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The map label for this gene is hutH [H]

Identifier: 159898407

GI number: 159898407

Start: 2270240

End: 2271898

Strand: Reverse

Name: hutH [H]

Synonym: Haur_1883

Alternate gene names: 159898407

Gene position: 2271898-2270240 (Counterclockwise)

Preceding gene: 159898408

Following gene: 159898395

Centisome position: 35.8

GC content: 48.88

Gene sequence:

>1659_bases
GTGAGCACCACCCTTATTTTAACTGGCGAAGGCTTGGGCATTGATGACGTTGTACGGGTTGCGCGGCATCAAGATCGGGT
TGAACTAACCACCGATCCAGCGATTTTAGCCCAGATCGAAGCGTCGTGTGCTTATATCAATCAGGCAGTGAAGGAGCATC
AGCCGGTTTATGGGGTAACAACTGGCTTTGGGGGCATGGCCAACGTAATTATCTCGCCTGAAGAAGCTGCCGAGTTGCAA
AATAATGCCATTTGGTATCATAAAACGGGGGCCGGCAAGCTCTTGCCATTTACCGATGTTCGCGCTGCGATGCTGTTGCG
AGCTAATTCGCATATGCGAGGTGCATCGGGTATTCGACTGGAAATCATTCAACGCATGGTGACGTTTCTGAATGCCAATG
TTACACCACATGTGCGTGAGTTTGGCTCAATTGGGGCAAGCGGTGATCTTGTGCCATTAATTAGCATCACTGGAGCTTTG
TTGGGCACAGATCAAGCTTTTATGGTTGATTTTAACGGCGAGACCCTTGATTGTATCAGTGCACTTGAACGTTTAGGGCT
GCCACGCCTCCGTTTGCAACCCAAAGAAGGCTTGGCGATGATGAATGGTACTTCGGTGATGACCGGAATCGCCGCCAATT
GCGTTCACGATGCGCGAATTCTCTTGGCCTTAGCCTTGGAAGCCCACGCCTTAATGATTCAAGGCTTACAAGGCACGAAT
CAATCGTTTCACCCGTTTATTCATCGCCACAAACCGCATACTGGCCAAGTTTGGGCCGCTGACCATATGCTCGAATTGCT
ACAAGGCTCGCAGCTTTCGCGCAATGAACTTGATGGTAGCCACGATTATCGCGATGGTGATTTGATTCAAGATCGCTATT
CGTTACGCTGTTTACCGCAATTTTTGGGGCCAATCATCGATGGAATGGCCTTTATTTCGCATCATCTGCGGGTCGAAATT
AACTCAGCCAACGATAATCCTTTGATCGACACTGCTAGCGCCGCGAGTTATCATGGTGGCAATTTCTTGGGTCAGTATAT
TGGCGTGGGGATGGATCAGCTGCGCTATTATATGGGGCTGATGGCCAAACATCTGGATGTGCAGATTGCGCTGTTAGTTT
CACCGCAGTTCAATAATGGTTTGCCAGCTTCGTTGGTTGGCAATATCCAGCGTAAGGTTAATATGGGGTTGAAAGGGCTA
CAGCTCACCGCCAACTCGATCATGCCAATCTTGACCTTTTTGGGCAATTCGTTGGCCGATCGTTTTCCAACTCATGCTGA
GCAATTTAACCAGAATATCAATAGCCAAGGCTTTGGTTCGGCCAACTTAGCCCGCCAAACAATCCAAACGCTTCAGCAAT
ATATTGCGATTACGCTGATGTTTGGGGTGCAAGCGGTGGATTTGCGTACCCACAAATTAGCAGGCCATTACAACGCTGCT
GAATTGCTCTCGCCGCTTACCGCAAAGATCTATCACGCCGTTCGTTCAATCGTCAAGCATCCGCCCTCGCCTGAACGCCC
TTATATCTGGAATGATGATGAACAAGTGCTCGAAGCGCATATTAGTGCCTTAGCTCATGATATTGCCAACGATGGCTCAT
TGGTGAGTGCCGTTGAACAAACGCTGAGCGGCTTGCGCTCAATTATTTTGTTCCGTTAA

Upstream 100 bases:

>100_bases
ATTACGTAATTCATAACCAAGAATGCGGCGTAGGGTTTATGCATTGGTTCGGCTTAACATCACCATCGCGATCCATTGAT
CTTATGCACTGGAGAAACTT

Downstream 100 bases:

>100_bases
ACAATCAATCCCCACATAGTTGATTAACCATGAACTATGTGGGGATTATTATTTAATCGCTAATCGAGCTGGTGCAATGC
TTGATTGATATAGGCTGCCA

Product: histidine ammonia-lyase

Products: NA

Alternate protein names: Histidase [H]

Number of amino acids: Translated: 552; Mature: 551

Protein sequence:

>552_residues
MSTTLILTGEGLGIDDVVRVARHQDRVELTTDPAILAQIEASCAYINQAVKEHQPVYGVTTGFGGMANVIISPEEAAELQ
NNAIWYHKTGAGKLLPFTDVRAAMLLRANSHMRGASGIRLEIIQRMVTFLNANVTPHVREFGSIGASGDLVPLISITGAL
LGTDQAFMVDFNGETLDCISALERLGLPRLRLQPKEGLAMMNGTSVMTGIAANCVHDARILLALALEAHALMIQGLQGTN
QSFHPFIHRHKPHTGQVWAADHMLELLQGSQLSRNELDGSHDYRDGDLIQDRYSLRCLPQFLGPIIDGMAFISHHLRVEI
NSANDNPLIDTASAASYHGGNFLGQYIGVGMDQLRYYMGLMAKHLDVQIALLVSPQFNNGLPASLVGNIQRKVNMGLKGL
QLTANSIMPILTFLGNSLADRFPTHAEQFNQNINSQGFGSANLARQTIQTLQQYIAITLMFGVQAVDLRTHKLAGHYNAA
ELLSPLTAKIYHAVRSIVKHPPSPERPYIWNDDEQVLEAHISALAHDIANDGSLVSAVEQTLSGLRSIILFR

Sequences:

>Translated_552_residues
MSTTLILTGEGLGIDDVVRVARHQDRVELTTDPAILAQIEASCAYINQAVKEHQPVYGVTTGFGGMANVIISPEEAAELQ
NNAIWYHKTGAGKLLPFTDVRAAMLLRANSHMRGASGIRLEIIQRMVTFLNANVTPHVREFGSIGASGDLVPLISITGAL
LGTDQAFMVDFNGETLDCISALERLGLPRLRLQPKEGLAMMNGTSVMTGIAANCVHDARILLALALEAHALMIQGLQGTN
QSFHPFIHRHKPHTGQVWAADHMLELLQGSQLSRNELDGSHDYRDGDLIQDRYSLRCLPQFLGPIIDGMAFISHHLRVEI
NSANDNPLIDTASAASYHGGNFLGQYIGVGMDQLRYYMGLMAKHLDVQIALLVSPQFNNGLPASLVGNIQRKVNMGLKGL
QLTANSIMPILTFLGNSLADRFPTHAEQFNQNINSQGFGSANLARQTIQTLQQYIAITLMFGVQAVDLRTHKLAGHYNAA
ELLSPLTAKIYHAVRSIVKHPPSPERPYIWNDDEQVLEAHISALAHDIANDGSLVSAVEQTLSGLRSIILFR
>Mature_551_residues
STTLILTGEGLGIDDVVRVARHQDRVELTTDPAILAQIEASCAYINQAVKEHQPVYGVTTGFGGMANVIISPEEAAELQN
NAIWYHKTGAGKLLPFTDVRAAMLLRANSHMRGASGIRLEIIQRMVTFLNANVTPHVREFGSIGASGDLVPLISITGALL
GTDQAFMVDFNGETLDCISALERLGLPRLRLQPKEGLAMMNGTSVMTGIAANCVHDARILLALALEAHALMIQGLQGTNQ
SFHPFIHRHKPHTGQVWAADHMLELLQGSQLSRNELDGSHDYRDGDLIQDRYSLRCLPQFLGPIIDGMAFISHHLRVEIN
SANDNPLIDTASAASYHGGNFLGQYIGVGMDQLRYYMGLMAKHLDVQIALLVSPQFNNGLPASLVGNIQRKVNMGLKGLQ
LTANSIMPILTFLGNSLADRFPTHAEQFNQNINSQGFGSANLARQTIQTLQQYIAITLMFGVQAVDLRTHKLAGHYNAAE
LLSPLTAKIYHAVRSIVKHPPSPERPYIWNDDEQVLEAHISALAHDIANDGSLVSAVEQTLSGLRSIILFR

Specific function: Unknown

COG id: COG2986

COG function: function code E; Histidine ammonia-lyase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAL/histidase family [H]

Homologues:

Organism=Homo sapiens, GI4504333, Length=505, Percent_Identity=33.0693069306931, Blast_Score=223, Evalue=4e-58,
Organism=Caenorhabditis elegans, GI17567831, Length=520, Percent_Identity=32.3076923076923, Blast_Score=211, Evalue=7e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005921
- InterPro:   IPR008948
- InterPro:   IPR001106
- InterPro:   IPR022313 [H]

Pfam domain/function: PF00221 PAL [H]

EC number: =4.3.1.3 [H]

Molecular weight: Translated: 60237; Mature: 60106

Theoretical pI: Translated: 6.65; Mature: 6.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTTLILTGEGLGIDDVVRVARHQDRVELTTDPAILAQIEASCAYINQAVKEHQPVYGVT
CCEEEEEECCCCCHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHCCCCEEEE
TGFGGMANVIISPEEAAELQNNAIWYHKTGAGKLLPFTDVRAAMLLRANSHMRGASGIRL
CCCCCCEEEEECCHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHH
EIIQRMVTFLNANVTPHVREFGSIGASGDLVPLISITGALLGTDQAFMVDFNGETLDCIS
HHHHHHHHHHCCCCCHHHHHHHCCCCCCCEEHHHHHHHHHHCCCCEEEEEECCCHHHHHH
ALERLGLPRLRLQPKEGLAMMNGTSVMTGIAANCVHDARILLALALEAHALMIQGLQGTN
HHHHCCCCCEEECCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
QSFHPFIHRHKPHTGQVWAADHMLELLQGSQLSRNELDGSHDYRDGDLIQDRYSLRCLPQ
CCCCHHHHCCCCCCCCEEHHHHHHHHHCCCCCCHHCCCCCCCCCCCCHHHHHHHHHHHHH
FLGPIIDGMAFISHHLRVEINSANDNPLIDTASAASYHGGNFLGQYIGVGMDQLRYYMGL
HHHHHHHHHHHHHHEEEEEEECCCCCCCEECCCCCCCCCCHHHHHHHCCCHHHHHHHHHH
MAKHLDVQIALLVSPQFNNGLPASLVGNIQRKVNMGLKGLQLTANSIMPILTFLGNSLAD
HHHHCCEEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHH
RFPTHAEQFNQNINSQGFGSANLARQTIQTLQQYIAITLMFGVQAVDLRTHKLAGHYNAA
HCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEEHHHHHCCCCCHH
ELLSPLTAKIYHAVRSIVKHPPSPERPYIWNDDEQVLEAHISALAHDIANDGSLVSAVEQ
HHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCHHHHHHHHHHHHHHHHCCCCHHHHHHHH
TLSGLRSIILFR
HHHHHHHHHHCC
>Mature Secondary Structure 
STTLILTGEGLGIDDVVRVARHQDRVELTTDPAILAQIEASCAYINQAVKEHQPVYGVT
CEEEEEECCCCCHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHCCCCEEEE
TGFGGMANVIISPEEAAELQNNAIWYHKTGAGKLLPFTDVRAAMLLRANSHMRGASGIRL
CCCCCCEEEEECCHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHH
EIIQRMVTFLNANVTPHVREFGSIGASGDLVPLISITGALLGTDQAFMVDFNGETLDCIS
HHHHHHHHHHCCCCCHHHHHHHCCCCCCCEEHHHHHHHHHHCCCCEEEEEECCCHHHHHH
ALERLGLPRLRLQPKEGLAMMNGTSVMTGIAANCVHDARILLALALEAHALMIQGLQGTN
HHHHCCCCCEEECCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
QSFHPFIHRHKPHTGQVWAADHMLELLQGSQLSRNELDGSHDYRDGDLIQDRYSLRCLPQ
CCCCHHHHCCCCCCCCEEHHHHHHHHHCCCCCCHHCCCCCCCCCCCCHHHHHHHHHHHHH
FLGPIIDGMAFISHHLRVEINSANDNPLIDTASAASYHGGNFLGQYIGVGMDQLRYYMGL
HHHHHHHHHHHHHHEEEEEEECCCCCCCEECCCCCCCCCCHHHHHHHCCCHHHHHHHHHH
MAKHLDVQIALLVSPQFNNGLPASLVGNIQRKVNMGLKGLQLTANSIMPILTFLGNSLAD
HHHHCCEEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHH
RFPTHAEQFNQNINSQGFGSANLARQTIQTLQQYIAITLMFGVQAVDLRTHKLAGHYNAA
HCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEEHHHHHCCCCCHH
ELLSPLTAKIYHAVRSIVKHPPSPERPYIWNDDEQVLEAHISALAHDIANDGSLVSAVEQ
HHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCHHHHHHHHHHHHHHHHCCCCHHHHHHHH
TLSGLRSIILFR
HHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]