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The map label for this gene is strD [H]

Identifier: 159900678

GI number: 159900678

Start: 5311411

End: 5312478

Strand: Direct

Name: strD [H]

Synonym: Haur_4165

Alternate gene names: 159900678

Gene position: 5311411-5312478 (Clockwise)

Preceding gene: 159900677

Following gene: 159900679

Centisome position: 83.69

GC content: 49.81

Gene sequence:

>1068_bases
ATGAAAGGTTTAGTTCTGAGTGGTGGTAAAGGCACACGCCTGCGCCCAATCACCTATACCAGCGCCAAGCAATTAGTGCC
TGTCGCCAACAAGCCAGTACTTTTTCGGGTAATCGAAGCCCTGCGCGATGCCAATATTGATGAAATTGGGATTGTAATCG
GTGATACTGGGGCCGAAGTGCGCAACGCCGTGGGCAATGGCTCACGCTGGGGCGTAAAGATCGAATATATTCCCCAAGAA
GCTCCGCTCGGCTTGGCTCACGCGGTCAAAATTAGTCGTCCGTTTATTGGTGACGATAAATTTGCACTCTTTTTGGGCGA
TAACTGCATCGAAGGCGGAGTTAGTTCGTTGGTGTCGGGCTTTGCTACATCCGATTACAATGCCCAAATTGTGCTCAAAC
AAGTTGCCAATCCACAGCAATATGGTGTCGCTGAGTTGCGTCACGATGGCTCGATCGAACGCTTGACTGAAAAACCGCGC
CAACCGCGCTCAGACTTGGCGTTGGTCGGCATTTATATGTTCGATCAGCATATTTGGGAAGCTGTTGAGGCGATCAAGCC
TTCTTGGCGGGGCGAGTTGGAAATTACCGATGCAATTCAATGGCTGATCGAGCACGATTACCATGTTCATGCCCATATTC
ACCAAGGCTGGTGGATCGATACTGGCAAACGCGCTGATATGCTCGATGCCAATCGTTTGGTGCTCGAAGAAATCACGCCC
CATGTATCGGGCTTCGTTGATCGCGATTCGCAATTAGTTGGCAAAGTAACGATCGAAAAAGGCGCTCAAGTGATCAACAG
CGTGATTCGTGGGCCAGCGATCATCGGCGAAGATACGCGGATCGTTAACTCATACGTTGGACCGTTTACCTCAATCTATC
ATCATTGTACGATTGAGGAAAGCGAAATTGAGCACTCGATTGTCTTGGAAAATAGCGAAATTATTCGCCTGCCCAACCGC
ATCGAAGATAGCTTGATTGGCCGCAATGTCAAATTGCATACCTCGCCGATGAAACCCAAAGCCTACCGCTTGATGCTCGG
CGATAACTCTGACGTGGGGCTGTTGTAA

Upstream 100 bases:

>100_bases
ATTATCTTGCAAAGTATTGGCGCATTGCTGGTAGCATGGCGATTAAGCGCAACTGCCACATCAACGCCAATTGCCTAGCG
CCAAGGAGACGACACAGCTC

Downstream 100 bases:

>100_bases
AGGCAAAAGGCAAAGGGCAGAAGGCAAAATAGGCACAAATTCAAGTTTTCTGCCCTGGGCTGATTACCATTCAAATGAAT
AAACCTGCTTTTGACTTTAA

Product: glucose-1-phosphate thymidyltransferase

Products: NA

Alternate protein names: Sugar-nucleotidylation enzyme; dTDP-glucose pyrophosphorylase; dTDP-glucose synthase [H]

Number of amino acids: Translated: 355; Mature: 355

Protein sequence:

>355_residues
MKGLVLSGGKGTRLRPITYTSAKQLVPVANKPVLFRVIEALRDANIDEIGIVIGDTGAEVRNAVGNGSRWGVKIEYIPQE
APLGLAHAVKISRPFIGDDKFALFLGDNCIEGGVSSLVSGFATSDYNAQIVLKQVANPQQYGVAELRHDGSIERLTEKPR
QPRSDLALVGIYMFDQHIWEAVEAIKPSWRGELEITDAIQWLIEHDYHVHAHIHQGWWIDTGKRADMLDANRLVLEEITP
HVSGFVDRDSQLVGKVTIEKGAQVINSVIRGPAIIGEDTRIVNSYVGPFTSIYHHCTIEESEIEHSIVLENSEIIRLPNR
IEDSLIGRNVKLHTSPMKPKAYRLMLGDNSDVGLL

Sequences:

>Translated_355_residues
MKGLVLSGGKGTRLRPITYTSAKQLVPVANKPVLFRVIEALRDANIDEIGIVIGDTGAEVRNAVGNGSRWGVKIEYIPQE
APLGLAHAVKISRPFIGDDKFALFLGDNCIEGGVSSLVSGFATSDYNAQIVLKQVANPQQYGVAELRHDGSIERLTEKPR
QPRSDLALVGIYMFDQHIWEAVEAIKPSWRGELEITDAIQWLIEHDYHVHAHIHQGWWIDTGKRADMLDANRLVLEEITP
HVSGFVDRDSQLVGKVTIEKGAQVINSVIRGPAIIGEDTRIVNSYVGPFTSIYHHCTIEESEIEHSIVLENSEIIRLPNR
IEDSLIGRNVKLHTSPMKPKAYRLMLGDNSDVGLL
>Mature_355_residues
MKGLVLSGGKGTRLRPITYTSAKQLVPVANKPVLFRVIEALRDANIDEIGIVIGDTGAEVRNAVGNGSRWGVKIEYIPQE
APLGLAHAVKISRPFIGDDKFALFLGDNCIEGGVSSLVSGFATSDYNAQIVLKQVANPQQYGVAELRHDGSIERLTEKPR
QPRSDLALVGIYMFDQHIWEAVEAIKPSWRGELEITDAIQWLIEHDYHVHAHIHQGWWIDTGKRADMLDANRLVLEEITP
HVSGFVDRDSQLVGKVTIEKGAQVINSVIRGPAIIGEDTRIVNSYVGPFTSIYHHCTIEESEIEHSIVLENSEIIRLPNR
IEDSLIGRNVKLHTSPMKPKAYRLMLGDNSDVGLL

Specific function: Involved in the biosynthesis of the streptose moiety of streptomycin. Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1209

COG function: function code M; dTDP-glucose pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=278, Percent_Identity=25.8992805755396, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI11761619, Length=278, Percent_Identity=25.8992805755396, Blast_Score=103, Evalue=3e-22,
Organism=Escherichia coli, GI1788351, Length=237, Percent_Identity=36.2869198312236, Blast_Score=159, Evalue=3e-40,
Organism=Escherichia coli, GI1790224, Length=237, Percent_Identity=36.2869198312236, Blast_Score=151, Evalue=8e-38,
Organism=Escherichia coli, GI1788355, Length=270, Percent_Identity=24.8148148148148, Blast_Score=85, Evalue=6e-18,
Organism=Escherichia coli, GI1787488, Length=268, Percent_Identity=26.1194029850746, Blast_Score=74, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI133931050, Length=336, Percent_Identity=27.3809523809524, Blast_Score=112, Evalue=4e-25,
Organism=Saccharomyces cerevisiae, GI6320148, Length=315, Percent_Identity=26.031746031746, Blast_Score=104, Evalue=2e-23,
Organism=Drosophila melanogaster, GI21355443, Length=330, Percent_Identity=25.7575757575758, Blast_Score=105, Evalue=6e-23,
Organism=Drosophila melanogaster, GI24644084, Length=330, Percent_Identity=25.7575757575758, Blast_Score=105, Evalue=6e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005908
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 39339; Mature: 39339

Theoretical pI: Translated: 6.19; Mature: 6.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGLVLSGGKGTRLRPITYTSAKQLVPVANKPVLFRVIEALRDANIDEIGIVIGDTGAEV
CCCEEEECCCCCEEEEEEECCCHHCCCCCCCCHHHHHHHHHHHCCCCEEEEEEECCCHHH
RNAVGNGSRWGVKIEYIPQEAPLGLAHAVKISRPFIGDDKFALFLGDNCIEGGVSSLVSG
HHHCCCCCCCCEEEEEECCCCCCCHHHEEEECCCCCCCCCEEEEECCCHHHHHHHHHHHH
FATSDYNAQIVLKQVANPQQYGVAELRHDGSIERLTEKPRQPRSDLALVGIYMFDQHIWE
CCCCCCCCEEEEEHHCCCHHCCHHHHHCCCCHHHHHHCCCCCCCCEEEEHHHHHHHHHHH
AVEAIKPSWRGELEITDAIQWLIEHDYHVHAHIHQGWWIDTGKRADMLDANRLVLEEITP
HHHHHCCCCCCCEEHHHHHHHHHHCCCEEEEEEECCEEEECCCCCCCCCCCHHHHHHHCH
HVSGFVDRDSQLVGKVTIEKGAQVINSVIRGPAIIGEDTRIVNSYVGPFTSIYHHCTIEE
HHHHHCCCCCCEEEEEEHHHHHHHHHHHHCCCEEECCCHHHHHHHHCHHHHHHHEECCCH
SEIEHSIVLENSEIIRLPNRIEDSLIGRNVKLHTSPMKPKAYRLMLGDNSDVGLL
HHCCEEEEECCCCEEECCCHHHHHHHCCCEEEECCCCCCCEEEEEECCCCCCCCC
>Mature Secondary Structure
MKGLVLSGGKGTRLRPITYTSAKQLVPVANKPVLFRVIEALRDANIDEIGIVIGDTGAEV
CCCEEEECCCCCEEEEEEECCCHHCCCCCCCCHHHHHHHHHHHCCCCEEEEEEECCCHHH
RNAVGNGSRWGVKIEYIPQEAPLGLAHAVKISRPFIGDDKFALFLGDNCIEGGVSSLVSG
HHHCCCCCCCCEEEEEECCCCCCCHHHEEEECCCCCCCCCEEEEECCCHHHHHHHHHHHH
FATSDYNAQIVLKQVANPQQYGVAELRHDGSIERLTEKPRQPRSDLALVGIYMFDQHIWE
CCCCCCCCEEEEEHHCCCHHCCHHHHHCCCCHHHHHHCCCCCCCCEEEEHHHHHHHHHHH
AVEAIKPSWRGELEITDAIQWLIEHDYHVHAHIHQGWWIDTGKRADMLDANRLVLEEITP
HHHHHCCCCCCCEEHHHHHHHHHHCCCEEEEEEECCEEEECCCCCCCCCCCHHHHHHHCH
HVSGFVDRDSQLVGKVTIEKGAQVINSVIRGPAIIGEDTRIVNSYVGPFTSIYHHCTIEE
HHHHHCCCCCCEEEEEEHHHHHHHHHHHHCCCEEECCCHHHHHHHHCHHHHHHHEECCCH
SEIEHSIVLENSEIIRLPNRIEDSLIGRNVKLHTSPMKPKAYRLMLGDNSDVGLL
HHCCEEEEECCCCEEECCCHHHHHHHCCCEEEECCCCCCCEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3118332 [H]