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The map label for this gene is cobD [H]

Identifier: 159897581

GI number: 159897581

Start: 1201129

End: 1202280

Strand: Reverse

Name: cobD [H]

Synonym: Haur_1052

Alternate gene names: 159897581

Gene position: 1202280-1201129 (Counterclockwise)

Preceding gene: 159897582

Following gene: 159897580

Centisome position: 18.94

GC content: 51.22

Gene sequence:

>1152_bases
ATGCAGCAGCCAATTCATGGGGCAATTGATTATGCTGAATTGCAGCAACGTGGGCTTGTAGCCAGCCAAATTGATGATTT
CAGCAGCAACGTCAATCCGCTTGGCACGCCGAGTTTTATTCGCGAAGCGCTGGCAACTGTTGATTTGGCGCATTACCCCG
ATCGTCAATCGTTGGCCTTGCGGGCGGCGCTGGCCAAACGCCATTGTTGTGAACTTGAACAGCTATTGATTGGTAATGGT
AGCAATGAGTTAATTCATCTGATTGCGCGGGCCTTGTTGCAACCAAACGATCCAGTTTTGTTGATTGAACCAACCTTTGG
CGAATATGCCTATGCTAGCAGCTTGGCTGGCGCTCAATTGTTGCGCTATCAAGCAACCAGCGAAACTGGATTTGCAATTG
ATATTGTAGCTTGTTGTCATTTGATCAAGCAACATCGCCCGCGCTTGGTTTGGCTGTGCAATCCCAATAATCCCACTGGC
AGCTATTTGGATGCTGAAGCGATTGCCCAACTTCAAGCAGCGTGTACCACAGTTCAAGCCTATTTGGTGCTCGATTTGGC
GTATGCTGATTTGGTTGTTGGGGATTGGGGATTGGGGATTGGGGATTGGGGATTGGGTGAATCGAATTCCTCTCGCCGAC
AAGACGGGCGAGAGTCTGGGAACGGGGGAAGGTTAACCAGCCCCCAGCTCCCAGCCCCCGACAACCATCATCAGATTATT
TATCTCTACTCGTTGACCAAAAGCTATGCCTTGGCGGGGTTGCGTTTGGGCTATGTGGTGGCTGAGCAAGCGGTTATCGC
TCGCTTGCAGCGTTGGCAGCCGCAATGGAGCGTCAATAGTTTGGCTCAGGCCGCAGGTCTAGCGATTTGCCAACATCCAC
ATTGGCTAGCCCAACAGCTTGAGCAATGGTGGATTTGGAGCGAACAATTACGCCAGGGTTTGAGCCAACTTAGCTTGAAG
GTCTTGCCAAGCTGCTTGCCATTTTTCTTAGTTGAAGTGGCGAACGCCCAGCAAACCCGTAGTGCGCTGCTTAACCACGC
TTGTTTGGTGCGCGATTGTAGCTCATTTGGTTTGCCGCAGTTTGTACGGATCGCCCCGCGCCAACCAGCGGCAAATCAAC
GCTTGTTGAATGCTTGGAGAAGTTTATGCTAG

Upstream 100 bases:

>100_bases
GAGCCAACCAGCAAATCGCCGCCGCTGCCAACGCAGTTTATCTGGTTGTGGCGGGCATTGCGATCGAAGTTCGCCAACTG
CAAGCAGCGTGGGCCAAGTA

Downstream 100 bases:

>100_bases
CCCCAGTTTTGATGGTTGTCGGAACCGCCTCATCAGTTGGTAAAAGCACCTTGGTTAGTGCACTTTGCCGCATTGCTGCC
CGCCGTGGCATTCGCGTCGC

Product: class I and II aminotransferase

Products: NA

Alternate protein names: L-threonine-O-3-phosphate decarboxylase [H]

Number of amino acids: Translated: 383; Mature: 383

Protein sequence:

>383_residues
MQQPIHGAIDYAELQQRGLVASQIDDFSSNVNPLGTPSFIREALATVDLAHYPDRQSLALRAALAKRHCCELEQLLIGNG
SNELIHLIARALLQPNDPVLLIEPTFGEYAYASSLAGAQLLRYQATSETGFAIDIVACCHLIKQHRPRLVWLCNPNNPTG
SYLDAEAIAQLQAACTTVQAYLVLDLAYADLVVGDWGLGIGDWGLGESNSSRRQDGRESGNGGRLTSPQLPAPDNHHQII
YLYSLTKSYALAGLRLGYVVAEQAVIARLQRWQPQWSVNSLAQAAGLAICQHPHWLAQQLEQWWIWSEQLRQGLSQLSLK
VLPSCLPFFLVEVANAQQTRSALLNHACLVRDCSSFGLPQFVRIAPRQPAANQRLLNAWRSLC

