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The map label for this gene is mutS [H]

Identifier: 159899700

GI number: 159899700

Start: 4025436

End: 4027292

Strand: Direct

Name: mutS [H]

Synonym: Haur_3182

Alternate gene names: 159899700

Gene position: 4025436-4027292 (Clockwise)

Preceding gene: 159899698

Following gene: 159899701

Centisome position: 63.43

GC content: 52.67

Gene sequence:

>1857_bases
ATGTCACTCCCAAATCAAGCCACCCCAATCGAGACCTATCGCCAACGCAGTGCTAGCTATCAACTTGAATTAGAGCAGCT
TCGCCAACGCTCAGATCGCTTTGCCAATCTCCGTTTGGTGTTGTTTGGCGCAGCGCTGTTTGCGGTGATTTTTGGCTTTG
CCAATGCACCATGGTGGTTTGCAGTCGCAGTTGGCTTGCTAATTGGCTTTGTTTGGGTCTTGATTCAGCATAATACGGTT
GAAGAACAGCGCCAACGCACTCAAGCGCTGTATCAATTAAATCACTATGGCGTGCAACGCTTGGAGCGCGATTGGGTCAA
TTTGCCCTTGCGTGTGCCAAGCCTCGACATTCCTGCCGATTCGTATGCTAACGATTTGGATTTGGTGGGCCGCGCCTCGT
TGTTGCACTTACTTGGCCATTTACCAACCGCCTTGGGCTTGGATACGCTGCTGAGTTGGCTTTTGGCTCCAGCAAATCCC
AGCACAATTACATCGCGTCAACAGGCGATCGCCGAACTAGCCCAAAACGTGCAATTGCGCGAAGAGTTGCATGTGGCAGC
CCATCATGTTACCGCTGAACGTGCTGATTTCGAGCAATTTCTGGTTTGGACAGAACAGCCAGCGCAGGTACTCAACCGGA
TGTGGGTGGTTTGGTTAGCGCGGTTGTTGCCAATCGGGCCAATCGCGGGCTTAGTGGCCTATTTGGCTGGCTGGACGAAT
GTGCCTTATTGGTTGGTGTTGTTTATTCTCAATATCATCGTCAGCAATGGCTTAGGCTTATGGGCCAATCAGGTGATTAT
GGCGGTCAGTGCACGGCGCAAAGGCTTTGCTGGCTTTGGCGCATTGTTTCGGGCGATCAACGAGCCGCAATTTCAAGCCG
CTTTGTTGCGCCAAGCCCAAAGCCAATTAACTGCCAATGGGGTTCGCGCCGATCATCAGATGGCGCGTTTGAGTCGCTTG
TTGAGCCTTGCTGATCAGCGATTTAGCTATTTTTATATTGTGCTCCAAGGCTTTAGTTTGTGGAATATTCACATTGGATG
GTTGCTTGAGCGTTGGCAGCGCGATGTGCGTGGTCAAGCCCGCGCTTGGCTCACAACCTTGGGCGAAATTGAAGCGCTTG
CCGCCCTCGCCACCTTACAAGCCGACCACCCAAATTGGACTCAAGCCCAACTGCATACCACTGATCAGGTGATTGCTAGC
GGTTTGGCCCATCCCTTGTTGCGGCCAGATAAAGCGGTGGCCAACGATTTGAGCATCGGGCCAGCAGGCACACTCTTTTT
GATTACTGGCTCGAATATGGCAGGCAAAAGCACCTTGATGCGAGCCATCGGCCTCAATATTGTGCTCGCCCAAACTGGCA
GTGTGGTGTGTGCCAGCAATTTGCAATTGCCAGTGCTGCGGCTTGCCACCAGCATGCGCATCAACGATTCGCTAGAACAA
GGCGTTTCGTACTACATGGCCGAATTGTTGCGGCTCAAAATGGTGTTGGGCGAGGTTGAGCAAGCGCGGGCAGCAGGCCA
ACCAGCCTTATTCTTGTTGGATGAGATTTTGCATGGCACCAACACGCGTGAACGTACCGTTGCTGCACGCCATATCATTG
CCCGCTTAATCGGTTTAGGTGCGATCGGCGCAGTTTCAACTCACGATTTGTCGCTGGCAACCGCGCCCGATATTGCCGCC
ATCAGCCAACCATGGTATTTGACCGAACACTTCGAGCGCGGCGATAATGGCCCAAGCATGACCTTCGATTATCAATTGCG
AGCTGGTTTAGCGCCGAGTACTAACGCCCTCAAGCTGATGGAAATCGTTGGTCTAGTCGATCAGGATGTGCCGTTGAGCG
TTGCCGCCAATAGTTAG

Upstream 100 bases:

>100_bases
GTGGATCAAACCCCGATCCCCAACAACCGACAACCGATCCCCGATATGGTATGATGACATGGGTTTACCCACCAACGAGT
CGAGTAGCGCAGGAATATAC

Downstream 100 bases:

>100_bases
CAGGCCGATTATGCGCCGACTGTTTGATATTTTGGCAATTTGTGTGCTTTTGGGCTACGCTTGGCTAGCTACACGCAGCC
AAGGCGGCGCTGATGATCCA

Product: DNA mismatch repair protein MutS domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 618; Mature: 617

Protein sequence:

>618_residues
MSLPNQATPIETYRQRSASYQLELEQLRQRSDRFANLRLVLFGAALFAVIFGFANAPWWFAVAVGLLIGFVWVLIQHNTV
EEQRQRTQALYQLNHYGVQRLERDWVNLPLRVPSLDIPADSYANDLDLVGRASLLHLLGHLPTALGLDTLLSWLLAPANP
STITSRQQAIAELAQNVQLREELHVAAHHVTAERADFEQFLVWTEQPAQVLNRMWVVWLARLLPIGPIAGLVAYLAGWTN
VPYWLVLFILNIIVSNGLGLWANQVIMAVSARRKGFAGFGALFRAINEPQFQAALLRQAQSQLTANGVRADHQMARLSRL
LSLADQRFSYFYIVLQGFSLWNIHIGWLLERWQRDVRGQARAWLTTLGEIEALAALATLQADHPNWTQAQLHTTDQVIAS
GLAHPLLRPDKAVANDLSIGPAGTLFLITGSNMAGKSTLMRAIGLNIVLAQTGSVVCASNLQLPVLRLATSMRINDSLEQ
GVSYYMAELLRLKMVLGEVEQARAAGQPALFLLDEILHGTNTRERTVAARHIIARLIGLGAIGAVSTHDLSLATAPDIAA
ISQPWYLTEHFERGDNGPSMTFDYQLRAGLAPSTNALKLMEIVGLVDQDVPLSVAANS

Sequences:

>Translated_618_residues
MSLPNQATPIETYRQRSASYQLELEQLRQRSDRFANLRLVLFGAALFAVIFGFANAPWWFAVAVGLLIGFVWVLIQHNTV
EEQRQRTQALYQLNHYGVQRLERDWVNLPLRVPSLDIPADSYANDLDLVGRASLLHLLGHLPTALGLDTLLSWLLAPANP
STITSRQQAIAELAQNVQLREELHVAAHHVTAERADFEQFLVWTEQPAQVLNRMWVVWLARLLPIGPIAGLVAYLAGWTN
VPYWLVLFILNIIVSNGLGLWANQVIMAVSARRKGFAGFGALFRAINEPQFQAALLRQAQSQLTANGVRADHQMARLSRL
LSLADQRFSYFYIVLQGFSLWNIHIGWLLERWQRDVRGQARAWLTTLGEIEALAALATLQADHPNWTQAQLHTTDQVIAS
GLAHPLLRPDKAVANDLSIGPAGTLFLITGSNMAGKSTLMRAIGLNIVLAQTGSVVCASNLQLPVLRLATSMRINDSLEQ
GVSYYMAELLRLKMVLGEVEQARAAGQPALFLLDEILHGTNTRERTVAARHIIARLIGLGAIGAVSTHDLSLATAPDIAA
ISQPWYLTEHFERGDNGPSMTFDYQLRAGLAPSTNALKLMEIVGLVDQDVPLSVAANS
>Mature_617_residues
SLPNQATPIETYRQRSASYQLELEQLRQRSDRFANLRLVLFGAALFAVIFGFANAPWWFAVAVGLLIGFVWVLIQHNTVE
EQRQRTQALYQLNHYGVQRLERDWVNLPLRVPSLDIPADSYANDLDLVGRASLLHLLGHLPTALGLDTLLSWLLAPANPS
TITSRQQAIAELAQNVQLREELHVAAHHVTAERADFEQFLVWTEQPAQVLNRMWVVWLARLLPIGPIAGLVAYLAGWTNV
PYWLVLFILNIIVSNGLGLWANQVIMAVSARRKGFAGFGALFRAINEPQFQAALLRQAQSQLTANGVRADHQMARLSRLL
SLADQRFSYFYIVLQGFSLWNIHIGWLLERWQRDVRGQARAWLTTLGEIEALAALATLQADHPNWTQAQLHTTDQVIASG
LAHPLLRPDKAVANDLSIGPAGTLFLITGSNMAGKSTLMRAIGLNIVLAQTGSVVCASNLQLPVLRLATSMRINDSLEQG
VSYYMAELLRLKMVLGEVEQARAAGQPALFLLDEILHGTNTRERTVAARHIIARLIGLGAIGAVSTHDLSLATAPDIAAI
SQPWYLTEHFERGDNGPSMTFDYQLRAGLAPSTNALKLMEIVGLVDQDVPLSVAANS

Specific function: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity [H]

COG id: COG0249

COG function: function code L; Mismatch repair ATPase (MutS family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutS family [H]

Homologues:

Organism=Homo sapiens, GI36949366, Length=213, Percent_Identity=29.5774647887324, Blast_Score=80, Evalue=5e-15,
Organism=Escherichia coli, GI1789089, Length=195, Percent_Identity=27.6923076923077, Blast_Score=66, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17508447, Length=203, Percent_Identity=27.5862068965517, Blast_Score=73, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6324482, Length=264, Percent_Identity=24.2424242424242, Blast_Score=69, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6319935, Length=268, Percent_Identity=23.8805970149254, Blast_Score=68, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6320302, Length=146, Percent_Identity=29.4520547945205, Blast_Score=64, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24664545, Length=209, Percent_Identity=29.1866028708134, Blast_Score=72, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005748
- InterPro:   IPR007695
- InterPro:   IPR000432
- InterPro:   IPR007861
- InterPro:   IPR007860
- InterPro:   IPR007696
- InterPro:   IPR016151 [H]

Pfam domain/function: PF01624 MutS_I; PF05188 MutS_II; PF05192 MutS_III; PF05190 MutS_IV; PF00488 MutS_V [H]

EC number: NA

Molecular weight: Translated: 68315; Mature: 68183

Theoretical pI: Translated: 7.32; Mature: 7.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLPNQATPIETYRQRSASYQLELEQLRQRSDRFANLRLVLFGAALFAVIFGFANAPWWF
CCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
AVAVGLLIGFVWVLIQHNTVEEQRQRTQALYQLNHYGVQRLERDWVNLPLRVPSLDIPAD
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCC
SYANDLDLVGRASLLHLLGHLPTALGLDTLLSWLLAPANPSTITSRQQAIAELAQNVQLR
CCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
EELHVAAHHVTAERADFEQFLVWTEQPAQVLNRMWVVWLARLLPIGPIAGLVAYLAGWTN
HHHHHHHHHHHHHHCCHHHHHEECCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCC
VPYWLVLFILNIIVSNGLGLWANQVIMAVSARRKGFAGFGALFRAINEPQFQAALLRQAQ
CHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHH
SQLTANGVRADHQMARLSRLLSLADQRFSYFYIVLQGFSLWNIHIGWLLERWQRDVRGQA
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCEEHHHHHHHHHHHHHHHHHH
RAWLTTLGEIEALAALATLQADHPNWTQAQLHTTDQVIASGLAHPLLRPDKAVANDLSIG
HHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCC
PAGTLFLITGSNMAGKSTLMRAIGLNIVLAQTGSVVCASNLQLPVLRLATSMRINDSLEQ
CCCEEEEEECCCCCHHHHHHHHHCCEEEEECCCCEEEECCCCCHHHHHHHHHHCCHHHHH
GVSYYMAELLRLKMVLGEVEQARAAGQPALFLLDEILHGTNTRERTVAARHIIARLIGLG
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCC
AIGAVSTHDLSLATAPDIAAISQPWYLTEHFERGDNGPSMTFDYQLRAGLAPSTNALKLM
CCCCCCCCCCCCCCCCCHHHCCCCCHHHHHHHCCCCCCCEEEEEEEECCCCCCCHHHHHH
EIVGLVDQDVPLSVAANS
HHHHHCCCCCCCEEECCC
>Mature Secondary Structure 
SLPNQATPIETYRQRSASYQLELEQLRQRSDRFANLRLVLFGAALFAVIFGFANAPWWF
CCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
AVAVGLLIGFVWVLIQHNTVEEQRQRTQALYQLNHYGVQRLERDWVNLPLRVPSLDIPAD
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCC
SYANDLDLVGRASLLHLLGHLPTALGLDTLLSWLLAPANPSTITSRQQAIAELAQNVQLR
CCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
EELHVAAHHVTAERADFEQFLVWTEQPAQVLNRMWVVWLARLLPIGPIAGLVAYLAGWTN
HHHHHHHHHHHHHHCCHHHHHEECCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCC
VPYWLVLFILNIIVSNGLGLWANQVIMAVSARRKGFAGFGALFRAINEPQFQAALLRQAQ
CHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHH
SQLTANGVRADHQMARLSRLLSLADQRFSYFYIVLQGFSLWNIHIGWLLERWQRDVRGQA
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCEEHHHHHHHHHHHHHHHHHH
RAWLTTLGEIEALAALATLQADHPNWTQAQLHTTDQVIASGLAHPLLRPDKAVANDLSIG
HHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCC
PAGTLFLITGSNMAGKSTLMRAIGLNIVLAQTGSVVCASNLQLPVLRLATSMRINDSLEQ
CCCEEEEEECCCCCHHHHHHHHHCCEEEEECCCCEEEECCCCCHHHHHHHHHHCCHHHHH
GVSYYMAELLRLKMVLGEVEQARAAGQPALFLLDEILHGTNTRERTVAARHIIARLIGLG
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCC
AIGAVSTHDLSLATAPDIAAISQPWYLTEHFERGDNGPSMTFDYQLRAGLAPSTNALKLM
CCCCCCCCCCCCCCCCCHHHCCCCCHHHHHHHCCCCCCCEEEEEEEECCCCCCCHHHHHH
EIVGLVDQDVPLSVAANS
HHHHHCCCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA