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The map label for this gene is copA [H]

Identifier: 159897610

GI number: 159897610

Start: 1237412

End: 1238533

Strand: Reverse

Name: copA [H]

Synonym: Haur_1081

Alternate gene names: 159897610

Gene position: 1238533-1237412 (Counterclockwise)

Preceding gene: 159897611

Following gene: 159897609

Centisome position: 19.51

GC content: 50.45

Gene sequence:

>1122_bases
ATGGATCGCAACGAACAACAACCTATCGAACAAGTATTAAATGCCCCAACCTCGCGCCGCAGCTTCTTGCGCTGGACAGG
GATGGCGGCAGCCGCAGGAACCATGGTCGCATGTGGCCGCGAAAGTGCGCTAACTGTTGAGCCAGCAACCGTACCACCAG
CAAGTGCCACGACCGCTGCCGCAGGCACCGATCATAGCAATGGTGGCCATAATAGCACTGGCAATGCTGGAACTCCTACC
ACCGACAGCGGGCTAAAAGCATGGGAAGAAATGGATAAGATGCATGAAGCCGGGGTTAAGCTGTTCCCAGCTAAAACCGA
AGGCCTGAGCATGCAGCCCCTCGAATATCGCATGGAAGGCGATGTAAAAGTTTTTGAATTGACCTGCGAAAAAACCATGT
GGGAAGTTGAACCAGGCCGCAAACTTGAAGCTTGGACCTATAATGGTCAATTGCCTGGACCAGAAATTCGCGTCACTGAA
GGCGACAAAGTGAAGATTTTGGTCACTAATAACCTTGATGAAAGCACCGCCGTTCACTGGCACGGTTTGTATGTGCCCAA
CAATCAAGATGGTGTGCCATTTATCACTCAGCCACCAATCACACCTGGCTCAACCTATACCTATGAGTTTACGGTGCGCA
ACTCTGGCTCGCATATGTATCACTCGCACCATAACTCGACCAAACAAGTTTCAATGGGCTTGCTTGGGCCATTTATCGTT
GAGCCAAAAGATAAGAGCAAAGATCCTGCATCGGACAAAGAATTTATTTTGGTGCTGAATGATACCGCCCAAGGTTTCAC
GATCAACGGCAAAGGCTTCCCAGCCACCCAACCATTGACTGCCAAATTGGGGCAAAAAATTCGCATTCGCTATATGAACG
AAGGCTTGATGATTCACCCAATGCACTTGCACGGCTTGCCCCAGTTGGTTTTTGCCAAAGATGGCTGGAACTTACCCCAA
CCATACATGTGCGATACGCTCAACGTCGCGCCAGGCGAACGCTGGGATGTAATTGTCGATTGTACTGACCCAGGTGTCTG
GGCCTTCCACTGCCACATTTTGTCACACGCCGAAAGTGAACACGGCATGTTTGGGATGGTTACAGCGCTAATCGTCGAAT
AG

Upstream 100 bases:

>100_bases
CGAACGGTAGACAAATCTTATAGTTTGGGCTGGGCATTGGCAAGTACACTACATCCATATCAAGGACGATATACCGTGTA
ATTTAGGGGGACACACGATC

Downstream 100 bases:

>100_bases
GAGCGCGACCATGAGTATCGTGTACGATATTTTGATCATTGGCGGCGGACCATCGGCATTGGCTGCGGCATTTTATGCCC
AAAACAAGCAATTACGCACG

Product: multicopper oxidase type 3

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 373; Mature: 373

Protein sequence:

>373_residues
MDRNEQQPIEQVLNAPTSRRSFLRWTGMAAAAGTMVACGRESALTVEPATVPPASATTAAAGTDHSNGGHNSTGNAGTPT
TDSGLKAWEEMDKMHEAGVKLFPAKTEGLSMQPLEYRMEGDVKVFELTCEKTMWEVEPGRKLEAWTYNGQLPGPEIRVTE
GDKVKILVTNNLDESTAVHWHGLYVPNNQDGVPFITQPPITPGSTYTYEFTVRNSGSHMYHSHHNSTKQVSMGLLGPFIV
EPKDKSKDPASDKEFILVLNDTAQGFTINGKGFPATQPLTAKLGQKIRIRYMNEGLMIHPMHLHGLPQLVFAKDGWNLPQ
PYMCDTLNVAPGERWDVIVDCTDPGVWAFHCHILSHAESEHGMFGMVTALIVE

Sequences:

>Translated_373_residues
MDRNEQQPIEQVLNAPTSRRSFLRWTGMAAAAGTMVACGRESALTVEPATVPPASATTAAAGTDHSNGGHNSTGNAGTPT
TDSGLKAWEEMDKMHEAGVKLFPAKTEGLSMQPLEYRMEGDVKVFELTCEKTMWEVEPGRKLEAWTYNGQLPGPEIRVTE
GDKVKILVTNNLDESTAVHWHGLYVPNNQDGVPFITQPPITPGSTYTYEFTVRNSGSHMYHSHHNSTKQVSMGLLGPFIV
EPKDKSKDPASDKEFILVLNDTAQGFTINGKGFPATQPLTAKLGQKIRIRYMNEGLMIHPMHLHGLPQLVFAKDGWNLPQ
PYMCDTLNVAPGERWDVIVDCTDPGVWAFHCHILSHAESEHGMFGMVTALIVE
>Mature_373_residues
MDRNEQQPIEQVLNAPTSRRSFLRWTGMAAAAGTMVACGRESALTVEPATVPPASATTAAAGTDHSNGGHNSTGNAGTPT
TDSGLKAWEEMDKMHEAGVKLFPAKTEGLSMQPLEYRMEGDVKVFELTCEKTMWEVEPGRKLEAWTYNGQLPGPEIRVTE
GDKVKILVTNNLDESTAVHWHGLYVPNNQDGVPFITQPPITPGSTYTYEFTVRNSGSHMYHSHHNSTKQVSMGLLGPFIV
EPKDKSKDPASDKEFILVLNDTAQGFTINGKGFPATQPLTAKLGQKIRIRYMNEGLMIHPMHLHGLPQLVFAKDGWNLPQ
PYMCDTLNVAPGERWDVIVDCTDPGVWAFHCHILSHAESEHGMFGMVTALIVE

