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The map label for this gene is mprA [H]

Identifier: 159897255

GI number: 159897255

Start: 835397

End: 835756

Strand: Direct

Name: mprA [H]

Synonym: Haur_0726

Alternate gene names: 159897255

Gene position: 835397-835756 (Clockwise)

Preceding gene: 159897254

Following gene: 159897256

Centisome position: 13.16

GC content: 46.67

Gene sequence:

>360_bases
ATGAGTGAACGCATCTTAGTTGTTGACGATAGCAAACTGGTTACCGATATTGTCAAAATGCGGCTGGAAATGTATGGCTA
TGCTGTCGATTTGGCCTACAGCGGCGAGGAAGCGCTGCAAAAAATCGGCGATCTCACGCCTGATTTGGTGGTGTTGGATG
TGCAGATGCCTGGAATTGATGGCTATGAGGTTTGCCGTCAGTTACGCGCCAATCCCTTGTTTGAAGAGCTGCCAATTATC
ATGCTAACTTCGATGGATGATAAACGGGCTGGCTTTGAAGCTGGGGTTGACGATTATCTCAACAAAGATCTTGATTTGCT
CGATTTGCCCAATCGGGTCAAACTGTTGTTGGGTATGTAA

Upstream 100 bases:

>100_bases
AGTTTGATCAAAGCAACTTGCTCGAAACGATTCATCAATTACTTGGCCGCTAAAATAGCGCAGCCCTGAAGGCCTATATT
CCCCTGCGAGGAGTTTTTCA

Downstream 100 bases:

>100_bases
TGATGACAGGGCCGCTTGCACCAATTCGAGTGTTAGTTGTCGATGATTCGGCGGTTTCGCGCCGAGTCATCAGCACTATT
TTAGCCAGTGATCCCGCGAT

Product: response regulator receiver protein

Products: NA

Alternate protein names: Mycobacterial persistence regulator A [H]

Number of amino acids: Translated: 119; Mature: 118

Protein sequence:

>119_residues
MSERILVVDDSKLVTDIVKMRLEMYGYAVDLAYSGEEALQKIGDLTPDLVVLDVQMPGIDGYEVCRQLRANPLFEELPII
MLTSMDDKRAGFEAGVDDYLNKDLDLLDLPNRVKLLLGM

Sequences:

>Translated_119_residues
MSERILVVDDSKLVTDIVKMRLEMYGYAVDLAYSGEEALQKIGDLTPDLVVLDVQMPGIDGYEVCRQLRANPLFEELPII
MLTSMDDKRAGFEAGVDDYLNKDLDLLDLPNRVKLLLGM
>Mature_118_residues
SERILVVDDSKLVTDIVKMRLEMYGYAVDLAYSGEEALQKIGDLTPDLVVLDVQMPGIDGYEVCRQLRANPLFEELPIIM
LTSMDDKRAGFEAGVDDYLNKDLDLLDLPNRVKLLLGM

Specific function: Member of the two-component regulatory system mprB/mprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. Functions as a tr

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1790860, Length=118, Percent_Identity=35.5932203389831, Blast_Score=70, Evalue=3e-14,
Organism=Escherichia coli, GI1786599, Length=120, Percent_Identity=30.8333333333333, Blast_Score=69, Evalue=8e-14,
Organism=Escherichia coli, GI1788394, Length=119, Percent_Identity=33.6134453781513, Blast_Score=67, Evalue=3e-13,
Organism=Escherichia coli, GI1789402, Length=117, Percent_Identity=31.6239316239316, Blast_Score=65, Evalue=1e-12,
Organism=Escherichia coli, GI1787375, Length=117, Percent_Identity=32.4786324786325, Blast_Score=62, Evalue=8e-12,
Organism=Escherichia coli, GI1788550, Length=109, Percent_Identity=31.1926605504587, Blast_Score=61, Evalue=2e-11,
Organism=Escherichia coli, GI1786784, Length=119, Percent_Identity=33.6134453781513, Blast_Score=60, Evalue=3e-11,
Organism=Escherichia coli, GI87082012, Length=117, Percent_Identity=30.7692307692308, Blast_Score=60, Evalue=4e-11,
Organism=Escherichia coli, GI1789809, Length=119, Percent_Identity=33.6134453781513, Blast_Score=59, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 13395; Mature: 13264

Theoretical pI: Translated: 4.03; Mature: 4.03

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
5.9 %Met     (Translated Protein)
6.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
5.1 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSERILVVDDSKLVTDIVKMRLEMYGYAVDLAYSGEEALQKIGDLTPDLVVLDVQMPGID
CCCCEEEEECCHHHHHHHHHHHHHHHEEEEEEECCHHHHHHHHCCCCCEEEEEEECCCCC
GYEVCRQLRANPLFEELPIIMLTSMDDKRAGFEAGVDDYLNKDLDLLDLPNRVKLLLGM
HHHHHHHHHCCCCHHHCCEEEEECCCCCCCCCCCCCHHHHCCCCCEEECCCHHHHEECC
>Mature Secondary Structure 
SERILVVDDSKLVTDIVKMRLEMYGYAVDLAYSGEEALQKIGDLTPDLVVLDVQMPGID
CCCEEEEECCHHHHHHHHHHHHHHHEEEEEEECCHHHHHHHHCCCCCEEEEEEECCCCC
GYEVCRQLRANPLFEELPIIMLTSMDDKRAGFEAGVDDYLNKDLDLLDLPNRVKLLLGM
HHHHHHHHHCCCCHHHCCEEEEECCCCCCCCCCCCCHHHHCCCCCEEECCCHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA