Click here to switch to the map view.

The map label for this gene is folD

Identifier: 159900984

GI number: 159900984

Start: 5716638

End: 5717498

Strand: Direct

Name: folD

Synonym: Haur_4471

Alternate gene names: 159900984

Gene position: 5716638-5717498 (Clockwise)

Preceding gene: 159900983

Following gene: 159900989

Centisome position: 90.07

GC content: 55.28

Gene sequence:

>861_bases
ATGACAGCGCTTTTGCTTGATGGTCGCGGGTTGGCCAAGGAATTGAAGGCTCAAATTAGCCAGCAAGGAGCTGAATTCAA
GGCTCGCACTGGCTATGCTCCCCAATTGGTGGTGATTCAAGTGGCGGGCAATGCTGCTTCCGATTGGTATGTGCGTTCAA
TTCGGCGTTCATGCGAAGGGGTTGGCTTTGGCTTTGCCCTGCAACGCTTGCCAGAAACCAGCGATCAAGCGACTTTAGAA
GCGGCCATTCAACAAGCCAGCAACGATCCCGCGATTCATGGCATTATTATTCAAATGCCGTTGCCCAGCCAGCTCTCGGC
TGATGGCGCGGTAGCCGCGCTCAATCCCCAAAAAGATGTTGATGGGTTGCACCCAACCAATGCAGGCCGTTTGGCCCAAG
GTTTGACCGCGCTTGTGCCCAATACGCCTGCTGGTGGTATGGCCTTGCTTGATCGCTATCAGATTAATCTGGCTGGCAAG
CATGCGGTGGTGGTTGGTCGCTCGAATGTGGTTGGCAAGCCGCTGGCTCAATTGTTGCTGGCGCGGCATGCCACCGTCAC
AATTTGCCATTCGCGCACTGCCAATTTGGCCGAGGTTATTCGCCAAGGCGATATTGTCGCGGCAGCGGTCGGCAAGGCTG
GCTTGGTCACTGGCGAGATGCTCAAACCTGGCGCGGTGGTGCTCGATTTTGGTATCAATGAGGTGGCTGAAGGCCAAGTA
GTTGGCGATGTTGATTGGGAAAGTGCCAGCAAGGTGGCGAGCGCAATTACCCCGGTACCAGGCGGCACTGGCCCGGTTAC
CAATATGATGTTGCTGCAAAACACCTTACAAGCAGCTCAATCGCTGGCCGAACAAGCCTAA

Upstream 100 bases:

>100_bases
CTGAGGCCGTGATGGCCTTAGTCAATCAACAGCTTCAGGGCTAAATGGTTTTCCAACGATGGCGGAGCGCAGGCTCCGCC
TTTTATTTGTAAAGGATGTT

Downstream 100 bases:

>100_bases
CCCGCAGCTAGGCTGAGGTTTTCTTGGCTGGCAATAATTAAATCGTTTAGTTGTTGCCAGCGCTCAGCCATTTCGTGGGC
GGGCAAGGCTGGTTTCTGCC

Product: methenyltetrahydrofolate cyclohydrolase

Products: NA

Alternate protein names: Methylenetetrahydrofolate dehydrogenase; Methenyltetrahydrofolate cyclohydrolase

Number of amino acids: Translated: 286; Mature: 285

Protein sequence:

>286_residues
MTALLLDGRGLAKELKAQISQQGAEFKARTGYAPQLVVIQVAGNAASDWYVRSIRRSCEGVGFGFALQRLPETSDQATLE
AAIQQASNDPAIHGIIIQMPLPSQLSADGAVAALNPQKDVDGLHPTNAGRLAQGLTALVPNTPAGGMALLDRYQINLAGK
HAVVVGRSNVVGKPLAQLLLARHATVTICHSRTANLAEVIRQGDIVAAAVGKAGLVTGEMLKPGAVVLDFGINEVAEGQV
VGDVDWESASKVASAITPVPGGTGPVTNMMLLQNTLQAAQSLAEQA

Sequences:

>Translated_286_residues
MTALLLDGRGLAKELKAQISQQGAEFKARTGYAPQLVVIQVAGNAASDWYVRSIRRSCEGVGFGFALQRLPETSDQATLE
AAIQQASNDPAIHGIIIQMPLPSQLSADGAVAALNPQKDVDGLHPTNAGRLAQGLTALVPNTPAGGMALLDRYQINLAGK
HAVVVGRSNVVGKPLAQLLLARHATVTICHSRTANLAEVIRQGDIVAAAVGKAGLVTGEMLKPGAVVLDFGINEVAEGQV
VGDVDWESASKVASAITPVPGGTGPVTNMMLLQNTLQAAQSLAEQA
>Mature_285_residues
TALLLDGRGLAKELKAQISQQGAEFKARTGYAPQLVVIQVAGNAASDWYVRSIRRSCEGVGFGFALQRLPETSDQATLEA
AIQQASNDPAIHGIIIQMPLPSQLSADGAVAALNPQKDVDGLHPTNAGRLAQGLTALVPNTPAGGMALLDRYQINLAGKH
AVVVGRSNVVGKPLAQLLLARHATVTICHSRTANLAEVIRQGDIVAAAVGKAGLVTGEMLKPGAVVLDFGINEVAEGQVV
GDVDWESASKVASAITPVPGGTGPVTNMMLLQNTLQAAQSLAEQA

Specific function: Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate

COG id: COG0190

COG function: function code H; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family

Homologues:

Organism=Homo sapiens, GI222136639, Length=294, Percent_Identity=38.7755102040816, Blast_Score=222, Evalue=2e-58,
Organism=Homo sapiens, GI222418558, Length=296, Percent_Identity=38.8513513513513, Blast_Score=174, Evalue=9e-44,
Organism=Homo sapiens, GI94721354, Length=295, Percent_Identity=37.6271186440678, Blast_Score=171, Evalue=5e-43,
Organism=Homo sapiens, GI36796743, Length=222, Percent_Identity=27.027027027027, Blast_Score=65, Evalue=6e-11,
Organism=Escherichia coli, GI1786741, Length=279, Percent_Identity=43.7275985663082, Blast_Score=232, Evalue=2e-62,
Organism=Caenorhabditis elegans, GI17568735, Length=291, Percent_Identity=38.1443298969072, Blast_Score=191, Evalue=4e-49,
Organism=Saccharomyces cerevisiae, GI6321643, Length=303, Percent_Identity=37.6237623762376, Blast_Score=204, Evalue=1e-53,
Organism=Saccharomyces cerevisiae, GI6319558, Length=285, Percent_Identity=41.7543859649123, Blast_Score=202, Evalue=3e-53,
Organism=Saccharomyces cerevisiae, GI6322933, Length=317, Percent_Identity=25.5520504731861, Blast_Score=75, Evalue=8e-15,
Organism=Drosophila melanogaster, GI62472483, Length=293, Percent_Identity=40.2730375426621, Blast_Score=212, Evalue=2e-55,
Organism=Drosophila melanogaster, GI45551871, Length=293, Percent_Identity=40.2730375426621, Blast_Score=212, Evalue=2e-55,
Organism=Drosophila melanogaster, GI24645718, Length=293, Percent_Identity=40.2730375426621, Blast_Score=212, Evalue=2e-55,
Organism=Drosophila melanogaster, GI17137370, Length=293, Percent_Identity=40.2730375426621, Blast_Score=212, Evalue=2e-55,
Organism=Drosophila melanogaster, GI17136816, Length=294, Percent_Identity=40.8163265306122, Blast_Score=208, Evalue=3e-54,
Organism=Drosophila melanogaster, GI17136818, Length=294, Percent_Identity=40.8163265306122, Blast_Score=208, Evalue=3e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FOLD_HERA2 (A9AZP9)

Other databases:

- EMBL:   CP000875
- RefSeq:   YP_001547231.1
- ProteinModelPortal:   A9AZP9
- SMR:   A9AZP9
- GeneID:   5736322
- GenomeReviews:   CP000875_GR
- KEGG:   hau:Haur_4471
- HOGENOM:   HBG328751
- OMA:   CLMMLRD
- ProtClustDB:   CLSK975315
- BioCyc:   HAUR316274:HAUR_4471-MONOMER
- GO:   GO:0005488
- HAMAP:   MF_01576
- InterPro:   IPR016040
- InterPro:   IPR000672
- InterPro:   IPR020630
- InterPro:   IPR020631
- Gene3D:   G3DSA:3.40.50.720
- PRINTS:   PR00085

Pfam domain/function: PF00763 THF_DHG_CYH; PF02882 THF_DHG_CYH_C

EC number: =1.5.1.5; =3.5.4.9

Molecular weight: Translated: 29569; Mature: 29438

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: PS00766 THF_DHG_CYH_1; PS00767 THF_DHG_CYH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTALLLDGRGLAKELKAQISQQGAEFKARTGYAPQLVVIQVAGNAASDWYVRSIRRSCEG
CEEEEECCCCHHHHHHHHHHHCCCCEEECCCCCCEEEEEEECCCCCCHHHHHHHHHHHCC
VGFGFALQRLPETSDQATLEAAIQQASNDPAIHGIIIQMPLPSQLSADGAVAALNPQKDV
CCHHHHHHHCCCCCHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCCCEEEECCCCCC
DGLHPTNAGRLAQGLTALVPNTPAGGMALLDRYQINLAGKHAVVVGRSNVVGKPLAQLLL
CCCCCCCHHHHHHCHHEECCCCCCCCHHHHHHEEEEECCCEEEEEECCCCCHHHHHHHHH
ARHATVTICHSRTANLAEVIRQGDIVAAAVGKAGLVTGEMLKPGAVVLDFGINEVAEGQV
HHCCEEEEEECCCCHHHHHHHCCCEEEEECCCCCCEECCCCCCCCEEEECCCCCCCCCCE
VGDVDWESASKVASAITPVPGGTGPVTNMMLLQNTLQAAQSLAEQA
EECCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TALLLDGRGLAKELKAQISQQGAEFKARTGYAPQLVVIQVAGNAASDWYVRSIRRSCEG
EEEEECCCCHHHHHHHHHHHCCCCEEECCCCCCEEEEEEECCCCCCHHHHHHHHHHHCC
VGFGFALQRLPETSDQATLEAAIQQASNDPAIHGIIIQMPLPSQLSADGAVAALNPQKDV
CCHHHHHHHCCCCCHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCCCEEEECCCCCC
DGLHPTNAGRLAQGLTALVPNTPAGGMALLDRYQINLAGKHAVVVGRSNVVGKPLAQLLL
CCCCCCCHHHHHHCHHEECCCCCCCCHHHHHHEEEEECCCEEEEEECCCCCHHHHHHHHH
ARHATVTICHSRTANLAEVIRQGDIVAAAVGKAGLVTGEMLKPGAVVLDFGINEVAEGQV
HHCCEEEEEECCCCHHHHHHHCCCEEEEECCCCCCEECCCCCCCCEEEECCCCCCCCCCE
VGDVDWESASKVASAITPVPGGTGPVTNMMLLQNTLQAAQSLAEQA
EECCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA