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The map label for this gene is lysK [H]

Identifier: 159899827

GI number: 159899827

Start: 4175476

End: 4176531

Strand: Direct

Name: lysK [H]

Synonym: Haur_3310

Alternate gene names: 159899827

Gene position: 4175476-4176531 (Clockwise)

Preceding gene: 159899826

Following gene: 159899829

Centisome position: 65.79

GC content: 55.02

Gene sequence:

>1056_bases
ATGAACGATCAACAAGCTTTGCAGTTAATTGAGGCCATGGTGGCAACACCCAGTGTTTCGGGCGACGAGGCCGCAATCGC
CCAATTGTTGGTTGAGCAGATGAATCAACTTGGCTTCGATGCCCATATTGATGCGGTTGGCAATGCAGTTGGCGTGATTG
GCGCTGCTGCTGAAACCGTCGTGTTGCTCGGACATATGGATACCGTGCCGGGCAATATTCCAGTCGAAGTGCGCGATGGC
GAGCTATGGGGGCGCGGTGCTGTCGATGCTAAAGGCTCGTTAGCCACGTTTATCGCTGCCGCCGCCCGCGCTCATGCCGA
ACAACGCCTAACCTATCGGGTAATTGTGGTTGGTTGCGTCGAAGAAGAAGTTGCTTCATCCAAAGGTGCGCATTTTGTAG
CCCAAACCATGGCTGCGCCACTTTGGTGCATCGTGGGCGAACCAAGCGGCGCAGATCGGCTCACCTTAGGCTACAAAGGC
AACTTGCGAGCGCAAATTCGCATCGAGCAAGATGCGGCCCATTCGGCCCACGCCAGCCACACCGCCGCCGAACATGGCTG
TGAATTATGGCAAGCGATCGCCCAACATGCTTATTCGATCAACCAAGGTCGCGAACGAGCTTTCGATCAATTGCTGCCAA
GTTTGGTAAAAATTGAATCAGGTGGCGATGGCTTGCGCGATTGGTGCGAATTGCTAGTCAATGTCCGTTTGCCGTTAGAT
CTTGATCCGGCGGCCTATACTGCGATGCTGCAACAACTGCTGCCCAATTATGCCCATTTAAAGGTAAGCGGCGCAACGCC
CGCGTTTAGTAGCGAACGCACATCAAGCATTGCGCGGCGCTTTGGGCGGGTGTTTCGCGCCAACGGCCAGCAACCGCGCT
ATGTGCAAAAAACTGGCACCGCCGACATGAATGTAGTTGGGCCAGCCTGGGGATGCCCAGTTGTCGCCTATGGTCCAGGC
GATGCAGCGCTTGATCATACGCCCCAAGAGCGCTTGCCCTTGGCCGAATATTTACAAGCGATCGCGGTATTGACAGCAGT
TTTGAGCAACGATTAA

Upstream 100 bases:

>100_bases
GCAGCAATGTGTTGCGCTTGCTCCCGCCGTTGGTGATTAATTGGGCTGAATTAGAACGCTTAGTGGCAACCTTACGCAGC
ATCTTCGAGGAGCCAAGCGC

Downstream 100 bases:

>100_bases
TTATTCTTGAATTAACTCAAGGCTATTGCCATCGGGATCAGTCACGATTGCCGCTTTGATGCCGCCTGCGCTTGGTGGCG
TGACGATCGTGCCGCCATGC

Product: acetyl-lysine deacetylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 351; Mature: 351

Protein sequence:

>351_residues
MNDQQALQLIEAMVATPSVSGDEAAIAQLLVEQMNQLGFDAHIDAVGNAVGVIGAAAETVVLLGHMDTVPGNIPVEVRDG
ELWGRGAVDAKGSLATFIAAAARAHAEQRLTYRVIVVGCVEEEVASSKGAHFVAQTMAAPLWCIVGEPSGADRLTLGYKG
NLRAQIRIEQDAAHSAHASHTAAEHGCELWQAIAQHAYSINQGRERAFDQLLPSLVKIESGGDGLRDWCELLVNVRLPLD
LDPAAYTAMLQQLLPNYAHLKVSGATPAFSSERTSSIARRFGRVFRANGQQPRYVQKTGTADMNVVGPAWGCPVVAYGPG
DAALDHTPQERLPLAEYLQAIAVLTAVLSND

Sequences:

>Translated_351_residues
MNDQQALQLIEAMVATPSVSGDEAAIAQLLVEQMNQLGFDAHIDAVGNAVGVIGAAAETVVLLGHMDTVPGNIPVEVRDG
ELWGRGAVDAKGSLATFIAAAARAHAEQRLTYRVIVVGCVEEEVASSKGAHFVAQTMAAPLWCIVGEPSGADRLTLGYKG
NLRAQIRIEQDAAHSAHASHTAAEHGCELWQAIAQHAYSINQGRERAFDQLLPSLVKIESGGDGLRDWCELLVNVRLPLD
LDPAAYTAMLQQLLPNYAHLKVSGATPAFSSERTSSIARRFGRVFRANGQQPRYVQKTGTADMNVVGPAWGCPVVAYGPG
DAALDHTPQERLPLAEYLQAIAVLTAVLSND
>Mature_351_residues
MNDQQALQLIEAMVATPSVSGDEAAIAQLLVEQMNQLGFDAHIDAVGNAVGVIGAAAETVVLLGHMDTVPGNIPVEVRDG
ELWGRGAVDAKGSLATFIAAAARAHAEQRLTYRVIVVGCVEEEVASSKGAHFVAQTMAAPLWCIVGEPSGADRLTLGYKG
NLRAQIRIEQDAAHSAHASHTAAEHGCELWQAIAQHAYSINQGRERAFDQLLPSLVKIESGGDGLRDWCELLVNVRLPLD
LDPAAYTAMLQQLLPNYAHLKVSGATPAFSSERTSSIARRFGRVFRANGQQPRYVQKTGTADMNVVGPAWGCPVVAYGPG
DAALDHTPQERLPLAEYLQAIAVLTAVLSND

Specific function: Displays A Broad Specificity And Can Also Deacylate Substrates Such As Acetylarginine, Acetylhistidine Or Acetylglutamate Semialdehyde. [C]

COG id: COG0624

COG function: function code E; Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M20A family. LysK subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790395, Length=365, Percent_Identity=27.9452054794521, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1788816, Length=191, Percent_Identity=30.8900523560209, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1789236, Length=190, Percent_Identity=29.4736842105263, Blast_Score=65, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001261
- InterPro:   IPR010175
- InterPro:   IPR002933 [H]

Pfam domain/function: PF01546 Peptidase_M20 [H]

EC number: 3.5.1.-

Molecular weight: Translated: 37354; Mature: 37354

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDQQALQLIEAMVATPSVSGDEAAIAQLLVEQMNQLGFDAHIDAVGNAVGVIGAAAETV
CCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHE
VLLGHMDTVPGNIPVEVRDGELWGRGAVDAKGSLATFIAAAARAHAEQRLTYRVIVVGCV
EEEECCCCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEEEEEC
EEEVASSKGAHFVAQTMAAPLWCIVGEPSGADRLTLGYKGNLRAQIRIEQDAAHSAHASH
HHHHHCCCCHHHHHHHHCCCEEEEECCCCCCCEEEEEECCCEEEEEEECCCCCCHHHHHH
TAAEHGCELWQAIAQHAYSINQGRERAFDQLLPSLVKIESGGDGLRDWCELLVNVRLPLD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHCCCCCC
LDPAAYTAMLQQLLPNYAHLKVSGATPAFSSERTSSIARRFGRVFRANGQQPRYVQKTGT
CCHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEHHCCC
ADMNVVGPAWGCPVVAYGPGDAALDHTPQERLPLAEYLQAIAVLTAVLSND
CCCEEECCCCCCCEEEECCCCCCCCCCCHHCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNDQQALQLIEAMVATPSVSGDEAAIAQLLVEQMNQLGFDAHIDAVGNAVGVIGAAAETV
CCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHE
VLLGHMDTVPGNIPVEVRDGELWGRGAVDAKGSLATFIAAAARAHAEQRLTYRVIVVGCV
EEEECCCCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEEEEEC
EEEVASSKGAHFVAQTMAAPLWCIVGEPSGADRLTLGYKGNLRAQIRIEQDAAHSAHASH
HHHHHCCCCHHHHHHHHCCCEEEEECCCCCCCEEEEEECCCEEEEEEECCCCCCHHHHHH
TAAEHGCELWQAIAQHAYSINQGRERAFDQLLPSLVKIESGGDGLRDWCELLVNVRLPLD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHCCCCCC
LDPAAYTAMLQQLLPNYAHLKVSGATPAFSSERTSSIARRFGRVFRANGQQPRYVQKTGT
CCHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEHHCCC
ADMNVVGPAWGCPVVAYGPGDAALDHTPQERLPLAEYLQAIAVLTAVLSND
CCCEEECCCCCCCEEEECCCCCCCCCCCHHCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10567266 [H]