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The map label for this gene is hemC [H]

Identifier: 159900065

GI number: 159900065

Start: 4465005

End: 4465907

Strand: Direct

Name: hemC [H]

Synonym: Haur_3548

Alternate gene names: 159900065

Gene position: 4465005-4465907 (Clockwise)

Preceding gene: 159900064

Following gene: 159900066

Centisome position: 70.35

GC content: 53.82

Gene sequence:

>903_bases
ATGAACATATTAACCATTGGAACGCGCAAAAGCCAATTGGCCTTGGTGCAAACCCACGCCATGCGCGATGCCTTGTTGGC
GGCGCATCCCCAATTAACGATCGAACTTGAACACATCACCACCAAGGGCGATGCGATTTTGGATCGACCATTGGCGGCGA
TTGGCGATAAGGGTCTGTTTGTCAGCGAAATTGAGGATGCCATGCGCAATGGCAAGGTCGATCTGGCGGTGCATAGTGCC
AAAGATTTGCCTTCAATTTTAGCGCCCGACATGACGATTGCAGCCTATCCCGAACGGGCCGACCCACGCGATGTCTTGGT
TGGAGCCGAAGGGCGCAGGCTTGCCGATTTGGTGCCTGGAGCCAAGGTTGGCACGAGTAGCCCGCGGCGTGCTGCCCAAT
TGCGCCATTTACGGCCCGATCTAACAATTATTGATATTCGCGGCAATGTTGATACGCGCTTGCGTAAACTTGACGAAGGC
CAATACGATGCGATTGTGTTGGCGGCAGCAGGCTTGCAACGCTTAGGATTATTGAAGCGTGTGACCCAATTTTTCGAGCC
AGCCGAAATGACTCCAGCGGTTTCGCAGGGCATTTTGGGCATCGAAGCACGGGCAGGCGATCAACGAGTTGCTGATTTGC
TCAAGGTGCTCGATCACGCTGAATCACGGGCGACTGCTGAAGCCGAAAAAGCCTTTTTGGCCACCATTGGCGGCGGTTGC
CAAGTGGCGGTTGGCGCATTTGCCACCTATCAAATAGGCCAATTGCACTTAATCGGTATGATTGGAGCACTTGATGGACG
CTTAGTGCGCGGTGAATTAACTGGCAGTGCGAGTACGGCGCAAGCGCTTGGGACAAGTCTAGCGCAACAATTATTGGCTC
AAGGTGGGAGAGAACTGCTCTAG

Upstream 100 bases:

>100_bases
GTTTCCCGCCTCGAGGCGGGACGGAAGGGTGGTGATCACCAATGATTATTAATCCACGAAAAATACTTTATTCACTTATT
CTATAGTTAAGAATGACAGC

Downstream 100 bases:

>100_bases
CTCGGTTGCGATTTAGAGCAGTTTTGGCATAACCGATCGTGCTTGAATTAACAGCGGGCAGGCCATAATCTTGTATACTA
CCAAGGCCGACGATTAATGA

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase [H]

Number of amino acids: Translated: 300; Mature: 300

Protein sequence:

>300_residues
MNILTIGTRKSQLALVQTHAMRDALLAAHPQLTIELEHITTKGDAILDRPLAAIGDKGLFVSEIEDAMRNGKVDLAVHSA
KDLPSILAPDMTIAAYPERADPRDVLVGAEGRRLADLVPGAKVGTSSPRRAAQLRHLRPDLTIIDIRGNVDTRLRKLDEG
QYDAIVLAAAGLQRLGLLKRVTQFFEPAEMTPAVSQGILGIEARAGDQRVADLLKVLDHAESRATAEAEKAFLATIGGGC
QVAVGAFATYQIGQLHLIGMIGALDGRLVRGELTGSASTAQALGTSLAQQLLAQGGRELL

Sequences:

>Translated_300_residues
MNILTIGTRKSQLALVQTHAMRDALLAAHPQLTIELEHITTKGDAILDRPLAAIGDKGLFVSEIEDAMRNGKVDLAVHSA
KDLPSILAPDMTIAAYPERADPRDVLVGAEGRRLADLVPGAKVGTSSPRRAAQLRHLRPDLTIIDIRGNVDTRLRKLDEG
QYDAIVLAAAGLQRLGLLKRVTQFFEPAEMTPAVSQGILGIEARAGDQRVADLLKVLDHAESRATAEAEKAFLATIGGGC
QVAVGAFATYQIGQLHLIGMIGALDGRLVRGELTGSASTAQALGTSLAQQLLAQGGRELL
>Mature_300_residues
MNILTIGTRKSQLALVQTHAMRDALLAAHPQLTIELEHITTKGDAILDRPLAAIGDKGLFVSEIEDAMRNGKVDLAVHSA
KDLPSILAPDMTIAAYPERADPRDVLVGAEGRRLADLVPGAKVGTSSPRRAAQLRHLRPDLTIIDIRGNVDTRLRKLDEG
QYDAIVLAAAGLQRLGLLKRVTQFFEPAEMTPAVSQGILGIEARAGDQRVADLLKVLDHAESRATAEAEKAFLATIGGGC
QVAVGAFATYQIGQLHLIGMIGALDGRLVRGELTGSASTAQALGTSLAQQLLAQGGRELL

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps [H]

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family [H]

Homologues:

Organism=Homo sapiens, GI20149500, Length=334, Percent_Identity=42.814371257485, Blast_Score=229, Evalue=3e-60,
Organism=Homo sapiens, GI66933009, Length=334, Percent_Identity=42.814371257485, Blast_Score=229, Evalue=3e-60,
Organism=Escherichia coli, GI48994974, Length=300, Percent_Identity=47.3333333333333, Blast_Score=261, Evalue=3e-71,
Organism=Saccharomyces cerevisiae, GI6319996, Length=313, Percent_Identity=35.4632587859425, Blast_Score=177, Evalue=2e-45,
Organism=Drosophila melanogaster, GI20130425, Length=287, Percent_Identity=41.1149825783972, Blast_Score=209, Evalue=2e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418 [H]

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC [H]

EC number: =2.5.1.61 [H]

Molecular weight: Translated: 31815; Mature: 31815

Theoretical pI: Translated: 6.90; Mature: 6.90

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNILTIGTRKSQLALVQTHAMRDALLAAHPQLTIELEHITTKGDAILDRPLAAIGDKGLF
CCEEEECCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCHHHHCCHHHHCCCCCC
VSEIEDAMRNGKVDLAVHSAKDLPSILAPDMTIAAYPERADPRDVLVGAEGRRLADLVPG
HHHHHHHHHCCCEEEEEECCCCCHHHHCCCCEEEECCCCCCCCCEEECCCCCCHHHHCCC
AKVGTSSPRRAAQLRHLRPDLTIIDIRGNVDTRLRKLDEGQYDAIVLAAAGLQRLGLLKR
CCCCCCCCHHHHHHHHCCCCCEEEEECCCHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHH
VTQFFEPAEMTPAVSQGILGIEARAGDQRVADLLKVLDHAESRATAEAEKAFLATIGGGC
HHHHCCCCCCCHHHHHCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCC
QVAVGAFATYQIGQLHLIGMIGALDGRLVRGELTGSASTAQALGTSLAQQLLAQGGRELL
EEEEHHHHHHCCCCEEEEEHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MNILTIGTRKSQLALVQTHAMRDALLAAHPQLTIELEHITTKGDAILDRPLAAIGDKGLF
CCEEEECCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCHHHHCCHHHHCCCCCC
VSEIEDAMRNGKVDLAVHSAKDLPSILAPDMTIAAYPERADPRDVLVGAEGRRLADLVPG
HHHHHHHHHCCCEEEEEECCCCCHHHHCCCCEEEECCCCCCCCCEEECCCCCCHHHHCCC
AKVGTSSPRRAAQLRHLRPDLTIIDIRGNVDTRLRKLDEGQYDAIVLAAAGLQRLGLLKR
CCCCCCCCHHHHHHHHCCCCCEEEEECCCHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHH
VTQFFEPAEMTPAVSQGILGIEARAGDQRVADLLKVLDHAESRATAEAEKAFLATIGGGC
HHHHCCCCCCCHHHHHCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCC
QVAVGAFATYQIGQLHLIGMIGALDGRLVRGELTGSASTAQALGTSLAQQLLAQGGRELL
EEEEHHHHHHCCCCEEEEEHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA