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The map label for this gene is rnz [H]

Identifier: 159899891

GI number: 159899891

Start: 4254263

End: 4255030

Strand: Direct

Name: rnz [H]

Synonym: Haur_3374

Alternate gene names: 159899891

Gene position: 4254263-4255030 (Clockwise)

Preceding gene: 159899887

Following gene: 159899892

Centisome position: 67.03

GC content: 52.99

Gene sequence:

>768_bases
ATGAGTAATTTGATTGTGCTTGGCTCTGGCACGGCACTTCCCGATGCTGAGCGTGAAAATAGTGGCTATGTTTGGCAAAG
CGCGGCTGGCCTAGTCTTGCTCGATTGTGGTGGTAGCCCGTATCGCCGAATGCTCAAATATGGGCTTGATCCACGTCAAC
TCCGCGCAATCTTCATCTCGCACAATCACCCCGACCACTTGATGGGCTTACCCAGTTTGTTGCTGCATTTGTGGCTGGCT
CAACACAACGGCGAATTGCTCGTGTTTGGTAATTCGCGCACGATTGCTACGGCAGAGGCGGTCGTGCAAGCCGCCGATTT
AGGCATTCACGCAATTAAGCCCCAATTTCAAACCCTCGATGATGCTGGTGGCAAGGTCGAATTACCCTTCGATTTAGGCG
CGACACTCACTACAGCCCCAACCTACCATAGCCGCCCAACCCTCGCCTTGCGGATCGATCAAACAGGCCAAGGCAGTTTG
GTGTATGGTGCTGATAGTGGGCCATGCGCTGCACTGGTTGAATTAAGCGATCATGCGCATACCTTGATTCATGAATGCAC
TGTTTCAACGCCCTTCGATACCCACTCAACACCTGAGCAAGCCGCTACCACCGCCCAAAATGCTGGAGTCCAACGTCTGA
TTCTGACCCACTACAGCCCGATCAATACCGCACCCGAAGCTGAGGTGCTGGCACGAGTTGCCACAATTTTCAAGGGCGAA
GTTTTGATCGCCTACGATGGTGCAGTTTTTGCATTGGATGCGGGCTAA

Upstream 100 bases:

>100_bases
GCTGCAAAATGTGAGTTTTGCACCCTTGTCGGGTCTTTTATGGCCTATTATACTAATTGCTGCGCTATCTGCGTATATTG
CACGACCAAAGGAGGTCCGC

Downstream 100 bases:

>100_bases
GCATGCTAAGATAGCGTTGTGGTTACGGCCACCTCTTTTTGTGTCAATTCCCAATAAGGAGCTACGCCAATGGTTGTGCG
CTTAGTTCGGTTAAAATTTG

Product: beta-lactamase domain-containing protein

Products: NA

Alternate protein names: RNase Z; tRNA 3 endonuclease; tRNase Z [H]

Number of amino acids: Translated: 255; Mature: 254

Protein sequence:

>255_residues
MSNLIVLGSGTALPDAERENSGYVWQSAAGLVLLDCGGSPYRRMLKYGLDPRQLRAIFISHNHPDHLMGLPSLLLHLWLA
QHNGELLVFGNSRTIATAEAVVQAADLGIHAIKPQFQTLDDAGGKVELPFDLGATLTTAPTYHSRPTLALRIDQTGQGSL
VYGADSGPCAALVELSDHAHTLIHECTVSTPFDTHSTPEQAATTAQNAGVQRLILTHYSPINTAPEAEVLARVATIFKGE
VLIAYDGAVFALDAG

Sequences:

>Translated_255_residues
MSNLIVLGSGTALPDAERENSGYVWQSAAGLVLLDCGGSPYRRMLKYGLDPRQLRAIFISHNHPDHLMGLPSLLLHLWLA
QHNGELLVFGNSRTIATAEAVVQAADLGIHAIKPQFQTLDDAGGKVELPFDLGATLTTAPTYHSRPTLALRIDQTGQGSL
VYGADSGPCAALVELSDHAHTLIHECTVSTPFDTHSTPEQAATTAQNAGVQRLILTHYSPINTAPEAEVLARVATIFKGE
VLIAYDGAVFALDAG
>Mature_254_residues
SNLIVLGSGTALPDAERENSGYVWQSAAGLVLLDCGGSPYRRMLKYGLDPRQLRAIFISHNHPDHLMGLPSLLLHLWLAQ
HNGELLVFGNSRTIATAEAVVQAADLGIHAIKPQFQTLDDAGGKVELPFDLGATLTTAPTYHSRPTLALRIDQTGQGSLV
YGADSGPCAALVELSDHAHTLIHECTVSTPFDTHSTPEQAATTAQNAGVQRLILTHYSPINTAPEAEVLARVATIFKGEV
LIAYDGAVFALDAG

Specific function: Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA [H]

COG id: COG1234

COG function: function code R; Metal-dependent hydrolases of the beta-lactamase superfamily III

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the RNase Z family [H]

Homologues:

Organism=Homo sapiens, GI260166619, Length=253, Percent_Identity=25.296442687747, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI145553959, Length=253, Percent_Identity=25.296442687747, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI260166622, Length=253, Percent_Identity=25.296442687747, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24652403, Length=279, Percent_Identity=27.5985663082437, Blast_Score=86, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR013471 [H]

Pfam domain/function: PF00753 Lactamase_B [H]

EC number: =3.1.26.11 [H]

Molecular weight: Translated: 27136; Mature: 27005

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNLIVLGSGTALPDAERENSGYVWQSAAGLVLLDCGGSPYRRMLKYGLDPRQLRAIFIS
CCCEEEEECCCCCCCCCCCCCCEEEECCCCEEEEECCCCHHHHHHHHCCCHHHEEEEEEE
HNHPDHLMGLPSLLLHLWLAQHNGELLVFGNSRTIATAEAVVQAADLGIHAIKPQFQTLD
CCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCEEHHHHHHHHHHCCEEEECCCHHHHC
DAGGKVELPFDLGATLTTAPTYHSRPTLALRIDQTGQGSLVYGADSGPCAALVELSDHAH
CCCCEEEECCCCCCEEEECCCCCCCCEEEEEECCCCCCCEEEECCCCCEEEEEEECCCHH
TLIHECTVSTPFDTHSTPEQAATTAQNAGVQRLILTHYSPINTAPEAEVLARVATIFKGE
HHHHHHCCCCCCCCCCCHHHHHHHHHHCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCC
VLIAYDGAVFALDAG
EEEEECCEEEEEECC
>Mature Secondary Structure 
SNLIVLGSGTALPDAERENSGYVWQSAAGLVLLDCGGSPYRRMLKYGLDPRQLRAIFIS
CCEEEEECCCCCCCCCCCCCCEEEECCCCEEEEECCCCHHHHHHHHCCCHHHEEEEEEE
HNHPDHLMGLPSLLLHLWLAQHNGELLVFGNSRTIATAEAVVQAADLGIHAIKPQFQTLD
CCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCEEHHHHHHHHHHCCEEEECCCHHHHC
DAGGKVELPFDLGATLTTAPTYHSRPTLALRIDQTGQGSLVYGADSGPCAALVELSDHAH
CCCCEEEECCCCCCEEEECCCCCCCCEEEEEECCCCCCCEEEECCCCCEEEEEEECCCHH
TLIHECTVSTPFDTHSTPEQAATTAQNAGVQRLILTHYSPINTAPEAEVLARVATIFKGE
HHHHHHCCCCCCCCCCCHHHHHHHHHHCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCC
VLIAYDGAVFALDAG
EEEEECCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]