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The map label for this gene is zwf [H]

Identifier: 159899540

GI number: 159899540

Start: 3816262

End: 3817788

Strand: Direct

Name: zwf [H]

Synonym: Haur_3021

Alternate gene names: 159899540

Gene position: 3816262-3817788 (Clockwise)

Preceding gene: 159899539

Following gene: 159899541

Centisome position: 60.13

GC content: 51.67

Gene sequence:

>1527_bases
GTGGAACAGCCAAATCCTTTGCGAGCAGGTTTACGAATTGCTCGCACCCCTGAAGCATGTACTGTGGTGATTTTCGGCGC
GACCGGAGATCTCACTGCCCGTAAATTATTGCCTGCACTCTACAACCTCGCCCGTGAAGGCATGGTTCCAGCAGGCTTTT
CGTTGCTTGGTGTTGGCCGTCGCCCATGGAGCGACGATGATTTTCGCGCTGAAATGCGCAAAAGTGCCGAGCAATTCTCA
CGCGTCCAGCCAATTAATGAAGAAGTTTGGCAAACCTTTGCTGAAGGTTTGTTCTGGGTTGGCGGCGAGTTTGGCGATAT
CAACACCTACGAGCAAATCGCCAGTCGCCTCGAACAAATCGATCAGCAACGGGGCACTGCTGGCAATCGGCTCTTTTATT
TGGCGATTCCACCATCGTGGTTTGATGATGCGATTAGCAATTTGCAAAAGGTCAATCTGACCAACCAAAGCCATGGCTGG
TCGCGAATTATCGTTGAAAAGCCGTTTGGTCACGATTACAAATCGGCCCAAGAACTCAACGATCTGGTCAGTCGCGCTTT
TGATGAAAGCCAAGTCTATCGAATTGACCATTATCTTGGCAAAGAAACCGTCCAAAACCTGTTGGTGGCGCGGTTTGCCA
ACGCCATTTTCGAGCCAATTTGGAACCGCAACTACATTGACCATGTGCAAATCACGGTCGCCGAAAGCCTTGGCATCGGC
AGTCGCGCAGGGTTTTATGAGGAAGCTGGGGCATTGCGCGATATGATCACCAATCATATGATGCAATTGCTGACCCTGAC
CGCCATGGAACCACCAGTTGAGTTTAACGAGCATGAAGTGCGCAGCGAAAAAGTCAAAGTGCTACATGCAATTCGCCCGA
TGAATGCTACTGATGTTGATCAATTTGCGCTGCGTGCTCAATATGATCATGGTACAATCAATGGCGATGAAGTGCCCAGT
TACTTGGCAGAGAAAGGGGTCAATCCAGCCTCACGCACACCCACATTCGTTGCACTCAAATTCGAGATCGACAATTGGCG
CTGGGCGGGCGTACCATTCTACTTGCGCACTGGCAAACGGCTGGCTAAACGGGTCACCGAAATTGCGATTCAATTCAAAA
AACCGCCGCTGCTGCTCTTCCCCGAAATCCGCGATGACATTGAATCGAACGTCTTAGCGCTGCGCATTCAGCCCAACGAA
GGCATCACCCTCAAATTTAGCGCCAAACAACCAGGCCAACGCATGATCATCCATCCGGTTAATATGGATTTTCGCTATGG
CTCATCGTTTGGGGTAGCTGCGCCCGAAGCTTACGAACGCTTGTTGCTCGATGCCATGCTCGGCGACGCAACCCTGTTTA
CCCGCCGCGATGAGGTCGAAGCCCAATGGGCCTTGATGACTCCCATCCTTGAGCGCTGGGAAAACGACGGCGTTGAGCAC
TTGCCACACTACGAGGCAGGCACGTGGGGGCCAGAGGAATCTGATCAATTTATGCAACGTGATGGCCGTGAGTGGCGCAA
ATTGTAG

Upstream 100 bases:

>100_bases
CCTCTGATCATTTAGTAAAACAGTGCTATGCTATAAGGCGCAACGGGGCTACACGGAAGGATGTAGCCCTGTCATTATGC
GTGGTTCCTAAGGAGGGCTT

Downstream 100 bases:

>100_bases
GAGGTGGCAACCATGATGGGCGAAATTTCCAATAGCCCACGTCCAGCCAATGTTGCTGAGATTGAAGATCAACTGCGCGA
TTTGTGGCGTGAATTGGGCG

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 508; Mature: 508

Protein sequence:

>508_residues
MEQPNPLRAGLRIARTPEACTVVIFGATGDLTARKLLPALYNLAREGMVPAGFSLLGVGRRPWSDDDFRAEMRKSAEQFS
RVQPINEEVWQTFAEGLFWVGGEFGDINTYEQIASRLEQIDQQRGTAGNRLFYLAIPPSWFDDAISNLQKVNLTNQSHGW
SRIIVEKPFGHDYKSAQELNDLVSRAFDESQVYRIDHYLGKETVQNLLVARFANAIFEPIWNRNYIDHVQITVAESLGIG
SRAGFYEEAGALRDMITNHMMQLLTLTAMEPPVEFNEHEVRSEKVKVLHAIRPMNATDVDQFALRAQYDHGTINGDEVPS
YLAEKGVNPASRTPTFVALKFEIDNWRWAGVPFYLRTGKRLAKRVTEIAIQFKKPPLLLFPEIRDDIESNVLALRIQPNE
GITLKFSAKQPGQRMIIHPVNMDFRYGSSFGVAAPEAYERLLLDAMLGDATLFTRRDEVEAQWALMTPILERWENDGVEH
LPHYEAGTWGPEESDQFMQRDGREWRKL

Sequences:

>Translated_508_residues
MEQPNPLRAGLRIARTPEACTVVIFGATGDLTARKLLPALYNLAREGMVPAGFSLLGVGRRPWSDDDFRAEMRKSAEQFS
RVQPINEEVWQTFAEGLFWVGGEFGDINTYEQIASRLEQIDQQRGTAGNRLFYLAIPPSWFDDAISNLQKVNLTNQSHGW
SRIIVEKPFGHDYKSAQELNDLVSRAFDESQVYRIDHYLGKETVQNLLVARFANAIFEPIWNRNYIDHVQITVAESLGIG
SRAGFYEEAGALRDMITNHMMQLLTLTAMEPPVEFNEHEVRSEKVKVLHAIRPMNATDVDQFALRAQYDHGTINGDEVPS
YLAEKGVNPASRTPTFVALKFEIDNWRWAGVPFYLRTGKRLAKRVTEIAIQFKKPPLLLFPEIRDDIESNVLALRIQPNE
GITLKFSAKQPGQRMIIHPVNMDFRYGSSFGVAAPEAYERLLLDAMLGDATLFTRRDEVEAQWALMTPILERWENDGVEH
LPHYEAGTWGPEESDQFMQRDGREWRKL
>Mature_508_residues
MEQPNPLRAGLRIARTPEACTVVIFGATGDLTARKLLPALYNLAREGMVPAGFSLLGVGRRPWSDDDFRAEMRKSAEQFS
RVQPINEEVWQTFAEGLFWVGGEFGDINTYEQIASRLEQIDQQRGTAGNRLFYLAIPPSWFDDAISNLQKVNLTNQSHGW
SRIIVEKPFGHDYKSAQELNDLVSRAFDESQVYRIDHYLGKETVQNLLVARFANAIFEPIWNRNYIDHVQITVAESLGIG
SRAGFYEEAGALRDMITNHMMQLLTLTAMEPPVEFNEHEVRSEKVKVLHAIRPMNATDVDQFALRAQYDHGTINGDEVPS
YLAEKGVNPASRTPTFVALKFEIDNWRWAGVPFYLRTGKRLAKRVTEIAIQFKKPPLLLFPEIRDDIESNVLALRIQPNE
GITLKFSAKQPGQRMIIHPVNMDFRYGSSFGVAAPEAYERLLLDAMLGDATLFTRRDEVEAQWALMTPILERWENDGVEH
LPHYEAGTWGPEESDQFMQRDGREWRKL

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI109389365, Length=485, Percent_Identity=37.9381443298969, Blast_Score=334, Evalue=1e-91,
Organism=Homo sapiens, GI108773793, Length=484, Percent_Identity=37.8099173553719, Blast_Score=334, Evalue=1e-91,
Organism=Homo sapiens, GI52145310, Length=480, Percent_Identity=29.7916666666667, Blast_Score=174, Evalue=1e-43,
Organism=Escherichia coli, GI1788158, Length=501, Percent_Identity=42.315369261477, Blast_Score=410, Evalue=1e-116,
Organism=Caenorhabditis elegans, GI17538218, Length=484, Percent_Identity=38.0165289256198, Blast_Score=354, Evalue=8e-98,
Organism=Saccharomyces cerevisiae, GI6324088, Length=495, Percent_Identity=35.959595959596, Blast_Score=309, Evalue=6e-85,
Organism=Drosophila melanogaster, GI24643350, Length=480, Percent_Identity=36.6666666666667, Blast_Score=317, Evalue=2e-86,
Organism=Drosophila melanogaster, GI24643352, Length=480, Percent_Identity=36.6666666666667, Blast_Score=316, Evalue=2e-86,
Organism=Drosophila melanogaster, GI221513548, Length=477, Percent_Identity=31.4465408805031, Blast_Score=239, Evalue=3e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 57957; Mature: 57957

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: PS00069 G6P_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEQPNPLRAGLRIARTPEACTVVIFGATGDLTARKLLPALYNLAREGMVPAGFSLLGVGR
CCCCCCHHHCCEEECCCCEEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEECCC
RPWSDDDFRAEMRKSAEQFSRVQPINEEVWQTFAEGLFWVGGEFGDINTYEQIASRLEQI
CCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCEEECCCCCCCCHHHHHHHHHHHH
DQQRGTAGNRLFYLAIPPSWFDDAISNLQKVNLTNQSHGWSRIIVEKPFGHDYKSAQELN
HHHCCCCCCEEEEEEECCCHHHHHHHHHEEECCCCCCCCCEEEEEECCCCCCHHHHHHHH
DLVSRAFDESQVYRIDHYLGKETVQNLLVARFANAIFEPIWNRNYIDHVQITVAESLGIG
HHHHHHCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEHHCCCC
SRAGFYEEAGALRDMITNHMMQLLTLTAMEPPVEFNEHEVRSEKVKVLHAIRPMNATDVD
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHH
QFALRAQYDHGTINGDEVPSYLAEKGVNPASRTPTFVALKFEIDNWRWAGVPFYLRTGKR
HHHHHEECCCCCCCHHHHHHHHHHCCCCCCCCCCEEEEEEEEECCEEECCCCCEEHHHHH
LAKRVTEIAIQFKKPPLLLFPEIRDDIESNVLALRIQPNEGITLKFSAKQPGQRMIIHPV
HHHHHHHHHHHCCCCCEEECCHHHHHHCCCEEEEEEECCCCEEEEECCCCCCCEEEEEEC
NMDFRYGSSFGVAAPEAYERLLLDAMLGDATLFTRRDEVEAQWALMTPILERWENDGVEH
CCCEEECCCCCCCCHHHHHHHHHHHHHCCHHEEECCCHHHHHHHHHHHHHHHHCCCCCCC
LPHYEAGTWGPEESDQFMQRDGREWRKL
CCCCCCCCCCCCCHHHHHHHCCHHHHCC
>Mature Secondary Structure
MEQPNPLRAGLRIARTPEACTVVIFGATGDLTARKLLPALYNLAREGMVPAGFSLLGVGR
CCCCCCHHHCCEEECCCCEEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEECCC
RPWSDDDFRAEMRKSAEQFSRVQPINEEVWQTFAEGLFWVGGEFGDINTYEQIASRLEQI
CCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCEEECCCCCCCCHHHHHHHHHHHH
DQQRGTAGNRLFYLAIPPSWFDDAISNLQKVNLTNQSHGWSRIIVEKPFGHDYKSAQELN
HHHCCCCCCEEEEEEECCCHHHHHHHHHEEECCCCCCCCCEEEEEECCCCCCHHHHHHHH
DLVSRAFDESQVYRIDHYLGKETVQNLLVARFANAIFEPIWNRNYIDHVQITVAESLGIG
HHHHHHCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEHHCCCC
SRAGFYEEAGALRDMITNHMMQLLTLTAMEPPVEFNEHEVRSEKVKVLHAIRPMNATDVD
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHH
QFALRAQYDHGTINGDEVPSYLAEKGVNPASRTPTFVALKFEIDNWRWAGVPFYLRTGKR
HHHHHEECCCCCCCHHHHHHHHHHCCCCCCCCCCEEEEEEEEECCEEECCCCCEEHHHHH
LAKRVTEIAIQFKKPPLLLFPEIRDDIESNVLALRIQPNEGITLKFSAKQPGQRMIIHPV
HHHHHHHHHHHCCCCCEEECCHHHHHHCCCEEEEEEECCCCEEEEECCCCCCCEEEEEEC
NMDFRYGSSFGVAAPEAYERLLLDAMLGDATLFTRRDEVEAQWALMTPILERWENDGVEH
CCCEEECCCCCCCCHHHHHHHHHHHHHCCHHEEECCCHHHHHHHHHHHHHHHHCCCCCCC
LPHYEAGTWGPEESDQFMQRDGREWRKL
CCCCCCCCCCCCCHHHHHHHCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]