Sequences:

>Translated_383_residues
MQQPIHGAIDYAELQQRGLVASQIDDFSSNVNPLGTPSFIREALATVDLAHYPDRQSLALRAALAKRHCCELEQLLIGNG
SNELIHLIARALLQPNDPVLLIEPTFGEYAYASSLAGAQLLRYQATSETGFAIDIVACCHLIKQHRPRLVWLCNPNNPTG
SYLDAEAIAQLQAACTTVQAYLVLDLAYADLVVGDWGLGIGDWGLGESNSSRRQDGRESGNGGRLTSPQLPAPDNHHQII
YLYSLTKSYALAGLRLGYVVAEQAVIARLQRWQPQWSVNSLAQAAGLAICQHPHWLAQQLEQWWIWSEQLRQGLSQLSLK
VLPSCLPFFLVEVANAQQTRSALLNHACLVRDCSSFGLPQFVRIAPRQPAANQRLLNAWRSLC
>Mature_383_residues
MQQPIHGAIDYAELQQRGLVASQIDDFSSNVNPLGTPSFIREALATVDLAHYPDRQSLALRAALAKRHCCELEQLLIGNG
SNELIHLIARALLQPNDPVLLIEPTFGEYAYASSLAGAQLLRYQATSETGFAIDIVACCHLIKQHRPRLVWLCNPNNPTG
SYLDAEAIAQLQAACTTVQAYLVLDLAYADLVVGDWGLGIGDWGLGESNSSRRQDGRESGNGGRLTSPQLPAPDNHHQII
YLYSLTKSYALAGLRLGYVVAEQAVIARLQRWQPQWSVNSLAQAAGLAICQHPHWLAQQLEQWWIWSEQLRQGLSQLSLK
VLPSCLPFFLVEVANAQQTRSALLNHACLVRDCSSFGLPQFVRIAPRQPAANQRLLNAWRSLC

Specific function: Decarboxylates L-threonine-O-3-phosphate to yield (R)-1- amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin [H]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR005860
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.1.1.81 [H]

Molecular weight: Translated: 42269; Mature: 42269

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
0.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQQPIHGAIDYAELQQRGLVASQIDDFSSNVNPLGTPSFIREALATVDLAHYPDRQSLAL
CCCCCCCHHHHHHHHHCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHH
RAALAKRHCCELEQLLIGNGSNELIHLIARALLQPNDPVLLIEPTFGEYAYASSLAGAQL
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHH
LRYQATSETGFAIDIVACCHLIKQHRPRLVWLCNPNNPTGSYLDAEAIAQLQAACTTVQA
HHHHCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHH
YLVLDLAYADLVVGDWGLGIGDWGLGESNSSRRQDGRESGNGGRLTSPQLPAPDNHHQII
HHHHHHHHHHHEEECCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCEEE
YLYSLTKSYALAGLRLGYVVAEQAVIARLQRWQPQWSVNSLAQAAGLAICQHPHWLAQQL
EEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCHHHHHHH
EQWWIWSEQLRQGLSQLSLKVLPSCLPFFLVEVANAQQTRSALLNHACLVRDCSSFGLPQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCH
FVRIAPRQPAANQRLLNAWRSLC
HHHCCCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure
MQQPIHGAIDYAELQQRGLVASQIDDFSSNVNPLGTPSFIREALATVDLAHYPDRQSLAL
CCCCCCCHHHHHHHHHCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHH
RAALAKRHCCELEQLLIGNGSNELIHLIARALLQPNDPVLLIEPTFGEYAYASSLAGAQL
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHH
LRYQATSETGFAIDIVACCHLIKQHRPRLVWLCNPNNPTGSYLDAEAIAQLQAACTTVQA
HHHHCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHH
YLVLDLAYADLVVGDWGLGIGDWGLGESNSSRRQDGRESGNGGRLTSPQLPAPDNHHQII
HHHHHHHHHHHEEECCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCEEE
YLYSLTKSYALAGLRLGYVVAEQAVIARLQRWQPQWSVNSLAQAAGLAICQHPHWLAQQL
EEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCHHHHHHH
EQWWIWSEQLRQGLSQLSLKVLPSCLPFFLVEVANAQQTRSALLNHACLVRDCSSFGLPQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCH
FVRIAPRQPAANQRLLNAWRSLC
HHHCCCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]