDVQVGMDTTLLPGTILKGRTTIGANCMIGPNSL
HHHHHHHHHHHHCCEEEECCCHHHCCCCEEECCCCEECCCCEECCCCEECCEEEECCCCC
IEDSQIGDHCKISYSVVEQAQMDLGANIGPYGHLRRGAHLMEHVHMGNFGEVKNATLGAG
CCCCCCCCCEEEEHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
TKMGHFSYVGDATIGENVNIGAGTITCNFTADGKKHRTEIGANAFIGSDSLLRAPVKIGA
CCCCCEEEECCCCCCCCCCCCCEEEEEEEECCCCHHHHHCCCCEEECCCHHHCCCHHHCC
GAITGAGSVVTKDIPDGGVAVGMPARVIRHRKLEQSENE
CEECCCCCEEEECCCCCCEEECCHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TLGVVVLAAGQGTRMRSSLPKVLHPVAGLPLVEHVTRLADAVGAQQIVLVVSEDTLAPI
CEEEEEEECCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEEEEECCCCCHH
SAAFGHRYRYVVQHERLGTGHAVAQARAELEGKVDEVLVLYGADPLMRHESLLELLAVRR
HHHHCCCEEEEEECCCCCCCHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHC
TTNAKAAIVSFQANPPTGYGRIVRDETGAVQAIVEERNATPEQRRITEVNQGVALYDGAW
CCCCCEEEEEEECCCCCCCCEEEECCCHHHHHHHHHHCCCHHHHHHHHHHCCEEEECCHH
LWNALDQIQPNSLNGEYYLTDLVEIALHEHGLGAVAAIQLRDPDEALGVNDRIQLAQVGA
HHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEECCCHHHCCCCCCCHHHHHHH
ILNARKIRALMLAGVTVVDPATTFVDHDVQVGMDTTLLPGTILKGRTTIGANCMIGPNSL
HHHHHHHHHHHHCCEEEECCCHHHCCCCEEECCCCEECCCCEECCCCEECCEEEECCCCC
IEDSQIGDHCKISYSVVEQAQMDLGANIGPYGHLRRGAHLMEHVHMGNFGEVKNATLGAG
CCCCCCCCCEEEEHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
TKMGHFSYVGDATIGENVNIGAGTITCNFTADGKKHRTEIGANAFIGSDSLLRAPVKIGA
CCCCCEEEECCCCCCCCCCCCCEEEEEEEECCCCHHHHHCCCCEEECCCHHHCCCHHHCC
GAITGAGSVVTKDIPDGGVAVGMPARVIRHRKLEQSENE
CEECCCCCEEEECCCCCCEEECCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA