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The map label for this gene is moeA [H]

Identifier: 159896919

GI number: 159896919

Start: 457158

End: 458393

Strand: Direct

Name: moeA [H]

Synonym: Haur_0387

Alternate gene names: 159896919

Gene position: 457158-458393 (Clockwise)

Preceding gene: 159896918

Following gene: 159896920

Centisome position: 7.2

GC content: 52.35

Gene sequence:

>1236_bases
ATGACTCTACTTGCTGTTGCTGATGCTCAAGCGGCGATTCTTGAGCGAATGACCACCCTCGCCAGCGAATCGATCGATCT
AAATGAGGCATTGGGGCGCGTGCTGGCCGCGCCAATGTATGCCGACCGCGATGCACCACCCTTTGCCAATTCGGCCATGG
ATGGCTATGCGGTATTGGTCACTGATTTGAACAATGCCAGTGCTGACAATTCGGTGGCGTTGCAGATTATCGAGCGGGTG
GCGGCGGGCGCTGTGCCGCAACACCAATTGCGGGCTGGTAGCGCGATTCGGATTATGACCGGGGCGCAAGTTCCTGCCAA
TGCCGAGGCAGTTGTGCCATTTGAAGAAACCGATGAAGGCCAAGCCAATGCCCAAACTGAGGTTGTACGCATGTTCCAGC
CAACCCAGCATGGTAATAATATTCGGCCTGCTGGCGAGGATATGCAGGCTGGTAGCTTGGTTTTAGCGGCTGGTCAGATG
TTGAACGCTGGCAGCATTGGGGTTTTGGCAACAATTGGCGCAGCGCAAGTACCAGTTTTTCGCCAACCACGGGTAGCCAT
TATTGCCACTGGCGATGAGTTGGTTGATGTTGGCGTTGAGCCAAAGGCTGGCCAAATTCGTAACTCGAATGGCTATGCTA
ACGCCGCCCAAGTGCGTGAAGCTGGGGCAATTCCAATTATGTTGCCGATTGTGCCCGATAATGCTGATGCCTTGCGAGCA
ACTTTAGCGCAAGCTGTAGCCCAAGTCGATGTATTATTGACTTCTGGCGGTGTATCGGTTGGTGATTACGATTTGGTCAA
GCAAATTTTGAACGAAGTGGGCAAATTAGAATTTTGGCGGGTGCGGATGCGCCCAGGCAAGCCCTTGGCTTTTGGCTCGA
TCAATGGCAAACCAATTTTTGGCTTGCCTGGCAATCCAGTTTCGGCCATGGTTTGTTTTGAGTTATTTGTACGGCCAGCG
TTACGGAAGATCGGCGGATATCAACAATTGCTCCGTCCAAGCGTTTGGGCGAAGTTACTTGATGCCGATTTGGAAAGTAA
CGAGCGTCGCCAATATCTGCGGGTGATCGTTAAAAGCAGCGCCACTGGCTTAACCGCTGAATTAACTGGGGCACAAGGTT
CGGGCTTGGTTAGCTCGATGGCGAGTGCTAATGGTTTATTGATTGTGCCCGAAGCAGGTCATGGCATTAATCGTGGTGCA
ATGGCCGAAGTTGTGTTATTTGGGGAACTGCACTAG

Upstream 100 bases:

>100_bases
GATTACCGAGGTTAAGGCTTTGTTGCCTGTTGGTGGTCGCTAGTTGTTGTGAGGAGTGTGCCATGGATTGGGTTTTGCGA
CCCATCCATGGCCTTTTTTT

Downstream 100 bases:

>100_bases
TTGAGGGAGCGTAGCGCATGCCGTTTGAGTCGTTTCAAGATCTGATAACAATGCTGGTGGTTATTCTCGTGCTCCAAGTG
AGCTTGGCATTGTTGTTAAT

Product: molybdenum cofactor synthesis domain-containing protein

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 411; Mature: 410

Protein sequence:

>411_residues
MTLLAVADAQAAILERMTTLASESIDLNEALGRVLAAPMYADRDAPPFANSAMDGYAVLVTDLNNASADNSVALQIIERV
AAGAVPQHQLRAGSAIRIMTGAQVPANAEAVVPFEETDEGQANAQTEVVRMFQPTQHGNNIRPAGEDMQAGSLVLAAGQM
LNAGSIGVLATIGAAQVPVFRQPRVAIIATGDELVDVGVEPKAGQIRNSNGYANAAQVREAGAIPIMLPIVPDNADALRA
TLAQAVAQVDVLLTSGGVSVGDYDLVKQILNEVGKLEFWRVRMRPGKPLAFGSINGKPIFGLPGNPVSAMVCFELFVRPA
LRKIGGYQQLLRPSVWAKLLDADLESNERRQYLRVIVKSSATGLTAELTGAQGSGLVSSMASANGLLIVPEAGHGINRGA
MAEVVLFGELH

Sequences:

>Translated_411_residues
MTLLAVADAQAAILERMTTLASESIDLNEALGRVLAAPMYADRDAPPFANSAMDGYAVLVTDLNNASADNSVALQIIERV
AAGAVPQHQLRAGSAIRIMTGAQVPANAEAVVPFEETDEGQANAQTEVVRMFQPTQHGNNIRPAGEDMQAGSLVLAAGQM
LNAGSIGVLATIGAAQVPVFRQPRVAIIATGDELVDVGVEPKAGQIRNSNGYANAAQVREAGAIPIMLPIVPDNADALRA
TLAQAVAQVDVLLTSGGVSVGDYDLVKQILNEVGKLEFWRVRMRPGKPLAFGSINGKPIFGLPGNPVSAMVCFELFVRPA
LRKIGGYQQLLRPSVWAKLLDADLESNERRQYLRVIVKSSATGLTAELTGAQGSGLVSSMASANGLLIVPEAGHGINRGA
MAEVVLFGELH
>Mature_410_residues
TLLAVADAQAAILERMTTLASESIDLNEALGRVLAAPMYADRDAPPFANSAMDGYAVLVTDLNNASADNSVALQIIERVA
AGAVPQHQLRAGSAIRIMTGAQVPANAEAVVPFEETDEGQANAQTEVVRMFQPTQHGNNIRPAGEDMQAGSLVLAAGQML
NAGSIGVLATIGAAQVPVFRQPRVAIIATGDELVDVGVEPKAGQIRNSNGYANAAQVREAGAIPIMLPIVPDNADALRAT
LAQAVAQVDVLLTSGGVSVGDYDLVKQILNEVGKLEFWRVRMRPGKPLAFGSINGKPIFGLPGNPVSAMVCFELFVRPAL
RKIGGYQQLLRPSVWAKLLDADLESNERRQYLRVIVKSSATGLTAELTGAQGSGLVSSMASANGLLIVPEAGHGINRGAM
AEVVLFGELH

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=422, Percent_Identity=37.2037914691943, Blast_Score=236, Evalue=4e-62,
Organism=Homo sapiens, GI10880983, Length=422, Percent_Identity=37.2037914691943, Blast_Score=235, Evalue=5e-62,
Organism=Escherichia coli, GI1787049, Length=390, Percent_Identity=37.9487179487179, Blast_Score=230, Evalue=1e-61,
Organism=Caenorhabditis elegans, GI25147659, Length=349, Percent_Identity=32.378223495702, Blast_Score=166, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI17562606, Length=339, Percent_Identity=26.8436578171091, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI17136978, Length=357, Percent_Identity=31.3725490196078, Blast_Score=151, Evalue=9e-37,
Organism=Drosophila melanogaster, GI24638841, Length=357, Percent_Identity=31.3725490196078, Blast_Score=151, Evalue=9e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 43052; Mature: 42921

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: PS01079 MOCF_BIOSYNTHESIS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLLAVADAQAAILERMTTLASESIDLNEALGRVLAAPMYADRDAPPFANSAMDGYAVLV
CEEEEECCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEE
TDLNNASADNSVALQIIERVAAGAVPQHQLRAGSAIRIMTGAQVPANAEAVVPFEETDEG
EECCCCCCCCHHHHHHHHHHHHCCCCHHHHCCCCEEEEEECCCCCCCCEEEECCCCCCCC
QANAQTEVVRMFQPTQHGNNIRPAGEDMQAGSLVLAAGQMLNAGSIGVLATIGAAQVPVF
CCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCEEEEECCCCCCCCC
RQPRVAIIATGDELVDVGVEPKAGQIRNSNGYANAAQVREAGAIPIMLPIVPDNADALRA
CCCCEEEEECCCCEEECCCCCCCCCEECCCCCCCHHHHHHCCCCEEEEEECCCCHHHHHH
TLAQAVAQVDVLLTSGGVSVGDYDLVKQILNEVGKLEFWRVRMRPGKPLAFGSINGKPIF
HHHHHHHHHEEEEECCCCCCCCHHHHHHHHHHHCCEEEEEEEECCCCCEEEECCCCCEEE
GLPGNPVSAMVCFELFVRPALRKIGGYQQLLRPSVWAKLLDADLESNERRQYLRVIVKSS
CCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCC
ATGLTAELTGAQGSGLVSSMASANGLLIVPEAGHGINRGAMAEVVLFGELH
CCCCEEEECCCCCCHHHHHHHCCCCEEEEECCCCCCCCCCCEEEEEEECCC
>Mature Secondary Structure 
TLLAVADAQAAILERMTTLASESIDLNEALGRVLAAPMYADRDAPPFANSAMDGYAVLV
EEEEECCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEE
TDLNNASADNSVALQIIERVAAGAVPQHQLRAGSAIRIMTGAQVPANAEAVVPFEETDEG
EECCCCCCCCHHHHHHHHHHHHCCCCHHHHCCCCEEEEEECCCCCCCCEEEECCCCCCCC
QANAQTEVVRMFQPTQHGNNIRPAGEDMQAGSLVLAAGQMLNAGSIGVLATIGAAQVPVF
CCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCEEEEECCCCCCCCC
RQPRVAIIATGDELVDVGVEPKAGQIRNSNGYANAAQVREAGAIPIMLPIVPDNADALRA
CCCCEEEEECCCCEEECCCCCCCCCEECCCCCCCHHHHHHCCCCEEEEEECCCCHHHHHH
TLAQAVAQVDVLLTSGGVSVGDYDLVKQILNEVGKLEFWRVRMRPGKPLAFGSINGKPIF
HHHHHHHHHEEEEECCCCCCCCHHHHHHHHHHHCCEEEEEEEECCCCCEEEECCCCCEEE
GLPGNPVSAMVCFELFVRPALRKIGGYQQLLRPSVWAKLLDADLESNERRQYLRVIVKSS
CCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCC
ATGLTAELTGAQGSGLVSSMASANGLLIVPEAGHGINRGAMAEVVLFGELH
CCCCEEEECCCCCCHHHHHHHCCCCEEEEECCCCCCCCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8682795; 11759840 [H]