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The map label for this gene is hemN [H]

Identifier: 159897530

GI number: 159897530

Start: 1145734

End: 1147008

Strand: Reverse

Name: hemN [H]

Synonym: Haur_1001

Alternate gene names: 159897530

Gene position: 1147008-1145734 (Counterclockwise)

Preceding gene: 159897532

Following gene: 159897529

Centisome position: 18.07

GC content: 51.29

Gene sequence:

>1275_bases
ATGACAACACATGCAATCAAACATCTTTACGTTCATATACCATTTTGCCAAACCCGTTGTGCCTATTGCGATTTCAATAC
CTTTGCCAATCGCGAAGATTTTATGCAGCGCTATATTGATGCGCTGTGCCTGCATCTCAAGCGCATGGCGAGCGGCGAGA
CAATCGCTGACCCAACATGGCCGCAGGTCGCGGATGGGCCGATTCCGTGGGCAAGCTATCAATTACACGATCTTGTTGGG
CCGTTACAACAGGCCGATTTGCCCGCGACGGTGTTTCTGGGCGGCGGCACGCCAACTGCGCTACCATTGCACTTACTTGA
ACAGTTGATGCAAACAATCGGCCAAATTATTCCGCTGGCGCAGGCCGAAGTAACCAGCGAAGCCAACCCAGGCACGGTGC
TCGACCACAATTATCTACGGGCAATGCGGTCGATGGGGATTAATCGCCTAAGTATGGGCGTGCAAACCTTGCATGACCCA
ACCTTGCGGGTGTTGGGGCGGATTCATACCGCCAGCGAGGCCTATGCCTCGTATCAAGCAGCTCGTAAAGTTGGCTTCGA
AAATATCAATCTTGATTTTATGTTTGGCTTACCAGGCCAAGATACTGCTCAATGGCGAGCGATGCTCAACGAAATTGTAG
GTTGGGATGCTGAGCATTTTGCGCTGTATTCATTAATTGTCGAGCCAAGCACACCGCTAGCCGCCCAAGTAACTGCTGGT
CGGGTCAGCATTCCCAACGACGATGCGACTGGCGAAATGTATGAAGCTGCGATGGAAATTTTAGGGGCGGCTGGTTATGG
CCATTATGAGATTTCCAATTGGGCCAAAACGCAGAACTCAGCGTTTAACCCAAGCGAGCGTTTGCCGGCCTATGCATCGC
GCCACAATGTGGCCTATTGGCTCAACGCCGATTATTTGGGAGTTGGGGCTGGTGCACATAGCCATTGGCGGGGCTGGCGC
TGGGTCGATCAACGGATCTTAGAGCCTTTTGCTCAGCAGGTTGAACATGGTCAAGCACCGTTAATCGATATCCAAGTATG
CGAGCCACAAGACCGCGATTTTGAAACAATTATGATGGGATTGCGGCTCAATTGTGGTTTAGGCTTTGCCCACTTTCAAC
AACGGACAGGCCACGATTTGCTTGCGCAGTATCAGCCGATAATCGAACAATTGGTTGGGCAAGGCTTGCTCGAACAAACC
ACCAACGCCATTCGGTTTACCCCCCGTGGCCGAATGGTTGGCAATCAAGTGATTGAACGTTTTTTGCTTGATTAA

Upstream 100 bases:

>100_bases
ACCTAGCTAGTGTACTACGAGTTAATCGCTTGCCAAGCCCTTGTCATAGATGTTCAAAAACAGCATGGCGTAAAGCCAAA
AATCGCACTACAATAGAGCC

Downstream 100 bases:

>100_bases
GCAGCAGCGATTTTGACATAAACCAAGCATCAACGCTACAATTGGGCCAGACCTCGCACTTGTCCCGCCGCTTGTGAGTA
CTAATTAGGAGGCATCTCAA

Product: putative oxygen-independent coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 424; Mature: 423

Protein sequence:

>424_residues
MTTHAIKHLYVHIPFCQTRCAYCDFNTFANREDFMQRYIDALCLHLKRMASGETIADPTWPQVADGPIPWASYQLHDLVG
PLQQADLPATVFLGGGTPTALPLHLLEQLMQTIGQIIPLAQAEVTSEANPGTVLDHNYLRAMRSMGINRLSMGVQTLHDP
TLRVLGRIHTASEAYASYQAARKVGFENINLDFMFGLPGQDTAQWRAMLNEIVGWDAEHFALYSLIVEPSTPLAAQVTAG
RVSIPNDDATGEMYEAAMEILGAAGYGHYEISNWAKTQNSAFNPSERLPAYASRHNVAYWLNADYLGVGAGAHSHWRGWR
WVDQRILEPFAQQVEHGQAPLIDIQVCEPQDRDFETIMMGLRLNCGLGFAHFQQRTGHDLLAQYQPIIEQLVGQGLLEQT
TNAIRFTPRGRMVGNQVIERFLLD

Sequences:

>Translated_424_residues
MTTHAIKHLYVHIPFCQTRCAYCDFNTFANREDFMQRYIDALCLHLKRMASGETIADPTWPQVADGPIPWASYQLHDLVG
PLQQADLPATVFLGGGTPTALPLHLLEQLMQTIGQIIPLAQAEVTSEANPGTVLDHNYLRAMRSMGINRLSMGVQTLHDP
TLRVLGRIHTASEAYASYQAARKVGFENINLDFMFGLPGQDTAQWRAMLNEIVGWDAEHFALYSLIVEPSTPLAAQVTAG
RVSIPNDDATGEMYEAAMEILGAAGYGHYEISNWAKTQNSAFNPSERLPAYASRHNVAYWLNADYLGVGAGAHSHWRGWR
WVDQRILEPFAQQVEHGQAPLIDIQVCEPQDRDFETIMMGLRLNCGLGFAHFQQRTGHDLLAQYQPIIEQLVGQGLLEQT
TNAIRFTPRGRMVGNQVIERFLLD
>Mature_423_residues
TTHAIKHLYVHIPFCQTRCAYCDFNTFANREDFMQRYIDALCLHLKRMASGETIADPTWPQVADGPIPWASYQLHDLVGP
LQQADLPATVFLGGGTPTALPLHLLEQLMQTIGQIIPLAQAEVTSEANPGTVLDHNYLRAMRSMGINRLSMGVQTLHDPT
LRVLGRIHTASEAYASYQAARKVGFENINLDFMFGLPGQDTAQWRAMLNEIVGWDAEHFALYSLIVEPSTPLAAQVTAGR
VSIPNDDATGEMYEAAMEILGAAGYGHYEISNWAKTQNSAFNPSERLPAYASRHNVAYWLNADYLGVGAGAHSHWRGWRW
VDQRILEPFAQQVEHGQAPLIDIQVCEPQDRDFETIMMGLRLNCGLGFAHFQQRTGHDLLAQYQPIIEQLVGQGLLEQTT
NAIRFTPRGRMVGNQVIERFLLD

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=356, Percent_Identity=31.7415730337079, Blast_Score=166, Evalue=4e-41,
Organism=Escherichia coli, GI1789325, Length=425, Percent_Identity=30.5882352941176, Blast_Score=184, Evalue=8e-48,
Organism=Escherichia coli, GI87082341, Length=426, Percent_Identity=24.8826291079812, Blast_Score=108, Evalue=7e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004559
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 47398; Mature: 47267

Theoretical pI: Translated: 5.78; Mature: 5.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTHAIKHLYVHIPFCQTRCAYCDFNTFANREDFMQRYIDALCLHLKRMASGETIADPTW
CCCHHEEEEEEECCHHHHHHHEECCHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
PQVADGPIPWASYQLHDLVGPLQQADLPATVFLGGGTPTALPLHLLEQLMQTIGQIIPLA
CCCCCCCCCCCCCHHHHHHCHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCH
QAEVTSEANPGTVLDHNYLRAMRSMGINRLSMGVQTLHDPTLRVLGRIHTASEAYASYQA
HHHHCCCCCCCCEECHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
ARKVGFENINLDFMFGLPGQDTAQWRAMLNEIVGWDAEHFALYSLIVEPSTPLAAQVTAG
HHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCHHHHEEEHEEECCCCCCEEEEECC
RVSIPNDDATGEMYEAAMEILGAAGYGHYEISNWAKTQNSAFNPSERLPAYASRHNVAYW
EEECCCCCCCHHHHHHHHHHHHCCCCCCEECCCHHHCCCCCCCCHHCCCCHHCCCCEEEE
LNADYLGVGAGAHSHWRGWRWVDQRILEPFAQQVEHGQAPLIDIQVCEPQDRDFETIMMG
ECCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHH
LRLNCGLGFAHFQQRTGHDLLAQYQPIIEQLVGQGLLEQTTNAIRFTPRGRMVGNQVIER
HHHCCCCCHHHHHHHCCHHHHHHHHHHHHHHHCCHHHHHCCCCEEECCCCCHHHHHHHHH
FLLD
HHCC
>Mature Secondary Structure 
TTHAIKHLYVHIPFCQTRCAYCDFNTFANREDFMQRYIDALCLHLKRMASGETIADPTW
CCHHEEEEEEECCHHHHHHHEECCHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
PQVADGPIPWASYQLHDLVGPLQQADLPATVFLGGGTPTALPLHLLEQLMQTIGQIIPLA
CCCCCCCCCCCCCHHHHHHCHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCH
QAEVTSEANPGTVLDHNYLRAMRSMGINRLSMGVQTLHDPTLRVLGRIHTASEAYASYQA
HHHHCCCCCCCCEECHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
ARKVGFENINLDFMFGLPGQDTAQWRAMLNEIVGWDAEHFALYSLIVEPSTPLAAQVTAG
HHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCHHHHEEEHEEECCCCCCEEEEECC
RVSIPNDDATGEMYEAAMEILGAAGYGHYEISNWAKTQNSAFNPSERLPAYASRHNVAYW
EEECCCCCCCHHHHHHHHHHHHCCCCCCEECCCHHHCCCCCCCCHHCCCCHHCCCCEEEE
LNADYLGVGAGAHSHWRGWRWVDQRILEPFAQQVEHGQAPLIDIQVCEPQDRDFETIMMG
ECCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHH
LRLNCGLGFAHFQQRTGHDLLAQYQPIIEQLVGQGLLEQTTNAIRFTPRGRMVGNQVIER
HHHCCCCCHHHHHHHCCHHHHHHHHHHHHHHHCCHHHHHCCCCEEECCCCCHHHHHHHHH
FLLD
HHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8757728; 8969508; 9384377; 1339421 [H]