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The map label for this gene is mre11 [H]

Identifier: 159899969

GI number: 159899969

Start: 4340323

End: 4341567

Strand: Direct

Name: mre11 [H]

Synonym: Haur_3452

Alternate gene names: 159899969

Gene position: 4340323-4341567 (Clockwise)

Preceding gene: 159899966

Following gene: 159899971

Centisome position: 68.39

GC content: 51.97

Gene sequence:

>1245_bases
ATGAAAATTCTTCACCTCGCAGATATTCACATTGGCATGGAAAATTATGGCCGAATCGATAGCACAACTGGCCTCAACAC
CCGCTTGATCGATTATCTTGATCGGTTTGCCGAGGCTTTGCAGATTGGCATCGAGCATGATGTCGATTTGGTGCTGATTG
CTGGCGATATTTACAAAAACCGCACGCCCAACCCAACCCATCAACGTGAATTTGCTCGTCGCCTGCGCAGTGTGCTCGAT
CGGGGCATTCCCGTATTTATGTTGGTTGGCAATCACGATGTTTCAGCCGCCGCAGGCAAAGCTCATTCGGTCGAAATTTT
CGATACCCTCGCCATCGATGGGGTAACAATTGCCGATCGGCTTGGGATTCATACGATCGAAACTCGCGCCGGTAGCATTC
AAATTGTGGCCGTGCCATGGATCAGCCGCCACGCCATTTTGACCAAAGATGATATTCGTGAGTTGCCATTTGCTGAACTC
GAAGCTGAATTATTGCGGCGGGTAGGGGCTTGGCTCGAACAAGTGCCCGAGCGGTTGCGCGGCGATTTACCAGCGATCTT
GACCTTTCATGGCACTGTTTCCAATGCCACCTATGGCGCTGAACGCTCGGTCATGTTGGGCAATGATCTGATTCTGCCGC
CATCACTTTTGGCCCAGCCAGGCATTCAATATGTCGCCTTGGGCCATATTCACCGCTATCAAGTGCTCAGCGAAAATCCC
CCAATGATCTACCCTGGCTCGATTGAGCGCATCGATTTTAGCGAGGAATCTGAGCAAAAACAAGTGGTAATTGTTGAAAT
TGAAAATAATTGGGAAGATGCCAGCTATCAGCCAATTGCGGTGCATCCGCGCCCATTCGTCACGATCAAAGTTGATGTAA
CTGGCAGCAGCGACCCCATGGAGCGGGTGGCCCAAGCGATTAGCAAGCGCGATTTAAATGGCGCGGTGGTGCGTTTGTTA
ATTAGCGCTACTGCTGAGCAACGCCCACAGCTTGATGAGACTGAACTGCGACGCTTGCTCGAGGCTGCCGAAACCCATGT
GATCGCCAGCATTGCGATTGAGGCCCAACGCAGCGAACGCACTCGCTATGCTGCGGTTGCCAGCGAATTGAATGAAGGAT
TAACTCCACGCCGCGCCCTCGAAATCTACCTTGAAAGCAGCAATATCAGCGCCACTCGCCGCGAACAGATGCTCAAAGCC
GCCGATGACTTGATCAAAGCCGAACAAGCACGTGAGCAAGCATGA

Upstream 100 bases:

>100_bases
CCCAAACAAGCTTGATTAACTGGCGGCCTTTTCAGTCTACCATGAGCCGCCGATTGTGGTAGACTAACCAAACACATGAG
CTATTAAAGGTATCTTGGGC

Downstream 100 bases:

>100_bases
AAGGCAAAAGTCAGAAGGCAAAAATCAAAAAGAGTAAGTGAGCGAGGGGCATTCCAACGTTCATGATTGATACGGTGGTT
CCCCCTCGCCTCGCGTGCAG

Product: nuclease SbcCD subunit D

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 414; Mature: 414

Protein sequence:

>414_residues
MKILHLADIHIGMENYGRIDSTTGLNTRLIDYLDRFAEALQIGIEHDVDLVLIAGDIYKNRTPNPTHQREFARRLRSVLD
RGIPVFMLVGNHDVSAAAGKAHSVEIFDTLAIDGVTIADRLGIHTIETRAGSIQIVAVPWISRHAILTKDDIRELPFAEL
EAELLRRVGAWLEQVPERLRGDLPAILTFHGTVSNATYGAERSVMLGNDLILPPSLLAQPGIQYVALGHIHRYQVLSENP
PMIYPGSIERIDFSEESEQKQVVIVEIENNWEDASYQPIAVHPRPFVTIKVDVTGSSDPMERVAQAISKRDLNGAVVRLL
ISATAEQRPQLDETELRRLLEAAETHVIASIAIEAQRSERTRYAAVASELNEGLTPRRALEIYLESSNISATRREQMLKA
ADDLIKAEQAREQA

Sequences:

>Translated_414_residues
MKILHLADIHIGMENYGRIDSTTGLNTRLIDYLDRFAEALQIGIEHDVDLVLIAGDIYKNRTPNPTHQREFARRLRSVLD
RGIPVFMLVGNHDVSAAAGKAHSVEIFDTLAIDGVTIADRLGIHTIETRAGSIQIVAVPWISRHAILTKDDIRELPFAEL
EAELLRRVGAWLEQVPERLRGDLPAILTFHGTVSNATYGAERSVMLGNDLILPPSLLAQPGIQYVALGHIHRYQVLSENP
PMIYPGSIERIDFSEESEQKQVVIVEIENNWEDASYQPIAVHPRPFVTIKVDVTGSSDPMERVAQAISKRDLNGAVVRLL
ISATAEQRPQLDETELRRLLEAAETHVIASIAIEAQRSERTRYAAVASELNEGLTPRRALEIYLESSNISATRREQMLKA
ADDLIKAEQAREQA
>Mature_414_residues
MKILHLADIHIGMENYGRIDSTTGLNTRLIDYLDRFAEALQIGIEHDVDLVLIAGDIYKNRTPNPTHQREFARRLRSVLD
RGIPVFMLVGNHDVSAAAGKAHSVEIFDTLAIDGVTIADRLGIHTIETRAGSIQIVAVPWISRHAILTKDDIRELPFAEL
EAELLRRVGAWLEQVPERLRGDLPAILTFHGTVSNATYGAERSVMLGNDLILPPSLLAQPGIQYVALGHIHRYQVLSENP
PMIYPGSIERIDFSEESEQKQVVIVEIENNWEDASYQPIAVHPRPFVTIKVDVTGSSDPMERVAQAISKRDLNGAVVRLL
ISATAEQRPQLDETELRRLLEAAETHVIASIAIEAQRSERTRYAAVASELNEGLTPRRALEIYLESSNISATRREQMLKA
ADDLIKAEQAREQA

Specific function: Involved in DNA double-strand break repair (DSBR). The rad50/mre11 complex possesses single-strand endonuclease activity and ATP-dependent double-strand-specific 3'-5' exonuclease activity [H]

COG id: COG0420

COG function: function code L; DNA repair exonuclease

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MRE11/RAD32 family [H]

Homologues:

Organism=Escherichia coli, GI1786598, Length=298, Percent_Identity=27.5167785234899, Blast_Score=78, Evalue=8e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003701
- InterPro:   IPR004843 [H]

Pfam domain/function: PF00149 Metallophos [H]

EC number: NA

Molecular weight: Translated: 46162; Mature: 46162

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKILHLADIHIGMENYGRIDSTTGLNTRLIDYLDRFAEALQIGIEHDVDLVLIAGDIYKN
CEEEEEEEEEECHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECHHHCC
RTPNPTHQREFARRLRSVLDRGIPVFMLVGNHDVSAAAGKAHSVEIFDTLAIDGVTIADR
CCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHCCCCCEEEEEEEHEECCEEEHHH
LGIHTIETRAGSIQIVAVPWISRHAILTKDDIRELPFAELEAELLRRVGAWLEQVPERLR
CCCEEEEECCCCEEEEEECCCCCCEEECHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHC
GDLPAILTFHGTVSNATYGAERSVMLGNDLILPPSLLAQPGIQYVALGHIHRYQVLSENP
CCCCEEEEEECCCCCCCCCCCCEEEECCCCCCCCHHHHCCCCCEEEECCCEEEEEECCCC
PMIYPGSIERIDFSEESEQKQVVIVEIENNWEDASYQPIAVHPRPFVTIKVDVTGSSDPM
CEEECCCCCEECCCCCCCCCCEEEEEEECCCCCCCCCCEEECCCCEEEEEEEECCCCCHH
ERVAQAISKRDLNGAVVRLLISATAEQRPQLDETELRRLLEAAETHVIASIAIEAQRSER
HHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHEEEEEEEEHHHHHH
TRYAAVASELNEGLTPRRALEIYLESSNISATRREQMLKAADDLIKAEQAREQA
HHHHHHHHHHHCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKILHLADIHIGMENYGRIDSTTGLNTRLIDYLDRFAEALQIGIEHDVDLVLIAGDIYKN
CEEEEEEEEEECHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECHHHCC
RTPNPTHQREFARRLRSVLDRGIPVFMLVGNHDVSAAAGKAHSVEIFDTLAIDGVTIADR
CCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHCCCCCEEEEEEEHEECCEEEHHH
LGIHTIETRAGSIQIVAVPWISRHAILTKDDIRELPFAELEAELLRRVGAWLEQVPERLR
CCCEEEEECCCCEEEEEECCCCCCEEECHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHC
GDLPAILTFHGTVSNATYGAERSVMLGNDLILPPSLLAQPGIQYVALGHIHRYQVLSENP
CCCCEEEEEECCCCCCCCCCCCEEEECCCCCCCCHHHHCCCCCEEEECCCEEEEEECCCC
PMIYPGSIERIDFSEESEQKQVVIVEIENNWEDASYQPIAVHPRPFVTIKVDVTGSSDPM
CEEECCCCCEECCCCCCCCCCEEEEEEECCCCCCCCCCEEECCCCEEEEEEEECCCCCHH
ERVAQAISKRDLNGAVVRLLISATAEQRPQLDETELRRLLEAAETHVIASIAIEAQRSER
HHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHEEEEEEEEHHHHHH
TRYAAVASELNEGLTPRRALEIYLESSNISATRREQMLKAADDLIKAEQAREQA
HHHHHHHHHHHCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]