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The map label for this gene is liaR [H]

Identifier: 159897633

GI number: 159897633

Start: 1264518

End: 1265174

Strand: Reverse

Name: liaR [H]

Synonym: Haur_1104

Alternate gene names: 159897633

Gene position: 1265174-1264518 (Counterclockwise)

Preceding gene: 159897634

Following gene: 159897632

Centisome position: 19.93

GC content: 51.9

Gene sequence:

>657_bases
ATGCAAGAGCAGATTCGAGTTGTTTTAGTTGATGATCATGTCGTGGTACGGGTAGGTTTACGTGCCTTCTTGGATACACA
GCCAGATATTGAAATTGTGGGCGAGGCCGCTTCGGGCGAAGAAGGCGTGCAGGTTGTGAGCCAAGTCTTGCCCGATGTGG
TGCTAATGGATTTGCTCATGCCTGGAATCGATGGCGTTGAAGCGACGCGCCAAGTGCGCGGAGCTTCACCACATACCCAA
GTAATCGTACTGACATCGTATAGCGAAGACGAGCGCATTTTTCCGGCGATCAAGGCTGGAGCACTCTCATATTTGCTCAA
AGATGTTGGGCCTGATGCCTTGGTGGCAGCAATTCGGGCAGCTCGACGGGGCGAGGCCACCTTACATCCAATGGTTGCTT
CACGCTTGATGACTGAACTTACCAGCTCACGCCGCTCGCCCTTGGACACCCTGACCGAGCGCGAACGCGAAGTATTGACG
TGCATTGCCCGTGGCATGAGCAACGCCGAAATTGCCGAGCATTTGGTGATCGGTGAGCGCACTGTCAAAACCCATGTCAG
CAATATTTTATCCAAATTACACCTGCAAGATCGAACTCAAGCAGCAATTATGGCTTTACGCGAGCGCTTAGTGCCACTTG
ATGACGAACAAAAATAA

Upstream 100 bases:

>100_bases
CTGCTGCGCCAGGCCAAGGCACAAGCCTACGCATCGTTGTACCACGAACCCAAACTGGGCTACTGGTCGAGCCACGTTGA
TAGCCAAGAAGGAAAGCACC

Downstream 100 bases:

>100_bases
TAAATGCTTGCAACAATTCATCGATTGTTAACGTTGTATCAACACCGCAGCTAGATTAGGAGCATTGTATGAGTGGAATC
GCAATTACTGCTGAAGGGTT

Product: two component LuxR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 218; Mature: 218

Protein sequence:

>218_residues
MQEQIRVVLVDDHVVVRVGLRAFLDTQPDIEIVGEAASGEEGVQVVSQVLPDVVLMDLLMPGIDGVEATRQVRGASPHTQ
VIVLTSYSEDERIFPAIKAGALSYLLKDVGPDALVAAIRAARRGEATLHPMVASRLMTELTSSRRSPLDTLTEREREVLT
CIARGMSNAEIAEHLVIGERTVKTHVSNILSKLHLQDRTQAAIMALRERLVPLDDEQK

Sequences:

>Translated_218_residues
MQEQIRVVLVDDHVVVRVGLRAFLDTQPDIEIVGEAASGEEGVQVVSQVLPDVVLMDLLMPGIDGVEATRQVRGASPHTQ
VIVLTSYSEDERIFPAIKAGALSYLLKDVGPDALVAAIRAARRGEATLHPMVASRLMTELTSSRRSPLDTLTEREREVLT
CIARGMSNAEIAEHLVIGERTVKTHVSNILSKLHLQDRTQAAIMALRERLVPLDDEQK
>Mature_218_residues
MQEQIRVVLVDDHVVVRVGLRAFLDTQPDIEIVGEAASGEEGVQVVSQVLPDVVLMDLLMPGIDGVEATRQVRGASPHTQ
VIVLTSYSEDERIFPAIKAGALSYLLKDVGPDALVAAIRAARRGEATLHPMVASRLMTELTSSRRSPLDTLTEREREVLT
CIARGMSNAEIAEHLVIGERTVKTHVSNILSKLHLQDRTQAAIMALRERLVPLDDEQK

Specific function: Member of the two-component regulatory system liaS/liaR probably involved in response to a subset of cell wall-active antibiotics that interfere with the lipid II cycle in the cytoplasmic membrane (bacitracin, nisin, ramoplanin and vancomycin). Seems also

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788521, Length=206, Percent_Identity=37.8640776699029, Blast_Score=139, Evalue=2e-34,
Organism=Escherichia coli, GI1788222, Length=209, Percent_Identity=34.4497607655502, Blast_Score=127, Evalue=4e-31,
Organism=Escherichia coli, GI1787473, Length=214, Percent_Identity=37.3831775700935, Blast_Score=124, Evalue=3e-30,
Organism=Escherichia coli, GI1790102, Length=199, Percent_Identity=33.6683417085427, Blast_Score=101, Evalue=3e-23,
Organism=Escherichia coli, GI1788712, Length=207, Percent_Identity=29.4685990338164, Blast_Score=99, Evalue=2e-22,
Organism=Escherichia coli, GI1786747, Length=190, Percent_Identity=25.7894736842105, Blast_Score=81, Evalue=7e-17,
Organism=Escherichia coli, GI87082052, Length=105, Percent_Identity=38.0952380952381, Blast_Score=72, Evalue=2e-14,
Organism=Escherichia coli, GI1787277, Length=114, Percent_Identity=35.0877192982456, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1788550, Length=109, Percent_Identity=34.8623853211009, Blast_Score=64, Evalue=8e-12,
Organism=Escherichia coli, GI1788546, Length=203, Percent_Identity=26.1083743842365, Blast_Score=61, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 23912; Mature: 23912

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00622 HTH_LUXR_1 ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQEQIRVVLVDDHVVVRVGLRAFLDTQPDIEIVGEAASGEEGVQVVSQVLPDVVLMDLLM
CCCCEEEEEECCHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHH
PGIDGVEATRQVRGASPHTQVIVLTSYSEDERIFPAIKAGALSYLLKDVGPDALVAAIRA
CCCCCHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
ARRGEATLHPMVASRLMTELTSSRRSPLDTLTEREREVLTCIARGMSNAEIAEHLVIGER
HHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCHH
TVKTHVSNILSKLHLQDRTQAAIMALRERLVPLDDEQK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MQEQIRVVLVDDHVVVRVGLRAFLDTQPDIEIVGEAASGEEGVQVVSQVLPDVVLMDLLM
CCCCEEEEEECCHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHH
PGIDGVEATRQVRGASPHTQVIVLTSYSEDERIFPAIKAGALSYLLKDVGPDALVAAIRA
CCCCCHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
ARRGEATLHPMVASRLMTELTSSRRSPLDTLTEREREVLTCIARGMSNAEIAEHLVIGER
HHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCHH
TVKTHVSNILSKLHLQDRTQAAIMALRERLVPLDDEQK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9639930; 9384377 [H]