Specific function: Mediates copper resistance by sequestration of copper in the periplasm along with the copper-binding protein CopC. May have oxidase activity [H]

COG id: COG2132

COG function: function code Q; Putative multicopper oxidases

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multicopper oxidase family. CopA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786314, Length=235, Percent_Identity=29.7872340425532, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1789394, Length=252, Percent_Identity=25.7936507936508, Blast_Score=75, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6323703, Length=120, Percent_Identity=45, Blast_Score=88, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6320714, Length=297, Percent_Identity=26.9360269360269, Blast_Score=78, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6321067, Length=226, Percent_Identity=30.0884955752212, Blast_Score=77, Evalue=7e-15,
Organism=Drosophila melanogaster, GI18859919, Length=231, Percent_Identity=31.1688311688312, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI24650186, Length=225, Percent_Identity=30.2222222222222, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI221330000, Length=243, Percent_Identity=31.2757201646091, Blast_Score=86, Evalue=6e-17,
Organism=Drosophila melanogaster, GI24585842, Length=243, Percent_Identity=31.2757201646091, Blast_Score=85, Evalue=6e-17,
Organism=Drosophila melanogaster, GI221329998, Length=243, Percent_Identity=31.2757201646091, Blast_Score=85, Evalue=6e-17,
Organism=Drosophila melanogaster, GI281360167, Length=243, Percent_Identity=31.2757201646091, Blast_Score=85, Evalue=7e-17,
Organism=Drosophila melanogaster, GI28574104, Length=105, Percent_Identity=44.7619047619048, Blast_Score=83, Evalue=3e-16,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001117
- InterPro:   IPR011706
- InterPro:   IPR011707
- InterPro:   IPR006376
- InterPro:   IPR002355
- InterPro:   IPR008972
- InterPro:   IPR006311 [H]

Pfam domain/function: PF00394 Cu-oxidase; PF07731 Cu-oxidase_2; PF07732 Cu-oxidase_3 [H]

EC number: NA

Molecular weight: Translated: 40992; Mature: 40992

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDRNEQQPIEQVLNAPTSRRSFLRWTGMAAAAGTMVACGRESALTVEPATVPPASATTAA
CCCCCCCHHHHHHCCCCCHHHHEEECCCHHHCCEEEECCCCCEEEECCCCCCCCCCCEEE
AGTDHSNGGHNSTGNAGTPTTDSGLKAWEEMDKMHEAGVKLFPAKTEGLSMQPLEYRMEG
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCEEEEECC
DVKVFELTCEKTMWEVEPGRKLEAWTYNGQLPGPEIRVTEGDKVKILVTNNLDESTAVHW
CEEEEEEEECCEEEECCCCCEEEEEEECCCCCCCEEEEECCCEEEEEEECCCCCCCEEEE
HGLYVPNNQDGVPFITQPPITPGSTYTYEFTVRNSGSHMYHSHHNSTKQVSMGLLGPFIV
EEEECCCCCCCCCEEECCCCCCCCEEEEEEEEECCCCEEEECCCCCCCEEECCCCCCEEE
EPKDKSKDPASDKEFILVLNDTAQGFTINGKGFPATQPLTAKLGQKIRIRYMNEGLMIHP
CCCCCCCCCCCCCEEEEEECCCCCCEEECCCCCCCCCCHHHHCCCEEEEEEECCCCEEEE
MHLHGLPQLVFAKDGWNLPQPYMCDTLNVAPGERWDVIVDCTDPGVWAFHCHILSHAESE
HHHCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCEEEEEEEEECCCCCC
HGMFGMVTALIVE
CCHHEEEEEHCCC
>Mature Secondary Structure
MDRNEQQPIEQVLNAPTSRRSFLRWTGMAAAAGTMVACGRESALTVEPATVPPASATTAA
CCCCCCCHHHHHHCCCCCHHHHEEECCCHHHCCEEEECCCCCEEEECCCCCCCCCCCEEE
AGTDHSNGGHNSTGNAGTPTTDSGLKAWEEMDKMHEAGVKLFPAKTEGLSMQPLEYRMEG
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCEEEEECC
DVKVFELTCEKTMWEVEPGRKLEAWTYNGQLPGPEIRVTEGDKVKILVTNNLDESTAVHW
CEEEEEEEECCEEEECCCCCEEEEEEECCCCCCCEEEEECCCEEEEEEECCCCCCCEEEE
HGLYVPNNQDGVPFITQPPITPGSTYTYEFTVRNSGSHMYHSHHNSTKQVSMGLLGPFIV
EEEECCCCCCCCCEEECCCCCCCCEEEEEEEEECCCCEEEECCCCCCCEEECCCCCCEEE
EPKDKSKDPASDKEFILVLNDTAQGFTINGKGFPATQPLTAKLGQKIRIRYMNEGLMIHP
CCCCCCCCCCCCCEEEEEECCCCCCEEECCCCCCCCCCHHHHCCCEEEEEEECCCCEEEE
MHLHGLPQLVFAKDGWNLPQPYMCDTLNVAPGERWDVIVDCTDPGVWAFHCHILSHAESE
HHHCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCEEEEEEEEECCCCCC
HGMFGMVTALIVE
CCHHEEEEEHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3372485; 1924351 [H]