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The map label for this gene is hpt [H]

Identifier: 159899547

GI number: 159899547

Start: 3824236

End: 3824778

Strand: Direct

Name: hpt [H]

Synonym: Haur_3028

Alternate gene names: 159899547

Gene position: 3824236-3824778 (Clockwise)

Preceding gene: 159899546

Following gene: 159899548

Centisome position: 60.26

GC content: 46.22

Gene sequence:

>543_bases
ATGCATCCTGATCTTGAGCGAGTATTAATTGATACCGCAACACTCCAAAACCGAGTTCAAGCGCTTGGCACAGCAATTGC
CCAAGCTACGGTTAACGCACCTGAGTTAGTGTTAGTTGGCATCTTAAAAGGTTCGTTGATCTTTATGGCCGATCTGATGC
GCTCGATCGGGCGCGAGGTTTGCTACGATTGCATTGCGGTTTCGTCATATGGAGCCAGCACCGAAAGCAGCGGCGTAGTT
CGTTTAAATAAAGATCTCGACCTTGATATCACTGGCAAGCATGTGATCATCGTCGAAGATATTATTGATAGTGGCCTGAC
ATTAAAATATGTGCATGATCTGCTGTTGCGGCGCAACCCAGCCGCTTTAGAGATTTGTGCCCTACTAAATAAACCTGAAC
GGCGCAATGTCAATGTGCAGGTTGATTACCGTGGTTTCGACATTCCCAACGAATTTGTTGTGGGATATGGACTGGACTAT
GCTGAACGCTACCGCAATTTGCCCTATATTGGGGTGTTAAGCCCACGTGTTTATACACATTAA

Upstream 100 bases:

>100_bases
GGGATACTTTGGATTCCTGGCTTGCTGATGGCCGAACATGCCCACCCAACGCCAGAAACAACCAACTTTTTGCTCATAAC
TTTGGAGGATACTCACGCCG

Downstream 100 bases:

>100_bases
CATATTGCTAATGGGCATTTCCCTTGCTAGGTAGGTAGCGCTTTGGTATAATTTTTGAAGGTCGCTGTACTCCGCATGGA
GTGCAGCAAAATTTTATGAG

Product: hypoxanthine phosphoribosyltransferase

Products: NA

Alternate protein names: HGPRT; HGPRTase [H]

Number of amino acids: Translated: 180; Mature: 180

Protein sequence:

>180_residues
MHPDLERVLIDTATLQNRVQALGTAIAQATVNAPELVLVGILKGSLIFMADLMRSIGREVCYDCIAVSSYGASTESSGVV
RLNKDLDLDITGKHVIIVEDIIDSGLTLKYVHDLLLRRNPAALEICALLNKPERRNVNVQVDYRGFDIPNEFVVGYGLDY
AERYRNLPYIGVLSPRVYTH

Sequences:

>Translated_180_residues
MHPDLERVLIDTATLQNRVQALGTAIAQATVNAPELVLVGILKGSLIFMADLMRSIGREVCYDCIAVSSYGASTESSGVV
RLNKDLDLDITGKHVIIVEDIIDSGLTLKYVHDLLLRRNPAALEICALLNKPERRNVNVQVDYRGFDIPNEFVVGYGLDY
AERYRNLPYIGVLSPRVYTH
>Mature_180_residues
MHPDLERVLIDTATLQNRVQALGTAIAQATVNAPELVLVGILKGSLIFMADLMRSIGREVCYDCIAVSSYGASTESSGVV
RLNKDLDLDITGKHVIIVEDIIDSGLTLKYVHDLLLRRNPAALEICALLNKPERRNVNVQVDYRGFDIPNEFVVGYGLDY
AERYRNLPYIGVLSPRVYTH

Specific function: This Enzyme Acts Exclusively On Hypoxanthine; It Does Not Act On Guanine (By Similarity). [C]

COG id: COG0634

COG function: function code F; Hypoxanthine-guanine phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4504483, Length=183, Percent_Identity=36.6120218579235, Blast_Score=101, Evalue=3e-22,
Organism=Homo sapiens, GI9910262, Length=183, Percent_Identity=33.3333333333333, Blast_Score=88, Evalue=4e-18,
Organism=Escherichia coli, GI87081689, Length=165, Percent_Identity=51.5151515151515, Blast_Score=166, Evalue=7e-43,
Organism=Caenorhabditis elegans, GI17510817, Length=180, Percent_Identity=35, Blast_Score=89, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005904
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.8 [H]

Molecular weight: Translated: 20000; Mature: 20000

Theoretical pI: Translated: 5.64; Mature: 5.64

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHPDLERVLIDTATLQNRVQALGTAIAQATVNAPELVLVGILKGSLIFMADLMRSIGREV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHCHHHHHHHHHHHHHHHH
CYDCIAVSSYGASTESSGVVRLNKDLDLDITGKHVIIVEDIIDSGLTLKYVHDLLLRRNP
HHHHHHHHCCCCCCCCCCEEEECCCCCEEECCCEEEEEEHHHCCCCHHHHHHHHHHCCCC
AALEICALLNKPERRNVNVQVDYRGFDIPNEFVVGYGLDYAERYRNLPYIGVLSPRVYTH
HHHHHHHHHCCCCCCCCEEEEEEECCCCCCCEEEECCCCHHHHHCCCCEEEEECCCEECC
>Mature Secondary Structure
MHPDLERVLIDTATLQNRVQALGTAIAQATVNAPELVLVGILKGSLIFMADLMRSIGREV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHCHHHHHHHHHHHHHHHH
CYDCIAVSSYGASTESSGVVRLNKDLDLDITGKHVIIVEDIIDSGLTLKYVHDLLLRRNP
HHHHHHHHCCCCCCCCCCEEEECCCCCEEECCCEEEEEEHHHCCCCHHHHHHHHHHCCCC
AALEICALLNKPERRNVNVQVDYRGFDIPNEFVVGYGLDYAERYRNLPYIGVLSPRVYTH
HHHHHHHHHCCCCCCCCEEEEEEECCCCCCCEEEECCCCHHHHHCCCCEEEEECCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12663927 [H]