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The map label for this gene is ppa [H]

Identifier: 159898236

GI number: 159898236

Start: 1992230

End: 1992766

Strand: Reverse

Name: ppa [H]

Synonym: Haur_1712

Alternate gene names: 159898236

Gene position: 1992766-1992230 (Counterclockwise)

Preceding gene: 159898238

Following gene: 159898233

Centisome position: 31.4

GC content: 47.3

Gene sequence:

>537_bases
GTGAATATTTGGCATGATGTGCCATTTGGCGAAGATGCACCAGAAGTTATTAACGTTGTGATTGAAATTCCCCGTGGCTC
CCGCAACAAGTATGAAATCGACAAAGATACGGGTTTGGTTAAGCTTGATCGGGTGCTTTCATCAGCCGTCTACTATCCAG
GTGATTATGGCTTGATTCCACAAACCTACTGCGAAGATGGCGACCCGCTGGATGTGATTTTACTGCTCAACTTCCCAACC
TTCCCTGGTTGTTTGGTTGAAGCCCGCCCAATTGGCGTGTTTGGCATGATCGACGGCGGCGAAAACGACGATAAAATTCT
GGCCGTGCCCGCCAATGACCCTTATTTTGCCAATATCAAAGATTTGGCCGATGTGCCACCCCACTTTATCAAAGAAGTGA
CCCAATTCTTTGCTTCATACAAAGCCTTGGAAAACAAAACGGTGCAAGTTGGCGAATGGCAAGGAGCCGAGGCTGCTAAG
CAACGTGTCCAAGATTCGATTCAACTCTACAACGAAAATTTCCGCAAAGCTGAGTAG

Upstream 100 bases:

>100_bases
GCAGATTTCTCTACAATGCAGTGCGTCAAACGCATTGCATTAGGCTAAAAACGTGGTATAGTTGCGCCGTTTTGACAACG
CATTTATGGAGGAATTCCCT

Downstream 100 bases:

>100_bases
GGATCAGAATTGAAGGGCCAGGGTCCAGGATTAAGGTTTAAGTATGCAGGGTTTACTTGCCCTGCATACTTTGTTTAAAT
CCGCAACCGCGAGGAGCGCA

Product: inorganic diphosphatase

Products: NA

Alternate protein names: Pyrophosphate phospho-hydrolase; PPase [H]

Number of amino acids: Translated: 178; Mature: 178

Protein sequence:

>178_residues
MNIWHDVPFGEDAPEVINVVIEIPRGSRNKYEIDKDTGLVKLDRVLSSAVYYPGDYGLIPQTYCEDGDPLDVILLLNFPT
FPGCLVEARPIGVFGMIDGGENDDKILAVPANDPYFANIKDLADVPPHFIKEVTQFFASYKALENKTVQVGEWQGAEAAK
QRVQDSIQLYNENFRKAE

Sequences:

>Translated_178_residues
MNIWHDVPFGEDAPEVINVVIEIPRGSRNKYEIDKDTGLVKLDRVLSSAVYYPGDYGLIPQTYCEDGDPLDVILLLNFPT
FPGCLVEARPIGVFGMIDGGENDDKILAVPANDPYFANIKDLADVPPHFIKEVTQFFASYKALENKTVQVGEWQGAEAAK
QRVQDSIQLYNENFRKAE
>Mature_178_residues
MNIWHDVPFGEDAPEVINVVIEIPRGSRNKYEIDKDTGLVKLDRVLSSAVYYPGDYGLIPQTYCEDGDPLDVILLLNFPT
FPGCLVEARPIGVFGMIDGGENDDKILAVPANDPYFANIKDLADVPPHFIKEVTQFFASYKALENKTVQVGEWQGAEAAK
QRVQDSIQLYNENFRKAE

Specific function: Unknown

COG id: COG0221

COG function: function code C; Inorganic pyrophosphatase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PPase family [H]

Homologues:

Organism=Homo sapiens, GI11056044, Length=168, Percent_Identity=31.547619047619, Blast_Score=70, Evalue=8e-13,
Organism=Escherichia coli, GI1790673, Length=167, Percent_Identity=42.5149700598802, Blast_Score=127, Evalue=5e-31,
Organism=Caenorhabditis elegans, GI71984895, Length=205, Percent_Identity=24.8780487804878, Blast_Score=67, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI71984880, Length=205, Percent_Identity=24.8780487804878, Blast_Score=67, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI71984883, Length=205, Percent_Identity=24.8780487804878, Blast_Score=67, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI71984889, Length=205, Percent_Identity=24.8780487804878, Blast_Score=67, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6319483, Length=203, Percent_Identity=25.615763546798, Blast_Score=70, Evalue=1e-13,
Organism=Drosophila melanogaster, GI45549187, Length=164, Percent_Identity=29.8780487804878, Blast_Score=70, Evalue=6e-13,
Organism=Drosophila melanogaster, GI221468704, Length=169, Percent_Identity=29.585798816568, Blast_Score=70, Evalue=7e-13,

Paralogues:

None

Copy number: 5480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 500 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 200 Molecules/Cell In: Early Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008162 [H]

Pfam domain/function: PF00719 Pyrophosphatase [H]

EC number: =3.6.1.1 [H]

Molecular weight: Translated: 19938; Mature: 19938

Theoretical pI: Translated: 4.22; Mature: 4.22

Prosite motif: PS00387 PPASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIWHDVPFGEDAPEVINVVIEIPRGSRNKYEIDKDTGLVKLDRVLSSAVYYPGDYGLIP
CCCCCCCCCCCCCHHHEEEEEECCCCCCCCEEECCCCCHHHHHHHHHHHCCCCCCCCCCC
QTYCEDGDPLDVILLLNFPTFPGCLVEARPIGVFGMIDGGENDDKILAVPANDPYFANIK
HHHCCCCCCEEEEEEEECCCCCCEEEECCCCEEEEEECCCCCCCEEEEEECCCCCEECHH
DLADVPPHFIKEVTQFFASYKALENKTVQVGEWQGAEAAKQRVQDSIQLYNENFRKAE
HHHCCCHHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MNIWHDVPFGEDAPEVINVVIEIPRGSRNKYEIDKDTGLVKLDRVLSSAVYYPGDYGLIP
CCCCCCCCCCCCCHHHEEEEEECCCCCCCCEEECCCCCHHHHHHHHHHHCCCCCCCCCCC
QTYCEDGDPLDVILLLNFPTFPGCLVEARPIGVFGMIDGGENDDKILAVPANDPYFANIK
HHHCCCCCCEEEEEEEECCCCCCEEEECCCCEEEEEECCCCCCCEEEEEECCCCCEECHH
DLADVPPHFIKEVTQFFASYKALENKTVQVGEWQGAEAAKQRVQDSIQLYNENFRKAE
HHHCCCHHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]