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The map label for this gene is fadR [H]

Identifier: 159896889

GI number: 159896889

Start: 426820

End: 427527

Strand: Direct

Name: fadR [H]

Synonym: Haur_0357

Alternate gene names: 159896889

Gene position: 426820-427527 (Clockwise)

Preceding gene: 159896888

Following gene: 159896890

Centisome position: 6.73

GC content: 51.41

Gene sequence:

>708_bases
ATGAGCGAATTACAACGACCAGCATCGTATTGCGAACAACAATTGATCAAACGAATTATTGGTGGTAGTTATGCCGCAGG
TAGCAGCCTGCCCAGCGAACGTGAGCTAGCAGTCCAGTTGGGAGTCACGCGGCCAACCCTGCGCGAAGCGATTCAACGCT
TGGCTCGCGATGGCTGGCTTGTCGTGCAACAAGGCAAGCCGACAATGGTTTGCAATATTTGGCATGATGGCGGCTTGGGC
GTATTGCGCAGTTTGGTGCAATATAGCACTGAGCTGCCAGCCCAAATTGTGCCGCAACTACTAGCGGTGCGCCTCGATTT
AGCGCCAAGTTACACCGCCATGGCGATCGAACATCACGCCGAAGCGATTGCGGCCTTATTACAAACCGCCCTGCCATTGG
CTGATAACGCGGCGGCCTACGCTCAATTCGATTGGCAATTACAGCATCAATTAACGATCGCTTCGACAAACCCAATTTAT
ACCTTGATTTTAAATGGCTTTCGTGGCTTCTACCAAATGATGGCCTTGGATTATTTTGAGCTAGCGCAGGCCCGCGAACA
TTCGGCGGCCTTTTATCGCACCCTGTTACAAGCTGCCCAAACTCGCGATGCCGATTTAGCTCGCCAAGCCAGCCAATTCG
CCATGCAGCAGAGCATCGAAGTTTGGCAATTGTTAGCCGCGAATATCAATAATACACAAAGGGGATAA

Upstream 100 bases:

>100_bases
AGGCTTATAAATAGATGTCGATAACAGCGCTTAAATTGCTTGACATAGCCTCAAGATTTCTTTATACTCGACTGGTAAGT
GGTCTGACCAGTTGGTGAAT

Downstream 100 bases:

>100_bases
TATGCGCCGTTGGAATGGTTGGGGCGACGAGAGCAAAGAGTATCCGGTTAAAGCCGGCATTTTAGGCTTGCTCAAGCAAT
TAATTGGTGCTGGCACGGCT

Product: regulatory protein GntR HTH

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 235; Mature: 234

Protein sequence:

>235_residues
MSELQRPASYCEQQLIKRIIGGSYAAGSSLPSERELAVQLGVTRPTLREAIQRLARDGWLVVQQGKPTMVCNIWHDGGLG
VLRSLVQYSTELPAQIVPQLLAVRLDLAPSYTAMAIEHHAEAIAALLQTALPLADNAAAYAQFDWQLQHQLTIASTNPIY
TLILNGFRGFYQMMALDYFELAQAREHSAAFYRTLLQAAQTRDADLARQASQFAMQQSIEVWQLLAANINNTQRG

Sequences:

>Translated_235_residues
MSELQRPASYCEQQLIKRIIGGSYAAGSSLPSERELAVQLGVTRPTLREAIQRLARDGWLVVQQGKPTMVCNIWHDGGLG
VLRSLVQYSTELPAQIVPQLLAVRLDLAPSYTAMAIEHHAEAIAALLQTALPLADNAAAYAQFDWQLQHQLTIASTNPIY
TLILNGFRGFYQMMALDYFELAQAREHSAAFYRTLLQAAQTRDADLARQASQFAMQQSIEVWQLLAANINNTQRG
>Mature_234_residues
SELQRPASYCEQQLIKRIIGGSYAAGSSLPSERELAVQLGVTRPTLREAIQRLARDGWLVVQQGKPTMVCNIWHDGGLGV
LRSLVQYSTELPAQIVPQLLAVRLDLAPSYTAMAIEHHAEAIAALLQTALPLADNAAAYAQFDWQLQHQLTIASTNPIYT
LILNGFRGFYQMMALDYFELAQAREHSAAFYRTLLQAAQTRDADLARQASQFAMQQSIEVWQLLAANINNTQRG

Specific function: Multifunctional regulator of fatty acid metabolism [H]

COG id: COG2186

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787436, Length=225, Percent_Identity=37.7777777777778, Blast_Score=167, Evalue=6e-43,
Organism=Escherichia coli, GI1789621, Length=243, Percent_Identity=25.1028806584362, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014178
- InterPro:   IPR008920
- InterPro:   IPR000524
- InterPro:   IPR011991 [H]

Pfam domain/function: PF07840 FadR_C; PF00392 GntR [H]

EC number: NA

Molecular weight: Translated: 26098; Mature: 25967

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSELQRPASYCEQQLIKRIIGGSYAAGSSLPSERELAVQLGVTRPTLREAIQRLARDGWL
CCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHCCCEE
VVQQGKPTMVCNIWHDGGLGVLRSLVQYSTELPAQIVPQLLAVRLDLAPSYTAMAIEHHA
EEECCCCEEEEEEEECCCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHH
EAIAALLQTALPLADNAAAYAQFDWQLQHQLTIASTNPIYTLILNGFRGFYQMMALDYFE
HHHHHHHHHHCCCCCCCHHHHHCCEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
LAQAREHSAAFYRTLLQAAQTRDADLARQASQFAMQQSIEVWQLLAANINNTQRG
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SELQRPASYCEQQLIKRIIGGSYAAGSSLPSERELAVQLGVTRPTLREAIQRLARDGWL
CHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHCCCEE
VVQQGKPTMVCNIWHDGGLGVLRSLVQYSTELPAQIVPQLLAVRLDLAPSYTAMAIEHHA
EEECCCCEEEEEEEECCCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHH
EAIAALLQTALPLADNAAAYAQFDWQLQHQLTIASTNPIYTLILNGFRGFYQMMALDYFE
HHHHHHHHHHCCCCCCCHHHHHCCEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
LAQAREHSAAFYRTLLQAAQTRDADLARQASQFAMQQSIEVWQLLAANINNTQRG
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA; DNA [C]

Specific reaction: Activates transcription of at least two genes required for unsaturated fatty acid biosynthesis; activates the iclR gene encoding the transcription regulator of the aceBAKoperon which in turn encodes the glyoxylate shunt enzymes Protein + DNA = Protein-DN

General reaction: NA

Inhibitor: Fatty acyl CoA compounds [C]

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA