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The map label for this gene is sdhA [H]

Identifier: 159898257

GI number: 159898257

Start: 2017974

End: 2019887

Strand: Reverse

Name: sdhA [H]

Synonym: Haur_1733

Alternate gene names: 159898257

Gene position: 2019887-2017974 (Counterclockwise)

Preceding gene: 159898258

Following gene: 159898256

Centisome position: 31.83

GC content: 52.04

Gene sequence:

>1914_bases
ATGCAATTGAACGCTAAAATTCCAGCAGGGCCGCTGGAAGATAAATGGGATCAGCACCGCTTCAATGTGAAGTTGGTTAA
CCCCGCCAATAAGCGCAAATACACCGTTTTGGTGGTTGGCTCGGGCTTGGCAGGCGCTTCTGCTGCTGCTTCATTGGCTG
AGCTTGGCTATAACGTGAAGTGTTTCTGCTTCCAAGATAGCCCCCGTCGCGCCCACAGTATCGCGGCGCAAGGTGGCATC
AACGCTGCCAAGAATTATCAAAACGACGGTGATAGTGTTCGCCGTTTGTTCTACGATACGATCAAAGGTGGCGATTATCG
GGCACGTGAAGGTAATGTGTATCGGTTGGCGCAAGTCAGCGTTAACATTATTGACCAATGTGTGGCCCAAGGTGTGCCGT
TCGCCCGCGAGTATGGCGGCGTAATGGCTAACCGTTCGTTTGGTGGCGCACAAGTTTCGCGCACGTTCTATGCCCGTGGT
CAAACTGGCCAACAATTGTTGATCGGCGCATATTCAGCGCTCGAACGCCAAATTGGCTTGAAAAAAGTCGCCATGTATTC
ACGTTGCGAAATGTTGGATATTGTTTTGGTCGATGGCAAAGCCCGTGGGATTATCACCCGCGATTTGATCAACGGCAAGA
TCGAACGTCACGCAGGCGATGCAGTGGTTTTGGCAACAGGCGGTTATGGCAACGTCTTCTACCTTTCAACCAATGCTAAA
GGTTGTAACGTTACTGCCAGCTATCGCGCCTACAAACGTGGTGCAGCCTTCGCCAACCCCTGCTTTACCCAAATTCACCC
AACCTGTATCCCGGTTGCTGGCGATCACCAATCAAAATTAACCTTGATGAGTGAATCGTTGCGTAACGACGGACGGATTT
GGGTTCCCAAGAAAGCTGGCGATAATCGCGCCGCCAAGGATATACCCGAAAGCGAACGCGATTATTATCTCGAACGCAAA
TATCCTTCGTTCGGCAACCTCTCGCCACGCGATATTTCTTCACGCGCAGCCAAAGAGGTGTGTGATGAAGGCCGTGGCGT
AGGCCCAGGCGGCTTGGGTGTCTATCTCGACTTCAGCGATTCGATCAAGCGCTTAGGCAAAAATATGATTGCCGAACGTT
ATGGCAACTTGTTCGAGATGTACGAACGCATCACTGGCGAAAATCCTTACGAAGTGCCAATGCGGATTTATCCCGCCGTG
CACTATACCATGGGCGGCTTGTGGGTTGATTACAACTTGATGAGCAATGTTGAAGGCTTGCACGTTTTGGGCGAAGCCAA
CTTCTCCGACCACGGAGCCAACCGACTTGGGGCCAGTGCCTTGATGCAAGGTTTGGCCGATGGCTACTTCATTCTGCCCT
ACACAATTGGCGATTACATTGCTAGCGCCAAATTAGCCCCAGTTAGCACCGATCACCCAGCTTTTGCCGAAACCGAGCGC
GAAGTAACCACACGGCTCAAGCAATTGCTCGAAATCAATGGCAAGCGCAGTGTTGATGATTTCCATCGCGAGCTTGGCAA
AGTGATGTGGGATTACTGTGGCATGGCGCGGAATGATGCTGGGTTGCGCACCGCCTTAGAGCGCATTCCCCAGATCCGCG
AAGAATTCTGGCGCGATTTGCGCGTGCCAGGCAGCGGCGAATACTTCAACCAAGAGTTGGAAAAAGCCGGACGTGTGGCC
GACTTCCTCGAATTTGCTGAATTGATGTGCCACGATGCGCTGATGCGCACCGAATCGTGTGGCGGTCACTTCCGCACCGA
AAGCCAAACCGAGGATGGCGAGGCCAAACGCGACGACGAGAACTTTACCTTTGTGGCTGCTTGGGAATACAAGGGCGTTG
GCACCAAACCAACCATGCACAAAGAAGTTCTCGAATTTGAAAACGTTCACCTTTCAACTCGTTCGTACAAGTAA

