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The map label for this gene is pdp [H]

Identifier: 159900695

GI number: 159900695

Start: 5334020

End: 5335324

Strand: Direct

Name: pdp [H]

Synonym: Haur_4182

Alternate gene names: 159900695

Gene position: 5334020-5335324 (Clockwise)

Preceding gene: 159900694

Following gene: 159900696

Centisome position: 84.05

GC content: 55.48

Gene sequence:

>1305_bases
ATGCGTGCGGTTGATCTGATTATTAAAAAACGCAATGGAGCACAGCTCTCAACCGAAGAAATTCAATGGCTGATTCAGGG
CTATACCAACGGCAGTGTGCCCGATTATCAGATGGCGGCGTGGGCCATGGCGGTTGTGCTCAAAGGCATGGATGATCGCG
AAACCACCGATTTAACCCTTGCCATGGCCGCTTCGGGCGATCAGCTCGATTTGCGTGATTTCGCGCCCGATGCCGTTGAT
AAGCACTCGACTGGCGGGGTTGGCGATAAAACTAGCCTTGTGCTGGGGCCAATGTTGGCAGCCGTTGGTTTGCAAGTTGC
CAAAATGTCGGGGCGGGGCTTGGGCTTTTCGGGCGGCACGCTCGATAAACTTGAGGCCATCCCCAACATGCGCATCGACC
TGAGCGAAGATGAGTTTCGCCATGCCATGCGTGAGATTGGCATGGTGATTATGGGCCAAACTGCTGATCTCGCACCTGCC
GACAAAAAGCTGTATGCGTTGCGCGATGTGACTGGCACTGTCGAATGTATTCCGCTGATTGCAGCCAGCATTATGAGCAA
AAAGCTGGCGGCTGGAGCCAAAAGCATCGTACTCGATGTCAAGGTTGGGGCGGGGGCGTTTATGAAAACCCTCGATCAAG
CCCGTGATTTGGCCCGAACGATGGTGCGGATCGGCCAATTGGCTGGCCGCAATGTCGCTGCGATCCTTTCGTCGATGGAG
CAACCGTTGGGCTTGACGATCGGTAATGCGCTGGAAGTGCGCGAAGCGATTGAAACGCTCCAAGGTCGCGGCCCCGGCGA
TTTGGTTGAAGTTTGTTTGACCCTTGGCTCACATCTGTTGGTTTTGGCTGGCAAGGCCCAAAATCTTGATGATGCCCGCC
AACAGTTGCAAGCAAGCTTGGATAACGGCCAAGCTTGGGCTAAATTCCGTGAGTTTGTTGCCCAGCAAGGCGGCGATCTC
ACGGTGATTGACCAACCAGAAACCCTGCCAATCGCCCCAATTCAAATCAGTTTGCTGGCCGAGAGCAGCGGCTTTGTCCA
ACGCATCGATGCCGAAACCTGTGGGATTGTGGCGACCGAGCTTGGAGCTGGTCGCGCCCGCAAAGAAGATGCGATCGATC
CGGCGGTGGGCTTGGTGCTTGAGCGTAAAGTTGGCGAGCCAGTTCAAGCGGGCGAGGCCTTGTTGACAGTGCATGCTGCT
GATCAGCAACGGGCCGAGGTTGCTTTGGCCGCACTCAAATCGGCAATTACGATCAGTGCTACGTCGGTTGAAGCCTTGCC
CTTGGTTTTCGAAAGCGTTGCCTAG

Upstream 100 bases:

>100_bases
TGGTTCGTGAAGAACTCGGCGAACGCGGCACCATTGCTAGCGATATTCTTAATCGCCTGCCCTTAGCATGGCGAAAACTT
ACAGAAGGCGGATTAAAATA

Downstream 100 bases:

>100_bases
CTACGCGTTGTGAGCACGGTTGCGTTGGTAGAGTTTGCGCTCTATCAACGCATTTTTTGTGGGTTTCGGCCTGTGGCGTG
GTATAATTATTAACGAAAAT

Product: pyrimidine-nucleoside phosphorylase

Products: NA

Alternate protein names: PYNP [H]

Number of amino acids: Translated: 434; Mature: 434

Protein sequence:

>434_residues
MRAVDLIIKKRNGAQLSTEEIQWLIQGYTNGSVPDYQMAAWAMAVVLKGMDDRETTDLTLAMAASGDQLDLRDFAPDAVD
KHSTGGVGDKTSLVLGPMLAAVGLQVAKMSGRGLGFSGGTLDKLEAIPNMRIDLSEDEFRHAMREIGMVIMGQTADLAPA
DKKLYALRDVTGTVECIPLIAASIMSKKLAAGAKSIVLDVKVGAGAFMKTLDQARDLARTMVRIGQLAGRNVAAILSSME
QPLGLTIGNALEVREAIETLQGRGPGDLVEVCLTLGSHLLVLAGKAQNLDDARQQLQASLDNGQAWAKFREFVAQQGGDL
TVIDQPETLPIAPIQISLLAESSGFVQRIDAETCGIVATELGAGRARKEDAIDPAVGLVLERKVGEPVQAGEALLTVHAA
DQQRAEVALAALKSAITISATSVEALPLVFESVA

Sequences:

>Translated_434_residues
MRAVDLIIKKRNGAQLSTEEIQWLIQGYTNGSVPDYQMAAWAMAVVLKGMDDRETTDLTLAMAASGDQLDLRDFAPDAVD
KHSTGGVGDKTSLVLGPMLAAVGLQVAKMSGRGLGFSGGTLDKLEAIPNMRIDLSEDEFRHAMREIGMVIMGQTADLAPA
DKKLYALRDVTGTVECIPLIAASIMSKKLAAGAKSIVLDVKVGAGAFMKTLDQARDLARTMVRIGQLAGRNVAAILSSME
QPLGLTIGNALEVREAIETLQGRGPGDLVEVCLTLGSHLLVLAGKAQNLDDARQQLQASLDNGQAWAKFREFVAQQGGDL
TVIDQPETLPIAPIQISLLAESSGFVQRIDAETCGIVATELGAGRARKEDAIDPAVGLVLERKVGEPVQAGEALLTVHAA
DQQRAEVALAALKSAITISATSVEALPLVFESVA
>Mature_434_residues
MRAVDLIIKKRNGAQLSTEEIQWLIQGYTNGSVPDYQMAAWAMAVVLKGMDDRETTDLTLAMAASGDQLDLRDFAPDAVD
KHSTGGVGDKTSLVLGPMLAAVGLQVAKMSGRGLGFSGGTLDKLEAIPNMRIDLSEDEFRHAMREIGMVIMGQTADLAPA
DKKLYALRDVTGTVECIPLIAASIMSKKLAAGAKSIVLDVKVGAGAFMKTLDQARDLARTMVRIGQLAGRNVAAILSSME
QPLGLTIGNALEVREAIETLQGRGPGDLVEVCLTLGSHLLVLAGKAQNLDDARQQLQASLDNGQAWAKFREFVAQQGGDL
TVIDQPETLPIAPIQISLLAESSGFVQRIDAETCGIVATELGAGRARKEDAIDPAVGLVLERKVGEPVQAGEALLTVHAA
DQQRAEVALAALKSAITISATSVEALPLVFESVA

Specific function: The Enzymes Which Catalyze The Reversible Phosphorolysis Of Pyrimidine Nucleosides Are Involved In The Degradation Of These Compounds And In Their Utilization As Carbon And Energy Sources, Or In The Rescue Of Pyrimidine Bases For Nucleotide Synthesis. [C

COG id: COG0213

COG function: function code F; Thymidine phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI166158925, Length=436, Percent_Identity=41.9724770642202, Blast_Score=285, Evalue=8e-77,
Organism=Homo sapiens, GI4503445, Length=436, Percent_Identity=41.9724770642202, Blast_Score=285, Evalue=8e-77,
Organism=Homo sapiens, GI166158922, Length=436, Percent_Identity=41.9724770642202, Blast_Score=285, Evalue=8e-77,
Organism=Escherichia coli, GI1790842, Length=437, Percent_Identity=41.6475972540046, Blast_Score=308, Evalue=6e-85,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- InterPro:   IPR013102
- InterPro:   IPR018090
- InterPro:   IPR000053
- InterPro:   IPR017872 [H]

Pfam domain/function: PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3; PF07831 PYNP_C [H]

EC number: =2.4.2.2 [H]

Molecular weight: Translated: 45798; Mature: 45798

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAVDLIIKKRNGAQLSTEEIQWLIQGYTNGSVPDYQMAAWAMAVVLKGMDDRETTDLTL
CCCEEEEEECCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEE
AMAASGDQLDLRDFAPDAVDKHSTGGVGDKTSLVLGPMLAAVGLQVAKMSGRGLGFSGGT
EEECCCCCCCHHHCCCCHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
LDKLEAIPNMRIDLSEDEFRHAMREIGMVIMGQTADLAPADKKLYALRDVTGTVECIPLI
HHHHHHCCCCEEECCHHHHHHHHHHCCEEEECCCCCCCCCCHHHEEHHHCCCHHHHHHHH
AASIMSKKLAAGAKSIVLDVKVGAGAFMKTLDQARDLARTMVRIGQLAGRNVAAILSSME
HHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHC
QPLGLTIGNALEVREAIETLQGRGPGDLVEVCLTLGSHLLVLAGKAQNLDDARQQLQASL
CCCCEECCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHH
DNGQAWAKFREFVAQQGGDLTVIDQPETLPIAPIQISLLAESSGFVQRIDAETCGIVATE
CCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCCEEEEEEECCCCCCEECCCCHHCEEEEC
LGAGRARKEDAIDPAVGLVLERKVGEPVQAGEALLTVHAADQQRAEVALAALKSAITISA
CCCCCCCCHHCCCHHHHHHHHHHCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHEEEE
TSVEALPLVFESVA
CCHHHHHHHHHHCC
>Mature Secondary Structure
MRAVDLIIKKRNGAQLSTEEIQWLIQGYTNGSVPDYQMAAWAMAVVLKGMDDRETTDLTL
CCCEEEEEECCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEE
AMAASGDQLDLRDFAPDAVDKHSTGGVGDKTSLVLGPMLAAVGLQVAKMSGRGLGFSGGT
EEECCCCCCCHHHCCCCHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
LDKLEAIPNMRIDLSEDEFRHAMREIGMVIMGQTADLAPADKKLYALRDVTGTVECIPLI
HHHHHHCCCCEEECCHHHHHHHHHHCCEEEECCCCCCCCCCHHHEEHHHCCCHHHHHHHH
AASIMSKKLAAGAKSIVLDVKVGAGAFMKTLDQARDLARTMVRIGQLAGRNVAAILSSME
HHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHC
QPLGLTIGNALEVREAIETLQGRGPGDLVEVCLTLGSHLLVLAGKAQNLDDARQQLQASL
CCCCEECCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHH
DNGQAWAKFREFVAQQGGDLTVIDQPETLPIAPIQISLLAESSGFVQRIDAETCGIVATE
CCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCCEEEEEEECCCCCCEECCCCHHCEEEEC
LGAGRARKEDAIDPAVGLVLERKVGEPVQAGEALLTVHAADQQRAEVALAALKSAITISA
CCCCCCCCHHCCCHHHHHHHHHHCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHEEEE
TSVEALPLVFESVA
CCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8987664; 9817849 [H]