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The map label for this gene is hbd [H]

Identifier: 159897732

GI number: 159897732

Start: 1385836

End: 1386684

Strand: Reverse

Name: hbd [H]

Synonym: Haur_1203

Alternate gene names: 159897732

Gene position: 1386684-1385836 (Counterclockwise)

Preceding gene: 159897733

Following gene: 159897731

Centisome position: 21.85

GC content: 51.24

Gene sequence:

>849_bases
ATGGCGATCACGAAAGTCGGGGTACTTGGCTGTGGCTTGATGGGCGCGGGCATTGCCCAAGTTGCCGCCCAAGCAGGTTT
TATGACGGTTGTGCGAGAAGTTAATCAAGCTGTGTTAGATAAAGGCTTGGATCGCATCAACGCTATTTTGGAAAAGGATG
TTAGCAAAGGCAAACTAAGTGCCGCCGACCGCGATGCAAGCTTGGCCCGCTTGTATGGCACCACTAGCTTCGAGGATTTG
GCAGATTGCGATTTGATTATTGAGGCGATTGTTGAGCAATTGCCAGCCAAACGCGAAGTTTTTACCGCGCTCGATGAATT
GTGTCCCCCCAGCACAATTTTTGTTTCCAACACCTCATCACTAACGATTATGGAAATGGCAGCAGTAACCAAGCGACCCG
ACCGCTTTGCTGGATTGCACTTCTTCAATCCGGTTCCGGTCATGAAATTGGTCGAAATCGTGCGTGCCCTTACTACCTCC
GATGAAACGATTGCCAGCCTGCATGAGTTTACCCGTGCTTTGGGTAAAACCCCGATTAACACCAGCGATACCACCGGATT
TATTGTCAATCGCTTGCTTGTACCATTTTTGCTCGATGCCGTGCGCTTGCTTGAAAGCGGCGTTGCCACCCGTGAGGACA
TCGACGAAGGCATGAAGCTTGGCTGTGGGCATCCGATGGGGCCATTAACCTTGCTCGATTTTGTGGGCATTGATACGGTC
TACTCGATCGCCAATATTATGTTTGATGAATTCCGTGAGCCACGCTTTGCCCCGCCGCCATTGCTCCGCCGCATGGTGCT
CGCCGGCCATTTCGGGCGCAAATCGGGCCAAGGTTTTTATTCTTACTAA

Upstream 100 bases:

>100_bases
GCGCCATAAGCCTATAGCCTTATCATCTCTGACGCACTGCATTCTAAGTCGGCTATAATAGTAGCAATCAATTGCTTGTT
GTAGCACAAGGAGATGATCG

Downstream 100 bases:

>100_bases
ATGAAAGTCAAAAGGCAAAGGGCAAAAGTCAAAATAAACCATTTGCTTGCTTGATTCACGCACTTGCCAGCAAATTCACC
TTTTTGCCTTCTGCCACAAT

Product: 3-hydroxybutyryl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 282; Mature: 281

Protein sequence:

>282_residues
MAITKVGVLGCGLMGAGIAQVAAQAGFMTVVREVNQAVLDKGLDRINAILEKDVSKGKLSAADRDASLARLYGTTSFEDL
ADCDLIIEAIVEQLPAKREVFTALDELCPPSTIFVSNTSSLTIMEMAAVTKRPDRFAGLHFFNPVPVMKLVEIVRALTTS
DETIASLHEFTRALGKTPINTSDTTGFIVNRLLVPFLLDAVRLLESGVATREDIDEGMKLGCGHPMGPLTLLDFVGIDTV
YSIANIMFDEFREPRFAPPPLLRRMVLAGHFGRKSGQGFYSY

Sequences:

>Translated_282_residues
MAITKVGVLGCGLMGAGIAQVAAQAGFMTVVREVNQAVLDKGLDRINAILEKDVSKGKLSAADRDASLARLYGTTSFEDL
ADCDLIIEAIVEQLPAKREVFTALDELCPPSTIFVSNTSSLTIMEMAAVTKRPDRFAGLHFFNPVPVMKLVEIVRALTTS
DETIASLHEFTRALGKTPINTSDTTGFIVNRLLVPFLLDAVRLLESGVATREDIDEGMKLGCGHPMGPLTLLDFVGIDTV
YSIANIMFDEFREPRFAPPPLLRRMVLAGHFGRKSGQGFYSY
>Mature_281_residues
AITKVGVLGCGLMGAGIAQVAAQAGFMTVVREVNQAVLDKGLDRINAILEKDVSKGKLSAADRDASLARLYGTTSFEDLA
DCDLIIEAIVEQLPAKREVFTALDELCPPSTIFVSNTSSLTIMEMAAVTKRPDRFAGLHFFNPVPVMKLVEIVRALTTSD
ETIASLHEFTRALGKTPINTSDTTGFIVNRLLVPFLLDAVRLLESGVATREDIDEGMKLGCGHPMGPLTLLDFVGIDTVY
SIANIMFDEFREPRFAPPPLLRRMVLAGHFGRKSGQGFYSY

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=288, Percent_Identity=47.9166666666667, Blast_Score=256, Evalue=2e-68,
Organism=Homo sapiens, GI296179427, Length=305, Percent_Identity=45.2459016393443, Blast_Score=245, Evalue=3e-65,
Organism=Homo sapiens, GI20127408, Length=282, Percent_Identity=37.2340425531915, Blast_Score=186, Evalue=2e-47,
Organism=Homo sapiens, GI261878539, Length=292, Percent_Identity=31.1643835616438, Blast_Score=146, Evalue=2e-35,
Organism=Homo sapiens, GI68989263, Length=292, Percent_Identity=31.1643835616438, Blast_Score=146, Evalue=2e-35,
Organism=Homo sapiens, GI115430219, Length=224, Percent_Identity=27.2321428571429, Blast_Score=79, Evalue=4e-15,
Organism=Escherichia coli, GI1787661, Length=281, Percent_Identity=43.4163701067616, Blast_Score=240, Evalue=6e-65,
Organism=Escherichia coli, GI1788682, Length=261, Percent_Identity=39.463601532567, Blast_Score=179, Evalue=2e-46,
Organism=Escherichia coli, GI1790281, Length=266, Percent_Identity=34.9624060150376, Blast_Score=164, Evalue=7e-42,
Organism=Caenorhabditis elegans, GI17549919, Length=287, Percent_Identity=44.2508710801394, Blast_Score=238, Evalue=3e-63,
Organism=Caenorhabditis elegans, GI17553560, Length=288, Percent_Identity=42.7083333333333, Blast_Score=237, Evalue=6e-63,
Organism=Caenorhabditis elegans, GI17563036, Length=291, Percent_Identity=42.2680412371134, Blast_Score=223, Evalue=1e-58,
Organism=Caenorhabditis elegans, GI25144276, Length=284, Percent_Identity=35.2112676056338, Blast_Score=172, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI17508953, Length=284, Percent_Identity=35.2112676056338, Blast_Score=171, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI17508951, Length=284, Percent_Identity=35.2112676056338, Blast_Score=171, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI17558304, Length=284, Percent_Identity=34.5070422535211, Blast_Score=171, Evalue=6e-43,
Organism=Caenorhabditis elegans, GI71985923, Length=280, Percent_Identity=31.7857142857143, Blast_Score=162, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI71985930, Length=280, Percent_Identity=30, Blast_Score=147, Evalue=9e-36,
Organism=Caenorhabditis elegans, GI193203623, Length=190, Percent_Identity=28.4210526315789, Blast_Score=74, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI115533614, Length=190, Percent_Identity=28.4210526315789, Blast_Score=74, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24583077, Length=282, Percent_Identity=38.6524822695035, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI24583079, Length=282, Percent_Identity=38.6524822695035, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI19921000, Length=282, Percent_Identity=38.6524822695035, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI45549573, Length=262, Percent_Identity=28.2442748091603, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI20129993, Length=226, Percent_Identity=27.4336283185841, Blast_Score=82, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 30628; Mature: 30497

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: PS00067 3HCDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAITKVGVLGCGLMGAGIAQVAAQAGFMTVVREVNQAVLDKGLDRINAILEKDVSKGKLS
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
AADRDASLARLYGTTSFEDLADCDLIIEAIVEQLPAKREVFTALDELCPPSTIFVSNTSS
CCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCEEEEECCCC
LTIMEMAAVTKRPDRFAGLHFFNPVPVMKLVEIVRALTTSDETIASLHEFTRALGKTPIN
HHHHHHHHHHCCCHHHCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCC
TSDTTGFIVNRLLVPFLLDAVRLLESGVATREDIDEGMKLGCGHPMGPLTLLDFVGIDTV
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
YSIANIMFDEFREPRFAPPPLLRRMVLAGHFGRKSGQGFYSY
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
AITKVGVLGCGLMGAGIAQVAAQAGFMTVVREVNQAVLDKGLDRINAILEKDVSKGKLS
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
AADRDASLARLYGTTSFEDLADCDLIIEAIVEQLPAKREVFTALDELCPPSTIFVSNTSS
CCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCEEEEECCCC
LTIMEMAAVTKRPDRFAGLHFFNPVPVMKLVEIVRALTTSDETIASLHEFTRALGKTPIN
HHHHHHHHHHCCCHHHCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCC
TSDTTGFIVNRLLVPFLLDAVRLLESGVATREDIDEGMKLGCGHPMGPLTLLDFVGIDTV
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
YSIANIMFDEFREPRFAPPPLLRRMVLAGHFGRKSGQGFYSY
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA