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The map label for this gene is guaB [H]

Identifier: 159897729

GI number: 159897729

Start: 1382713

End: 1384191

Strand: Direct

Name: guaB [H]

Synonym: Haur_1200

Alternate gene names: 159897729

Gene position: 1382713-1384191 (Clockwise)

Preceding gene: 159897727

Following gene: 159897735

Centisome position: 21.79

GC content: 53.35

Gene sequence:

>1479_bases
ATGCCAATCGATTGGAGTGCTAAGTTCGCGTTTGAAGGGCTGACCTATGATGATGTGCTGTTGATTCCAGCCTACTCGGA
TGTCTTGCCTTCACAAATCGACGTTAGCACGTGGCTAACCCGCGAGATTCGTTTGAACATTCCAGTTGTCTCATCTGCGA
TGGATACGGTGACCGAAGATCGCATGGCAATTGCGCTGGCTCGCGAAGGTGGCCTTGGCATTATTCACAAAAATATGGCT
CCTGCCCAACAAGCAGATTTGGTGCGGCGGGTCAAACGCTCAGAAAGTGGCATGATCACTGATCCCATCACTTTGCGCCC
CGAACAAACCATCGGCGAAGCCTGGGAACTCATGAGCGATTACCATATTTCAGGGGTGCCGATTACCAGCGCTGCTGGCG
AACTCGTCGGGATACTTACCAACCGCGATTTACGCTTTGAAACCGACCCCAGCCGCAAAATCAGCGAATTGATGACCAGC
GAAGAATTGGTCACCGTGCCAGTTGGCACAACCCTCGAACAAGCCAAACAAGCCTTGCATCAACACCGGATCGAAAAGGT
TTTGGTGGTTGATGAACATGGCAAACTCAATGGTCTGATCACGGTCAAGGATATTCAAAAGCAGATCGAACATCCTAACG
CCACCAAAGATGCTTATGGCCGCTTGCGAGTTGGCGCTGCCGTCGGCGCTTCGACCAGCGAACTCGAGCGGGTGCGTTTG
TTGGTTGAGGCTGGGGTTGATGTGATTGCGGTCGATACTGCTCATGGCCACTCCAAAGCCGTGCTCGATGCAATTGCCCG
CATCAAACAACAATATCCTGAGCTGCAAATCATTGGTGGGAATGTGAGTACTGGCGAAGGTGCTCGTGCCTTGATCGAAC
ACGGCGCTGATGCGGTTAAGGTCGGACAAGGGCCCGGATCGATTTGTACCACTCGGGTGGTATCAGGTGCGGGGATGGCC
CAAGTTACAGCGGTAATGGAGTGTGTTAAAGCTGCCGAAGAAGCTGGCGTGCCAATCATTGCTGATGGTGGGATTAAGTA
TAGTGGTGATGTGGCCAAAGCACTGGCTGCCGGCGCACACACGGTTATGCTGGGTGGCTTATTAGCAGGAACCGACGAAT
CGCCAGGCGAGATGATTCTCTACCAAGGCCGCTCATTCAAATCGTATCGTGGCATGGGTTCGATTGGTGCGATGCAGCAA
GGCAGTAGCGACCGCTATTTCCAAAGCAACCAGCCTGCTCGCAAGTTGGTGGCCGAAGGAATTGAAGGGATGGTTCCCTA
CAAAGGCGCATTGGCCGATACCATTTATCAATTGGTCGGTGGTTTGCGCTCAGGTATGGGCTATGTTGGGGCGCATAATG
TTGATGAATTGCGCAAGAATGCCCGCTTCTCGCGGATTTCGCCCGCAGGTTTGGCCGAAAGCCATCCCCACGATGTAACG
ATCACCAACGAAGCTCCCAACTACGAGCGCCGCGGCTAG

Upstream 100 bases:

>100_bases
ATCGGCAATCGGACAACTGAAGGATGACGCAAGGTTCTGCGTCGGATGGCTCACTGCATCCTGCGGTGAGCTTTTCATAT
ATCCCAAGGAGGATAACCCC

Downstream 100 bases:

>100_bases
AATTCAAACCAGCCCTGCTTCCTTAAAATTGGAAGCAGGGCTGAAATGTTAACCAACCTGAGCGCTATCGTTGCCAACAG
CGGCTAAGGTTTCCTTTAAA

Product: inosine-5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 492; Mature: 491

Protein sequence:

>492_residues
MPIDWSAKFAFEGLTYDDVLLIPAYSDVLPSQIDVSTWLTREIRLNIPVVSSAMDTVTEDRMAIALAREGGLGIIHKNMA
PAQQADLVRRVKRSESGMITDPITLRPEQTIGEAWELMSDYHISGVPITSAAGELVGILTNRDLRFETDPSRKISELMTS
EELVTVPVGTTLEQAKQALHQHRIEKVLVVDEHGKLNGLITVKDIQKQIEHPNATKDAYGRLRVGAAVGASTSELERVRL
LVEAGVDVIAVDTAHGHSKAVLDAIARIKQQYPELQIIGGNVSTGEGARALIEHGADAVKVGQGPGSICTTRVVSGAGMA
QVTAVMECVKAAEEAGVPIIADGGIKYSGDVAKALAAGAHTVMLGGLLAGTDESPGEMILYQGRSFKSYRGMGSIGAMQQ
GSSDRYFQSNQPARKLVAEGIEGMVPYKGALADTIYQLVGGLRSGMGYVGAHNVDELRKNARFSRISPAGLAESHPHDVT
ITNEAPNYERRG

Sequences:

>Translated_492_residues
MPIDWSAKFAFEGLTYDDVLLIPAYSDVLPSQIDVSTWLTREIRLNIPVVSSAMDTVTEDRMAIALAREGGLGIIHKNMA
PAQQADLVRRVKRSESGMITDPITLRPEQTIGEAWELMSDYHISGVPITSAAGELVGILTNRDLRFETDPSRKISELMTS
EELVTVPVGTTLEQAKQALHQHRIEKVLVVDEHGKLNGLITVKDIQKQIEHPNATKDAYGRLRVGAAVGASTSELERVRL
LVEAGVDVIAVDTAHGHSKAVLDAIARIKQQYPELQIIGGNVSTGEGARALIEHGADAVKVGQGPGSICTTRVVSGAGMA
QVTAVMECVKAAEEAGVPIIADGGIKYSGDVAKALAAGAHTVMLGGLLAGTDESPGEMILYQGRSFKSYRGMGSIGAMQQ
GSSDRYFQSNQPARKLVAEGIEGMVPYKGALADTIYQLVGGLRSGMGYVGAHNVDELRKNARFSRISPAGLAESHPHDVT
ITNEAPNYERRG
>Mature_491_residues
PIDWSAKFAFEGLTYDDVLLIPAYSDVLPSQIDVSTWLTREIRLNIPVVSSAMDTVTEDRMAIALAREGGLGIIHKNMAP
AQQADLVRRVKRSESGMITDPITLRPEQTIGEAWELMSDYHISGVPITSAAGELVGILTNRDLRFETDPSRKISELMTSE
ELVTVPVGTTLEQAKQALHQHRIEKVLVVDEHGKLNGLITVKDIQKQIEHPNATKDAYGRLRVGAAVGASTSELERVRLL
VEAGVDVIAVDTAHGHSKAVLDAIARIKQQYPELQIIGGNVSTGEGARALIEHGADAVKVGQGPGSICTTRVVSGAGMAQ
VTAVMECVKAAEEAGVPIIADGGIKYSGDVAKALAAGAHTVMLGGLLAGTDESPGEMILYQGRSFKSYRGMGSIGAMQQG
SSDRYFQSNQPARKLVAEGIEGMVPYKGALADTIYQLVGGLRSGMGYVGAHNVDELRKNARFSRISPAGLAESHPHDVTI
TNEAPNYERRG

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI217035146, Length=455, Percent_Identity=43.5164835164835, Blast_Score=363, Evalue=1e-100,
Organism=Homo sapiens, GI156616279, Length=455, Percent_Identity=43.5164835164835, Blast_Score=362, Evalue=1e-100,
Organism=Homo sapiens, GI34328930, Length=455, Percent_Identity=43.5164835164835, Blast_Score=362, Evalue=1e-100,
Organism=Homo sapiens, GI34328928, Length=455, Percent_Identity=43.5164835164835, Blast_Score=362, Evalue=1e-100,
Organism=Homo sapiens, GI66933016, Length=455, Percent_Identity=42.4175824175824, Blast_Score=355, Evalue=4e-98,
Organism=Homo sapiens, GI217035152, Length=449, Percent_Identity=43.2071269487751, Blast_Score=352, Evalue=4e-97,
Organism=Homo sapiens, GI217035148, Length=455, Percent_Identity=42.6373626373626, Blast_Score=350, Evalue=1e-96,
Organism=Homo sapiens, GI217035150, Length=455, Percent_Identity=40.6593406593407, Blast_Score=323, Evalue=2e-88,
Organism=Homo sapiens, GI156104880, Length=260, Percent_Identity=39.2307692307692, Blast_Score=176, Evalue=3e-44,
Organism=Homo sapiens, GI50541956, Length=246, Percent_Identity=41.0569105691057, Blast_Score=176, Evalue=4e-44,
Organism=Homo sapiens, GI50541954, Length=246, Percent_Identity=41.0569105691057, Blast_Score=176, Evalue=4e-44,
Organism=Homo sapiens, GI50541952, Length=246, Percent_Identity=41.0569105691057, Blast_Score=176, Evalue=4e-44,
Organism=Homo sapiens, GI50541948, Length=246, Percent_Identity=41.0569105691057, Blast_Score=176, Evalue=4e-44,
Organism=Escherichia coli, GI1788855, Length=482, Percent_Identity=59.9585062240664, Blast_Score=523, Evalue=1e-149,
Organism=Escherichia coli, GI1786293, Length=256, Percent_Identity=38.28125, Blast_Score=168, Evalue=6e-43,
Organism=Caenorhabditis elegans, GI71994385, Length=497, Percent_Identity=34.8088531187123, Blast_Score=282, Evalue=3e-76,
Organism=Caenorhabditis elegans, GI71994389, Length=423, Percent_Identity=36.8794326241135, Blast_Score=269, Evalue=2e-72,
Organism=Caenorhabditis elegans, GI17560440, Length=259, Percent_Identity=38.996138996139, Blast_Score=177, Evalue=8e-45,
Organism=Saccharomyces cerevisiae, GI6323585, Length=494, Percent_Identity=40.6882591093117, Blast_Score=358, Evalue=1e-99,
Organism=Saccharomyces cerevisiae, GI6322012, Length=494, Percent_Identity=40.6882591093117, Blast_Score=357, Evalue=3e-99,
Organism=Saccharomyces cerevisiae, GI6323464, Length=464, Percent_Identity=42.6724137931034, Blast_Score=353, Evalue=5e-98,
Organism=Saccharomyces cerevisiae, GI6319352, Length=338, Percent_Identity=42.603550295858, Blast_Score=269, Evalue=9e-73,
Organism=Saccharomyces cerevisiae, GI6319353, Length=122, Percent_Identity=40.9836065573771, Blast_Score=88, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24641071, Length=494, Percent_Identity=40.080971659919, Blast_Score=347, Evalue=7e-96,
Organism=Drosophila melanogaster, GI24641073, Length=494, Percent_Identity=40.080971659919, Blast_Score=347, Evalue=7e-96,
Organism=Drosophila melanogaster, GI28571163, Length=452, Percent_Identity=39.6017699115044, Blast_Score=305, Evalue=6e-83,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 52606; Mature: 52474

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIDWSAKFAFEGLTYDDVLLIPAYSDVLPSQIDVSTWLTREIRLNIPVVSSAMDTVTED
CCCCCCCCEEECCCCCCCEEEEECHHHHCCCCCCHHHHEEEEEEECCCCHHHHHHHHHHC
RMAIALAREGGLGIIHKNMAPAQQADLVRRVKRSESGMITDPITLRPEQTIGEAWELMSD
CEEEEEECCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCEEECCHHHHHHHHHHHHC
YHISGVPITSAAGELVGILTNRDLRFETDPSRKISELMTSEELVTVPVGTTLEQAKQALH
CCCCCCCCCCCCCCEEEEEECCCEEECCCCHHHHHHHHCCCCEEEEECCCCHHHHHHHHH
QHRIEKVLVVDEHGKLNGLITVKDIQKQIEHPNATKDAYGRLRVGAAVGASTSELERVRL
HHHCCEEEEEECCCCCCCEEEHHHHHHHHCCCCCCHHHHCEEEECCCCCCCHHHHHHHHH
LVEAGVDVIAVDTAHGHSKAVLDAIARIKQQYPELQIIGGNVSTGEGARALIEHGADAVK
HHHCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCEEEECCCCCCCCHHHHHHHCCCCEEE
VGQGPGSICTTRVVSGAGMAQVTAVMECVKAAEEAGVPIIADGGIKYSGDVAKALAAGAH
ECCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCEEEECCCEEECCHHHHHHHCCCH
TVMLGGLLAGTDESPGEMILYQGRSFKSYRGMGSIGAMQQGSSDRYFQSNQPARKLVAEG
HHHHHHEEECCCCCCCCEEEEECCCCHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHH
IEGMVPYKGALADTIYQLVGGLRSGMGYVGAHNVDELRKNARFSRISPAGLAESHPHDVT
HCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCEE
ITNEAPNYERRG
ECCCCCCCCCCC
>Mature Secondary Structure 
PIDWSAKFAFEGLTYDDVLLIPAYSDVLPSQIDVSTWLTREIRLNIPVVSSAMDTVTED
CCCCCCCEEECCCCCCCEEEEECHHHHCCCCCCHHHHEEEEEEECCCCHHHHHHHHHHC
RMAIALAREGGLGIIHKNMAPAQQADLVRRVKRSESGMITDPITLRPEQTIGEAWELMSD
CEEEEEECCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCEEECCHHHHHHHHHHHHC
YHISGVPITSAAGELVGILTNRDLRFETDPSRKISELMTSEELVTVPVGTTLEQAKQALH
CCCCCCCCCCCCCCEEEEEECCCEEECCCCHHHHHHHHCCCCEEEEECCCCHHHHHHHHH
QHRIEKVLVVDEHGKLNGLITVKDIQKQIEHPNATKDAYGRLRVGAAVGASTSELERVRL
HHHCCEEEEEECCCCCCCEEEHHHHHHHHCCCCCCHHHHCEEEECCCCCCCHHHHHHHHH
LVEAGVDVIAVDTAHGHSKAVLDAIARIKQQYPELQIIGGNVSTGEGARALIEHGADAVK
HHHCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCEEEECCCCCCCCHHHHHHHCCCCEEE
VGQGPGSICTTRVVSGAGMAQVTAVMECVKAAEEAGVPIIADGGIKYSGDVAKALAAGAH
ECCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCEEEECCCEEECCHHHHHHHCCCH
TVMLGGLLAGTDESPGEMILYQGRSFKSYRGMGSIGAMQQGSSDRYFQSNQPARKLVAEG
HHHHHHEEECCCCCCCCEEEEECCCCHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHH
IEGMVPYKGALADTIYQLVGGLRSGMGYVGAHNVDELRKNARFSRISPAGLAESHPHDVT
HCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCEE
ITNEAPNYERRG
ECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]