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The map label for this gene is queD [H]

Identifier: 159899359

GI number: 159899359

Start: 3606420

End: 3606917

Strand: Direct

Name: queD [H]

Synonym: Haur_2840

Alternate gene names: 159899359

Gene position: 3606420-3606917 (Clockwise)

Preceding gene: 159899358

Following gene: 159899360

Centisome position: 56.82

GC content: 48.19

Gene sequence:

>498_bases
ATGAGCCAACGTATTTACCGCTTGCAAGTAACTAAGGATCAGCTTGGTTTTGCGGCGGCGCATTTTATTACCATGCGCGG
CAAATGTGAGCGGCTGCATGGCCATAATTATCGCGTAACGGTCGAAGTAGAAGGCTTTTTATGCGAAGATCAATATGTGG
TAGATTTTGGGGTGTTGAAAAAACACGCCGCCGAAATTGCCCGCACGCTTGATCATCGGGTCTTGTTGGCCGCCGAGAAT
CCTAAAATCGAGTATAGCCAAAACGAGCAGCATTTAACAGTACGCTACGAAGATAAATATTATGTCTTCCCAATCGCCGA
AGTGATTATGCTGCCAATTCAAAATACCACGGCTGAATTGTTGGCAACCTATTTTTGTGCCGAATTGTGCGAACGCCTGC
GCCAAGATGGTGTTGATACGCTCAAAATGGTCGGGGTTTGGGTTTCCGAAGGCCCAGGCCAGCAAGCCTTCGCCAGCCGC
GAATGGGTACAAAGCTAA

Upstream 100 bases:

>100_bases
GCTGTGGCTCGCGTGAAAATCTAGTCACGCCCTGTCATACAGGCGTGCCTTTTCGGTTGTGCCAACATTGTTACACCTGC
CACATTGAGGAGTCTCTGGC

Downstream 100 bases:

>100_bases
TGCTGAGGGATACGTTATGGATGGAATGAGCGCTTTGGTGGTGATTATCGGGGCAGTTGGCTTAATTACCCTCTTGATTA
TGCGCACCAAAACCTATCGC

Product: 6-pyruvoyl tetrahydrobiopterin synthase

Products: 6-pyruvoyl-5,6,7,8-tetrahydropterin; triphosphate

Alternate protein names: CPH4 synthase; Archaeosine biosynthesis protein queD [H]

Number of amino acids: Translated: 165; Mature: 164

Protein sequence:

>165_residues
MSQRIYRLQVTKDQLGFAAAHFITMRGKCERLHGHNYRVTVEVEGFLCEDQYVVDFGVLKKHAAEIARTLDHRVLLAAEN
PKIEYSQNEQHLTVRYEDKYYVFPIAEVIMLPIQNTTAELLATYFCAELCERLRQDGVDTLKMVGVWVSEGPGQQAFASR
EWVQS

Sequences:

>Translated_165_residues
MSQRIYRLQVTKDQLGFAAAHFITMRGKCERLHGHNYRVTVEVEGFLCEDQYVVDFGVLKKHAAEIARTLDHRVLLAAEN
PKIEYSQNEQHLTVRYEDKYYVFPIAEVIMLPIQNTTAELLATYFCAELCERLRQDGVDTLKMVGVWVSEGPGQQAFASR
EWVQS
>Mature_164_residues
SQRIYRLQVTKDQLGFAAAHFITMRGKCERLHGHNYRVTVEVEGFLCEDQYVVDFGVLKKHAAEIARTLDHRVLLAAENP
KIEYSQNEQHLTVRYEDKYYVFPIAEVIMLPIQNTTAELLATYFCAELCERLRQDGVDTLKMVGVWVSEGPGQQAFASRE
WVQS

Specific function: Catalyzes the conversion of 7,8-dihydroneopterin triphosphate (H2NTP) to 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) and acetaldehyde [H]

COG id: COG0720

COG function: function code H; 6-pyruvoyl-tetrahydropterin synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTPS family. QueD subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007116
- InterPro:   IPR007115 [H]

Pfam domain/function: PF01242 PTPS [H]

EC number: 4.2.3.12

Molecular weight: Translated: 19028; Mature: 18897

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQRIYRLQVTKDQLGFAAAHFITMRGKCERLHGHNYRVTVEVEGFLCEDQYVVDFGVLK
CCCEEEEEEECHHHHHHHHHHHEEECCCHHHHCCCCEEEEEEEEEEEECCCEEEHHHHHH
KHAAEIARTLDHRVLLAAENPKIEYSQNEQHLTVRYEDKYYVFPIAEVIMLPIQNTTAEL
HHHHHHHHHHCCEEEEEECCCCEEECCCCCEEEEEECCEEEEEEHHHEEEECCCCCHHHH
LATYFCAELCERLRQDGVDTLKMVGVWVSEGPGQQAFASREWVQS
HHHHHHHHHHHHHHHCCCCEEEHEEEEECCCCCCHHHHHHHHHCC
>Mature Secondary Structure 
SQRIYRLQVTKDQLGFAAAHFITMRGKCERLHGHNYRVTVEVEGFLCEDQYVVDFGVLK
CCEEEEEEECHHHHHHHHHHHEEECCCHHHHCCCCEEEEEEEEEEEECCCEEEHHHHHH
KHAAEIARTLDHRVLLAAENPKIEYSQNEQHLTVRYEDKYYVFPIAEVIMLPIQNTTAEL
HHHHHHHHHHCCEEEEEECCCCEEECCCCCEEEEEECCEEEEEEHHHEEEECCCCCHHHH
LATYFCAELCERLRQDGVDTLKMVGVWVSEGPGQQAFASREWVQS
HHHHHHHHHHHHHHHCCCCEEEHEEEEECCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 6-[(1S,2R)-1,2-dihydroxy-3-triphosphooxypropyl]-7,8-dihydropterin

Specific reaction: 6-[(1S,2R)-1,2-dihydroxy-3-triphosphooxypropyl]-7,8-dihydropterin = 6-pyruvoyl-5,6,7,8-tetrahydropterin + triphosphate

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]