Upstream 100 bases:

>100_bases
CTCGGCATTGGCACCTTGTTGTTTTTGGGAAATATTTCGATTCCAATTGCGGTCTTAGTTGGTTTCCTAAAGCCAATCTA
GTACAAATAGGTGACGCATT

Downstream 100 bases:

>100_bases
TCGCTGAGGTGCTTCAATGAAATTAAAATTGCACATTTGGCGACAAGATAACGCCAAAACAGCGGGCAAAATGGTTAGCT
ACGATGCCAACCATGTTAGC

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 637; Mature: 637

Protein sequence:

>637_residues
MQLNAKIPAGPLEDKWDQHRFNVKLVNPANKRKYTVLVVGSGLAGASAAASLAELGYNVKCFCFQDSPRRAHSIAAQGGI
NAAKNYQNDGDSVRRLFYDTIKGGDYRAREGNVYRLAQVSVNIIDQCVAQGVPFAREYGGVMANRSFGGAQVSRTFYARG
QTGQQLLIGAYSALERQIGLKKVAMYSRCEMLDIVLVDGKARGIITRDLINGKIERHAGDAVVLATGGYGNVFYLSTNAK
GCNVTASYRAYKRGAAFANPCFTQIHPTCIPVAGDHQSKLTLMSESLRNDGRIWVPKKAGDNRAAKDIPESERDYYLERK
YPSFGNLSPRDISSRAAKEVCDEGRGVGPGGLGVYLDFSDSIKRLGKNMIAERYGNLFEMYERITGENPYEVPMRIYPAV
HYTMGGLWVDYNLMSNVEGLHVLGEANFSDHGANRLGASALMQGLADGYFILPYTIGDYIASAKLAPVSTDHPAFAETER
EVTTRLKQLLEINGKRSVDDFHRELGKVMWDYCGMARNDAGLRTALERIPQIREEFWRDLRVPGSGEYFNQELEKAGRVA
DFLEFAELMCHDALMRTESCGGHFRTESQTEDGEAKRDDENFTFVAAWEYKGVGTKPTMHKEVLEFENVHLSTRSYK

Sequences:

>Translated_637_residues
MQLNAKIPAGPLEDKWDQHRFNVKLVNPANKRKYTVLVVGSGLAGASAAASLAELGYNVKCFCFQDSPRRAHSIAAQGGI
NAAKNYQNDGDSVRRLFYDTIKGGDYRAREGNVYRLAQVSVNIIDQCVAQGVPFAREYGGVMANRSFGGAQVSRTFYARG
QTGQQLLIGAYSALERQIGLKKVAMYSRCEMLDIVLVDGKARGIITRDLINGKIERHAGDAVVLATGGYGNVFYLSTNAK
GCNVTASYRAYKRGAAFANPCFTQIHPTCIPVAGDHQSKLTLMSESLRNDGRIWVPKKAGDNRAAKDIPESERDYYLERK
YPSFGNLSPRDISSRAAKEVCDEGRGVGPGGLGVYLDFSDSIKRLGKNMIAERYGNLFEMYERITGENPYEVPMRIYPAV
HYTMGGLWVDYNLMSNVEGLHVLGEANFSDHGANRLGASALMQGLADGYFILPYTIGDYIASAKLAPVSTDHPAFAETER
EVTTRLKQLLEINGKRSVDDFHRELGKVMWDYCGMARNDAGLRTALERIPQIREEFWRDLRVPGSGEYFNQELEKAGRVA
DFLEFAELMCHDALMRTESCGGHFRTESQTEDGEAKRDDENFTFVAAWEYKGVGTKPTMHKEVLEFENVHLSTRSYK
>Mature_637_residues
MQLNAKIPAGPLEDKWDQHRFNVKLVNPANKRKYTVLVVGSGLAGASAAASLAELGYNVKCFCFQDSPRRAHSIAAQGGI
NAAKNYQNDGDSVRRLFYDTIKGGDYRAREGNVYRLAQVSVNIIDQCVAQGVPFAREYGGVMANRSFGGAQVSRTFYARG
QTGQQLLIGAYSALERQIGLKKVAMYSRCEMLDIVLVDGKARGIITRDLINGKIERHAGDAVVLATGGYGNVFYLSTNAK
GCNVTASYRAYKRGAAFANPCFTQIHPTCIPVAGDHQSKLTLMSESLRNDGRIWVPKKAGDNRAAKDIPESERDYYLERK
YPSFGNLSPRDISSRAAKEVCDEGRGVGPGGLGVYLDFSDSIKRLGKNMIAERYGNLFEMYERITGENPYEVPMRIYPAV
HYTMGGLWVDYNLMSNVEGLHVLGEANFSDHGANRLGASALMQGLADGYFILPYTIGDYIASAKLAPVSTDHPAFAETER
EVTTRLKQLLEINGKRSVDDFHRELGKVMWDYCGMARNDAGLRTALERIPQIREEFWRDLRVPGSGEYFNQELEKAGRVA
DFLEFAELMCHDALMRTESCGGHFRTESQTEDGEAKRDDENFTFVAAWEYKGVGTKPTMHKEVLEFENVHLSTRSYK

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=570, Percent_Identity=26.8421052631579, Blast_Score=164, Evalue=2e-40,
Organism=Escherichia coli, GI1790597, Length=543, Percent_Identity=29.097605893186, Blast_Score=209, Evalue=5e-55,
Organism=Escherichia coli, GI1786942, Length=558, Percent_Identity=26.5232974910394, Blast_Score=129, Evalue=5e-31,
Organism=Escherichia coli, GI1788928, Length=578, Percent_Identity=25.9515570934256, Blast_Score=128, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17505833, Length=547, Percent_Identity=28.1535648994516, Blast_Score=176, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI17550100, Length=540, Percent_Identity=27.5925925925926, Blast_Score=161, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6322701, Length=582, Percent_Identity=28.6941580756014, Blast_Score=187, Evalue=5e-48,
Organism=Saccharomyces cerevisiae, GI6322416, Length=604, Percent_Identity=27.4834437086093, Blast_Score=170, Evalue=8e-43,
Organism=Drosophila melanogaster, GI17137288, Length=596, Percent_Identity=27.8523489932886, Blast_Score=179, Evalue=5e-45,
Organism=Drosophila melanogaster, GI24655642, Length=596, Percent_Identity=27.8523489932886, Blast_Score=179, Evalue=5e-45,
Organism=Drosophila melanogaster, GI24655647, Length=596, Percent_Identity=27.8523489932886, Blast_Score=179, Evalue=5e-45,
Organism=Drosophila melanogaster, GI24663005, Length=585, Percent_Identity=25.8119658119658, Blast_Score=142, Evalue=7e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011280 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 70797; Mature: 70797

Theoretical pI: Translated: 7.89; Mature: 7.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLNAKIPAGPLEDKWDQHRFNVKLVNPANKRKYTVLVVGSGLAGASAAASLAELGYNVK
CCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCEEEEEEEECCCCCHHHHHHHHHCCCCEE
CFCFQDSPRRAHSIAAQGGINAAKNYQNDGDSVRRLFYDTIKGGDYRAREGNVYRLAQVS
EEEECCCCCHHHHHHHHCCCCHHHCCCCCHHHHHHHHHHHHCCCCEECCCCCEEEEEHHH
VNIIDQCVAQGVPFAREYGGVMANRSFGGAQVSRTFYARGQTGQQLLIGAYSALERQIGL
HHHHHHHHHCCCCCHHHHCCEEECCCCCCCHHHHEEEECCCCCCHHHHHHHHHHHHHHHH
KKVAMYSRCEMLDIVLVDGKARGIITRDLINGKIERHAGDAVVLATGGYGNVFYLSTNAK
HHHHHHHHCCEEEEEEECCCCCCEEEHHHHCCCHHCCCCCEEEEEECCCCCEEEEECCCC
GCNVTASYRAYKRGAAFANPCFTQIHPTCIPVAGDHQSKLTLMSESLRNDGRIWVPKKAG
CCCEEHHHHHHHCCCCCCCCHHHCCCCEEEEECCCCCHHHHHHHHHHCCCCCEEEECCCC
DNRAAKDIPESERDYYLERKYPSFGNLSPRDISSRAAKEVCDEGRGVGPGGLGVYLDFSD
CCCCHHCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEEECHH
SIKRLGKNMIAERYGNLFEMYERITGENPYEVPMRIYPAVHYTMGGLWVDYNLMSNVEGL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCEEEECCEEEEEHHHCCCCCE
HVLGEANFSDHGANRLGASALMQGLADGYFILPYTIGDYIASAKLAPVSTDHPAFAETER
EEEECCCCCCCCCHHHHHHHHHHHHCCCEEEEEEEHHHHHHCCCCCCCCCCCCCHHHHHH
EVTTRLKQLLEINGKRSVDDFHRELGKVMWDYCGMARNDAGLRTALERIPQIREEFWRDL
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHC
RVPGSGEYFNQELEKAGRVADFLEFAELMCHDALMRTESCGGHFRTESQTEDGEAKRDDE
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
NFTFVAAWEYKGVGTKPTMHKEVLEFENVHLSTRSYK
CEEEEEEEEECCCCCCCHHHHHHHHHHCCEEECCCCC
>Mature Secondary Structure
MQLNAKIPAGPLEDKWDQHRFNVKLVNPANKRKYTVLVVGSGLAGASAAASLAELGYNVK
CCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCEEEEEEEECCCCCHHHHHHHHHCCCCEE
CFCFQDSPRRAHSIAAQGGINAAKNYQNDGDSVRRLFYDTIKGGDYRAREGNVYRLAQVS
EEEECCCCCHHHHHHHHCCCCHHHCCCCCHHHHHHHHHHHHCCCCEECCCCCEEEEEHHH
VNIIDQCVAQGVPFAREYGGVMANRSFGGAQVSRTFYARGQTGQQLLIGAYSALERQIGL
HHHHHHHHHCCCCCHHHHCCEEECCCCCCCHHHHEEEECCCCCCHHHHHHHHHHHHHHHH
KKVAMYSRCEMLDIVLVDGKARGIITRDLINGKIERHAGDAVVLATGGYGNVFYLSTNAK
HHHHHHHHCCEEEEEEECCCCCCEEEHHHHCCCHHCCCCCEEEEEECCCCCEEEEECCCC
GCNVTASYRAYKRGAAFANPCFTQIHPTCIPVAGDHQSKLTLMSESLRNDGRIWVPKKAG
CCCEEHHHHHHHCCCCCCCCHHHCCCCEEEEECCCCCHHHHHHHHHHCCCCCEEEECCCC
DNRAAKDIPESERDYYLERKYPSFGNLSPRDISSRAAKEVCDEGRGVGPGGLGVYLDFSD
CCCCHHCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEEECHH
SIKRLGKNMIAERYGNLFEMYERITGENPYEVPMRIYPAVHYTMGGLWVDYNLMSNVEGL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCEEEECCEEEEEHHHCCCCCE
HVLGEANFSDHGANRLGASALMQGLADGYFILPYTIGDYIASAKLAPVSTDHPAFAETER
EEEECCCCCCCCCHHHHHHHHHHHHCCCEEEEEEEHHHHHHCCCCCCCCCCCCCHHHHHH
EVTTRLKQLLEINGKRSVDDFHRELGKVMWDYCGMARNDAGLRTALERIPQIREEFWRDL
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHC
RVPGSGEYFNQELEKAGRVADFLEFAELMCHDALMRTESCGGHFRTESQTEDGEAKRDDE
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
NFTFVAAWEYKGVGTKPTMHKEVLEFENVHLSTRSYK
CEEEEEEEEECCCCCCCHHHHHHHHHHCCEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3027051; 8969504; 9384377; 3086287; 3021212 [H]