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The map label for this gene is lon2

Identifier: 159899515

GI number: 159899515

Start: 3783092

End: 3785539

Strand: Direct

Name: lon2

Synonym: Haur_2996

Alternate gene names: 159899515

Gene position: 3783092-3785539 (Clockwise)

Preceding gene: 159899511

Following gene: 159899516

Centisome position: 59.61

GC content: 52.17

Gene sequence:

>2448_bases
ATGGCAGATGATCGACAGTTGGTGGATGAAATTTCGGCAGCAACCACGCTGGAATTGCCAGTGCTTCCACTCATCAATAC
CGTGCTTTTCCCAACAATGGTCACCCCACTTTTTGTAGCCCGCGAGCTATCAATGGCTGCGATCGAGGCGGCGATGAGCG
CCGATCGGCAAATTGTCGCGGTAGCGCAACGCGCAATTGAAATCGAGGAGCACGATACCAGCCAACTGTATCAGGTCGGG
GTGATTGCCCATATTGAGCGGGTGCTCAAACTGCCCGATGGCACAACCTCGGTCTTGGTGCAAGGCCAACAGCGGGTGCA
AATTGTCGATTGGCTGGCAACTGAACCCTACATTAATGCGCAAGTGCAAATCATCGAGCCAGATCATGAATCGAGTTTGG
CGATTGAGGCCATGATGCGCGGCGTATTGGCTTCCTACGAAAAAGTGGTCAAACTAAGCCGCACTATGCCCGATGATGCC
TATGTTGCGGCGCTCAACCTTGAAGATGCGAGCGCCTTGGCCGACTTAATTGCCTCGACCTTGCCGCTTGATATCGTGCG
TCGCCAACAATTGCTCGAACTTTTTGAGGTCGAGGAGCGCTTGCGGCGGCTGAGTGTGGTGCTCTCACAAGAGATTGATG
TGCTTGAATTAGAGCATCATATTCAAAATCAGGTGCAAAAAGAGGTCGATAAGTCGCAACGTGATTTCTTCCTGCGCGAA
CAACTCAAGGCCATCCAAACCGAGCTGGGTCAAGAAGATCCATTGACCCGCGAATTGAATGAACTGCATGATCGGATTGT
TGCGGCCAATTTGCCTGCCAAAGCCCAAGCCAAAGCCTTAGAAGAACTTGGCCGCTTGGAGATGATGCCGCCAGCCGCAC
CCGAATATAGCGTTATTCGGACGTATTTGGATTGGTTGCTAGAACTGCCTTGGTCAAAAACCAGCGCCGATGTTGCTGAT
CTTGAAGTGGCGGCCAAGGTGCTCGAAAACAACCACTATGGCTTGAAAAAAGTCAAAGAACGGATTTTAGAATTTATCGC
CGTGCGCATGCTGGCTGGTGATAGTACCAAATCGCCAATTTTATGTTTTGTTGGCCCGCCAGGTGTCGGCAAAACTAGCC
TTGGCCGTTCGGTCGCCGAGGCGTTAGGCCGCGAGTTTGTGCGGCTTTCGCTTGGTGGCGTGCACGATGAGGCTGAAATT
CGTGGCCATCGCCGCACCTATATTGGAGCCATGCCAGGCCGCATCATCCAAACCATGAAAGATGCAGGCACGATCAACCC
AGTTTTTATGCTTGATGAGATCGATAAGCTGGGCAATGATTTCCGCGGCGATCCAGCGGCGGCCTTGCTTGAGGTGCTTG
ATCCTGAGCAAAATAATACCTTTGCCGATCACTACCTTGATCTGCCGTATGATCTTTCGAAGATTATGTTTATTACCACC
GCCAACATGCTTGACCCAATCGACGAGCCATTGCTTGATCGGATGGAGATTGTTGAGCTACCAGGCTATATCGAAGAAGA
AAAAGTGCAAATTGCCCGTAAATTCTTGATTCCCAAGCAAATCGAAGCTAACGGTTTAAAGCAACATCCAATTACGATCA
GCGATGAAGCCTTGCGCCAAATCATTCGCACCTACACCTGGGAAGCGGGCGTGCGCAACCTTGAGCGCGAAATTGGCGGT
ATTTGTCGCAAAATTGCTCGCCGTGTTGCCGAGAAAAAGCGCTATCCACGCCGAATCACGCCAACCATGCTCACCGATTT
CCTTGGTCAGCCGCCGTTTGACTACAGCCGCGCCAATGATCGTGATGAAATTGGGGTAGCGACAGGCATGGTTTGGTCGA
GCAACGGCGGCGATGTGGTCGCAATCGAAACCGCGATTGTTGATGGCAAAGGCACAACGACCCTCACTGGCCAACTTGGC
GATGTGATGCAAGAATCGGCCCAAGCAGCGCTTTCGTATGCCCGAGCTTCATCGCGCCGTTTAGGCATCGATGGCAAACG
CTTCGAAAAAATCGATATTCATATTCACGTACCCGAAGGCGGTGTGCCCAAAGACGGGCCATCGGCAGGGATTACCTTAG
CCTGTTCGGTGATTTCAGCCTTAACTCATCGGCCATTGCGTCGCGATGTGGCCATGACTGGCGAAATTACCCTACGCGGG
CGGGTGCTGCCAATCGGCGGGTTACGTGACAAAATTTTAGGGGCATATCGCGCAGGCATCACCACCATGCTGATTCCCAA
AAAGAATTTGCGTGATTTGGAAGAAGTGCCCAACAATGTGCGCCGCCAAATAACCGTGGTTGCGGTTGAACATATGGATG
AGGTCTTGCCAATTGCCTTTGTCTCGAACCCGCTTGAGCGCGGTAGCCAACACACCAGCGACGGCGATCAAACCAGCGTG
GTACTACCGACGATCACCCAACCGCAGCTTGGATCAGTCGAATTGTGA

Upstream 100 bases:

>100_bases
AGACCGACCCGCAACCGTTCATCGCAAGAAGGCTGTGCTATAATGCCCCGTATGTTTCAACGAGCAACCCAAGCCAGAAT
TGCGATAAAAGGTGTAACCC

Downstream 100 bases:

>100_bases
TTTATTGCGCAAGTTGGTAAGCTCGGAAGTAAACTCACCCTCGTAAGCTAGGATTAAAGTCATCCATTCAAGTAGCACAA
TCGCGTACTCTTGGCATGAT

Product: ATP-dependent protease La

Products: NA

Alternate protein names: ATP-dependent protease La 2

Number of amino acids: Translated: 815; Mature: 814

Protein sequence:

>815_residues
MADDRQLVDEISAATTLELPVLPLINTVLFPTMVTPLFVARELSMAAIEAAMSADRQIVAVAQRAIEIEEHDTSQLYQVG
VIAHIERVLKLPDGTTSVLVQGQQRVQIVDWLATEPYINAQVQIIEPDHESSLAIEAMMRGVLASYEKVVKLSRTMPDDA
YVAALNLEDASALADLIASTLPLDIVRRQQLLELFEVEERLRRLSVVLSQEIDVLELEHHIQNQVQKEVDKSQRDFFLRE
QLKAIQTELGQEDPLTRELNELHDRIVAANLPAKAQAKALEELGRLEMMPPAAPEYSVIRTYLDWLLELPWSKTSADVAD
LEVAAKVLENNHYGLKKVKERILEFIAVRMLAGDSTKSPILCFVGPPGVGKTSLGRSVAEALGREFVRLSLGGVHDEAEI
RGHRRTYIGAMPGRIIQTMKDAGTINPVFMLDEIDKLGNDFRGDPAAALLEVLDPEQNNTFADHYLDLPYDLSKIMFITT
ANMLDPIDEPLLDRMEIVELPGYIEEEKVQIARKFLIPKQIEANGLKQHPITISDEALRQIIRTYTWEAGVRNLEREIGG
ICRKIARRVAEKKRYPRRITPTMLTDFLGQPPFDYSRANDRDEIGVATGMVWSSNGGDVVAIETAIVDGKGTTTLTGQLG
DVMQESAQAALSYARASSRRLGIDGKRFEKIDIHIHVPEGGVPKDGPSAGITLACSVISALTHRPLRRDVAMTGEITLRG
RVLPIGGLRDKILGAYRAGITTMLIPKKNLRDLEEVPNNVRRQITVVAVEHMDEVLPIAFVSNPLERGSQHTSDGDQTSV
VLPTITQPQLGSVEL

Sequences:

>Translated_815_residues
MADDRQLVDEISAATTLELPVLPLINTVLFPTMVTPLFVARELSMAAIEAAMSADRQIVAVAQRAIEIEEHDTSQLYQVG
VIAHIERVLKLPDGTTSVLVQGQQRVQIVDWLATEPYINAQVQIIEPDHESSLAIEAMMRGVLASYEKVVKLSRTMPDDA
YVAALNLEDASALADLIASTLPLDIVRRQQLLELFEVEERLRRLSVVLSQEIDVLELEHHIQNQVQKEVDKSQRDFFLRE
QLKAIQTELGQEDPLTRELNELHDRIVAANLPAKAQAKALEELGRLEMMPPAAPEYSVIRTYLDWLLELPWSKTSADVAD
LEVAAKVLENNHYGLKKVKERILEFIAVRMLAGDSTKSPILCFVGPPGVGKTSLGRSVAEALGREFVRLSLGGVHDEAEI
RGHRRTYIGAMPGRIIQTMKDAGTINPVFMLDEIDKLGNDFRGDPAAALLEVLDPEQNNTFADHYLDLPYDLSKIMFITT
ANMLDPIDEPLLDRMEIVELPGYIEEEKVQIARKFLIPKQIEANGLKQHPITISDEALRQIIRTYTWEAGVRNLEREIGG
ICRKIARRVAEKKRYPRRITPTMLTDFLGQPPFDYSRANDRDEIGVATGMVWSSNGGDVVAIETAIVDGKGTTTLTGQLG
DVMQESAQAALSYARASSRRLGIDGKRFEKIDIHIHVPEGGVPKDGPSAGITLACSVISALTHRPLRRDVAMTGEITLRG
RVLPIGGLRDKILGAYRAGITTMLIPKKNLRDLEEVPNNVRRQITVVAVEHMDEVLPIAFVSNPLERGSQHTSDGDQTSV
VLPTITQPQLGSVEL
>Mature_814_residues
ADDRQLVDEISAATTLELPVLPLINTVLFPTMVTPLFVARELSMAAIEAAMSADRQIVAVAQRAIEIEEHDTSQLYQVGV
IAHIERVLKLPDGTTSVLVQGQQRVQIVDWLATEPYINAQVQIIEPDHESSLAIEAMMRGVLASYEKVVKLSRTMPDDAY
VAALNLEDASALADLIASTLPLDIVRRQQLLELFEVEERLRRLSVVLSQEIDVLELEHHIQNQVQKEVDKSQRDFFLREQ
LKAIQTELGQEDPLTRELNELHDRIVAANLPAKAQAKALEELGRLEMMPPAAPEYSVIRTYLDWLLELPWSKTSADVADL
EVAAKVLENNHYGLKKVKERILEFIAVRMLAGDSTKSPILCFVGPPGVGKTSLGRSVAEALGREFVRLSLGGVHDEAEIR
GHRRTYIGAMPGRIIQTMKDAGTINPVFMLDEIDKLGNDFRGDPAAALLEVLDPEQNNTFADHYLDLPYDLSKIMFITTA
NMLDPIDEPLLDRMEIVELPGYIEEEKVQIARKFLIPKQIEANGLKQHPITISDEALRQIIRTYTWEAGVRNLEREIGGI
CRKIARRVAEKKRYPRRITPTMLTDFLGQPPFDYSRANDRDEIGVATGMVWSSNGGDVVAIETAIVDGKGTTTLTGQLGD
VMQESAQAALSYARASSRRLGIDGKRFEKIDIHIHVPEGGVPKDGPSAGITLACSVISALTHRPLRRDVAMTGEITLRGR
VLPIGGLRDKILGAYRAGITTMLIPKKNLRDLEEVPNNVRRQITVVAVEHMDEVLPIAFVSNPLERGSQHTSDGDQTSVV
LPTITQPQLGSVEL

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain

Homologues:

Organism=Homo sapiens, GI31377667, Length=843, Percent_Identity=39.3831553973903, Blast_Score=553, Evalue=1e-157,
Organism=Homo sapiens, GI21396489, Length=618, Percent_Identity=41.9093851132686, Blast_Score=518, Evalue=1e-146,
Organism=Escherichia coli, GI1786643, Length=769, Percent_Identity=49.5448634590377, Blast_Score=766, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=653, Percent_Identity=41.6539050535988, Blast_Score=500, Evalue=1e-141,
Organism=Caenorhabditis elegans, GI17556486, Length=797, Percent_Identity=34.504391468005, Blast_Score=454, Evalue=1e-128,
Organism=Saccharomyces cerevisiae, GI6319449, Length=723, Percent_Identity=37.6210235131397, Blast_Score=481, Evalue=1e-136,
Organism=Drosophila melanogaster, GI221513036, Length=624, Percent_Identity=43.9102564102564, Blast_Score=524, Evalue=1e-148,
Organism=Drosophila melanogaster, GI24666867, Length=625, Percent_Identity=43.84, Blast_Score=523, Evalue=1e-148,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): LON2_HERA2 (A9B3R2)

Other databases:

- EMBL:   CP000875
- RefSeq:   YP_001545762.1
- ProteinModelPortal:   A9B3R2
- GeneID:   5734868
- GenomeReviews:   CP000875_GR
- KEGG:   hau:Haur_2996
- HOGENOM:   HBG566281
- OMA:   PEIHLHF
- ProtClustDB:   CLSK973665
- BioCyc:   HAUR316274:HAUR_2996-MONOMER
- GO:   GO:0005737
- GO:   GO:0006508
- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568
- PRINTS:   PR00830
- SMART:   SM00382
- SMART:   SM00464
- TIGRFAMs:   TIGR00763

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C; SSF88697 PUA-like; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =3.4.21.53

Molecular weight: Translated: 90407; Mature: 90276

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: PS01046 LON_SER

Important sites: ACT_SITE 688-688 ACT_SITE 731-731

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADDRQLVDEISAATTLELPVLPLINTVLFPTMVTPLFVARELSMAAIEAAMSADRQIVA
CCCHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
VAQRAIEIEEHDTSQLYQVGVIAHIERVLKLPDGTTSVLVQGQQRVQIVDWLATEPYINA
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHEECCCHHHHHHHHHHCCCCCCC
QVQIIEPDHESSLAIEAMMRGVLASYEKVVKLSRTMPDDAYVAALNLEDASALADLIAST
EEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHH
LPLDIVRRQQLLELFEVEERLRRLSVVLSQEIDVLELEHHIQNQVQKEVDKSQRDFFLRE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
QLKAIQTELGQEDPLTRELNELHDRIVAANLPAKAQAKALEELGRLEMMPPAAPEYSVIR
HHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCEECCCCCCCCHHHHH
TYLDWLLELPWSKTSADVADLEVAAKVLENNHYGLKKVKERILEFIAVRMLAGDSTKSPI
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCE
LCFVGPPGVGKTSLGRSVAEALGREFVRLSLGGVHDEAEIRGHRRTYIGAMPGRIIQTMK
EEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCEEECCCCHHHHHHHH
DAGTINPVFMLDEIDKLGNDFRGDPAAALLEVLDPEQNNTFADHYLDLPYDLSKIMFITT
HCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCHHHHHCCCCCCHHHHHHHHH
ANMLDPIDEPLLDRMEIVELPGYIEEEKVQIARKFLIPKQIEANGLKQHPITISDEALRQ
HHHHCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCEEECHHHHHH
IIRTYTWEAGVRNLEREIGGICRKIARRVAEKKRYPRRITPTMLTDFLGQPPFDYSRAND
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCCCC
RDEIGVATGMVWSSNGGDVVAIETAIVDGKGTTTLTGQLGDVMQESAQAALSYARASSRR
CCHHHHEECEEEECCCCCEEEEEEEEECCCCCEEECCHHHHHHHHHHHHHHHHHHHCCCC
LGIDGKRFEKIDIHIHVPEGGVPKDGPSAGITLACSVISALTHRPLRRDVAMTGEITLRG
CCCCCCCEEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHEEECEEEEEE
RVLPIGGLRDKILGAYRAGITTMLIPKKNLRDLEEVPNNVRRQITVVAVEHMDEVLPIAF
EEEECCCHHHHHHHHHHHCCEEEEECCHHHHHHHHHHHHHHHHHHEEEHHHHHHHHHHHH
VSNPLERGSQHTSDGDQTSVVLPTITQPQLGSVEL
HCCHHHCCCCCCCCCCCCEEEEECCCCCCCCCCCC
>Mature Secondary Structure 
ADDRQLVDEISAATTLELPVLPLINTVLFPTMVTPLFVARELSMAAIEAAMSADRQIVA
CCHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
VAQRAIEIEEHDTSQLYQVGVIAHIERVLKLPDGTTSVLVQGQQRVQIVDWLATEPYINA
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHEECCCHHHHHHHHHHCCCCCCC
QVQIIEPDHESSLAIEAMMRGVLASYEKVVKLSRTMPDDAYVAALNLEDASALADLIAST
EEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHH
LPLDIVRRQQLLELFEVEERLRRLSVVLSQEIDVLELEHHIQNQVQKEVDKSQRDFFLRE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
QLKAIQTELGQEDPLTRELNELHDRIVAANLPAKAQAKALEELGRLEMMPPAAPEYSVIR
HHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCEECCCCCCCCHHHHH
TYLDWLLELPWSKTSADVADLEVAAKVLENNHYGLKKVKERILEFIAVRMLAGDSTKSPI
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCE
LCFVGPPGVGKTSLGRSVAEALGREFVRLSLGGVHDEAEIRGHRRTYIGAMPGRIIQTMK
EEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCEEECCCCHHHHHHHH
DAGTINPVFMLDEIDKLGNDFRGDPAAALLEVLDPEQNNTFADHYLDLPYDLSKIMFITT
HCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCHHHHHCCCCCCHHHHHHHHH
ANMLDPIDEPLLDRMEIVELPGYIEEEKVQIARKFLIPKQIEANGLKQHPITISDEALRQ
HHHHCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCEEECHHHHHH
IIRTYTWEAGVRNLEREIGGICRKIARRVAEKKRYPRRITPTMLTDFLGQPPFDYSRAND
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCCCC
RDEIGVATGMVWSSNGGDVVAIETAIVDGKGTTTLTGQLGDVMQESAQAALSYARASSRR
CCHHHHEECEEEECCCCCEEEEEEEEECCCCCEEECCHHHHHHHHHHHHHHHHHHHCCCC
LGIDGKRFEKIDIHIHVPEGGVPKDGPSAGITLACSVISALTHRPLRRDVAMTGEITLRG
CCCCCCCEEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHEEECEEEEEE
RVLPIGGLRDKILGAYRAGITTMLIPKKNLRDLEEVPNNVRRQITVVAVEHMDEVLPIAF
EEEECCCHHHHHHHHHHHCCEEEEECCHHHHHHHHHHHHHHHHHHEEEHHHHHHHHHHHH
VSNPLERGSQHTSDGDQTSVVLPTITQPQLGSVEL
HCCHHHCCCCCCCCCCCCEEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA