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The map label for this gene is icd [H]

Identifier: 159897978

GI number: 159897978

Start: 1691699

End: 1692439

Strand: Reverse

Name: icd [H]

Synonym: Haur_1453

Alternate gene names: 159897978

Gene position: 1692439-1691699 (Counterclockwise)

Preceding gene: 159897979

Following gene: 159897977

Centisome position: 26.67

GC content: 49.66

Gene sequence:

>741_bases
ATGGCTCATCGGGTTACCTTGATTCGTGGTGACGGAACAGGACCAGAACTTGCCGAAGCTACACGCCGGGTCTTAGAAGC
TACAGGCGTGGCTTTTGATTGGGATATTCAGGATGCAGGGGTCGATGTAATGGAGCAATTAGGGACTCCATTGCCCGATT
CCGTGCTCGAATCAATTCGTTCAACCAAAGTGGCGTTAAAAGCGCCGATTACCACCCCCGTTGGCACAGGTTTTCGCTCA
GTCAATGTGGCGATTCGTAAAGAACTCGACCTCTATGCCTGTGTTCGGCCATGTCGTTCCTACCCTGGCGTGCGCTCGCG
CTTTGAAAACATCGATCTTGTGGTTGTGCGCGAAAACACCGAAGATCTCTACGCTGGGATCGAGTTTGAGCGTGGCACTG
ATGAAGTAGCCGAATTGCGCAACTGGTTGCTGCAAAAACGCCCAAATGCCTTGATCAAAGAGCCAGGTGGTATCTCAATC
AAGCCCATGTCGGTGCCTGGCTCAGAGCGAATTGTGCGCTTTGCCTTTGAATATGCCCGCGCCAACAAACGCAAAAAAGT
CACGGCAGTGCATAAAGCCAATATTATGAAGTTCAGCGATGGCTTATTCTTAGAAGTTGCCCGTGAAGTCGCCAAAGAGT
ATCCCGATATCGAGTTCGATGATCGGATTGTCGATAATATGTGTATGCAGTTGGTGCAAAAACCAGAACTCTATGATGTG
ATGGTATTGCCCAATTTGTGA

Upstream 100 bases:

>100_bases
TGCTCATCCCTTTTTTGTCGCTTCAGCCCGCAGGATGCTATAATGCTGCTACGGTTCGACCGTACAAATGCAGGGGCTTT
TGAATCGAAAGGATCAATCA

Downstream 100 bases:

>100_bases
TAGTGCTGGCGAACCCTGTTTGTGCGGTGCAGTACGGTCTCTTGCCCGCGATCTTCGGCTATCATGGAATCTGCTCTGTT
GATGGATGCACCACCGGTGC

Product: isocitrate/isopropylmalate dehydrogenase

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 246; Mature: 245

Protein sequence:

>246_residues
MAHRVTLIRGDGTGPELAEATRRVLEATGVAFDWDIQDAGVDVMEQLGTPLPDSVLESIRSTKVALKAPITTPVGTGFRS
VNVAIRKELDLYACVRPCRSYPGVRSRFENIDLVVVRENTEDLYAGIEFERGTDEVAELRNWLLQKRPNALIKEPGGISI
KPMSVPGSERIVRFAFEYARANKRKKVTAVHKANIMKFSDGLFLEVAREVAKEYPDIEFDDRIVDNMCMQLVQKPELYDV
MVLPNL

Sequences:

>Translated_246_residues
MAHRVTLIRGDGTGPELAEATRRVLEATGVAFDWDIQDAGVDVMEQLGTPLPDSVLESIRSTKVALKAPITTPVGTGFRS
VNVAIRKELDLYACVRPCRSYPGVRSRFENIDLVVVRENTEDLYAGIEFERGTDEVAELRNWLLQKRPNALIKEPGGISI
KPMSVPGSERIVRFAFEYARANKRKKVTAVHKANIMKFSDGLFLEVAREVAKEYPDIEFDDRIVDNMCMQLVQKPELYDV
MVLPNL
>Mature_245_residues
AHRVTLIRGDGTGPELAEATRRVLEATGVAFDWDIQDAGVDVMEQLGTPLPDSVLESIRSTKVALKAPITTPVGTGFRSV
NVAIRKELDLYACVRPCRSYPGVRSRFENIDLVVVRENTEDLYAGIEFERGTDEVAELRNWLLQKRPNALIKEPGGISIK
PMSVPGSERIVRFAFEYARANKRKKVTAVHKANIMKFSDGLFLEVAREVAKEYPDIEFDDRIVDNMCMQLVQKPELYDVM
VLPNL

Specific function: Unknown

COG id: COG0473

COG function: function code CE; Isocitrate/isopropylmalate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI5031777, Length=248, Percent_Identity=41.1290322580645, Blast_Score=186, Evalue=1e-47,
Organism=Homo sapiens, GI28178821, Length=247, Percent_Identity=39.6761133603239, Blast_Score=170, Evalue=9e-43,
Organism=Homo sapiens, GI28178816, Length=247, Percent_Identity=39.6761133603239, Blast_Score=170, Evalue=1e-42,
Organism=Homo sapiens, GI4758582, Length=246, Percent_Identity=41.0569105691057, Blast_Score=169, Evalue=3e-42,
Organism=Homo sapiens, GI28178838, Length=246, Percent_Identity=41.0569105691057, Blast_Score=168, Evalue=3e-42,
Organism=Homo sapiens, GI28178819, Length=79, Percent_Identity=62.0253164556962, Blast_Score=110, Evalue=1e-24,
Organism=Escherichia coli, GI1787381, Length=282, Percent_Identity=36.5248226950355, Blast_Score=155, Evalue=2e-39,
Organism=Escherichia coli, GI1788101, Length=259, Percent_Identity=29.3436293436293, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI87081683, Length=264, Percent_Identity=28.030303030303, Blast_Score=98, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI71986051, Length=248, Percent_Identity=45.1612903225806, Blast_Score=209, Evalue=1e-54,
Organism=Caenorhabditis elegans, GI25144293, Length=252, Percent_Identity=42.0634920634921, Blast_Score=178, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI17505779, Length=246, Percent_Identity=41.4634146341463, Blast_Score=167, Evalue=6e-42,
Organism=Caenorhabditis elegans, GI17550882, Length=250, Percent_Identity=38.8, Blast_Score=159, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6324709, Length=247, Percent_Identity=39.6761133603239, Blast_Score=190, Evalue=2e-49,
Organism=Saccharomyces cerevisiae, GI6324291, Length=245, Percent_Identity=41.2244897959184, Blast_Score=178, Evalue=7e-46,
Organism=Saccharomyces cerevisiae, GI6322097, Length=257, Percent_Identity=31.9066147859922, Blast_Score=119, Evalue=4e-28,
Organism=Saccharomyces cerevisiae, GI6319830, Length=264, Percent_Identity=26.8939393939394, Blast_Score=73, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24643270, Length=247, Percent_Identity=42.1052631578947, Blast_Score=213, Evalue=9e-56,
Organism=Drosophila melanogaster, GI24643268, Length=247, Percent_Identity=42.1052631578947, Blast_Score=213, Evalue=1e-55,
Organism=Drosophila melanogaster, GI24661184, Length=248, Percent_Identity=40.7258064516129, Blast_Score=188, Evalue=3e-48,
Organism=Drosophila melanogaster, GI161078635, Length=246, Percent_Identity=42.6829268292683, Blast_Score=185, Evalue=2e-47,
Organism=Drosophila melanogaster, GI161078633, Length=246, Percent_Identity=42.6829268292683, Blast_Score=185, Evalue=3e-47,
Organism=Drosophila melanogaster, GI24650122, Length=246, Percent_Identity=42.6829268292683, Blast_Score=185, Evalue=3e-47,
Organism=Drosophila melanogaster, GI161078637, Length=246, Percent_Identity=42.6829268292683, Blast_Score=185, Evalue=3e-47,
Organism=Drosophila melanogaster, GI161078639, Length=242, Percent_Identity=42.1487603305785, Blast_Score=179, Evalue=2e-45,
Organism=Drosophila melanogaster, GI281362242, Length=246, Percent_Identity=42.2764227642276, Blast_Score=174, Evalue=4e-44,
Organism=Drosophila melanogaster, GI24648872, Length=246, Percent_Identity=42.2764227642276, Blast_Score=174, Evalue=4e-44,
Organism=Drosophila melanogaster, GI20130355, Length=245, Percent_Identity=32.6530612244898, Blast_Score=127, Evalue=7e-30,

Paralogues:

None

Copy number: 8180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 27622; Mature: 27491

Theoretical pI: Translated: 5.51; Mature: 5.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAHRVTLIRGDGTGPELAEATRRVLEATGVAFDWDIQDAGVDVMEQLGTPLPDSVLESIR
CCCEEEEEECCCCCHHHHHHHHHHHHHHCCEEEECCCCCCHHHHHHCCCCCCHHHHHHHH
STKVALKAPITTPVGTGFRSVNVAIRKELDLYACVRPCRSYPGVRSRFENIDLVVVRENT
HHHEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCEEEEECCC
EDLYAGIEFERGTDEVAELRNWLLQKRPNALIKEPGGISIKPMSVPGSERIVRFAFEYAR
CHHHCCCCCCCCCHHHHHHHHHHHHCCCCHHHCCCCCCEEEECCCCCHHHHHHHHHHHHH
ANKRKKVTAVHKANIMKFSDGLFLEVAREVAKEYPDIEFDDRIVDNMCMQLVQKPELYDV
CCCCHHHHHHHHHHHEEECCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCEEE
MVLPNL
EECCCC
>Mature Secondary Structure 
AHRVTLIRGDGTGPELAEATRRVLEATGVAFDWDIQDAGVDVMEQLGTPLPDSVLESIR
CCEEEEEECCCCCHHHHHHHHHHHHHHCCEEEECCCCCCHHHHHHCCCCCCHHHHHHHH
STKVALKAPITTPVGTGFRSVNVAIRKELDLYACVRPCRSYPGVRSRFENIDLVVVRENT
HHHEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCEEEEECCC
EDLYAGIEFERGTDEVAELRNWLLQKRPNALIKEPGGISIKPMSVPGSERIVRFAFEYAR
CHHHCCCCCCCCCHHHHHHHHHHHHCCCCHHHCCCCCCEEEECCCCCHHHHHHHHHHHHH
ANKRKKVTAVHKANIMKFSDGLFLEVAREVAKEYPDIEFDDRIVDNMCMQLVQKPELYDV
CCCCHHHHHHHHHHHEEECCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCEEE
MVLPNL
EECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1539996 [H]